You should make a video reacting to The Thought Emporium curing his lactose intolerance with genetic engineering. I think you'll be amazed. I certainly was when i first saw it!
Love the fact that several professionals have watched Nile's videos and have been amazed by him. Just goes to shows how far one kid with a passion for learning and a deep interest can go with the internet.
I think the reason Aspirin brand name is used pretty much everywhere is because they were first of course, but secondly it was because they never made their prices absurdly high, as long as I remember you could buy the generic brand for just a little less, but the real aspirin would sit next to it for basically the same price too.
There is no They. Aspirin was a brand name of the German company Bayer AG, and they mostly lost the brand as part of the First World War (both as economic warfare and later as reparations). So for over a century the generics have *also* been allowed to use the “aspirin” name.
Aspirin’s early history is all tied up in World War I. Bayer is a German company, and their trademarks and patents were voided or seized in much of the world. In the US, the trademark on Aspirin was voided in the 1920s and all aspirin is generic regardless of manufacturer. Even the name Bayer was kicked around among unrelated American pharmaceutical companies until the original German company bought it back in the 90s.
Can confirm that that is in fact.... a medium bottle of lubricant. The pharmacy ones are the most expensive ways to buy the stuff, but about 24ish dollars will get you a big bottle with a pump on it. There are even cheaper ways to get better lubricants than that, but the main point is that the stuff definitely comes in larger containers when sold at shops specifically catering to its use. Side note: Good thing to let patients know about, if they regularly experience vaginal dryness and/or wish to engage in anal intercourse regularly, it helps to buy in volume.
There's a legendary Amazon listing from a Lube company. They sell their product from travel size to industrial/retail size (200+ Liter Pallet Barrel) in the same listing, and they had some extremely goofy size reference pictures.
As a tech, I would often get asked sexual health questions, and sometimes it was difficult for me to interject and explain that I was just there to count pills and run the register. Being 6'3'' people didn't always figure out that I was sometimes as young as 16. (It was also really weird knowing which of my classmates had genital herpes outbreaks...)
@@KikinCh1kin Fun fact.... it's also one of the top 3 (I think?) most common STIs in the world. It didn't get it's "gross" stigma until there were commercial products to treat the outbreaks. What sells better than anything? Avoiding the social stigma we helped create to sell our product! YAY!!! .....before then it was just another infection and you kinda shrugged. It's not like you'd go out of your way to get it, obviously, but people now think that it's somehow evidence that you're a "dirty" person because you have it. I.E. you must have done something "bad" to get it, which is laughably incorrect. Funny how much misery and suffering we're willing to heap on a group of people just to sell a product, huh?
IDK, in that particular video it is mostly like: Nigel: *make a statement* Ina: Yeah, that guy is absolutely right. Don't get me wrong, independent validation by a specialist in the field is also important. So, what had we learned? That NileRed is a trustworthy source. Was it a valuable info? Yes. Very much so. Her validation is much more important info than any secondary factoids she shared. I would even argue that the fact she had so little to add or clarify is a testament to the quality of Nigel's videos. I respect him now even more now. Thank you, Ina, don't hesitate to release more videos like that. Independent validation is important.
Aspirin is derived from the bark of a willow tree, because the bark of a willow tree contains Salisylic Acid. Which is why survivalists always say that even if you have a slight pain or headache, chewing on willow bark will relieve the pain.
It will ravage your mucus membranes though. That is why Salicylic Acid was acetylated in the first play to make the drug Aspirin. The free acid is quite acidic and damages the lining of your gut. It had the same effect but this side effect made it unsustainable for longer use.
Aspirin is not made from willow bark poopsie, and it never was. Salicylic acid and Acetysalicylic Acid are not the same molecule. It’s significantly easier and cheaper from a chemistry and materials standpoint to break off all the additional molecules in coal tar leaving only the one you want than try to shove an acetyl group onto salicylic acid boiled out of TONS of willow bark. 4:43
I'm from the UK, we don't say Tylenol, I'm not sure we have it here or not, but we just say "Paracetamol", and its our most common generic pain killer / cold medicine. Aspirin usage is nowhere near as common as it used to be. If someone is going to take an NSAID here, they will take Ibuprofen rather than aspirin.
Australian, and we tend to say Panadole when talking about paracetamol be Use that's the most common brand. Asprin is also not as common, ibuprofen (more commonly referred to by the common brand, nurofen) is also the more coming NSAID. having said that, I have started including Asprin in place of ibuprofen as I get frequent headaches (chronic illness, yay) and taking ibuprofen too often isn't good for the gut. And my guts are alrwady faulty enough
Med Sci/MD student from Australia here: We typically call it paracetamol as Tylenol is a brand name, while paracetamol/acetaminophen is the actual drug name. Commonly, most people will refer to paracetamol by the brand name "Panadol", however many off-brand versions are available for purchase, including off-brand formulations produced by supermarkets such as Woolworths (of Woolworths Group) and Coles (of Coles Group).
@@RadicalInteger Based on what criteria, exactly? Paracetamol uses fewer letters to convey the same information as acetaminophen, saving clinicians time when charting/writing orders. It's easier for people with various accents to say, and intuitive to pronounce based solely on how it is spelt.
@@RadicalInteger To most people, it probably does make you sound smarter. To myself (and other people in medical science/medicine, etc.) it makes you sound pretentious and insecure about your own knowledge.
