The fibrin formation is just a soft clot formation. The end stage of blood coagulation is the formation of a stable clot the crosslinks fibrin. Factor XIII, a transglutaminase, comes in to crosslink fibrin that contains reactive glutamine and lysine to form isopeptide bond which is now a stable a mature clot.
I'm a physiology lecturer, after much studies I still do come to your channel to watch and listen to your videos and it makes my work so easy when explaining to my students, this has made me super and massively loved by my students because of you. It's been a blessing following you Dr.Mike . God blesses You .
I cannot thank you enough for saving my life from giving up on my 3 bio subjects. You made them so much easier to get into my head. Thank you Dr Mike!!!
I wish I could give you a zillion dollars because we need more people in this world teaching us at a level we can all recognize and appreciate. The beauty of these videos is that I can re watch them over and over until the information sticks and I don’t have to feel stupid or embarrassed because something doesn’t make sense.
You explained this so well. Thank you. I wish you were my professor but this is covid so I don't know if my professor could've made this or any subject interesting. I need this energy.
Thanks Dr. Mike for this video, I am struggling with understanding of coagulant process, I will be very thankful, if you can upload coagulation cascade video, please. Thanks
I am currently doing my 2nd year medical internship (South African), I am just reading preparing for my part 1 which I plan to write next year. Very helpful video. Thank you.
All I can say is YOU are an amazing MAN and HUMAN. Your videos saved my life so many times. In these times of Covid and increased anxiety, your way of teaching...Understanding our challenges and creating videos that meet those needs! You are the best at what you do! No video explains the difference between vasoconstriction in the smooth muscles v vasodilation of the blood vessel in general
I have a question regarding coagulation cascade. How do intrinsic and extrinsic pathways occur simultaneously? Or is it like this that intrinsic only occurs when there's blood trauma and extrinsic occurs only when there's damage to vessel wall? When stimulus is different then how can they occur simultaneously?
I was made to feel stupid by my father. I said "based on what I've studied; while small to moderate amounts of alcohol thin the blood, large amounts increase platelets and therefore more fibrinogen which causes coagulation". Dad said I was wrong and got angry/nasty XD I used salt as an example I.E in small amounts it retains fluid, in large amounts it dehydrates you. and he was like "bullshit" Guess school and biology books are/were a waste of time. Wish I could have someone confirm what I suggested.
First of all Thank you so much. This is an amazing video. In less time you had explained a important concept thoroughly. Feeling curious to learn more from you .
wow, mate, gotta hand it to you I came here for hemostasis and I needed to learn about prothrombin but I wasn't expecting to get such a great overview. thanks for the vid mate you are saving the lives of people and students lol cheers.
0:45 Wouldn’t vasoconstriction also increase the velocity of the fluid which would also increase the number of platelets going by leading to a higher rate of aggregation? 4:30 Spike proteins that attach to ACE-2 receptors on cell membranes. Since spike proteins produced by mRNA vaccines are not covered by sugar, I assume there are more active sites on the spike proteins which your immune system will generate antigens for. Wouldn’t this create a thrombus-like growth composed of spike proteins and antigens? If so, wouldn’t blood flow create increase stress upon endothelial cells which could tear the membrane resulting in conventional thrombosis on top of the spike protein/antigen pseudo-“thrombosis”? Also, basic fluid dynamics would predict a higher velocity of plasma through smaller blood vessels creating higher stresses on endothelium cells. This would contribute to endothelial damage triggering conventional thrombosis.
This made more sense than the 50 minute lecture I endured. Sometimes the basics and illustrations are the best way to lay foundations down. We just never get any foundations! 50 minutes of panic and existential crises...
Thank you so much for your video. I have looked at many videos trying to explain and illustrate the coagulation process and none of them helped. Your video is very clear and easy to follow. Finally I understand the process without making it super complicated.
Teachers now a days don’t take the time to illustrate what’s going on. Only powerpoints. I love this channel ❤️❤️❤️❤️
RIGHT!!!! 😑
Seriously his videos are wonderful
Literally. They get paid 80,000-150,000 a year and don’t even teach 🤦🏼♀️
Iove leaning online@@lcdp9459
Exactly
I was taught this in three months but did not get a good view. you made it simple in 5 minutes. Many thanks
Explained in a really simple and quick way
Your impact and inspiration is top notch... Thank you so much for saving my day!
