Low-Carbohydrate vs. Carbohydrate Quality: What Really Improves Metabolic Health? | The Proof EP
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- Опубліковано 22 гру 2024
- Is going low-carbohydrate the best way to lose weight and improve metabolic health? In this clip, experts discuss why total carbohydrate restriction isn't always necessary and how carbohydrate quality might matter more. Learn why sustainable strategies often involve moderate carbohydrate, fiber, exercise, and healthy fats - and why extreme low-carbohydrate diets might not be the solution for everyone.
#LowCarbohydrate, #MetabolicHealth, #WeightLossTips, #DietQuality,
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Eating 16:8 made maintaining a 21 BMI very easy for me. Lowering my carbohydrate intake to under 20% of my calories got me very lean. I also notice a feeling of being extremely full when I eat any refined/processed carbohydrates.
I have been 18:6 for 2 years with low carb (around 50g/day). I cycle between glycolysis and ketosis (~2mmol/L) daily and all my metabolic labs are very good (light years better than when I was high carb).
My BMI is 17.8 and it is trivial for me to maintain that. I am actually trying to move that up with resistance training to build muscle.
They are suggesting 40-60 percent carbohydrates. Joel Fuhrman suggests 50-70 but with more emphasis on not consuming too much energy in total, so the absolute amounts of carbohydrate are probably pretty similar to each other.
Recently went back to low carb (not keto) due to migraines seemingly being triggered by consuming them. There is a noticeable positive difference so far. Low carb has its use cases for certain.
Did you try moderate carb intake but with different types? Like more veggies, legumes etc. instead of rice and pasta?
N=1
@@bigpicturegains seasonal eating regulates everything. Fasting here and there cures most the issues people feel from “too many carbs”
I've maintained a ketogenic lifestyle for 15 years. Reversed 10+ years of T2D, hypertension, IBS-D, dyslipidemia, obesity, and sleep apnea. For me eliminating the frequent episodic diarrhea is the primary reason why I find it sustainable.
N=1
I love being in keto state mentally ..but my sleep quality suffers on keto despite magnesium /electrolytes etc ..why do you think that is ? Thanks
Great. I think it is pretty individual with IBS what you can and can not eat. My grandma has issues with some fruit and nuts, certain saturated fats, fatty meat. Oats, seeds and wheat is great. I'm curious. Reverse dyslipedemia? For most people on keto, LDL-C increases beyond the normal level. Would be interesting if there is a way to avoid that. The other effects are probably a result of weight loss.
@@jeffj318 for that individual N=1 science is the most impactful.
@@EcomDetectiveprobably stress related as ketosis is after all a state of stress, better to switch in and out of it to stay metabolic flexible once your problems are fixed by therapeutic ketosis
Exercise science & dpt student here. They said that it is an adherence problem around the 2:00 minute mark. End of discussion. Anything further about how a low-carb diet doesn't work is the same as saying that exercise doesn't help fitness because people fail to adhere. Nonsense. Nobody reasonably thinks that exercise is a problem just because of adherence issues. All it means, and this is clear in the literature, that both personal factors and environmental factors directly affect outcomes such as adherence - be it behaviors related to diet, physical activity, or otherwise.
Claims of what's sustainable as made by this lady are purely subjective, and I would suggest biased on her part. As for nutrients, there are no essential nutrients that must be obtained from plant sources. In fact, the overwhelming majority of plant sources include absorption inhibitors which is what necessitates a variety of plant foods to secure a complete nutrient profile that can be absorbed by humans. Animal products do not have this issue. This isn't even a question or a debate - it's already proven.
Dietary patterns and physical activity patterns are the two primary components of health outcomes, and physical activity levels alone can significantly improve health outcomes and to a large extent compensate for poor dietary patterns. If anything, you can assess physical activity levels by themselves, but under no circumstances can you assess a dietary pattern without considering activity levels. This is because a high amount of low-intensity aerobic activity improves fat metabolism, and high amounts of high-intensity anaerobic activity and/or muscular strength training activity improves so-called carbohydrate metabolism (basically you used a ton of glycogen and therefore have an appropriate usage for consuming it). Therefore, once again, you cannot assess a dietary pattern without taking into account the physical activity pattern.
Even in the case of high activity levels, you can have around 400 grams of glycogen store in the body. That's 4 calories per gram resulting in 1600 calories worth of energy. Do you know how much work you need to do to use all of that? And you're not going to be using exclusively muscle glycogen during even the most intense workouts because the body will continue to use respiration for fat metabolism, it just cannot rely solely on that once your intensity reaches a certain point. Gluconeogenesis from fat storage is perfectly capable of replenishing muscle glycogen stores over the course of a day. Outside extreme sports or wartime efforts, you wouldn't even need to consume carbohydrates for the purpose of replenishing muscle glycogen stores in a reasonable rate over a given day.