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12:00 "We don't usually see drugs in their original powder form" Me, a compounding tech (student), "I do!" Jokes aside, lidocaine is a very common API to be seen like this in our practice. (Though hydrocortisone is the most common by far. Good old HC in clotrimazole)
In Switzerland, the most prevalent paracetamol branded drug is Dafalgan. I think Belgium also uses the same name. Great to watch your videos and insight on medication.
A Chinese-Canadian reacting to a Japanese-Canadian! XD And it's really fun to hear your two perspectives on the same chemicals and processes, one from chemistry and the other from pharmacology and medicine!
In my country they call it paracetamol here in Trinidad, didn't know about Tylenol or acetaminophen. Unfortunately all that different name is basically the same thing.
I'm from Norway, and I think in Europe we use the term acetylsalicylic acid more than we use the brand name Aspirin. Then again, I am a paramedic. I didn't even know the two were the same until quite recently.
I'm from Germany and I've never heard the term acetylaldkfkdjd.. I don't know about paramedics, but as a layman I and everyone I know uses the term Aspirin basically exclusively.
I had never heard of aspirin before this 😂😂 Only knew about the existence of acetylsalicylic acid because a friend of me gave me a drink that (I later sound out) was based on some plant containing it.
I don't know if you've seen/heard it but when NileRed was on Trash Taste he and they made fun of the fact he stated it was "Unused". Over all that was an enjoyable listen. Hearing the guys freak out over what he did in his childhood was funny since a great deal of what he did I did as well and never thought any of it was odd.
On the subject of medication names, my senior year history teacher used to work as a nurse for an inpatient psychiatric hospital. He had a few stories about that, but the one that has stuck with me the most (and has probably developed into a complex at this point) is when he told us about a "drug trial" they performed on patients, namely on those with a history of substance abuse as an alternative to methadone treatment. "You know, the number of people that it had a positive effect of on is higher than I expected, considering it was just a placebo, but those that tried it swore up and down by it. What surprises me, though, is that none of the patients figured that out, especially with the number of paranoid schizophrenics there, cause it was called 'Obecalp,' or placebo backwards." And now I always look at strange words in reverse to see if they spell anything out, like when I saw someone new in a chatroom and noticed that their username was a fairly common name spelled backwards. They were surprised when I just greeted them by name. "Wait, how do you know my name?" "It's your username backwards. Just a guess."
Years ago I read that the mode of action might be that the lithium atom is smaller than a sodium atom. If the problem involves a defective sodium channel possibly too tight to accept a sodium atom, but the lithium atom could get through providing the same function as sodium.
Another comment in the older videos he doesn't eat it because he didn't care but in the newer videos he actually intends to eat it meaning he takes greater care to keep it chemically pure or purifies to eat it
I did my apprenticeship at Bayer AG. In the first week we learnd all kinds of stuff about the company history (regardless of the kind of job we choose). What they produced in the past, who build the company. . . . and we also learnd about Acetylsalicylsäure. Up to this time i did not know that in the past it was extracted from Willow bark (not the Acetylsalicylsäure) but Salizin. But if you injest Salizin it is transformed to Salicylsäure in your body. Fun fact. In the past it was sold as a powder not tablets (you would get a small folded paper bag with the powder inside no tablets). And if it is stored dry and at not to high temps it can be stored for a very very long time. We have seen pictures of a very old apothecary bottle that was found that still had the powder inside. And it was still good to use after multiple decades.
Its not just a Canada thing I have been to a couple of the states that share the boarder with Canada and they have English and French on the packaging there too all that Canadian influence haha
Interestingly, seeing the ingredients list there, Aspirin Extra-Strength tablets aren't vegan either, as they have shellac which is produced by insects. That may also be something of note for people with shellfish allergies, as sometimes they react to insect-derived ingredients like shellac or carmine.
14:07 apparently you need to find a different type of aspirin for vegans too. Shellac is secreted by an insect (female lac bugs), so it's an animal product. Also, when they harvest it, there will be dead insects mixed in. It's also used as a coating on some candies.
Considering that shellac is usually used as red food colouring, I'm guessing that it's actually just used to paint the red Bayer logo on the pills, so any other brand should be good enough.
@@tokiliam6015 your thinking of carmine. That's from the cochineal insect. Shellac is transparent or faintly yellowish. But good point. Vegans should stay away from pills with red logos too. 😄
Nice video, Nilered does some nice videos and he's very good about being educational about it. Definitely the kind of stuff that you only want to do if you're a trained chemist. I'm surprised that you do compounding.. Around here, where I live there aren't any compounding pharmacies any longer.
In Sweden we call it paracetamol. Aspirin is not a big brand here, our biggest acetylsalicylic acid drugs are called Treo and Magnecyl. We usually use the name "aceylsalicylsyra" which is acetylsalicylic acid in Swedish. We usually use the drug name when talking orally ingested pain killers, Paracetamol, acetylsalicylic acid, and Ibuprofen. Brands doesn't matter that much here, the rules for advertising drugs here are very strict.
He *really* knows what he's doing here. He's putting the lithium at exactly the fastest rate he can without problems. In the next part, he's trying to get a fire. He used a piece that is big enough to reliably start a fire and small enough to stay away from an explosion. This is not dangerous. This is a master of his craft.