You are a great teacher thank you so much love from Egypt
Same من مصر بردو 😂😂
@@roaaahmed5884 ✌️❤️😂
♥😂😦عاش
انتو ف كليه اي
@@asmaabakr3119 طب بشري وانت ؟
excellent video dr matt/dr mike. i will always remember you
The fibrin formation is just a soft clot formation. The end stage of blood coagulation is the formation of a stable clot the crosslinks fibrin. Factor XIII, a transglutaminase, comes in to crosslink fibrin that contains reactive glutamine and lysine to form isopeptide bond which is now a stable a mature clot.
Thanks Dr for this informational ❤️❤️
Wow ..superb explanation..Thanks a lot ..
This dude can draw!
I wish my professor would explain as well as you do
Thank you dr ♥️♥️♥️
Thanks!
Am going to be better in biology 😊 🙏🏻
What is the difference between extrinsic and intrinsic pathway?
Do you have video on bleeding disorders
Hi,doc.I have a one question.After the sell do mitosis and fill the hole, what happens to fibrin(protein string)
Thank you 💙💙
Thanks man!
thank you! do you have a video on the coagulation cascade?
🐐
🏆🏆🏆
10 slides of lecture explained in less than 5mins. Thank you Dr. Mike!
I'm a physiology lecturer, after much studies I still do come to your channel to watch and listen to your videos and it makes my work so easy when explaining to my students, this has made me super and massively loved by my students because of you. It's been a blessing following you Dr.Mike . God blesses You .
I cannot thank you enough for saving my life from giving up on my 3 bio subjects. You made them so much easier to get into my head. Thank you Dr Mike!!!
Took you 4 minutes to explain what my professor tried to explain in 2 hours. THANK YOU!!!
I wish I could give you a zillion dollars because we need more people in this world teaching us at a level we can all recognize and appreciate. The beauty of these videos is that I can re watch them over and over until the information sticks and I don’t have to feel stupid or embarrassed because something doesn’t make sense.
You explained this so well. Thank you. I wish you were my professor but this is covid so I don't know if my professor could've made this or any subject interesting. I need this energy.
THE BEST!!! I usually don't write in the comments for social media, but this is a must. This is the best explanation! Thank you a million!
Nice information...This herb is formulated from various herbs that provide a calming effect on whole of the body.
Thanks Dr. Mike for this video, I am struggling with understanding of coagulant process, I will be very thankful, if you can upload coagulation cascade video, please. Thanks
You deserve millions of subscriber! You save my day Everytime I attemp to cry when I open Guyton
I am currently doing my 2nd year medical internship (South African), I am just reading preparing for my part 1 which I plan to write next year. Very helpful video. Thank you.
my absolute favourite Dr better than lecturers I pay 9K a year for
Thank you so much dear Dr . great explained .
Thank you Dr mike💖💖💖
All I can say is YOU are an amazing MAN and HUMAN. Your videos saved my life so many times. In these times of Covid and increased anxiety, your way of teaching...Understanding our challenges and creating videos that meet those needs! You are the best at what you do! No video explains the difference between vasoconstriction in the smooth muscles v vasodilation of the blood vessel in general
I have a question regarding coagulation cascade.
How do intrinsic and extrinsic pathways occur simultaneously?
Or is it like this that intrinsic only occurs when there's blood trauma and extrinsic occurs only when there's damage to vessel wall?
When stimulus is different then how can they occur simultaneously?
Did they answered your question about intrinsic and extrinsic?
@@salvadorgutierrez4080 nope. Not yet
I was made to feel stupid by my father.
I said "based on what I've studied; while small to moderate amounts of alcohol thin the blood, large amounts increase platelets and therefore more fibrinogen which causes coagulation".
Dad said I was wrong and got angry/nasty XD
I used salt as an example I.E in small amounts it retains fluid, in large amounts it dehydrates you.
and he was like "bullshit"
Guess school and biology books are/were a waste of time.
Wish I could have someone confirm what I suggested.
10 slides just explained in 5 minutes ❤ .
MUCH APPRECIATED ❤
First of all
Thank you so much.
This is an amazing video. In less time you had explained a important concept thoroughly. Feeling curious to learn more from you .
Thanks!
My notes mention that calcium is important for this process. Can you highlight where that would be important and also explain why?
.....Nobody explained the thing WHY THIS ?
But ur video....is exceptional.