Now, there are certainly use cases for carbs in the diet, but for the average person seeking to simply be healthy and fit, then there is absolutely nothing wrong with excluding carbs from the diet. It's not something that should be viewed as extreme or a fad or whatever. It's simply a dietary pattern that works, and the same can be said of a dietary pattern that does include carbohydrates. You simply have to adjust the overall profile of the person both in diet and physical activity.
I find that reasoning strange, as it is not an adherence problem that the different diet patterns work to the same degree. They both achieve weight loss and glucose control to the same degree, as shown in different studies where there was no issue with adherance. (see mediterranean vs keto on glucose control). Newer studies about diabetes type 2 reversal show that the main driver of that is weight loss, as it even is acchieved by weight loss surgery.
Low carb diets do have disadvantages, looking at cardiovascular risk factors and all case mortality. There are risks of nutrient deficiency, especially as keto diets cause mineral and water loss. Keto is a medical diet developed to treat epilepsy. You will find more info in those studies on what nutrients you might become low on/ you need to watch. People are advocating online for low carb diets as the cure it all, even claiming it would cure cancer while at the same time call carbohydrates poison. That's why peole call it a fad diet, not because it is not usefull at all.
The part about needing to exercise a lot with high carb is also not true. It's simple CICO. If you eat more then you use, it gets stored as fat. De novo lipogenisis does only happen at a low rate. It is mostly the fat getting stored and the glucose used right away. So macro composition does not matter.
You can induce fatty liver and insulin with a high saturated fat diet as well as with a high carb diet in mice, if it is hypercaloric.
I think there always should be a risk-benefit consideration.
Animal products are low on several nutrients - including vitamin C. A healthy diet is not about just surviving, but actually about maintaining optimal body function. Micronutrients are important for that. If you are referring to antinutrients, look at their actual doses. And in some cases - e.g. high stress - heme iron uptake is blocked, making plant iron combined with vitamin C far more bioavailable then animal sourced. It has been shown fiber reduces all cause mortality in a dose dependent way. It is the main way to get short chain fatty acids via fermentation providing the enterocytes with energy. Other primates can do that to a higher degree. We lack some gut bacteria they still have.
@@stellasternchen I don't really feel like responding because you either misunderstood me or are deliberately misrepresenting some of my points. I mean, the lady straight up admitted it verbatim that it is an adherence problem. Are you just not paying attention or willfully ignoring it?
Low carb isn't a cure-all, but there are no more risks associated with it than a typical diet. It's arguably easier to maintain without nutrient deficiency because of the lack of nutrient competitor antagonists that accompany plant sources.
I did not say you need to exercise more with high carb, but that you make better use of carbs in your diet when you do engage in more and higher-intensity exercise. That's not a question up for debate either. The science on the physiological ability to efficiently use consumed carbs is crystal clear that it improves in people that engage in high-intensity exercise regularly. I said nothing about weight loss or diabetes and CICO in this context. That's you making a strawman argument that I didn't even mention.
Animal products have less vitamin C, but that's perfectly fine because you need much less of it when you eliminate competitor agonists from the diet equation. You seem to understand the difference between heme and non-heme iron and how you only need vitamin C to absorb non-heme (plant-based) iron sources. Then you setup a favorable hypothetical about stress affecting absorption. Well, sure, but that's a pathetic and unfair metric to use because stress throws all kinds of physiological processes off. You cannot make a good faith argument based on that alone to justify a non-heme iron source or to claim that animal products are less capable. That's pure bias and a bad faith argument.
As for fiber, those are metrics based on a bad assumption about fiber being necessary to a dietary pattern. You can find just as many studies demonstrating it is completely unnecessary, especially in a low/zero-fiber diet pattern like low-carb or carnivore. Other primates can do it to a higher degree because they have a significantly different digestive tract than humans. It's silly that you even made the comparison for this.
So, yeah, disagree if you want, but at least make reasonable points. So far, you've done nothing but misrepresent my points, make strawman arguments, and otherwise make poorly crafted arguments. I don't really care what a person does, but don't pretend like these nuances do not exist.
@@someguyusa
I disagree with the lady in the video based on studies I've read. I wrote that in my comment. Maybe you misunderstood?
