I've had CRPS since 2011, I'm now 55 and havnt been able to loose weight. Pain is exhausting. Since I was put on oxempic in May 2023 I have lost 36lbs but... my pain has reduced by around 75%. I can't believe it. My skin sensitivity has gone done down and the muscle shocks have stopped.I've slept so much better too. I am still needing to loose weight but that's OK. Great podcast guys.
There is a set point of weight. If someone eats junk food, the body isn't getting what it needs. The body raises set weight. The solution is to stop eating junk food.
Thank you that was really awesome. I do not need this treatment as I have been able to use my change in diet with intermittent fasting (lost 50lbs 2021 no medication) and eating to keep my type 2 diabetes in remission. I do have so many friends who cannot do what I did, but if they had the systemic pain I had; I had a choice of one! This VID is the best information great answers, and I will be passing it on to my many friends and colleagues who are struggling.
Over the last 15 years I had gained some 15 kg (stopped smoking after 40 years, menopause) and at the beginning of this year due to high cholesterole and not wanting to take medication I decided to change my diet and way of living. From January I counted calories for 3.5 months until the 15 kg were lost (BMI from nearly 27 to now under 21). I stopped buying any kind of highly processed food, stopped sugar (and all equivalents) practically completely (apart from an icecream a week in summer) and keep to intermittend fasting (16:8). I am never hungry, eat good great portions , discovered lots of new and tasty dishes and keep my weight. Resistance training helps with muscle build-up (so important when getting to the end of one's Sixties). I avoid any kind of pills or medication wherever possible - and would rather walk 20 km a day than take drugs to loose weight. For me a scary idea.
I agree. I am going to do it your way also. Already fast a lot either 18-6 or 20-4, some prolonged 2 to 4 day fasts, honestly never was a big eater and was one who eats to live rather than lived to eat. I don't like taking medication either and at 72 -dont take any required prescriptions. Not diabetic, though it's rampant in my family, I try to eat healthy and walk as much as possible. Hopefully, I'll eventually lose some weight. I just don't trust their fast fix method. Still too new and too many unknowns.
They are indeed dangerous without radical life changes. Calories counting is rubbish and makes you hungry, Realistically people should eat high good quality fats, proteins and zero sugar and carbs to lose weight ands keep it off.
Remember you have an increased risk of multiple cancers as well as significantly more health risks like stroke and cardiac issues *if you remain obese.* That often far outweighs the risk of the extremely rare serious problems with semiglutide - one that isn't even proven in humans yet. I was wary when I started semiglutide for my obesity, but as my husband pointed out: when the public conversation turns to overly moralizing debates and the drug is continuously proven safe and effective, it's probably not about the drug itself. I've experienced no side effects on this medication, other than slightly increased heartburn that is entirely manageable. I can't even tell if that is a side effect of the medication or my healthier eating habits. The moment I took semiglutide, I could tell my weight problem was chemical, since I could suddenly follow nutrition plans with ease and felt content with food for the first time in my life.
Well we HOPE that outweighs it. We don't know yet. It will be a while before the true cost of being on these drugs for life is known. This isn't a dig at Ozempic, it's just that is how long true side effect profiles take to come up. Look at Zantac. How long did it take for the stomach cancer issues to become known? It look 100s of millions of people taking it for decades. Now it's not considered a good risk:reward by some health authorities. There was no way this concern was going to show up in the initial trials. And it isn't a binary choice between obesity and Ozempic. Many, many people beat obesity without it. If you can't and it stops you being obese then you very well may be correct and it is the drug for you.
So true, especially "the moment I took semaglutide, I could tell my weight problem was chemical". I used to never make excuses for my weight and never bought into the idea that fat ppl like myself just have some chemical imbalance, but after taking this drug it makes me think again haha.
Some respond better than others, that heartburn increases your risk of esophageal cancer, there are lots of questions on this new “game changer”. Its curious that he compares it to antidepressants which really are not solving the problem.
I just had a mini stroke last week. Almost lost my eyesight....thank God it's been restored and I am okay. I've been fighting obesity for decades. Yes, I've lost weight and have made changes. I just have not been able to maintain it. I was against any intervention.... that's changed. I am going to use any tool necessary to lose weight and live.