Dang, when I heard "crystal form of menthol", I just visualised one part of my job as a maintenance tech in a cigarette factory. We had to take care of th menthol dosing unit for cigs. It was a big heating tank (to melt menthol) with a precise pump for injecting it into tobacco rods. Calibration required collecting menthol from a special tube and putting it on weight. The slight problem of that task was evaporation of menthol. It was a "joke" made on fresh techs, showing them how to do the task and then just waiting untill they go to toilet without washing hands furiously. The effect of "cowboy walk" from the toilet was hilarious 🤣 One of the mean jokes was to put some crystals of menthol in someone's car. The best place to put it was air vents 😈
That might also entice some people to replicate the experiment for actual treatment which would put a lot more pressure on Nile. If it's just "useless" fooling around with chemistry then he can be a bit more carefree.
Aspirin has always sounded american to me, as a brit, i think it is popular over here but i've never used it or seen it. i've only had Paracetamol or ibuprofen, tho mainly just paracetamol as i've been told I shouldnt have much ibuprofen cause of my asthma meds.
We use a different chemical name, "acetaminophen", but it's the same stuff as paracetamol. I have a memory of freaking out because I took a dose of each one (Tylenol followed by cold meds) _then_ looked them up to see they were the same thing 😟 Classic organic chem.
Great video. I think you did a better job than most of the 'experts react' videos out there as you went threw a more complete break down with context of the source. You might like the movie 'Formula 51' it has pharmacist stuff and might be on prime video.
Here in Iceland we mostly use paracetamol and use that name for it. Aspirin we never us it, I have never heard anyone use it nor seen it in pharmacy's. The only time I hear that name is any visual or audio media coming from America.
Acetylsalicylic acid is not the chemical name for Aspirin. Aspirin is a brand name for ASA tablets from the German pharmaceutical company Bayer. Acetylsalicylic acid is the trivial name for 2-acetoxybenzoic acid.
@@hantrio4327 I only used the term "chemical name" in an indirect quote here. It was quite obvious that "chemical name" was used as "systematic name" here since the other option for acetylsalicylic acid would rather be a "medical name" or a "pharmaceutical name" than a "chemical name".
I'm from Sweden, we call it paracetamol rather than acetaminophen, and while Aspirin is one available brand of ASA, I don't think it's the most common one! AFAIK, it's not as commonly used as paracetamol or ibuprofen.
@@chri-k IIRC research shows that it's faster acting than ASA alone, and achieves better pain reduction than ASA alone after the same amount of time has passed. Only semi-related, one of the studies I've read that I find the most interesting is one that shows that the combination of paracetamol and ibuprofen is not only more effective than either substance alone, but it also has lessened adverse side effects than either taken alone.
I have 2 chemistry degrees and I was really stoned one night and came up with a rather interesting hypothesis as how lithium works on a biochemical level. My hypothesis is that people with mood disorders have a higher than normal level of nerve signaling that may be externally viewed as a mood disorder. Sodium ions and potassium ions play a role in this signaling pathway. Na and K both also have discrete charges that are associated with them. Both are +1. Lithium being an alkali metal as well carries the same charge. However all the ions have different sizes. So effectively they all have different charge densities associated with them. Larger ions more readily chelate with water, or in lay terms, K and Na will naturally have more water molecules around them than Li. Here’s the punch line, Li has to be outcompeting K and Na in certain signaling pathways that correspond to mood in the central nervous system due to the fact that it takes less energy for the ion to move around. That’s as far I can go. Someone with a good understanding of neurobiology would have to explain all the cellular dynamics that are WAY beyond me.
in australia we call tylenol panadol, and each pill is actually 500mg each. so more active ingredient, making nilereds yield worse relatively to that :)
I was just diagnosed with Bipolar type 2 and put on Vraylar. I have a weird anxiety about being on it, but I do feel better on it. I think it's because I don't trust big pharma and the gimmicky way it looks...idk... Personally, I'd rather be on something more natural, but thoughts on Vraylar?
I was actually inspired by that nile red video about Aspirin to use it to produce my own acne cream, specially with higher concentrations for peelings and such, since they seem quite expensive here - so I just went ahead and bought like 200usd of glassware just to make sure it was never gonna be worth it financially lol By the way Ina Nile red is not the mad chemist on youtube at all, he is the most righteous one (at least the procedures) If you wanna see mad chemistry maybe go see Tom from Explosions&Fire (and also Extractions&Ire, one just as good) Prussian Blue (yt channel) likes to synthesize stuff one probably shouldn't, but he does have better lab equip setup than Tom
2 місяці тому
I knew Nigel is canadian when i bumped into him in. Montréal area Tim Hortons.
Chemistry is cool but complicated subject, they many chemical reaction that could be performed & some can create the same ingredient in different pathways. But only draw back is they sometime very low yielding & waste products. Btw really enjoyed watching your video, I do learn from Nile Red as well, he seem to do it pretty legit for a home chemist. I think it's cool that your a oncology pharmacist, I'm still poor in oncology, learning about receptors, growth hormone, mutation, antibodies, inhibitor, etc.
where im from we call it panadol because thats the most common brand here!! i had no idea it was the same as aspirin honestly i thought they were different
I'm pretty sure the chemist who worked at Bayer who first synthesised aspirin (ASA) back at the turn of the last century was also the same guy who first synthesised heroin. Imagine being the guy who "invented" both aspirin and heroin. That's quite the achievement.