There are countles studies showing the side effects of keto. It is a medical treatment, so there have been clinical trials. I'm not going over all of them in detail now. i don't know why you try to deny that. There are also countless studies showing LDL-C and apo B increase with people on that diet.
The exercise part was refering to something this lady claimed in the video you mentioned being wrong. I agree with you on that it is nonsense. I don't get why you think I was arguing against.
Have you ever checked your sources? Or read about anti nutrients, their concentrations, how large their impact is? Have you considered what nutrients are in animal products? How much you need of them? Have you looked at the nutrient loss in minerals due to keto? Inform yourself instead of repeating the stuff influencers say. Look at data yourself.
Have you looked at where the claim comes from that you would need less vitamin C on a low carb or even carnivore diet? It's not based on any data. It is a hypothesis of one of the carnivore doctors, who looked up a mechanism how this could happen in theory. You can find a mechanism for anything you want. Sources are crucial. People on the internet like to lie to you to sell you stuff.
No, the argument about iron I made is not unfair, but has real concequences for women. Hepdicin blocks heme-iron absorption. It is elevated in stress, before and during womes period, during infection and inflammation. Eating more iron rich before the period decreases PMS and period side effects. But only if the iron comes from plant foods. There are studies on this. Both animal and plant sources of iron are important.
I don't know where you think I wrote that fiber is necessary for survival. I clearly pointed out that just surviving is not the same as functioning optimally. Humans are robust and can survive on almost anything for a period of time. We evolved to be flexible.
I wrote that fiber lowers all case mortality in a dose dependent manner, eg. prolongs your life the more you have in your diet. Or the other way arround, less fiber in your diet increases your risk of death from all causes.
I'm not talking about different other animals, I'm talking about great apes. Their digestive tract is very close to ours with the same pouches used for fermentation called haustra that we have.
I see, you are part of the carnivore bubble, that mistrusts science in general, calls everything a big conspiracy of big food and big pharma. It surprises me as you seem to want to choose a career in the medical field based on evidence based treatment. I've given up discussing with people that see personal anecdotes as evidence superior to peer reviewed studies.
You do not seem like somebody that would fit that description to me. And I don't get why you get so offended when I criticize the way diets are promoted by influencers and the misinformation spread by them and not you personally.
Basically, you're saying we should moderately restrict cards, but eat soluble fibre to slow down absorption and do exercise to burn them off - doesn't make carbs sound very healthy, does it?
Indeed tried low carb but realize just need low Refined carbs, have as much complex carbs especially in fruits and veg. That’s it
A lot of discussions on low carb online can be very scientific evidence based,but they don't take into account the human factor and psychology. Initial greater weight loss on keto motivates people more to keep on track and continue the program while somewhat alleviating adherence problems. Unfortunately keto is most often than not done in a way that harms heart health. Speaking from personal experience losing roughly 30% of body weight on keto/carnivore plus IF/PF/OMAD. Unfortunately regained all and now try to lose it again with a healthy low-ish carb, plant predominant heart healthy diet.
Demonizing carbs has been the goofiest trend
How about the demonizing of red meat. Even calling it a “trend” is so ridiculous considering how humans evolved eating mostly meat with a very few seasonal herbs, spices, vegetables or fruits where available.
@ that’s completely false, most humans ate over 80% plants. Natives didn’t have captivity or slaughter of animals. That was introduced by European Christian colonizers. They ate meat when they had no other options for strictly survival. Regular slaughter of animals is actually based in religious ritual animal sacrifice and burnt offerings for a deity or deities.
@@bonnieschmidt5882 depends on where humans lived. The Inuit certainly survived almost entirely on a carnivore diet. People in the Amazon basin however, survived on a mostly plant based carbohydrate rich diet
The human organism is adapted well to either environment.
The one thing that was consistent between all traditional cultures was:.
1. Periods of scarcity
2. Almost no consumption of refined fructose
@@Insight-music I agree. It’s an all or nothing mentality. Been in the keto camp for over 7 years. I liked being able to maintain my weight. But it is too restrictive. And struggled at times. I am fairly healthy and don’t need to be in ketosis. I am slowly adding healthy complex carbs back. I am following the high protein, lower healthy complex carbs for the minerals and fats for hormone production. I been following Dr Ted Naimans P:E diet and building my diet around proteins.
I feel great on keto. I feel great on carnivore and i also feel great on high carb low fat. So i have no clue which one is acually the best for me. Not enough people talk about what is the best for an acual healthy person like me.
Sure they do. Long term studies and the evidence signals out WFPB as the healthiest diet.