Major but rare side effects are retinopathy and acute pancreatitis which I why I stopped taking this. Since stopping taking it and switching to a low carb (
@My OpenMind low carb diets, especially ultra low carb diets, can have severe side effects as well. And I say that as someone who is currently doing a low carb and has been on and off it for years. Everything has risk, but to me, being obese is the biggest risk. Keto plus semaglutide sounds like an effective combination.
I’ve been ketogenic for 13 years couldn’t get below 118 while it’s only 3 pounds over what my highest weight should be it was discouraging and I’d give up and binge eat right back up to 132 I’m doing the diet and taking the medication hoping to get to my healthy goal weight
I don’t understand why the issues of all the hormones being injected into the meats and chicken we are eating aren’t also being addressed by the medical community. Fish like talapia salmon shrimp etc. that are being farm raised and eating their own waste product has a definite affect on our bodies as well. These foods that we ingest day to day are not naturally consuming the environment around them any longer and common sense would suggest it’s changing our hormones and body mass due to the unnatural birth and growth of these animals. Then there’s the fruits and vegetable issues. Also what about our society moving from the Industrial Age into the internet age children are not playing outside as we did before riding bikes swimming walking for blocks to get to a store or a friends house or a phone booth all are practically gone in our society today. So people are more sedentary now. So we as a society have completely changed our activity and food consumption within our own bodies and those of childrens’ bodies and what is disturbing for me is that every issue we humans have all comes down to a pill an injection or another pill if that pill isn’t working. Your podcast is great and super informative and please I’m not throwing shade on your medical knowledge cause that’s not my intention. I just wanted to point out that we are a society that has become one that opens the cabinet to solve the problem. Not all cause yes I recognize there are exceptions to one’s issue but look around our society today and listen to all the commercials pushing this drug or that one. There is so much more contributing to the obesity craze and it truly is killing us slowly whether the drugs make us thinner or the affects on our bodies after we’ve used the drugs. Pretty scary as whole but thank you again for your podcast.
I used Semaglutide for about 5 weeks. I lost 4% weight. The nauseous side effect made it difficult to continue. My rebound after this course was a resort to bad eating habits and excessive hunger. +6% Despite my poor willpower and adherence to a diet I would not try it again. I can see the assistance this drug gives but it's not for me. I think my weight loss endeavours just involve controlling what goes into my mouth!
Lost about 16% of my body weight in a year with Ozempic. Would switch to Wegovy, but it's so damn expensive I can't really afford the extra cost. Been very happy with my results with Ozempic, but at the moment, I've been holding my weight at a somewhat higher body weight where I'd like to end up, so I've now been looking more into what changes I can make in my habits to get to my target weight. I'd like to lose 6-7 kg more. My health improved measurably, and significantly - and my quality of sleep improved. A general improvement in quality of life. I was also lucky in that I never had any side effects from the drug.
It is a lifesaver. Mine is Mounjaro instead of Semaglutide. It is a great adjunct therapy to bariatric surgery. After losing 120 lbs with Bariatric surgery, I took some other medications that brought the return of my gut wrenching hunger. I still couldn’t eat much, but I would get hungry too often. I gained half of my weight back, and with Mounjaro, I am below my low weight with surgery.
The benefit won't last indefinitely - I see no sign of that. But you could use this time to change to a more healthy diet which would reduce your need for so much insulin.
@@eileenfb1948 I am actually not insulin resistant. I do suffer from biological obesity, Lipedema, Dercum’s disease, and Ehler’s Danlos. I have had good habits for years. I simply have painful hunger that must be caused by a hormone imbalance. In fact, the research shows the effects do last for most who stay on the medication even at a maintenance dose. The small number of people who can go off the medication appear to be those who have only been obese for a shorter period of time. That is what clinicians are reporting. Those of use who have suffered from obesity for much of our lives are in a different boat. Until I took the meds that caused my hunger to return, I maintained my weight loss from Bariatric Surgery for three years. I had previously lost most of my weight through diet and exercise six times, but as the research shows, the body fights against this, and I could never maintain for more than six months even starving myself.
@@eileenfb1948not sure where she says she's on insulin or hasn't made adjustments to her diet? Having made the latter is actually implied, given that she's had bariatric surgery.
@@moergb I know two people who had bariatric surgery and they put on a lot of weight. Both were buying sweets, etc and not eating well. Quite likely you are correct, I hope so.