It should be noted that while lubricant is generally reccomended, ones with lidocaine or generally local anesthetics are generally not reccomended as they can mask pain that should be a clear indication that something is wrong.
Can you correct me or expand my knowledge on this? I’ve been told by countless people that there is NO significant difference between many different over the counter medications such as Tylenol. I’ve been told they all have roughly the same inactive ingredients and almost always the same amount of the active ingredient unless specified it is a higher dose in milligrams due to the FDA stating they can only have said amount of ingredients in the pill. I want to state I know there is a difference between different medicines my question is say the medicines that do the same exact thing and have the same amount of said thing, why are they priced different? Is it because of a free market? If not then why does the FDA not make all drugs that do the same the same prices?
That’s a great question! You are probably talking about brand name vs generic medications. There’s a lot involved in why prices are what they are so I will let you read into that yourself!
given that nilered has the organic chemistry knowledge to turn asperin into tylenol, i wonder if he would have the knowledge to turn adderall or dexamphetamine into meth
6:00 YOu are talking about zinc-carbon. Most batteries when we all are kids are zinc-carbon batteries. It have ammonium carbon powder inside the battery
Acetyl-salicylic acid, was also invented at the same time as diacetylmorphine, or heroin but they thought it was more dangerous and so released heroin first…
Would love to hear your view on why add Titanium dioxide to so many tablets when its sole purpose is aesthetic (making the pill sparkly white) and while it is very likely a carcinogenic compound...
Are you able to discuss the difference between Lithium Carbonate and Lithium Orotate. The Orotate form seems to be able to cross the BBB easier than the Carbonate form.
You should make a video reacting to The Thought Emporium curing his lactose intolerance with genetic engineering. I think you'll be amazed. I certainly was when i first saw it!
Thanks for recommending! ☺️
I second this, some of the most fascinating content on UA-cam!
@@max.lindgren Yeah TTE is like a scientific fever dream.
@@InaYu2024sadly wasn't permanent but if I remember right he was good on dairy for a few years
@@Falcodrinnot sadly, it was intentionally not permanent
Love the fact that several professionals have watched Nile's videos and have been amazed by him. Just goes to shows how far one kid with a passion for learning and a deep interest can go with the internet.
I think the reason Aspirin brand name is used pretty much everywhere is because they were first of course, but secondly it was because they never made their prices absurdly high, as long as I remember you could buy the generic brand for just a little less, but the real aspirin would sit next to it for basically the same price too.
Oooh that’s a good observation 🧐 never thought about it that way
There is no They. Aspirin was a brand name of the German company Bayer AG, and they mostly lost the brand as part of the First World War (both as economic warfare and later as reparations). So for over a century the generics have *also* been allowed to use the “aspirin” name.
Aspirin’s early history is all tied up in World War I. Bayer is a German company, and their trademarks and patents were voided or seized in much of the world. In the US, the trademark on Aspirin was voided in the 1920s and all aspirin is generic regardless of manufacturer. Even the name Bayer was kicked around among unrelated American pharmaceutical companies until the original German company bought it back in the 90s.
Also it's much easier to say that asa
In Europe, Aspirin is the generic name, because Bayer had their trademark taken off them following WW2.
12:46 turning cheap drug to expensive drug: finasteride 5mg (for prostate) -> finasteride 1mg (for bald) 😂😂
Wow A+ student 😊
@@InaYu2024try ru58841 it's better
Can confirm that that is in fact.... a medium bottle of lubricant. The pharmacy ones are the most expensive ways to buy the stuff, but about 24ish dollars will get you a big bottle with a pump on it. There are even cheaper ways to get better lubricants than that, but the main point is that the stuff definitely comes in larger containers when sold at shops specifically catering to its use.
Side note: Good thing to let patients know about, if they regularly experience vaginal dryness and/or wish to engage in anal intercourse regularly, it helps to buy in volume.
No wonder!! learned something new today 🤣
There's a legendary Amazon listing from a Lube company. They sell their product from travel size to industrial/retail size (200+ Liter Pallet Barrel) in the same listing, and they had some extremely goofy size reference pictures.
Me and the boys buying a barrel of lube for reasons
@@acceptablecasualty5319😂 I was about to mention this, the Amazon 55 gal drum of lube is hilarious. Would make for a great prank gift 🤣
When you nailed the Lithium guess right at the beginning... ♪ Yeah! Yeah! ♪
Yes very proud of myself 😝
I like it, I'm not gonna crack!
As a tech, I would often get asked sexual health questions, and sometimes it was difficult for me to interject and explain that I was just there to count pills and run the register. Being 6'3'' people didn't always figure out that I was sometimes as young as 16. (It was also really weird knowing which of my classmates had genital herpes outbreaks...)
At least you knew who to not have sex with in your class.
Oh wow! That's a little awkward, but it's great insider information 😂
@@KikinCh1kin Fun fact.... it's also one of the top 3 (I think?) most common STIs in the world. It didn't get it's "gross" stigma until there were commercial products to treat the outbreaks. What sells better than anything? Avoiding the social stigma we helped create to sell our product! YAY!!! .....before then it was just another infection and you kinda shrugged. It's not like you'd go out of your way to get it, obviously, but people now think that it's somehow evidence that you're a "dirty" person because you have it. I.E. you must have done something "bad" to get it, which is laughably incorrect.
