Homebrewing phenylhydrazine
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- Опубліковано 12 вер 2023
- A literal textbook example of diazotisation, based on a method from 1922. Not just useful, but visually spectacular as well.
Based on Org. Syn. 2 (1922), 71, DOI 10.15227/orgsyn.002.0071 and US Patent 3,203,989. - Наука та технологія
Orange impurity is probably 4-aminoazobenzene, also known as aniline yellow. Can be formed when unreacted aniline reacts with the diazonium salt.
yeah, that makes sense
Great...kindly do a video on melatonin synthesis
funnily enough, that is actually one of my long-term plans
Very nice narration. The deadpan humor is much appreciated.
I'm always happy when i find a new chem channel
Me too
Fantastic video. Looking forward to future syntheses!
best regards from Poland! happy to see you use our reagents XD
I must say you have a great voice for narrating, very calming :)
thank you very much!
amateur chemistry here would be much harder without certain Polish firms - besides organic solvents and sodium nitrite, I also use a Polish parcel forwarding service, with a warehouse in Germany, to get more exotic reagents shipped over the water from suppliers who don't ship their goods outside the mainland EU (or to Greece, Sweden or Finland for that matter)
niech żyje Polska!
@@yorkshirechemist Niech żyje!
I will wait for your future videos then!
Appreciate the video.
Ohhh, a new chem channel. Excellent! Lovely accent by the way. :)
in all honesty I can't claim credit for it, ah wor born wi'it in me ears
Interesting. Thanks. Liked the aproach.
Thanks for sharing 👍
Very cool! This is very interesting chemistry!
Interesting stuff. I wonder if you would consider doing a synthesis of phenelzine, the hydrazine antidepressant. I imagine it would be quite different, but I don't really know the synthesis for it at all.
Also I should note I love your presentation style. Very information dense but still easy to follow, compared to most other chemistry youtubers that I've watched.
thank you very much!
phenelzine is an aliphatic hydrazine (phenylhydrazine is aromatic), and is prepared by substitution of phenethyl chloride with hydrazine itself, so the synthesis takes a very different route
with regards to presentation, I record a voiceover from a script and edit the footage to fit the script; a UA-camr who takes a very similar approach is Jago Hazzard, who makes 5-10 minute videos about certain aspects and features of the London Underground, and makes them absolutely fascinating, even for people like me who haven't set foot in London for 20+ years and have no intention of going there unless it's absolutely unavoidable
Good video 😊
I'll definitely be trying this one
Awesome videoooo. Im waiting for more syntheses :D
Very nice video. I'm planning on making phenylhydrazine too, but I'm not sure which reductant I will use maybe I'll test both procedures and see what works best.
thank you, glad you liked it!
Bro holy moly you sound exactly like Jim Browning…
Great video! Subbed.
That’s great,
But
What are you doing up at this ungodly hour?!
What kind of pump do you use as vacuum source? In my days I used a refrigeration compressor, they have a low flow rate but can pull a decent vacuum, ~50 mmHg easily. When you put a fan on it you can even do lengthy vacuum distillations with it. And they're basically free (dumpster diving).
Ez sub. Keep up the great videos!
Now THIS would be fun tobsee complexed with a transition metal, like nickel or iron or even zinc!
The best thing about your videos are the little experimental tips like mentioning the reaction is getting too hot when you see nitrogen being released. Knowing this would have saved me much pain with failrd diazotisaztion reactions. Could this reaction be done at dry ice and acetone temps for those of us less patient, or is there a minimum temperature for this?
the minimum temperature is the the freezing point of water - you could try running the reaction in the solid state, but expect disappointment
sensitivity to temperature varies enormously by the nature of the molecule; generally speaking, the less stable the carbocation resulting from nitrogen loss, the more irreversible the reaction becomes, and the more sensitive it is
Subscribed! :-) well made.
Great video! Very thorough. Wouldn't it work if you added the aniline to a solution of nitrite instead?
it probably would, but the procedure I followed said to do it this way round
when I get some spare time I'll have a crack at doing it the other way
@@yorkshirechemist That would be awesome, thank you.
Keep up the good work, you will blow up even more mate!
As a fellow British person, I ask you sincerely,
HOW DO YOU GET ALL THOSE CHEMICALS?!?!
APC Pure and HD Chemicals sell the most readily available ones, the more exotic ones come from N2O3 (in Poland) or Laboratorium Discounter (in the Netherlands, via a Polish parcel forwarding service with physical premises in Germany; as it stands, LD don't ship outside the EU)
Techmate are also a UK distributor for Carl Roth lab-grade chemicals that sells to individuals, but they cost an arm and a leg so they're strictly a last resort
And….
Theres a minor complication
Im kinda, 13…
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Hmm.. why would you need that, I wonder.
Lots of things are made by amateur chemists with no real purpose besides to do it. If he were making DMT it would be much cheaper and easier to extract it from the appropriate plant source.
@@chemistryofquestionablequa6252it would probably be easier to synthesize it from Tryptophan