A very interesting episode. It was noticeable that the term 'weight loss' was used rather than 'body fat loss', and the negative effects on muscle mass and bone density not mentioned at all. That said, the potential is great, and hopefully subsequent versions may improve.
Thyroid tumours are a side effect in rats, who have GLP1 receptors in their thyroid cells. My understanding is that most humans do not have GLP1 receptors in their thyroid cells, and that as such most people are not at risk of thyroid cancer from GLP1 agonists.
Rare side effects are actually gallbladder stones (1 of 100), direct pancreatitis (rare, but pretty dangerous), paralysis of intestines and other digestive problems. I have not heard of any registered thyroid cancer cases. There have been some pancreatic cancer cases in the USA - they are still trying to prove the connection in courts and scientific community. You can check the medications on the official sites of producers. There is a whole list of them: Ozempic (Wegovy), Trulicity, Saxenda etc... There are also a lot of such medicines for diabetes used daily.
I am 72, and I took it for 7 months, and I was able to reduce my A1C to 4.9, eliminate all blood pressure meds, loose 42 pounds, and my BMI is know 26. This is after a lifetime of obesity. I have been off Mounjaro for a month, and maintaining all these stats.
Type 1 Diabetes, and Type two Diabetes, should be given different names, as they are not the SAME disease, and should not be confused by giving them the same name.
When I checked online, the cost of the drug is about $1000 per weekly shot. How can that be a game changer? $1000 per week is approaching the median household income in the United States. I suppose if people spend all of their income on the drug, they won't have any money for food, and they could lose weight that way. But seriously, by following the advice on Zoe and other UA-cam channels, in less than a year (the same period as the trial Dr. Kushner conducted), I lost fully 30% of my body weight, by walking, intermittent fasting and reducing but not eliminating carbs. I also lost 20% body fat and went form obese to a normal BMI. And I saved $1000/week over buying this drug, not to mention the doctors' fees, etc. that I also didn't spend money on. This was 3 years ago and I have not regained the weight. To be honest, without being critical, it feels a bit like extortion.
In Europe it's about £140 a MONTH when bought privately. And everyone in the supply chain is making profit at that price. How you get to these ludicrous costs in the USA is a question you might want to ask your politicians, because the drugs simply don't cost anywhere near that.
If you are in the US and do not have insurance then the cost is about $1,000 per month, not per week. Many insurance plans cover these drugs, and they pay far less than cash paying patients. My cost to take Mounjaro was $42 per month.
Wegovy with no insurance is between 1200 to 1500 a month. With approval by insurance $25, compound pharmacy semaglutide $250 a month it's do-able. Not for everyone but many can make this work
My first fast food in uk was in the 80s when kfc opened up. I also got food poisoning from it too with short hospital stay but that's another story! Fast food has exploded in uk. You can't go shopping, work, leisure without passing a food outlet. Maybe there should be more local laws on how many food outlets are allowed
Great video. Very informative. It has changed my mind about using the drug now though as who can afford to stay on it for life. Unless you stop eating altogether.
This doesn't sound great. If people still need to take a drug after losing weight that is failure because the problem is 90% because of processed foods.
Thank you for this very informative podcast. From this video, I understand that Semaglotide (I hope I have the correct spelling) is a hormone produced in the guts. What I’d like to know is how does a healthy body creates it? Is there a natural way to help your guts into producing enough of it to avoid obesity totally? What do we know about the hormone in healthy individuals who may just be fighting with maintaining their weight despite a healthy lifestyle? Would diabetic people be prone to lack this hormone? When one has an impaired endocrine system, like polyglandular autoimmune syndrome type 2, could they be prone to semaglotide hormone deficiency?
I have been using Ozempic for 4 weeks now at .25 and just upped to .5 have never experienced more nausea and vomiting in my life (i am from canada and my healthcare OHIP coveres my perscription entirely)
Hollywood director Paul Schrader posted extensively about the horrible side-effects he has been experiencing from this drug. It is sad to see ZOE turning into a drug-pushing enterprise.
