Biological Information beyond Genes: Bioelectricity | Michael Levin
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- Опубліковано 22 чер 2024
- Extract from "Cell Intelligence in Physiological & Morphological Spaces", kindly contributed by Michael Levin in SEMF's 2022 Spacious Spatiality.
Full talk: • Michael Levin | Cell I...
MICHAEL LEVIN
Department of Biology, Tufts University: as.tufts.edu/biology
Tufts University profile: ase.tufts.edu/biology/labs/le...
Wyss Institute profile: wyss.harvard.edu/team/associa...
Wikipedia: en.wikipedia.org/wiki/Michael...)
Google Scholar: scholar.google.com/citations?...
Twitter: / drmichaellevin
LinkedIn: / michael-levin-b0983a6
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So glad you made shorter versions. It is hard to get people to watch long form videos. Hopefully these will get in front of more people's eyes than the hour long version.
Thanks for the feedback, it is really appreciated! Look forward to further extracted content like this in the future!
@@SEMF but still, keep the hour long content coming :D
@@levtrot3041 Plenty of that kind of content on the way!
So, in short, you have found the JTAG pins in the PCB of life...
Delightful. Thank you Michael.
Thank you for your comment!
Another extremely interesting video and has opened my eyes to a branch of science I didn't know existed. Thanks
It really is fascinating!
@@SEMF Do you think this line of research has any relevance to acupuncture and/or Scenar (which I've used very successfully for about 20 years) ?
@@MikeKleinsteuber Acupuncture practices may realistically have some meaningful interaction with bioelectricity patterns indeed, although it is not at all obvious to what extent can you extrapolate from the simpler and developing organisms of Michael's experiments to an already developed human being, and how (if possible) to do it (maybe acupuncture methods are not the precise way).
@@SEMF Interesting. Thx
@@MikeKleinsteuber Thanks for your thoughtful comments!
Mind freaking blowing! So much insight, thank you so much!
It really is mind blowing research!
This is fascinating!
We thought so too! Glad you are enjoying our content.
Why aren't more doctors/scientists paying attention to this guy?
Michael Levin is getting quite a bit of attention, it is only a matter of time that we see medical applications of this work!
Yes, after watching this video it is very clear to me that Michael Levin and his colleagues should immediately be given either the Nobel Prize in Physiology or a 15 to 30-year sentence for fraud and investment scams.
@@castonyoung7514 Why fraud? The science is being developed still...
Wow! This appears to have amazing potential for treatment of disease and cancer. This 'Bioelectric Patterns of Memory' is some ways seems like a holographic emergence into existence based upon force fields, considering the idea that there is memory for the 'future', that has yet to exist. Whether true or not, some amazing research here!!!
Indeed very promising for those applications you mention!
@@SEMF Awesome to hear, seems like grounds breaking great work, hope it takes off!
@@tomkwake2503 Hopefully yes!
Starts to sound like the whole "morphogenetic fields" and stuff a la Rupert Sheldrake, considered very fringey ... but who knows? Today's kooky fringe _just might_ become tomorrow's hard science - if we could predict which ones do and don't, science wouldn't be necessary, as we'd have already done it!
Stunning
this is some of the most fascinating stuff and I'm not even a biologist
It really is fascinating!
Wow. super cool research
We thought so too!
And this is just the bebinning. The introduction of the biosoftware has limitless possibilities. Changing shape/form, uplifting of animals, programmable matter, bio exoskelets, biorobots in native environmet like in deep ocean, etc, etc, ... just wow.
It really is just the beginning! Exciting times!
This is awesome.
We thought so too!
I did not find your page on Instagram and I did not see your page on Facebook but I am following you on Twitter. I am so happy.❤🎉😂
twitter.com/semf_nexus for latest news!
@@SEMF yes sir I typed you in and Twitter but I couldn’t find you on Facebook either on Instagram
@@SEMF I don’t believe I’m talking to Michael Levine personally but that’s fine. Anyone from his laboratory knows more than I.
@@andreybogoslowsky For Michael Levin's website: www.drmichaellevin.org/
It is so interesting I got 1 question on some of the info that was here and the external medicine interview Id like to ask Dr Levin but overall im impressed.
He will be coming to our Multidisciplinary School in a few weeks, so stay tuned!
Regeneration + Galton Board + Fingertip Amputation = See if you can knock out about "Half Inch Blankness"...Half Way through The Galton Board Experiment @ The Bottom..You probably have to support it..Say Column #3 either side...??...You'd be looking for "Abnormal Greater Accumulation On Top Of Column #3"..Like..??..Experiment was trying to make up for the missing/amputation below...It may be better If the columns branched out like fingers @ bottom..."Bell Curve Like"...
KARL GRANSE photographed the "human bioelectric field" back in the 1970s using kirlian photography. He identified two separate fields in a pregnant woamn. One for the mother and one for the baby inside her.