There are no studies of the carnivore or keto diets that compare in length and depth of the WFPB diet. Mostly they are observational/antidotal. Regardless, what makes the WFPB diet so healthy is limited or none existent in the other two.
So short term a person may do well on those two but long term could be detrimental. Especially with the carnivore diet. Of course there are always exceptions to the rule so some will be okay on low carb (not keto or carnivore) long term.
Physiologically we are plant based.
@@fallguy6196 if it makes no difference then you have to ask yourself, do I want to feel good and harm animals or feel good and not harm animals
In my opinion, the one that is easiest for you to adhere to is the best.
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Please spill some sugar about the bi-weekly stuff you mentioned.
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Statistics are the worse for dietary conclusions. Normal people don't know how to count carbs, what is fiber, what's protein, they don't even know what they ate 2 days ago
Statistics are the primary ingredient for disinformation.
Why do people that look so unhealthy talk about how to be healthy?
Two possibilities. One, our perception of looking healthy is just wrong. Two, formerly unhealthy people may still look less healthy while they have learned how to be healthier, perhaps because of their unhealthy experience.
The bold guy right? Definite is insulated resistant by looking at his pot belly lol
@@sabincioflec8413 Most cardiologists are overweight or obese yet they give much better advice than the average hot media influencer on steroids.
Knowing is not doing. I know how to play the piano, but I suck at it.
Exactly
Human Cholesterol Metabolism
- Carbohydrates
- Thyroid T3
- Vitamin-C
- Fiber
- Adipose Tissue
- Carbohydrates
Yes, the amount of carbohydrates in your diet can affect your levels of triiodothyronine (T3), the active form of thyroid hormone:
High-carb diets: These diets are associated with higher T3 levels.
Low-carb diets: These diets can reduce the activity of the enzyme that converts T4 into T3, resulting in lower T3 levels.
Fasting: Prolonged fasting or calorie restriction can reduce T3 production
When you drastically reduce or eliminate carbohydrates from your diet, your T3 thyroid hormone levels can decrease, as carbohydrates play a crucial role in the conversion of T4 (inactive thyroid hormone) to the active T3 form, meaning a lack of carbs can potentially impair thyroid function and lead to lower T3 levels; this is particularly concerning for individuals with hypothyroidism.
- Thyroid T3
Yes, thyroid hormone T3 is closely linked to cholesterol levels:
Underactive thyroid (hypothyroidism)
When the thyroid doesn't produce enough T3, the liver can't process and remove excess cholesterol from the body. This can lead to high levels of LDL and total cholesterol.
T3, the active form of thyroid hormone, plays a significant role in regulating cholesterol levels by stimulating the conversion of cholesterol into bile acids, thereby promoting the elimination of excess cholesterol from the body through bile secretion; essentially, when T3 levels are adequate, it helps the liver efficiently process and remove cholesterol by increasing bile acid production and excretion.
- Vitamin-C
Vitamin C is involved in regulating cholesterol metabolism and the production of bile acids:
Vitamin C is necessary for the transformation of cholesterol into bile acids. The liver's rate of cholesterol to bile acid conversion is reduced in animals with vitamin C deficiency. This can lead to cholesterol accumulating in the liver and blood serum.
A deficiency in vitamin C can indirectly lower cholesterol absorption. This is due to a reduction in the availability of bile acids, monoglycerides, and fatty acids
Humans and other primates, like apes, are unable to synthesize vitamin C because of a mutation in the gene for gulonolactone oxidase, the enzyme that's needed to produce
- Fiber
Dietary fiber, particularly soluble fiber, can lower cholesterol levels by binding to bile acids in the intestines, preventing their reabsorption back into the bloodstream and ultimately leading to their excretion from the body, thus reducing the amount of cholesterol that can be absorbed from food; this process is key to the cholesterol-lowering effect of fiber-rich diets.
- Adipose Tissue
Adipose tissue, or fat tissue, is a major storage site for cholesterol in the body. In fact, more than half of the body's cholesterol can be stored in adipose tissue in people who are obese
"The only way to produce atherosclerosis in a carnivore is to take out the thyroid gland; then, for some reason, saturated fat and cholesterol have the same effect as in herbivores."
"Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.[1]"
"Thyroid Disease and the Heart"
"Review of multiple cross-sectional studies demonstrates that ≈30% of patients with congestive heart failure have low T3 levels. The decrease in serum T3 is proportional to the severity of the heart disease as assessed by the New York Heart Association functional classification"
"Reduced serum T3 is a strong predictor of all-cause and cardiovascular mortality and, in fact, is a stronger predictor than age, left ventricular ejection fraction, or dyslipidemia"
"Thyroid Dysfunction and Atherosclerosis: A Systematic Review"
"Hypothyroidism and subclinical hypothyroidism (SH), which is characterized by elevated thyroid stimulating hormone (TSH) levels and normal circulating free thyroid hormones, are independent risk factors for the pathogenesis of atherosclerosis and cardiovascular disease, affecting adversely the endothelial function (1-3). More specifically, they are correlated with i) high levels of low-density-lipoprotein cholesterol (LDL), ii) abnormal diastolic blood pressure, iii) low-grade inflammation and iv) hypercoagulability (4)."
"Besides affecting cardiovascular risk factors, longstanding mild thyroid hormone deficiency can lead to structural changes in the arterial wall."
"Evidence from in vitro and animal model studies have demonstrated a remarkable effect of thyroid hormones to fibroblasts, especially in regards to collagen type I expression."
"Thyroid function influences serum apolipoprotein B-48 levels in patients with thyroid disease"
"Conclusion: Increased serum apoB-48 concentrations and CMR may contribute to the increased risk of atherosclerosis and premature coronary artery disease in the hypothyroid state"
"Thyroid hormones and coronary artery calcification in euthyroid men and women"
"Overt and subclinical hypothyroidism are well-established risk factors for atherosclerosis.1,2 Patients with subclinical hypothyroidism are more likely to have an increased CIMT and a higher prevalence of carotid plaques"
"In a large cohort of apparently healthy young and middle-aged euthyroid men and women, low-normal free thyroxin and thyroid-stimulating hormone were associated with a higher prevalence of subclinical coronary artery disease and with a greater degree of coronary calcification."
"Triiodothyronine (T3) therapy can rapidly lower plasma lipoprotein(a) (Lp(a)) levels in patients with hypothyroidism. This is because thyroid hormone regulates plasma Lp(a) and apo-B in a parallel manner"
"Hypothyroidism is associated with increased levels of Lp(a), which can increase the risk of cardiovascular disease. This is because hypothyroidism also increases levels of other lipid profile markers, such as total cholesterol, triglycerides, and low-density lipoprotein (LDL) cholesterol"
"An Amazon-based Bolivian tribe called the Tsimane may hold the secret to perfect health and longevity for their 16,000 members, according to new research published in the Journals of Gerontology. For two decades, researchers have sought to understand why this indigenous tribe has lived almost completely free of heart disease, obesity, diabetes, and age-related cognitive decline."
"Indigenous South American group has healthiest arteries of all populations yet studied"
"An 80-year-old from the Tsimane (pronounced chee-MAH-nay) group had the same vascular age as an American in his or her mid-fifties"
'World's Healthiest Arteries' Found to Be the Most Elastic
"These arteries recently were found to be exceptionally elastic and to age more gradually, according to a study presented at the 2023 Annual Congress of the American Heart Association in Philadelphia."
"Some of the world's lowest rates of dementia found in Amazonian indigenous group"
"A new study reveals that two indigenous groups in the Bolivian Amazon have among the lowest rates of dementia in the world"
"Their diet is largely carbohydrate-based (72%) and includes non-processed carbohydrates which are high in fibre such as rice, plantain, manioc, corn, nuts and fruits. Protein constitutes 14% of their diet. The diet is very low in fat with fat compromising only 14% of the diet -- equivalent to an estimated 38 grams of fat each day, including 11g saturated fat and no trans fats."
"The Tsimane diet is most like the Okinawa diet, named after the island in Japan whose inhabitants have some of the highest life expectancies in the world. Okinawans eat a lot of rice and purple sweet potato and limit their consumption of meat, seafood and dairy to small amounts. Both diets focus on complex, not refined, carbohydrates."
"According to research, the Tsimane people, an indigenous population in Bolivia, have exceptionally low LDL cholesterol levels, averaging around 72mg/dL"
🤷♂IDK🤷♂
Looks like eating a simple and clean low fat diet high in complex carbs with lots of fruits/veggies/fiber/vitamin-c and lean proteins is the optimal diet?
If you want hyperthyroidism, hypercholesterolemia, insulin resistance and a great risk at developing atherosclerosis/CVD you can try a keto/carnivore diet.
Insulin Resistance/T2DM
- Free Fatty Acids (high fat foods)
- Advanced glycation Endproducts (high fat foods/grilling/frying/baking ect...)