I agree. We thought we could trust Zoe - in the pocket of drug company means I don't know if I can believe the information they have been given by the company
To be fair, the drugs have helped some celebrities like Mindy Kaling, etc. And Dr. Robert Kushner has mentioned a list of side effect at 23:53. Although, I'm not sure whether the list is complete or not. Edit: I don't think Zoe tried to cash in from this session. They invited Dr. Will B. into the conversation to bring the scepticism about the drugs. And he did! He brought up "concern" about pancreatitis and thyroid which had not previously included in the list of risks mentioned by Dr. Robert Kushner. I think the problem is neither the drugs nor the clinical trials have been used or performed long enough to show any long-term serious risks. The drugs might be useful to ease people into clean eating, carb reduction, & fasting. After your body get used to all that, you can reduce the drugs little by little.
I have no connections to Zoe. I can't even join their program because of my country of residence. I don't see how anyone who listened to the entire episode could accuse Zoe of being "in the pockets of the drug industry." This was a balanced discussion about the pros and cons of using this medication as one tool to combat a public health crisis. The accusation that Zoe is a "drug pushing enterprise" is ludicrous, since Zoe does not sell the medication. Indeed, if this medication becomes widely administered for obesity, it could reduce demand for Zoe's services.
@@eileenfb1948If people like Zoe don’t talk about about what is being heralded as the greatest breakthrough in obesity then all I’m left with is information I really don’t trust.
so it turns out NICE (in the UK) have recommended this stuff for a *maximum* of 2 years. Which according to the discussion about what happens when you stop (from about 39:23), makes it basically pointless and set up to fail. Right?
Yep. NICE sometimes make their recommendations based on the cost of a treatment or the number of healthcare professionals available to give that care, rather than on the amount of care needed to give benifit.
Yeah I have been on semaglutide for about 3 years now. I never really feel hunger anymore and find I eat out if habits and seems to have bad habits that are out of control. It was the weight management service that put me on it and talking to my diabetic nurse or GPs, they don't want to take me off until my weight is lower. Hearing about it should be closely monitored does concern me, no one has ever reviewed things (at least I don't believe they have)
Taking you off the meds will make you regain the weight, There is no endpoint to weight loss if your weight loss depends on the "medication". I don't get your healthcare team's reasoning.
@@myggggeneration I think the drugs meant to ease obese people into a healthier lifestyle. If they change their eating habits by lowering carbs consumption, eliminating ultra processed food, and fasting regularly, the weight will be kept off although they stop taking the drugs.
Normalizing use of a hormonal drug makes me very wary. My mother's terminal cancer may well have resulted from many years of hormonal replacement treatment (HRT) for a hysterectomy. I think I'll stick to a whole foods plant based diet...it's working and I'm down 14 lbs so far.
Went to see my endo doctor just the other day. I have had thyroid cancer. My diabetes is in remission, blood pressure is regulated, not on statins anymore. My weight was 267 I have managed to get it down to 187. I found it strange that I was given literature on this product when I asked about my concerns I was told I would get skinny. Then I asked about the lifetime injections and weight coming back and was told that it would be my fault if I stopped and gained it back. Was also told that my insurance would not approve cause I had lost so much weight. Was given a info where I could call and possibly negotiate a price. I just think there maybe some good but it seems like its not for me. I went through injections for what I thought was PSA and it was not. Think I am gonna work my way down and continue to heal my body.
It is disappointing to hear in this channel, which I thought its main purpose was to promote health by improving diet and living style, what seems to be now a promotion of a drug.
I'm slightly alarmed by the complete medicalisation of obesity demonstrated by this doctor. It very much reminds me of how depression is looked at now: it's a chemical imbalance...here is a pill. My brother take anti-depressants. They seem to help a bit. However, why is he depressed? Well maybe it has something to do with his destructive behaviour patterns and beliefs that have damaged his life over the last 30 years! Of course he's depressed. I would be too. Chemical imbalance? Maybe but why? I know, it's bloody obvious LOL. We were not fat here in the UK until really the late 70s early 80s when the obesity crisis started to kick in. Our bodies didn't change but the food environment and work/life behaviours sure did through the 80s and beyond. THAT is why we're a nation of fat people. But have we got the guts to change it? It would seem not.
