This video is amazing! I would add that during ischemia, ATP is actually still being made via anaerobic respiration, but at more minute levels compared to oxidative phosphorylation. This will result in increased lactic acid levels (lactate) and consequently lowers pH as well. Excellent explanation of reperfusion injury. This helped me a lot! Thank you.
Also bonus tip to help other viewers remember the antioxidants, think ACE-G: beta carotene (precursor to vitamin A), vitamins C and E, and glutathione.
Great video, but I have 2 questions: why can't the cell produce antioxidants anymore? And what's with the cellular processes such as necroptosis and apoptosis, that the cell can't perform during hypoxia, and are initiated during reperfusion (I learned, that this is the mechanism of reperfusion injury)?
I m a PhD student in cardiovascular science department...Thanks for uploading this video, its really useful for me...great explanation in reperfusion injury and ischemia..never seen such an awesome video before..
Thank you so much for taking the time to make this video! I just started nursing school and needed a visual to connect the dots for antioxidants in relation to reperfusion injury. This helped!
hi great video, really helps understanding the whole pic. i wanted to ask you guys- i've learned that Arrhythmias in the myocardium happens due to automaticity of cells which are in a depolarized state due to increasing levels of sodium and calcium that makes the cells switch from a fast respons state into slow response myocard cells. is this explanation incompatible with your explanation of arrhythmias by swelling of the cells? thaks a lot
you saved my day , i have a presentaion session about SCD pathophysiology , and i came into ichemia- reprefusion injury ,, thank you :)))))))
Mhan I feel like hugging u now....u've made my day....my head was bashing with all this reperfusion thing...thanks for ur explanation
I felt the same way until I realized that I need to put it out there in a way people can actually understand!
@@MarvelMedicine sure you really did a good job thanks so much
Thank you so much for this video! I'm in nursing school right now learning about this topic and needed more info on it
i love the way you integrate info in your videos. keep it up. you're awesome!!
Thank you! Will do!
how antioxidants are formed or where does it present
This video is amazing! I would add that during ischemia, ATP is actually still being made via anaerobic respiration, but at more minute levels compared to oxidative phosphorylation. This will result in increased lactic acid levels (lactate) and consequently lowers pH as well. Excellent explanation of reperfusion injury. This helped me a lot! Thank you.
Also bonus tip to help other viewers remember the antioxidants, think ACE-G: beta carotene (precursor to vitamin A), vitamins C and E, and glutathione.
good points! Thanks!
@@RajanPatel i know im late but thanks!!
Excellent! Thank you!
really good thank u alot
Great Video , Thank you so much
You are welcome!
You are the BEST!!!!!!!
Great video, but I have 2 questions: why can't the cell produce antioxidants anymore? And what's with the cellular processes such as necroptosis and apoptosis, that the cell can't perform during hypoxia, and are initiated during reperfusion (I learned, that this is the mechanism of reperfusion injury)?
interventions to ameliorate IRI :
1. Allopurinol
2. free radical scavengers
3. complement inhibitors: TP10 and pexelizumab
4. Therapeutic hypothermia
5. Cyclosporin
YOU ARE GREAT!!!
I m a PhD student in cardiovascular science department...Thanks for uploading this video, its really useful for me...great explanation in reperfusion injury and ischemia..never seen such an awesome video before..
May i know what university you are studying at?
Hello Sir,
Does ischemia repurfusion injury occurs in small Microvassel such as our genital nerves and tissues?
Thank you sir
نجكلياااا this how we say I am grateful in my country
This is actually my hw asking about 50 yo guy with reperfusion injury
Why does Ca+ influx happen in repercussion injury?
Thank you so much ..well understood😊
Oh my god this was so helpful. Thank you so much!
Thank you so much for taking the time to make this video! I just started nursing school and needed a visual to connect the dots for antioxidants in relation to reperfusion injury. This helped!
Glad it helped Linda!
Very interesting. Thank you.
Great video! very helpful!
Doc, I have a question if you don't mind... Can you give an IV bolus of Heparin during STEMI's (or severe ST Depression)?
Thank you so much for this! Great summary of the processes involved.
Absolutely, happy to help Megan
Thank you
Man this is perfect!
So production of antioxidants is reduced in ischemia? What are the exact names of the antioxidants? I tried googling it and I can't find it
I find your explanation to simplified. Miss the part about increased calcium level especially in the phase of reperfusion.
Thank you for explaining it so well and correlating all the events. It makes so much more sense than my book!
Glad it was helpful!
Im glad it helped you!
Good speech, thanks! Hence, you mean that Dr. should give patient (Tpa + Vit.E) .
Thanq pal .... nice explanation :)
The way you are correlated many things together is very good and useful brother
Hey thanks for saving my day ... really can you please redirect us on where to find practice questions for pathophysiology if possible of course
it was pretty cool))
Great lecture. You've explained it so clearly. Thank you.
Appreciate it!
thank you so much for this.
You're very welcome!
this type of co relate videos are much helpful for studying
wow, really opens up the textbook explanations and makes it relatable , thank you
Yes! The whole goal is for people to actually be able to understand the concepts!
made it all actually understandable....thanxx alot.
That's an amazing way of simplifying it!!
Thanku🥰🥰
I really appreciate this video, very clear and smart.
Thanks to this video I finally understand IR injury!! Thank you !!
thank you for the video...that was amazing way of explaining
Thank you sooooooo much
Welcome 😊
Reperfusion injury @9:50
thank you it's very useful
❤️ thanks
Great Video! Thanks
Thanks!
Excellent! Thank you!
Thank you, that was so easy to understand finally!
Excellent😆😆😆😆😕
Very well explained 👌👌
simply amazing thank u ^_^
Thank you very much. This was very helpful!
Thank you
so helpful!!!
Thank you!
hi great video, really helps understanding the whole pic. i wanted to ask you guys- i've learned that Arrhythmias in the myocardium happens due to automaticity of cells which are in a depolarized state due to increasing levels of sodium and calcium that makes the cells switch from a fast respons state into slow response myocard cells. is this explanation incompatible with your explanation of arrhythmias by swelling of the cells? thaks a lot