I'm lookin for more forward.
Are two mildly "leaking valves" enough to cause a floating thrombus in the right atrium? And cause it to have possible moved BACKWARDS into the IVC?!
A beautiful video and the explaning so nice thank you very much 💙
Hmm I cannot confirm or deny whether prothrombin activator is released by trombocytes?
im a student from sri lanka and damn the lesson went through all my brain cells wow, thank you so much
you are the bbbeeeessstttttttt!!!!!!
From now I don't have to feel stupid and embarrassed because something doesn't make sense 😢❤
Good video but it's pronounced 'fī′brĭn' not 'fibrĭn'. Long 'i' sound because fibrin is fibrous.
Is this the same as von willebrand disease INCLUDING factor 8
I wish every time I watch your video it would just automatically like itself.
Such a terrific explanation, A billion thanks😃🌌
Prothrombin activator is called Thrombokinase ...it is better to mention its name for more marks
Thank you very much, I'm Iranian,your teach very good
Thank you Doctor. Keep making helpful videos like these, they help me so much!!!!!!!!
THANK YOU FOR MAKING THIS SO UNDERSTANDABLE! OMG! Now, for the rest of the coagulation cascade...
Thank you for making it simple to understand...
Best explain
Thank you from a Factor V Leiden person with current DVT from knee replacement surgery. You're an amazing teacher.
Why does he blip into existence at the start lol
Thanks you for helping me in 4m only 🌹🌹
Thank u sir ..I got to khow a very good teacher for my anatomy..
wow, mate, gotta hand it to you I came here for hemostasis and I needed to learn about prothrombin but I wasn't expecting to get such a great overview. thanks for the vid mate you are saving the lives of people and students lol cheers.
0:45 Wouldn’t vasoconstriction also increase the velocity of the fluid which would also increase the number of platelets going by leading to a higher rate of aggregation?
4:30 Spike proteins that attach to ACE-2 receptors on cell membranes. Since spike proteins produced by mRNA vaccines are not covered by sugar, I assume there are more active sites on the spike proteins which your immune system will generate antigens for.
Wouldn’t this create a thrombus-like growth composed of spike proteins and antigens?
If so, wouldn’t blood flow create increase stress upon endothelial cells which could tear the membrane resulting in conventional thrombosis on top of the spike protein/antigen pseudo-“thrombosis”?
Also, basic fluid dynamics would predict a higher velocity of plasma through smaller blood vessels creating higher stresses on endothelium cells. This would contribute to endothelial damage triggering conventional thrombosis.
Thank you for explaining this so well!!!
Why can’t my teacher explain it like this ?:/
I got an A in API because of this man and here I am again for AP II
Dr. Mike with the fresh shirt and the fire lectures!
But why happened heart attack after clothing
You're amazing love from Namibia ❤❤❤
Also please make videos on immunology series.
excellent presentation Dr. Mike!!
Thanks Dr.Mike. Your videos are always AMAZING!
This made more sense than the 50 minute lecture I endured. Sometimes the basics and illustrations are the best way to lay foundations down. We just never get any foundations! 50 minutes of panic and existential crises...
Amazing! Thank u Dr
Great and simple explanation! Perfect for revision, thank you!
excellent!! Thank you
The illustration is helping soooo much we need wayyyy more of this. Especially us visual learners🙌🏽 awesome lesson teacher 👍🏽
Thank you so much for your video. I have looked at many videos trying to explain and illustrate the coagulation process and none of them helped. Your video is very clear and easy to follow. Finally I understand the process without making it super complicated.
Sir naku kalinadhi neck chootu blood clotting hyenadhi normal skin vachutaku
Dr Mike you are a life saver ❤️
He was not there in the first frame😂
Tyyy
Thank you soo much!!!
TYSM
Is this the clotting casade?
Thanks so much 🙏❤Dr
very clear and understandable DR MIKE
Well explained thank yu
thank you thank you thank youuuu
❤❤❤ amazing thanks Dr❤❤❤❤❤❤❤❤❤❤
They should make w heat pad tp wrap around the damaged area to try and burn the clot out
beyond 40° C. ... the blood does not coagulate at all
Amazing videos and explenation keep going 🤩
Fabulous explanation of a difficult concept. Keep up the great work!
Thanks a lot Sir for making hemostasis simple
wonderful
provide some slides
can u plz upload wound healing lecture?