My first fast food in uk was in the 80s when kfc opened up. I also got food poisoning from it too with short hospital stay but that's another story! Fast food has exploded in uk. You can't go shopping, work, leisure without passing a food outlet. Maybe there should be more local laws on how many food outlets are allowed
This is a big deal. I know someone who this has worked for. Regaining weight back is something I have seen time and again on conventional diets. The person I know has never eaten well nutritionally and still eats poorly. Just less of it. I also know a person who has no appetite because if she gets stressed she can't eat and also does not eat for nutritional reasons.
I’d try a lot of things before this. It did bring to light some interesting knowledge about biochemistry and eating. Sometimes we just need patience and certainly we need to believe in protocol. The body systems are complex.
At the end of the diet when you aren't losing weight, if you keep eating the same and drop volume of excercise, you will start to build muscle and fat will remain the same. Increase food as muscle gain stops. In no time you will need more energy than before the diet started. You can increase your energy requirements more, or return to the diet once all metabolic adaptation is reversed
How about a video on the biology and math regarding calories burned by the body. Eg can you divide your bmr by 24 to determine calories burned per hour? What are other factors?
Giving 'it' back to them is a bit misleading as it is artificial so how can you be giving it back. What happens in the blood with this product is the same as giving them even more insulin? How does insulin resistance fit in with this product when it looks like it will make it worse? I know people who are around BMI of 30 and they tell me that they eat too much and they eat when they are not hungry. Others say it is because they eat fast food. Another has had surgery but buys sweets made of sugar and keeps putting weight on. Others eat to help them cope with their emotions. I am appalled that Zoe is giving air time to promote this product.
I don't think it's a promotion. Zoe was trying to tackle the current hot issue which currently trending on the society, health-wise. They invited Dr. Will B. to bring sceptcism to the conversation, and he did. The problem is the both the clinical trials and the use of the drugs have not been long enough to really prove there is no serious side effect.
I think Zoe is simply sharing the science of this drug with their audience so they can make their own mind up about using it or not. Some may consider taking it and want to know what the science says about it, whether it is safe and to hear why they should not take it.
The drug sound very awful. 😅 It is really for patients who have no choice. However, isn't we should be asking why are we obese in the first place, solve the problem from it's core please.
Sounds like all the drugs pushed on giving up smoking too. People invariably go back to smoking. There needs to be a non drug way of supporting people to eat healthier to loose and keep a healthy weight.
True, however, in the UK prescriptions are mostly free, those who have to pay are charged under £10. The cost of healthy eating is huge, so for many, the drug will be viewed as a weight and budget friendly fix. It may not encourage a healthy diet
Big pharma makes money out of all the aides given for quitting smoking, patches, logenges, gum etc. And almost all return to smoking within a year. Allen Carr's book and methods work but have not received funding to research his methods as there is no profit. Yet his approach works. It did for me. Looking at our mental blocks and not preachy.
Wow, aren’t you a f*cking revolutionary. No one has ever suggested such a thing before. It’s not like fat people aren’t constantly demonized, villainized, and shamed by people to try and make us lose weight- if ONLY you could “find a way”. Now they come up with an actually effective medication that is helping people control the “food noise” in their heads that has plagued them for a lifetime and - “no we don’t want that, we still want you fatties to suffer and do it the hard way because you deserve any kind of actual help” Get f*cked.
I used the drug Champix to give up cigarettes. The first time I gave up for 2 years then, after battling the flood in the UK in 2007 until 4am, I thought I would just have one. I went straight back on them. Second time I was wiser, I knew if I had just one cigarette I would be back on them again. That was 5 years ago and I haven't had one since. The drug 'made me' not want one and that was how I wanted to give up. I wanted to not want one. Horses for courses I guess.
I am type 2 diabetic and I had a horrible experience with Ozempic. I made a video on that if any body wants to watch. It's on my channel. I will NEVER take this drug again.
AVOID THIS LIKE THE PLAGUE - My wife was put on Dulagutide (the same medicine different name) for Diabeties, within a week she had severe abdomial pain. Our doctor said persevere and the pain will go away - IT DID NOT - After two months she had an ultra sound and had a mass on her pancreas and liver, she then had a scan booked but another 2 months ahead - they gave her an appointment with a Consultant another 2 months ahead. In the meanwhile she then investigated the drug and company and found 178 litigations against the company in the USA because of Cancer. She was eventually diagnosed with terminal Pancreatic cancer and died in March 2022. DO NOT take my word for it - you must check it out for yourself. I am sure this drug causes pancreatic cancer and I stand to be corrected. If you want to lose weight eat less and exercise it's as easy as that.