Funny how much misery and suffering we're willing to heap on a group of people just to sell a product, huh?
What I really love about NileRed is his militant honesty and thoughtful and thorough research.
the fusion of academic and professional knowledge with twitch/youtube meme/deep cuts is actually refreshing. Subbed!
Glad you enjoyed it!! ☺️
Watching your reactions is like getting double the facts👍
Glad you enjoyed it!!
IDK, in that particular video it is mostly like:
Nigel: *make a statement*
Ina: Yeah, that guy is absolutely right.
Don't get me wrong, independent validation by a specialist in the field is also important.
So, what had we learned? That NileRed is a trustworthy source.
Was it a valuable info? Yes. Very much so. Her validation is much more important info than any secondary factoids she shared.
I would even argue that the fact she had so little to add or clarify is a testament to the quality of Nigel's videos. I respect him now even more now.
Thank you, Ina, don't hesitate to release more videos like that. Independent validation is important.
Aspirin is derived from the bark of a willow tree, because the bark of a willow tree contains Salisylic Acid. Which is why survivalists always say that even if you have a slight pain or headache, chewing on willow bark will relieve the pain.
So just drink your face wash?
It will ravage your mucus membranes though. That is why Salicylic Acid was acetylated in the first play to make the drug Aspirin. The free acid is quite acidic and damages the lining of your gut. It had the same effect but this side effect made it unsustainable for longer use.
Aspirin is not made from willow bark poopsie, and it never was. Salicylic acid and Acetysalicylic Acid are not the same molecule. It’s significantly easier and cheaper from a chemistry and materials standpoint to break off all the additional molecules in coal tar leaving only the one you want than try to shove an acetyl group onto salicylic acid boiled out of TONS of willow bark. 4:43
You are a girl of course you never opened a battery. That’s the crazy and fun stuff us boys did as kids. 😂
What does this have to do with the video? Also it's salicylic not salisylic.
Two chemistry UA-camrs that both made meme medicinal compounds are Chemdelic, who made the precursor to 2,5-DMA and Chemiolis who made PCMO.
7up was originally lithium bicarbonate soda and was marketed towards stay at home mothers
I'm from the UK, we don't say Tylenol, I'm not sure we have it here or not, but we just say "Paracetamol", and its our most common generic pain killer / cold medicine. Aspirin usage is nowhere near as common as it used to be. If someone is going to take an NSAID here, they will take Ibuprofen rather than aspirin.
In the US there's a headache drug called Excedrin. It's three things at once: Paracetamol, aspirin, and caffeine. Good stuff.
Acetaminophen
@@picasso566 Acetaminophen and paracetamol are the same drug
Australian, and we tend to say Panadole when talking about paracetamol be Use that's the most common brand.
Asprin is also not as common, ibuprofen (more commonly referred to by the common brand, nurofen) is also the more coming NSAID. having said that, I have started including Asprin in place of ibuprofen as I get frequent headaches (chronic illness, yay) and taking ibuprofen too often isn't good for the gut. And my guts are alrwady faulty enough
Med Sci/MD student from Australia here:
We typically call it paracetamol as Tylenol is a brand name, while paracetamol/acetaminophen is the actual drug name.
Commonly, most people will refer to paracetamol by the brand name "Panadol", however many off-brand versions are available for purchase, including off-brand formulations produced by supermarkets such as Woolworths (of Woolworths Group) and Coles (of Coles Group).
acetaminophen is the best name
@@RadicalInteger Based on what criteria, exactly?
Paracetamol uses fewer letters to convey the same information as acetaminophen, saving clinicians time when charting/writing orders. It's easier for people with various accents to say, and intuitive to pronounce based solely on how it is spelt.
@@TimFlynn-rd6dz it makes me sound smarter
@@RadicalInteger To most people, it probably does make you sound smarter.
To myself (and other people in medical science/medicine, etc.) it makes you sound pretentious and insecure about your own knowledge.
@@TimFlynn-rd6dzI like acetaminophen cus it sounds more fun to say. Like a tongue twister.
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In germany we call it Paracetamol. I've never seen other names, and i work in the medical field
12:00 "We don't usually see drugs in their original powder form"
Me, a compounding tech (student), "I do!"
Jokes aside, lidocaine is a very common API to be seen like this in our practice. (Though hydrocortisone is the most common by far. Good old HC in clotrimazole)
Compounding pharm techs...you guys have access to all the true goodies, lol.
"I enjoyed watching niel red make drugs in his old home" lmao
just musing... I reckon the large sticky brown clump of impurities was probably sugar from the lube, looks a lot like a caramel colour
UA-camr @NurdRage has a (pretty long) multi-part series of synthesizing pyrimethamine, brand name Daraprim, from (mostly) household chemicals.
Aspirin to Tylenol is what got me into his channel and into pharmacy/chemistry.
In Switzerland, the most prevalent paracetamol branded drug is Dafalgan. I think Belgium also uses the same name. Great to watch your videos and insight on medication.
Dafalgan! What a cool name 😎
A Chinese-Canadian reacting to a Japanese-Canadian! XD And it's really fun to hear your two perspectives on the same chemicals and processes, one from chemistry and the other from pharmacology and medicine!
13:00 yep ive heard of acetraminophen before but didnt know what it was, we call it paracetamol here in Brasil
In my country they call it paracetamol here in Trinidad, didn't know about Tylenol or acetaminophen. Unfortunately all that different name is basically the same thing.
