Hemostasis: Lesson 3 - Coagulation Cascade and Fibrinolysis

An overview of the coagulation cascade and fibrinolysis, with emphasis on the contemporary model of coagulation (as opposed to the traditional extrinsic vs. intrinsic pathways). The role of vitamin K is also discussed.

[@abumais100]

Three > Two > One ... Doctor Eric is the best One

[@sunving]

Great lecture , I was shocked to find out that I watched this 3 year ago already. Time fly !

[@islammmi]

Keep up ... I like your very organized way in simplifying issues ... Waiting for the rest of hemostasis lectures ?. You are such a genius

[@StrongMed]

Thanks for the message. The rest of the hemostasis videos are coming, but I took a 2 week break over the holidays, and am going to post a few non-hemostasis videos in early Jan, so subscribers who aren't interested in hemostasis don't get too bored. But they are coming over the next couple of weeks to months.

[@danielkiprov7998]

Incredibly well explained and visualized. These lectures are a real gem!

[@Eric-bq5ou]

Thank you for making concise, yet still very detailed videos! Can't wait for the rest of them in this series!

[@rosun3437]

systematic presentation is what makes your lectures easy to learn... I find it very useful

[@mariuspheiffer214]

Still the best lectures I have come across on coagulation. Brilliant! FOAMed rocks!

[@Owmed]

These lectures are so dense and detailed, I love em! Thanks again, you are a life saver!

[@nadawaheed6812]

Sir you are a true legend!!!
You never failed to break down the hardest topics for me..
I'm so grateful for you and your efforts may Allah bless you.💙💙💙💙💙

[@omairkashif]

subhanAllah

[@veronikapleskova3349]

Thank you so much for this video! This is the first understandable explanation of hemostasis which I've ever met.

[@shawnbalk9611]

This was very helpful. If you pause it and memorize things for a few minutes in between slides, slides will build on each other enough to understand and remember the material. I spent an hour on this video and feel that I can remember most of the material.

[@jennydanielsbacka]

Thank you again...now hemostasis is so mych more clear than before I watched these lessons!

[@sunving]

Thank you Dr Strong . I may need to watch a couple more time to get .

[@nsparvana]

Thanks for this wonderful educational video. Please post the next in the series at your earliest.

[@sumanraja21]

excellent video sir, so difficult topic made clearly understandable !!!
You are a Genius.

[@eduardodonascimentoalbano7921]

Amazing, i finally mastered this topic. Thank you!

[@789DarkWolf]

Finally, I understand this difficult topic. Thank you!

[@mariociencia12]

Please make a video about interactions amid factor XII, prekallikrein, and HMW-kininogen!. I think it is not such a useless pathway. For example, this pathway is related to the formation of bradykinin, a remarkable molecule related to inflammation. Furthermore, this pathway is also associated with the creation of polyanions from ATP. These polyanions also seem to be linked to the immune system. It would also be a delightful video about the molecular mechanism of HIT (heparin-induced thrombocytopenia). Once more time, very thankful for this handy video!

[@mokhles703]

Fantastic video.

[@TheMagicStrawberry]

Thank you very much for this video! Im always waiting for a new
One so i can learn more!! Keep up this excellent work

[@sclairev7669]

You deserve to be followed! I Subscribed!

[@StrongMed]

Thanks for watching!

[@Fahad-iw5to]

You are my hero ❤

[@doctormushahid6470]

great sir i like all of your videos it help me to build concepts which i have missed in my basic sciences subjects thanks for all and keep it up

[@tablettesamsung9769]

Very nicely explained

[@stevenruizmontes4354]

congratulations. you are a great profesor.

[@mariociencia12]

Excellent video! However, I missed more animations, as in the previous video of this magnificent series about hemostasis. Instead of just indicate the name of molecules in a scheme, it would be much more interesting showing them in the form of geometric figures. Despite that, the video was very helpful!

[@pilids3514]

At 7:23, what activated the factor V? II thought trhombin activates it but at this point of the initiation phase there isn't activated thrombin?

[@jaquelinemanuel5716]

Well explained! Thank you!

[@wejdanalwael7702]

Thank you sir for making it understandable.

[@Eric-bq5ou]

You may have mentioned this, but what allows for the coagulation cascade to initially prevail over the antithrombitic? Is it just based on the magnitude of TF present after endothelial damage?

[@ohoodalmalki1542]

Thank u, I am master student u help me a lot

[@beaucheinternationaluk9678]

Where are the rest of the haemostasis lectures? Please upload them.. I am a fan!

[@nidhinidhi213]

Plz post mire videos..some are not complete
Excellent job

[@patrickwillyongbwa9547]

thank's for this great presentation

[@snoopytroops]

that EM image is a beaut!

[@charlotte9777]

thank you so much for this video!!

[@ferdiefatiga3443]

Thank you! 😊

[@romeolhk1008]

Dr. Eric, your videos are superb!
May I ask 1 question? How does platelet aggregation and coagulation cascade rely on each other as you stated in 18:21 ?
I know thrombin could activate platelet as you stated in Lesson 2 9:08, but how could platelet aggregation influence coagulation cascade? Thank you.

[@romeolhk1008]

Oh I found the answer in Lesson 2, platelet will secret factor V when activated. So excited to find these videos interlinked. Thank you.

[@gracezhang0708]

Thank you so much!!!!!

[@sunving]

Thanks ! Good lecture but how could I remember that :(

[@zhafirahramadhanty]

helped a lot. thanks xoxo

[@kurootsuki3326]

everything makes sense now

[@fishribbon]

Epic

[@Dazzletoad]

Why is vitamin K being discussed after fibrinolysis?
Without relevant factor gammacarboxylation, there won't even be a clot to breakdown. 🤦🏻‍♂️

[@asmaa2315]

o my god i didnt understand any thing