So sorry for your loss and certainly links with cancer need to be investigated. But you are wrong on your final point. If you listened to the science as explained on the podcast, it is clearly not "as easy as that". People who have been obese are fighting against hundreds of thousands of years of evolution and biology. Eating less is not easy when your body is ramping up appetite and cravings to force you to eat more. And your body will even reduce the energy burning impact of exercise to foil weight loss efforts.
It sounds dangerous if given to people who dont want to change their lifestyle and diet. They do gradually regain weight unless they dollow a ketodiet abd intermittent fastibg.
I wonder what will happen if I drink semagglutin and do not apply it to the muscle? will it have the same effect but much weaker or none at all? thank you (when applying to the muscle, I had extremely undesirable effects with 1 ml and I would need to carefully reduce the dose)
@@n.p.8223 I don't think you should drink it personally as it's not formulated for that. Generally speaking drugs are formulated for different intake routes and cannot be administered interchangeably
With are you talking about lol, the muscle lol, you inject into a 1 inch squeezed bit of flesh 2 inches from your navel, and just go in the length of the tiny diabetic insulin needles. Unless you have the pen which is basically exactly the same instructions but you push in the button and the needle pops into your flesh and releases the meds for you. No it's not meant to be digested
Wow, lifetime medication (alarm bells ringing!) and some questions that were asked, had an answer of unknown as yet. He very quickly skimmed over the cancer question to the point of changing the subject to talk about other side effects. Definitely not for me! What is needed is something to get the patient started that can be continued on their own with follow up therapy maybe? Why is it injected and not a pill that can be gently reduced? I can see only the benefits for people who have reached the point of trying everything and a way of avoiding going under the knife (and to be fair, he did kind of own that point at the end). Does the NHS have access to this and if so, how much does it cost the NHS per person per year?
There are plenty of people who are on medications for a lifetime - diabetics on insulin, transplant patients on immune suppressants, obese people on cholesterol and/or blood pressure medication, HIV patients on antiretrovirals, etc. people who have spent a lifetime fighting a losing fight with their bodies don’t need your judgment about being relieved over there _finally_ being a medication to help them that actually *works* even if it means they have to take it forever to maintain as healthy weight. No one is helped by your moralizing.
I guess confusing the body to think starvation is fine will work. How healthy do these people end up though. You can lose weight by eating before you are hungry, so you make better choices. Eat lots of low energy carbohydrate and a good blend of fat and protein with it, to make it filling before you get enough. Add pumping iron and the weight will fall off, slowly, without the need for drugs
None of that works when your hunger and satiety hormones are screaming at you all day long that you are starving. What is it about that people like you don’t understand? It isn’t a matter of willpower when your body is being signaled constantly that you need to eat - it is a biologically and hormonally driven need that can’t just be ignored no matter how often random people on the internet call you “weak willed” when they’ve literally never experienced it. Instead of offering useless unsolicited advice that literally EVERY fat person has heard before, maybe you could try actually _listening_ for once.
@@brucejensen3081 that changes nothing. Your experience isn’t the same as everyone else’s. Why is that so hard to understand? First, you’re a man and don’t have to deal with estrogen or menopause or constantly fluctuating hormones, so your experience is literally different than 50% of the population. But that aside, there are people is PCOS, people on steroids, people with lipedema, people with thyroid issues, people with depression, etc. YOU have no idea what someone else is going through by simply looking at them. If “pumping iron” and eating less was sustainable and worked for you, then you were one of the few lucky ones, but that’s clearly not the case for most people.
@@brucejensen3081 you’re acting as if losing weight is the easiest thing in the world while also claiming that you have a condition that causes weight gain, so either you’re pretending that it’s easy so you can smugly act superior to people who struggle, or you’re full of sh*t. Either way, I really don’t care.
Ummmm...I want some to eat lots of Candy bars,Doughnuts, Ice-Cream & see if you still lost weight on this Ozempic whne he said NO! No worries if take it...