I'm from Norway, and I think in Europe we use the term acetylsalicylic acid more than we use the brand name Aspirin. Then again, I am a paramedic. I didn't even know the two were the same until quite recently.
I'm from Germany and I've never heard the term acetylaldkfkdjd..
I don't know about paramedics, but as a layman I and everyone I know uses the term Aspirin basically exclusively.
@@Jehty_ Maybe it's more of a Nordic thing, because the term's definitely used more in Sweden and Iceland.
I had never heard of aspirin before this 😂😂
Only knew about the existence of acetylsalicylic acid because a friend of me gave me a drink that (I later sound out) was based on some plant containing it.
I don't know if you've seen/heard it but when NileRed was on Trash Taste he and they made fun of the fact he stated it was "Unused". Over all that was an enjoyable listen. Hearing the guys freak out over what he did in his childhood was funny since a great deal of what he did I did as well and never thought any of it was odd.
The pink color of the flask at 14:47 reminds me of a perfect titration with phenolphthalein.
On the subject of medication names, my senior year history teacher used to work as a nurse for an inpatient psychiatric hospital. He had a few stories about that, but the one that has stuck with me the most (and has probably developed into a complex at this point) is when he told us about a "drug trial" they performed on patients, namely on those with a history of substance abuse as an alternative to methadone treatment.
"You know, the number of people that it had a positive effect of on is higher than I expected, considering it was just a placebo, but those that tried it swore up and down by it. What surprises me, though, is that none of the patients figured that out, especially with the number of paranoid schizophrenics there, cause it was called 'Obecalp,' or placebo backwards."
And now I always look at strange words in reverse to see if they spell anything out, like when I saw someone new in a chatroom and noticed that their username was a fairly common name spelled backwards. They were surprised when I just greeted them by name. "Wait, how do you know my name?"
"It's your username backwards. Just a guess."
Years ago I read that the mode of action might be that the lithium atom is smaller than a sodium atom. If the problem involves a defective sodium channel possibly too tight to accept a sodium atom, but the lithium atom could get through providing the same function as sodium.
Turning a cheap drug into an expensive drug? Ah so like turning pseudoephedrine into meth like Walter White
Another comment in the older videos he doesn't eat it because he didn't care but in the newer videos he actually intends to eat it meaning he takes greater care to keep it chemically pure or purifies to eat it
Here in Poland acetaminophene is known as APAP
I did my apprenticeship at Bayer AG. In the first week we learnd all kinds of stuff about the company history (regardless of the kind of job we choose). What they produced in the past, who build the company. . . . and we also learnd about Acetylsalicylsäure. Up to this time i did not know that in the past it was extracted from Willow bark (not the Acetylsalicylsäure) but Salizin. But if you injest Salizin it is transformed to Salicylsäure in your body. Fun fact. In the past it was sold as a powder not tablets (you would get a small folded paper bag with the powder inside no tablets). And if it is stored dry and at not to high temps it can be stored for a very very long time. We have seen pictures of a very old apothecary bottle that was found that still had the powder inside. And it was still good to use after multiple decades.
That’s really cool
the government be like "okay nilered what are you doing now oh you are just making some aspirin as you were"
Its not just a Canada thing I have been to a couple of the states that share the boarder with Canada and they have English and French on the packaging there too all that Canadian influence haha
The osmosis effect 💪
Loving your videos. Editor here one thing i would do is maybe turn your background music down a little bit. It's not crazy distracting but its a bit.
1:55 Wellbutrin is the only antidepressant used normally for bipolar. SSRIs trigger mania.
Interestingly, seeing the ingredients list there, Aspirin Extra-Strength tablets aren't vegan either, as they have shellac which is produced by insects. That may also be something of note for people with shellfish allergies, as sometimes they react to insect-derived ingredients like shellac or carmine.
Really appreciate your professional explanations in your interstitial segments!
14:07 apparently you need to find a different type of aspirin for vegans too. Shellac is secreted by an insect (female lac bugs), so it's an animal product. Also, when they harvest it, there will be dead insects mixed in. It's also used as a coating on some candies.
Considering that shellac is usually used as red food colouring, I'm guessing that it's actually just used to paint the red Bayer logo on the pills, so any other brand should be good enough.
@@tokiliam6015 your thinking of carmine. That's from the cochineal insect. Shellac is transparent or faintly yellowish.
But good point. Vegans should stay away from pills with red logos too. 😄
Nile is like an alchemists of old
Nice video, Nilered does some nice videos and he's very good about being educational about it. Definitely the kind of stuff that you only want to do if you're a trained chemist. I'm surprised that you do compounding.. Around here, where I live there aren't any compounding pharmacies any longer.
In Sweden we call it paracetamol.
Aspirin is not a big brand here, our biggest acetylsalicylic acid drugs are called Treo and Magnecyl. We usually use the name "aceylsalicylsyra" which is acetylsalicylic acid in Swedish.
We usually use the drug name when talking orally ingested pain killers, Paracetamol, acetylsalicylic acid, and Ibuprofen.
Brands doesn't matter that much here, the rules for advertising drugs here are very strict.
Nyle is insane with the type of stuff he can do it's really awesome
5:53 I actually think the lithium will explode here 😂😂
He *really* knows what he's doing here. He's putting the lithium at exactly the fastest rate he can without problems. In the next part, he's trying to get a fire. He used a piece that is big enough to reliably start a fire and small enough to stay away from an explosion.