- Lack of Antioxidants
- Free Fatty Acids (high fat foods)
Nathan Pritikin on Diabetes
ua-cam.com/video/BcHHDmuyPv4/v-deo.html
Great Diabetes theory paper by Brownlee (it's an AO)
ua-cam.com/video/xcUie_4ovuI/v-deo.html
"Obesity and Free Fatty Acids (FFA)"
"I will review evidence demonstrating that free fatty acids (FFA) cause both insulin resistance and inflammation in the major insulin target tissues (skeletal muscle, liver and endothelial cells) and thus are an important link between obesity, insulin resistance, inflammation and the development of T2DM, hypertension, dyslipidemia, disorders of coagulation and ASVD"
"However, any substance, in order to qualify as a physiological link between obesity and insulin resistance, should meet at least the following 3 criteria: 1) the substance should be elevated in the blood of obese people; 2) raising it’s blood level (within physiologic limits) should increase insulin resistance and 3) lowering it’s blood level should decrease insulin resistance. So far, only FFA can meet these 3 criteria in human subjects. Plasma FFA levels are elevated in most obese individuals (5); raising plasma FFA levels increases insulin resistance (6) and lowering of FFA improves insulin resistance"
"A "high fat meal" would contain a significant amount of free fatty acids (FFAs), which are individual fatty acid molecules released when dietary fats are broken down during digestion; examples of foods that would contribute a high amount of FFAs in a meal include: oily fish like salmon, avocados, nuts like almonds and walnuts, full-fat dairy products like yogurt, chia seeds, and flaxseeds; essentially, any food rich in dietary fats will contain a higher level of FFAs when consumed."
- Advanced glycation Endproducts (high fat foods/griling/frying/baking ect...)
"A high-fat meal, especially one containing cooked meat with a lot of fat, is likely to be high in advanced glycation end products (AGEs) because the cooking process at high temperatures can significantly increase AGE formation, particularly in protein-rich foods with high fat content like red meat; making it a key contributor to high AGE intake in the diet"
"Advanced glycation end-products: modifiable environmental factors profoundly mediate insulin resistance"
"Endogenous-sourced AGEs accumulate in the body over time and are associated with physiological changes that characterize aging, especially IR.(41,51,56,79,85) Serum levels of AGEs in diabetes patients are about 50% greater than that of healthy age-matched controls."
"Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1"
"Thus, prolonged oral exposure to MG-AGEs can deplete host-defenses AGER1 and SIRT1, raise basal OS/Infl, and increase susceptibility to dysmetabolic IR. "
"Because exposure to AGEs can be decreased, these insights provide an important framework for alleviating a major lifestyle-linked disease epidemic."
"Advanced glycation end products (AGEs) are molecules formed through a chemical reaction between sugar and protein, and research indicates they can significantly contribute to insulin resistance by triggering inflammation, oxidative stress, and impairing the normal function of insulin signaling pathways, potentially leading to the development of type 2 diabetes"
- Lack of Antioxidants
"Insulin resistance is a cellular antioxidant defense mechanism"
"In summary, the fact that mitochondrial O2•− is upstream of IR is of major significance suggesting that IR may be part of the antioxidant defense mechanism to protect cells from further oxidative damage"
Yes, mitochondrial superoxide production is a common feature of insulin resistance:
Mitochondrial oxidative stress
Mitochondrial reactive oxygen species, such as superoxide radical anion and hydrogen peroxide, are key players in the development of insulin resistance"
"Superoxide dismutase (SOD) is an antioxidant enzyme that plays a significant role in regulating insulin resistance, with research showing that low SOD activity is often associated with increased insulin resistance; meaning when SOD levels are decreased, the body becomes more resistant to the effects of insulin due to increased oxidative stress caused by the accumulation of free radicals"
Foods that are rich in superoxide dismutase (SOD) include:
Broccoli, Cabbage, Brussels sprouts, Wheatgrass, Barley grass, Melons, and Cruciferous vegetables.
Keto for 8 years! So far i feel amazing. Never going back no matter what anyone says
N=1
So being here is the same as when the atheist goes to the church. Or having doubts?
@@jeffj318We are all individuals, some people respond better to different ways of eating. If we all just had what's best for the average of the population, there would be problems at each end of the bell curve. With the advancement in technology and being able to track what works on an individual level N=1 is the future of nutritional science.
@@paulfortone3049 you find it undesirable to go back because you’ve created a biological bias to where when you consume carbs you’ve basically engineered yourself to be intolerant. It’s not that whole carbs are bad for you, you’ve just created the situation to where you’re body rejects what it’s not used to. That’s it that’s all. Ketogenic state is a secondary form of energy for the brain, essentially putting your system into survival mode all the time. It’s healthy in periodic times, but doesn’t make any difference in the long run more just a placebo effect to validate an identity of being a part of “keto club”
@@Insight-music Tell that to my autoimmune conditions that are now gone. Grains give me major problems and sugar makes me feel sick. So for me, its optimal. Sorry but YOU cannot make that decision for me. High carb diets ARE the problem for many.