Am I the only one who notices? The guy on the right claims that after stopping taking the drug people go back to their old weight. Bob points out that they gain weight but don't go back to their old weight but they may do if the study went on long enough. They can't both be right, isn't it Jonathon's role to sort this out, there shouldn't be conflicting claims. The guy on the right should be asked to give his evidence or apologise for making things up. Later Bob says that gastric bands are one of the few ways a person can change the tendancy of people to return to their former weight. Guy on the right contradicts this. Again Jonathon needs to sort out the facts. Either Zoe should endeavour to sort the fact from the fiction or it's just another psuedo-science, snake oil, fleece the overweight bunch of chancers.
These ppl need to discuss Andrew (bariatric surgeon’s) jenkinson’s book - why we eat (too much) - discusses all this and more much better based on current research)
Jonathan’s ability to summarize is amazing
I've had CRPS since 2011, I'm now 55 and havnt been able to loose weight. Pain is exhausting. Since I was put on oxempic in May 2023 I have lost 36lbs but... my pain has reduced by around 75%. I can't believe it. My skin sensitivity has gone done down and the muscle shocks have stopped.I've slept so much better too. I am still needing to loose weight but that's OK. Great podcast guys.
I lost Two Stone by changing to a plant based diet. This was three years ago. I have not regained the weight.
Plants are for rabbits
@@donpepsi ...and gorillas
Same here. Eating a whole foods plant based diet, SOS-free. So far, so good.
Same but it was 45lbs. I still eat a lot.
There is a set point of weight. If someone eats junk food, the body isn't getting what it needs. The body raises set weight. The solution is to stop eating junk food.
Thank you that was really awesome. I do not need this treatment as I have been able to use my change in diet with intermittent fasting (lost 50lbs 2021 no medication) and eating to keep my type 2 diabetes in remission. I do have so many friends who cannot do what I did, but if they had the systemic pain I had; I had a choice of one! This VID is the best information great answers, and I will be passing it on to my many friends and colleagues who are struggling.
Over the last 15 years I had gained some 15 kg (stopped smoking after 40 years, menopause) and at the beginning of this year due to high cholesterole and not wanting to take medication I decided to change my diet and way of living. From January I counted calories for 3.5 months until the 15 kg were lost (BMI from nearly 27 to now under 21). I stopped buying any kind of highly processed food, stopped sugar (and all equivalents) practically completely (apart from an icecream a week in summer) and keep to intermittend fasting (16:8). I am never hungry, eat good great portions , discovered lots of new and tasty dishes and keep my weight. Resistance training helps with muscle build-up (so important when getting to the end of one's Sixties). I avoid any kind of pills or medication wherever possible - and would rather walk 20 km a day than take drugs to loose weight. For me a scary idea.
Agreed - I’ve lost 60 pounds by your same regime
I agree. I am going to do it your way also. Already fast a lot either 18-6 or 20-4, some prolonged 2 to 4 day fasts, honestly never was a big eater and was one who eats to live rather than lived to eat. I don't like taking medication either and at 72 -dont take any required prescriptions. Not diabetic, though it's rampant in my family, I try to eat healthy and walk as much as possible. Hopefully, I'll eventually lose some weight. I just don't trust their fast fix method. Still too new and too many unknowns.
They are indeed dangerous without radical life changes. Calories counting is rubbish and makes you hungry, Realistically people should eat high good quality fats, proteins and zero sugar and carbs to lose weight ands keep it off.
Remember you have an increased risk of multiple cancers as well as significantly more health risks like stroke and cardiac issues *if you remain obese.* That often far outweighs the risk of the extremely rare serious problems with semiglutide - one that isn't even proven in humans yet. I was wary when I started semiglutide for my obesity, but as my husband pointed out: when the public conversation turns to overly moralizing debates and the drug is continuously proven safe and effective, it's probably not about the drug itself.
I've experienced no side effects on this medication, other than slightly increased heartburn that is entirely manageable. I can't even tell if that is a side effect of the medication or my healthier eating habits. The moment I took semiglutide, I could tell my weight problem was chemical, since I could suddenly follow nutrition plans with ease and felt content with food for the first time in my life.
Well we HOPE that outweighs it. We don't know yet. It will be a while before the true cost of being on these drugs for life is known. This isn't a dig at Ozempic, it's just that is how long true side effect profiles take to come up. Look at Zantac. How long did it take for the stomach cancer issues to become known? It look 100s of millions of people taking it for decades. Now it's not considered a good risk:reward by some health authorities. There was no way this concern was going to show up in the initial trials.