That's a great reference! Thanks for pointing it out. We would value you sharing these on our online community. You can join by following this link:
semf.org.es/participate/join.html
More proof the child within is as much a separate human as the child born?
@@friendlyone2706 How so?
@@friendlyone2706 correct
@@SEMF Individual life forms have separate fields.
"Face" is a pattern derived from a Kosmic Actor: Exotic Vacuum Objects (also known as Itonic Clusters or ball lightening on a macro scale.) MFMP on YT with Bob Greenyer is an important aggregator of all matters related to the torroidal nature of life.
What is a Kosmic Actor? What do you mean by "torroidal"?
how dose this circuit arise during embryo develepment ?
For decades, physical therapists used pulsed radio-frequency waves to improve or initiate healing in many human and animal health conditions. These were profoundly effective, even in non-healing fractures, chronic non-healing wounds, and otherwise untreatable conditions.
Very little of this was patentable, the profit motive was limited.
These athermal (non-heating) EMF waves shared characteristics with what was to be used in mobile phones.
An "inconvenient truth," of course, since the phone industry and regulators insist that without heat in the tissue, these waves have no biological effect and people have nothing to worry about.
As I stated, the biological effects are well known, verifiable, but incompletely understood.
Your presentation underscores the need for further open source research on how drugs, and electromagnetics, toxins and foods work at the cellular level and further down your memory chain.
That's an interesting direction. Any references or links on it?
Very good point. We need go review how these things affect bioelectricity, since evidently what we've been looking at this whole time wasn't everything
@SEMF no problem, I'll dig out some stuff. There were old articles in the journal IEEE in the 70s, with NASA interest owing to potential effects of RF exposure in astronauts etc.
@@stevepk5421 Indeed!
@@alveolus2854 Thanks! We encourage you to join our community and share that information with our members: semf.org.es/participate/join.html
makes one wonder... how much of evolution is just evolving bioelectric patterns while the genes stay relatively identical?
Bioelectricity derived from a source. That source has the imprinted information ( the message) for Biological formation.
What source do you mean?
@@SEMF Think about it. Your human molecule evolved by the source that is within the molecule. That source is the fusing of elements at atomic level.
Ask yourself how can the fusing of elements form the intelligent species. Once elements are fused, they are the imprinted knowledge to form the biological matter for a purpose. Understand that and you will understand the missing link purpose.
Amazing.
We think so too! Glad to be able to share such fascinating research!
@@SEMF I am thinking of potential applications in hearing loss, spinal nerve damage, and as you mentioned cancer research. I have always thought that a century hence, they will look back at chemotherapy as equivalent to pouring boiling oil in wounds or blood letting. This is not to say chemotherapy has been a failure, just to note that as knowledge advances, so will therapy. Newton said he stood on the shoulders of giants because knowledge is cumulative.
@@seaknightvirchow8131 That's exactly right! Very good analogy.
This is absolutely mindblowing! Incredible! Driving cells through morphospace by changing their electrical properties!!! Absolute paradigm shift!! But got so many questions! How do they introduce the electrical memory into the planaria?? By introducing mRNA that codes for a specific channel, or molecules that change the state of the channels, as to obtain a specific voltage that codes for the morphospace within the hyper-depolarization continum? And that info from the mRNA or channel modulators stays dormant, long after the mRNA/modulator has degraded, until it´s activated by a signal? What signal in the case of the eye in the fish? I am not sure I dare try read one of the papers!! Amazing and groundbreaking stuff...... Long life the ion channels, specially the voltage gated ones! hehehehhe
Thanks for the comment it is really mindblowing research!
More research showing biological response to electric fields: ua-cam.com/video/B3jf_d_TVc8/v-deo.html
As a brain metastasis lung cancer patient , I have been under TTF treatment (new way of tumor treatment by electric fields for the 25 months. So far so good. So I became more n more interested in such areas as.... maybe.. bioelectricity, too. could you give me a more detailed expanations on how where what to study.....???????????
Follow the links in the description!
Amazing. I have a couple of questions:
You say that no EMFs are added. If you were to use them, can you manipulate the patterns further?
If you change the electrical potential of the environment the cells are developing in, how are ion channels and their development affected, if at all?
Two excellent questions!
These are very relevant questions! I encourage you to join the SEMF community to discuss them with other members and have access to future events with Michael Levin. You can find all the relevant information here: semf.org.es/participate/join.html
DNA as an antennae: ua-cam.com/video/B3jf_d_TVc8/v-deo.html
Apparently there's more to life than news, weather and sports ;-)
Very much so!
Wow, just wow.......
A good summary... ;)
Wow, so interesting!! What does this mean in terms of all the artificially created electric fields we live in?
Unless they are applied to developing organisms, not much!