I mostly disagree. From my own experience. I've been low-carb, focusing on low glycemic index foods for about two years. It reduced my A1C, but not enough to cure my diabetes. I slipped after that, eating more higher GI foods again and my numbers went up again. Until I finally had enough. I did keto (ketovore) for a short time and now my diabetes is gone. My insuline resistance has disappeared. I can eat what I want, although I restrict my carbs when I eat foods that have a high GI. I don't want my diabetes to come back. So, as in the study, my adherence didn't last very long, but that is because I don't need to restrict my carbs so much any more. I have no need to adhere, so the motivation to do so is gone. In my experience a ketogenic diet is best as long as you need to fix your metabolism and/or need to lose weight.
Then about fruits and vegetables. You don't need to eat fruits and vegetables when you eat ketogenic (although they can be part of a ketogenic diet). You need extra vitamin C to help you deal with carbs. In a ketogenic diet that is not a problem. On a full carnivore diet you get all the nutrients you need from the meat. If you want to do a diet that contains all these slow carbs, then yes you are going to need some fruits and vegetables for extra vitamin C.
You only get enough nutrients from a carnivore diet if you eat nose to tail grass fed beef. I feel it a good short term diet as an elimination diet. It’s not what you’re eating, it’s what you’re not eating….
This scientists opinion (I so far have not seen her citing a broad comparative range of studies supporting her hypothesis) is not my experience. Why is everyone pushing that the same kind of diet will be optimal for the majority or all of humanity rather than it varies by individual. Over a number of years low carb (not deliberate keto) has transformed my metabolic health and markers. I know carnivore has become a bit of a cult but for some of those people talking about their own experience it has transformed their lives incredibly for the better and while perhaps in some ideal world they might just progressively work out what they should eliminate for a non carnivore diet to work better for them but it seems that is a step too far for some and for them a carnivore diet may be the best personal option long term
Look at people in south east asia a lot of white rice but slim and strong 💪
Look at people in Hong Kong. Highest meat consumption, highest life expectancy. Look at people in India. Lowest meat consumption, lowest life expectancy.
Correlation is not causation.
In Japan, the rice consumption peaked in 1962 at around 118kg pr capita. In 2020 it was 51kg. What is probably more relevant is, that the average caloric intake is less than 1900 calories, according to Ourworldindata.
Fairly certain, that carbs in an ad lib diet is a major component in metabolic syndrome, nicely explained by David Ludwig.
@@joostgolsteyn3193 south east Asia has the highest rates of abdominal obesity and diabetes.
The overall quality of the diet matters a lot too. Macros matter, but not that much.
They also have a different microbiome that can deal with the increased carb load, what most people don't understand is you can't just look at what works for a specific population and then assume everyone will have the same results on said diet.
Some Japanese people have Bacteroides plebeius which we believe was acquired from marine animals, that helps with the digestion of seaweed, for them seaweed has a different nutritional profile compared to Billy from Texas.
Most halfwit diet tribe warriors don't even understand this simple concept and try to copy, paste diets from around the world and think they are going to get the same benefits.
@@cantstandya157 microbiome also varies from person to person, even in the same family. But most people are fine with white rice.
Cue the anecdotes 🙂
I'm not convinced that we have compelling scientific evidence to support the idea that low glycemic load carbohydrates are superior to high glycemic load carbohydrates when considering whole foods. For instance, comparing whole grains to tubers, the fact that potatoes can activate more de novo lipogenesis (DNL) is not particularly significant. Many populations consume high glycemic load carbohydrates in large quantities and maintain good metabolic health. Ultimately, the situation is more complex than simply focusing on a specific pathway. The only strong evidence we have supports the idea that refined grains are less beneficial than whole grains, and this is due to multiple factors, not just the glycemic index.
That's all fine until you realize we need fat in our diet for optimal health. High carb can work. High fat can work. Pick one. You can't be healthy eating high fat and high carb. What we're left with is this - Which one is a dietary requirement? Carbs or fat? If you picked carbs then you're delusional.
@lotembenatar7163 agree. In simpler words, if it goes trough the blood, it spikes insulin. If enough goes trough the blood for a long enough period of time, it will create insulin resistance, with all its glorious effects.