This is not dangerous. This is a master of his craft.
Been really enjoying your videos glad UA-cam recommended your channel
Glad you enjoy them and appreciate you being here! ☺️
Dang, when I heard "crystal form of menthol", I just visualised one part of my job as a maintenance tech in a cigarette factory. We had to take care of th menthol dosing unit for cigs. It was a big heating tank (to melt menthol) with a precise pump for injecting it into tobacco rods. Calibration required collecting menthol from a special tube and putting it on weight. The slight problem of that task was evaporation of menthol. It was a "joke" made on fresh techs, showing them how to do the task and then just waiting untill they go to toilet without washing hands furiously. The effect of "cowboy walk" from the toilet was hilarious 🤣
One of the mean jokes was to put some crystals of menthol in someone's car. The best place to put it was air vents 😈
I imagine if he turns a very cheap drug into a very expensive drug that the Eli Lily's of the world would take exception with that
Haha thats true, infringing on patented products 🤣
That might also entice some people to replicate the experiment for actual treatment which would put a lot more pressure on Nile. If it's just "useless" fooling around with chemistry then he can be a bit more carefree.
Paracetamol is what it is in Australia. The first time I saw acetaminophen was in China
Thanks for re explaining the pharmacological effects and different perspective.
Here in Singapore and the rest of SEA, we call it Panadol. It is also a cure-all miracle drug that we take for practically everything
Very interesting. Thanks for sharing your reaction!
In Germany its called paracetamol and aspirin would be ASS (Acetylsalicylsäure) for short.
Aspirin has always sounded american to me, as a brit, i think it is popular over here but i've never used it or seen it. i've only had Paracetamol or ibuprofen, tho mainly just paracetamol as i've been told I shouldnt have much ibuprofen cause of my asthma meds.
Asprin is the brand name. The chemical is acetylsalicylic acid.
I learned that from The Tick!
@@Null_Experis yes? this was covered in the video you're commenting under.
@@SmolYui Beware the second head of Science! It bites!
@@Null_Experis I'm sorry, i'm not sure What you mean.
The Aspirin name was first used by Bayer, a German company, in 1899.
I am in love with your sarcasm lol
OMG, I always heard about tynoal in america and thought it was something hectic. Mean time it's just panado/ paracetamol lol
We use a different chemical name, "acetaminophen", but it's the same stuff as paracetamol. I have a memory of freaking out because I took a dose of each one (Tylenol followed by cold meds) _then_ looked them up to see they were the same thing 😟 Classic organic chem.
@@myboatforacarWhy does the USA always have to do everything differently from the rest of the world
@@chri-k As a Canadian, I also have to ask, since they drag us along with them 😐
Whenever NileRed does make foods or something, he is careful to test thoroughly via NMR and other tests to check for impurities first
I feel like adding music to nilered videos would be a nice touch. Never thought about it until now
Great video. I think you did a better job than most of the 'experts react' videos out there as you went threw a more complete break down with context of the source.
You might like the movie 'Formula 51' it has pharmacist stuff and might be on prime video.
THANK YOU I appreciate that! I’ll check out the movie!
Here in Iceland we mostly use paracetamol and use that name for it.
Aspirin we never us it, I have never heard anyone use it nor seen it in pharmacy's. The only time I hear that name is any visual or audio media coming from America.
10:44 that cracked me down , can't have clean thoughts about it.
It is kind of wild to me how much we don’t understand about our bodies and brains, and how many medications we use that we don’t understand
Acetylsalicylic acid is not the chemical name for Aspirin. Aspirin is a brand name for ASA tablets from the German pharmaceutical company Bayer. Acetylsalicylic acid is the trivial name for 2-acetoxybenzoic acid.
Trivial names are chemical names. You mean IUPAC name
@@hantrio4327 I only used the term "chemical name" in an indirect quote here. It was quite obvious that "chemical name" was used as "systematic name" here since the other option for acetylsalicylic acid would rather be a "medical name" or a "pharmaceutical name" than a "chemical name".
i remmember him wanting to make antibiotics, but he never published the last step, his argument was that he didnt have a way to test its efficiency
13:11 Something similar here in South East Asia, paracetamol is commonly called by a brand named panadol 😂😂
I'm from Sweden, we call it paracetamol rather than acetaminophen, and while Aspirin is one available brand of ASA, I don't think it's the most common one! AFAIK, it's not as commonly used as paracetamol or ibuprofen.
Also, the Swedish word for acetylsalicylic acid is "acetylsalicylsyra" which I've always found to be very fun to say, haha!
ASA in general isn't very commonly used since paracetamol became a thing
@@chri-k The ASA preparations that are sold however do tend to be combined with caffeine, much more commonly than just being ASA.
@@wwklnd that's... interesting
@@chri-k IIRC research shows that it's faster acting than ASA alone, and achieves better pain reduction than ASA alone after the same amount of time has passed.
Only semi-related, one of the studies I've read that I find the most interesting is one that shows that the combination of paracetamol and ibuprofen is not only more effective than either substance alone, but it also has lessened adverse side effects than either taken alone.
In Poland most people will call Tylenol Paracetamol
If its silicone based lube? Not sure he said if it was or wasnt. Maybe thats what that weird black chunk was.