This implies, a lot: ua-cam.com/video/B3jf_d_TVc8/v-deo.html
how can we know one voltage pattern uniquely produce one organ?
Very very good question.
I think the different homeotic genes (like the original "homeobox", first discovered in aberrant fruit-flies), maybe are connected to the control of the electric system on a larger scale of the organism than the separate organs. The concept of the "morfogenetic field" (Rupert Sheldrake and others), comes to mind. It is not stated what the nature of the "field" is, so it may just as well be the electrical charge of the Cells. I simply don't know what is really the science behind this hypothesis. I know that neurobiological principles are very important for other tissues as well!
Thanks for pointing out this issue, although it's not entirely new.
Novel developments in the field of organisms and organs development are really required!
That's a very relevant comment. Thanks for sharing your thoughts on this!
how far can biolectric patterns guide tissue development away from that species? using a suitable pattern of ion channels, can we make frogs grow wings?
Certain times of day/cycles plus electricity could change information.
That's certainly a possibility!
does every organ have a special type of ion channel?
So eventually we might be able to grow human hearts from scratch for transplant?
3D printing organs never made sense to me when they literally have the ability to self assemble... It's like deliberately picking the harder path that has worse outcomes. But I guess it has its applications outside of complex organs.
Something like this is really far off, but it does become more plausible!
I actually think this works derivatives would supersede the need for a transplant. We could just reprogram the faulty heart
@@stevepk5421 That may be the case indeed!
Does that suggest that, when for example, a marsupial such as the Tasmanian Tiger appears very much like a dog, it has the same electrical arrangement?
That's certainly a related question. Ontogenesis is one of the main focuses of Michael's work.
Has the impact of quantum fluctuations in bioelectricity been discussed as a possibility ?
We have not heard it from Michael Levin yet.
You're telling me some time in the future I might be able to shock my arms, cut them off and regrow flippers 👁️👄👁️
Really cool stuff. I can't help but think that the model you present here is the same model one would present if one viewed biology as intelligently designed. Instead of comment descent, the model you present could be explained as the Designer not tree-shaking his code or perhaps the extra plans were put there to aid discovery. I do find it absurd anyone could think random mutations and a process of selection could create these eloquent designs.
The issue with an intelligent design hypothesis is, as usual, to explain or characterize intelligence. You can boil it down to "if life is designed by an intelligent being/phenomenon, what is that entity and how does its intelligence emerge from known physical laws?", in a way intelligent design simple moves the goal post but, in doing so, one loses empirical reach.
@@SEMF nah, the evidence is overwhelmingly on the side of an uncaused creator (self existant) whose existance does not depend on this universe. The "pushing back" of problems is what the Darwinists do. Panspermia anyone? ID is the position that has a definite beginner. I would point out here the known universe has a definite beginning. An observation I've made is how "natural selection" has become the "god of the gaps" for the committed Darwinists so much so the it shows up in origin of life papers in a pre-biotic world
What is evidence for an uncaused creator? The question here is that there are mechanisms at work that we don't understand, as very beautifully illustrated by Michael Levin's work, even within the realm of causation where we have good empirical reach. It seems unnecessary to invoke entities "outside" the universe or whose existence is "independent" of our universe.
@@SEMF "seems unnecessary"??? That statement baffles me. How can any complex machine exist by means of random chance and a selection process? Can you think of one? More fundemtally, do you know of any specified and complex information that came to be without an intelligence? Have you looked at the state of origin of life research lately? It hasn't moved since they debunked the lighting-in-a-primordial-soup hypthosesis. Their current theories are laughable (see James Tour).
I wonder if the folks who discovered the Rosetta stone thought is seemed unecessary to consider an intelligence was involved or if they just chalked it up to wind and erossion. A living cell is vastly more complext than the most complext thing humans have every created. We still have no idea how to build one from scratch. But the real nail in the coffin of a godless universe has to atp synthase, you need it before you can have it and you can't make it until you've already made it. I think if you look around a bit your "seems unnecessary" will go away.
@@RipRyness There is no apparent reason why information dynamics of the known basic laws of physics wouldn't give rise to life as an emergent phenomenon. Arguably life is the most complex of all known emergent systems but analogous mechanisms have been quite successfully understood without the need of an intelligent entity who/which designs from outside the universe.
Why is it a "memory" though? why wouldn't the effect decay away?
can the descendants of two-headed planaria be reversed to one head?
hehe, my hardware is wonky, that's actually nice to hear, even though your hardware is wonky, some of your software can make up for it. Philosophical where it was not inteded. Ow yeah VERY interesting, yet again!
Unintended philosophy is the best kind of philosophy!
Amazing technology, like Star Trek level
Not that far off!
so many questions
Michael Levin will be at one of our events soon. Stay tuned!
So if not in the DNA, where is the information on body shape and cell types stored?