The ability of the food to reduce oxidative stress may play a major role. There was a study showing refined sugar vs fruit reduced the life of fruit flies dramatically however adding açai extract to the refined sugar diet not only removed the life reduction but they flies fed refined sugar plus açai lived even longer than the flies eating fruit
The key is keeping fats low in conjunction with carb intake
'High Carb, Low Fat' is the most avoided diet profile in most if not all of the discourse around metabolic dysfunction --folks will talk around it, and almost broach the subject directly, but then quickly return to the periphery
I recently heard Attia talking with someone about the Pima Indians in AZ about their high diabetes rates. The Pima largely eat the standard American diet.
What wasn't discussed were the close cousins to the Pima, just south of the border in northern Mexico, the Tarahumara Indians, who eat their traditional diet of corn, tubers, grains etc. They're all lean, and have zero diabetes & heart disease
You'd think that having 2 ~similar populations in relative close proximity with vastly different diets would be a perfect epidemiological subject to interrogate....but nope.
I am really not sure what the point of this discussion was. The title was not reflected in the body of the video.
No scientific citations. so Yet another opinion based on years of biased training. Yes, there is science on adherence, and it can take some willpower to resist tasty things for your health. If people cannot maintain ketosis, that is their choice, but that does not really indicate it is any negatives aspect with keto diets. Keto works; if you stop something, it does not mean it does not work. Most people cannot sustain an exercise program, either.
The systemic issue seems to quite often circle back to self-discipline of "life style" behavior.
Wasted 8:40min of my life
That jacket has got to go.
Can someone explain why its only humans that need a " balanced diet "
Humans don't need Carbs, why the obsession with eating them ?
Food is not just macros.
@@michaelcooke5050 your brain a primary source of energy is literally carbohydrates. You need carbs, fats and protein. Makes no sense to demonize one macro nutrient and praise the others.
Bull shit
N=1
I'm wondering where we got 40% carbohydrates in our diet during the ice age. There was a fruit shortage for 99% of our existence.
roots and tubers (potatoes)
@@MrJupats Roots and tubers in the wild have fairly low content of carbohydrates, compared to modern potatoes. Carbs are fairly rare in nature, unless we are talking cellulose. Well, let’s rephrase that: Carbohydrates bioavailable to the digestive system of man is fairly rare. While a modern potato is about 26g of carbohydrates pr 100g, roots and tubers in nature are considerably lower. That is a whole lot of laborintensive work to gather 1000 kcal pr tribesmember pr. day. 3 skilled persistence hunters could bring home 60-80kg of kudu or gazelle from a single hunt. Even if only every third hunt was successful, it’s still economical, from a caloric perspective.
Earliest evidence of cooking starchy foods is about 170000 years old. This is relevant due to considerable amounts of lectins.
Grains and seeds are rich in lectins as well.
@@MrJupatsLet’s see, if youtube let this pass:
bec.ucla.edu/wp-content/uploads/sites/108/archive/papers/Schoeninger1.pdf
Areas near the equator line where we probably originated would be relatively unaffected and would retain carbohydrate sources during an ice age. Just because we may have left that area and survived in areas with low carbohydrates does not mean it is what is best for health or even what we are best adapted to eat.
@@knockingseeker There was a lot of grassland but nothing grew near the equator. It was a 300,000 year drought.
I HATE the term "Carbs". Please always use the correct term "Carbohydrate"! Why? The term "Carbs" has been used so much in negative publicity. Never thought such a serious blogger, Simon Hill that is, would use that term as a click bait. Do better please!
Starches
Some might call that being pedantic.
What about pedo and the one with philes in it ? Which one do you prefer ?
These earnest people don't understand that it ain't all about weight. My issue is oxalate absorption. If I never ate a vegetable or fruit again I would live longer then if I was on a Mediterranean diet. I haven't met a doctor that knew anything about it.....here's a pill that might work? Food can also be an addiction. I ate cake at a friends house for lunch, holiday season. This morning I ate eggs and loin steak for breakfast. Maybe next year, cake for my birthday? Some of us adults have commitment's to diets, people and causes. Others go willy-nilly through life. Some are foolishly earnest about things they don't understand.
We are omnivores... not herbivores... or carnivores... People are so biased.... like their politics....Now you have Trump...LOL
Mumbo jumbo
Nobody needs fruit. We all need protein and fat. It's pretty simple.
Culture has always dictated everything for the vast majority of people. Nothing is new.
@ToniCroX oh intelligent being...pls do tell...
@@fooballers7883 Im telling you that you are speaking gibberish.