I have 2 chemistry degrees and I was really stoned one night and came up with a rather interesting hypothesis as how lithium works on a biochemical level. My hypothesis is that people with mood disorders have a higher than normal level of nerve signaling that may be externally viewed as a mood disorder. Sodium ions and potassium ions play a role in this signaling pathway. Na and K both also have discrete charges that are associated with them. Both are +1. Lithium being an alkali metal as well carries the same charge. However all the ions have different sizes. So effectively they all have different charge densities associated with them. Larger ions more readily chelate with water, or in lay terms, K and Na will naturally have more water molecules around them than Li. Here’s the punch line, Li has to be outcompeting K and Na in certain signaling pathways that correspond to mood in the central nervous system due to the fact that it takes less energy for the ion to move around. That’s as far I can go. Someone with a good understanding of neurobiology would have to explain all the cellular dynamics that are WAY beyond me.
I thought the lithium process was done in a fume hood, holy ship did he not???
Back when he still made the videos in his parents garage he didn't have access to fume hoods and other fancier equipment.
He did use a fume hood
in australia we call tylenol panadol, and each pill is actually 500mg each. so more active ingredient, making nilereds yield worse relatively to that :)
I was just diagnosed with Bipolar type 2 and put on Vraylar. I have a weird anxiety about being on it, but I do feel better on it. I think it's because I don't trust big pharma and the gimmicky way it looks...idk... Personally, I'd rather be on something more natural, but thoughts on Vraylar?
I was actually inspired by that nile red video about Aspirin to use it to produce my own acne cream, specially with higher concentrations for peelings and such, since they seem quite expensive here - so I just went ahead and bought like 200usd of glassware just to make sure it was never gonna be worth it financially lol
By the way Ina
Nile red is not the mad chemist on youtube at all, he is the most righteous one (at least the procedures)
If you wanna see mad chemistry maybe go see Tom from Explosions&Fire (and also Extractions&Ire, one just as good)
Prussian Blue (yt channel) likes to synthesize stuff one probably shouldn't, but he does have better lab equip setup than Tom
I knew Nigel is canadian when i bumped into him in. Montréal area Tim Hortons.
I'm from Denmark, we say paracetamol, and we actually also say acetylsalicylic acid, in Danish ofc 😅
Chemistry is cool but complicated subject, they many chemical reaction that could be performed & some can create the same ingredient in different pathways. But only draw back is they sometime very low yielding & waste products. Btw really enjoyed watching your video, I do learn from Nile Red as well, he seem to do it pretty legit for a home chemist. I think it's cool that your a oncology pharmacist, I'm still poor in oncology, learning about receptors, growth hormone, mutation, antibodies, inhibitor, etc.
where im from we call it panadol because thats the most common brand here!! i had no idea it was the same as aspirin honestly i thought they were different
NileRed drinking game - take a drink when he says lube 😂
The real money would be turning the meds into batteries 😂
I'm pretty sure the chemist who worked at Bayer who first synthesised aspirin (ASA) back at the turn of the last century was also the same guy who first synthesised heroin.
Imagine being the guy who "invented" both aspirin and heroin. That's quite the achievement.
The FF music really made the video.
It's 'Paracetamol' in Australia.
It should be noted that while lubricant is generally reccomended, ones with lidocaine or generally local anesthetics are generally not reccomended as they can mask pain that should be a clear indication that something is wrong.
Can you correct me or expand my knowledge on this? I’ve been told by countless people that there is NO significant difference between many different over the counter medications such as Tylenol. I’ve been told they all have roughly the same inactive ingredients and almost always the same amount of the active ingredient unless specified it is a higher dose in milligrams due to the FDA stating they can only have said amount of ingredients in the pill. I want to state I know there is a difference between different medicines my question is say the medicines that do the same exact thing and have the same amount of said thing, why are they priced different? Is it because of a free market? If not then why does the FDA not make all drugs that do the same the same prices?
That’s a great question! You are probably talking about brand name vs generic medications. There’s a lot involved in why prices are what they are so I will let you read into that yourself!
@@InaYu2024 thank you for pointing me in the right direction!
Good vid. Very informative and fun!
In Brazil we call it Paracetamol! 13:12
given that nilered has the organic chemistry knowledge to turn asperin into tylenol, i wonder if he would have the knowledge to turn adderall or dexamphetamine into meth
i could watch this for hours :D
Wait what!! Here in New Zealand we call it paracetamol, and theres a slightly stronger one; Ibuprofen
6:00 YOu are talking about zinc-carbon. Most batteries when we all are kids are zinc-carbon batteries. It have ammonium carbon powder inside the battery
Acetyl-salicylic acid, was also invented at the same time as diacetylmorphine, or heroin but they thought it was more dangerous and so released heroin first…
Also yeah it's Paracetamol in the UK.
Lithium carbonate pushes out other more hazardous heavy metals
Would love to hear your view on why add Titanium dioxide to so many tablets when its sole purpose is aesthetic (making the pill sparkly white) and while it is very likely a carcinogenic compound...
I love Nile(Red / Blue)! And I think I love you!
Are you able to discuss the difference between Lithium Carbonate and Lithium Orotate. The Orotate form seems to be able to cross the BBB easier than the Carbonate form.
this was super enjoyable
Love Neil
Ireland 🇮🇪 we call it paracetamol
We also have asperin with the Brand name Disperin. There's generic versions too.