From Michael's work it seems that the bioelectricity network holds substantial information about shape and development.
ua-cam.com/video/bXzauli1TyU/v-deo.html two-minute papers video on regenerative cellular automata. If you play around with this program you can also make two-headed symmetrical shapes that auto-regenerate when cut off.
Thank you so much for the link, that's an amazing UA-cam channel, strongly recommended from us!
🤯
Mind blown.. puhhffss \ | /
That's a common sentiment around here!
Good luck.
That's an interesting thought! Why not share it with our online community. You can join at no cost other than filling a quick form here: semf.org.es/participate/join.html
"Victor"...(Snare Roll/Bass Drum/Cymbal Crash).."Electric Face Creation" = "2 Way Quantum Spin/Split".."Eyes" = "Bob & Alice".."Brain = Eve"..Take Care...Bye.."Igor"....
Cryptic but suggesting...
This should put the boot right into abiogenesis. No way could any blind unguided process form life out of non life. Biology is light years ahead of anything man can devise and build.
How does Michael's research make abiogenesis less plausible?
@@SEMF Did you not watch the video?
@@rl7012 We hosted the event. What makes you think this research implies abiogenesis is less likely?
@@SEMF I am sorry I have to state the obvious but the title of this video is called 'Biological Information beyond Genes: Bioelectricity' and the content is explaining the wonders of bioelectric networks. So how that makes abiogenesis even less plausible is because now there are even greater wonders to explain. Because in abiogenesis, not only is it necessary to explain how chemicals 'accidentally' bumped together on prebiotic earth and 'accidentally' formed the exact right molecules for life, in the exact right form and amount, then 'accidentally' put themselves together, millions of parts in a very sequence specific order, and thus 'accidentally' invented life. Now you have to explain even more of the wonders of a 'mindless blind' process that also includes bioelectric networks.
@@rl7012 That's a fair point. However, as far as we can see from the content of Michael's work, there is nothing too special about bioelectricity compared to other biological phenomena.
You contradict yourself between the 2 min. mark and 2:22. You stated the following: "To actually write new information into it. The way we do it, we don't use any applied electric fields, there are no waves, there are no magnets, there is no electromagnetic radiation." Then you go on to state, "What we do is: we do exactly what neuroscientists do. We modify the endogenous mechanisms by which cells establish electrical signals. So, either ion channels, we can open or close them, we can use light or drugs to do that." Light is electromagnetic radiation and behaves as both a particle and a wave!
Quantum mechanical effects don't seem to be relevant in these systems.
You do use Light to stimulate the opening of voltage gated channels!
@@ronaldpearson2476 But the outcome does not depend on the QM effects, that's the upshot.
I don’t know much but it may be that a human , as we are now is not capable of understanding this kind of stuff if nature can do what is talked about in this video nature can also install in our intelligence a stop mechanism in us that shuts off our quest for the answer maybe you need to find this shut off switch first then you will be answered 😮
BIoelectricity…. next Biodynamcs
Why not ;)
What I Said Below...You may not have to "Ground The Wire In The Water"...??..."It's There".."Even Undectectable"...."Creatures May Be The Ground"..??..Try it for a month..??..."When You Play With Low Voltage"..."Don't Filter Out The Memory"..."Happy New Year Too"....Bye.....
Autism???
?
Try "Silver Petri Dishes"..Or "A Piece Of Silver In The Water"..."Silver Has Weird Old Time Properties"....Bye..
"Victor".."Try Low Voltage Video Signal In The Water"...Prefereby 1 Channel "CNN News"..??..Or maybe try "Raw Cable Wire Too No Box".."Real Low Voltage"..See if you notice any difference..??.."Anything With Sensible Memory"..Take Care.."I"Gore...."Blucher"...
He expresses it badly!
The entire body layout is encoded in the DNA.
But as an emergent quality. Not directly in the lowest level, like the proteins of the cells.
I didn't watch the entire video because that slip was just too large for me to accept. I assumed he wouldn't be very clear about the rest either.
How exactly would that work?
“You can take this planarian, cut off the head “ - he says casually at 11:53... where is the respect for other feeling, living creature? Who gave this man a permission to modify and torture this immortal being? In what kind of world are we living that such things are allowed and even treated as NORMAL? It is dreadful what is being done to these and other creatures in the name of false so- called “science”.
The capacity for suffering of planarians seems rather limited. What is problem with Michael's experiments?
@@SEMF How do you know that "the capacity for suffering of planarians seems rather limited". Any proof of this?
@@childoflight8982 The small and relatively underdeveloped nervous system. Not out of the realm of possibility that planarians experience something similar to suffering but it appears highly unlikely.
@@SEMF But this is really your ASSUMPTION, we don't now this for sure. Besides, we should treat ALL beings with respect, and not to cut their body parts off for the sake of some dubious experiment.
@@childoflight8982 Not an assumption but an observation based on empirical evidence.