And it isn't a binary choice between obesity and Ozempic. Many, many people beat obesity without it. If you can't and it stops you being obese then you very well may be correct and it is the drug for you.
So true, especially "the moment I took semaglutide, I could tell my weight problem was chemical". I used to never make excuses for my weight and never bought into the idea that fat ppl like myself just have some chemical imbalance, but after taking this drug it makes me think again haha.
Some respond better than others, that heartburn increases your risk of esophageal cancer, there are lots of questions on this new “game changer”. Its curious that he compares it to antidepressants which really are not solving the problem.
Unbelievable ,I am going to continue to work out and eat better and cut calories.
I just had a mini stroke last week. Almost lost my eyesight....thank God it's been restored and I am okay. I've been fighting obesity for decades. Yes, I've lost weight and have made changes. I just have not been able to maintain it. I was against any intervention.... that's changed. I am going to use any tool necessary to lose weight and live.
Major but rare side effects are retinopathy and acute pancreatitis which I why I stopped taking this. Since stopping taking it and switching to a low carb (
Why not both?
@@StevenShakarisaz who needs to risk the complications?
@My OpenMind low carb diets, especially ultra low carb diets, can have severe side effects as well. And I say that as someone who is currently doing a low carb and has been on and off it for years. Everything has risk, but to me, being obese is the biggest risk. Keto plus semaglutide sounds like an effective combination.
I’ve been ketogenic for 13 years couldn’t get below 118 while it’s only 3 pounds over what my highest weight should be it was discouraging and I’d give up and binge eat right back up to 132 I’m doing the diet and taking the medication hoping to get to my healthy goal weight
@@Michele-f5p do you find yourself eating when you are not hungry?
I don’t understand why the issues of all the hormones being injected into the meats and chicken we are eating aren’t also being addressed by the medical community. Fish like talapia salmon shrimp etc. that are being farm raised and eating their own waste product has a definite affect on our bodies as well. These foods that we ingest day to day are not naturally consuming the environment around them any longer and common sense would suggest it’s changing our hormones and body mass due to the unnatural birth and growth of these animals. Then there’s the fruits and vegetable issues. Also what about our society moving from the Industrial Age into the internet age children are not playing outside as we did before riding bikes swimming walking for blocks to get to a store or a friends house or a phone booth all are practically gone in our society today. So people are more sedentary now. So we as a society have completely changed our activity and food consumption within our own bodies and those of childrens’ bodies and what is disturbing for me is that every issue we humans have all comes down to a pill an injection or another pill if that pill isn’t working. Your podcast is great and super informative and please I’m not throwing shade on your medical knowledge cause that’s not my intention. I just wanted to point out that we are a society that has become one that opens the cabinet to solve the problem. Not all cause yes I recognize there are exceptions to one’s issue but look around our society today and listen to all the commercials pushing this drug or that one. There is so much more contributing to the obesity craze and it truly is killing us slowly whether the drugs make us thinner or the affects on our bodies after we’ve used the drugs. Pretty scary as whole but thank you again for your podcast.
I used Semaglutide for about 5 weeks. I lost 4% weight. The nauseous side effect made it difficult to continue. My rebound after this course was a resort to bad eating habits and excessive hunger. +6%
Despite my poor willpower and adherence to a diet I would not try it again. I can see the assistance this drug gives but it's not for me. I think my weight loss endeavours just involve controlling what goes into my mouth!
(This is with a staggered dose escalation.)
Thank you for your input. Ive had side effects from other drugs and had to stop using them.
Some have a degree of success with intermittent fasting - 14 hours (overnight +) as this can be varied to suit how they feel that day.
@@eileenfb1948 thank you!
Lost about 16% of my body weight in a year with Ozempic. Would switch to Wegovy, but it's so damn expensive I can't really afford the extra cost. Been very happy with my results with Ozempic, but at the moment, I've been holding my weight at a somewhat higher body weight where I'd like to end up, so I've now been looking more into what changes I can make in my habits to get to my target weight. I'd like to lose 6-7 kg more.
My health improved measurably, and significantly - and my quality of sleep improved. A general improvement in quality of life. I was also lucky in that I never had any side effects from the drug.
Thank you Zoe. Thank you. Thank you.
Why - does no one discuss the most serious side effct - COST ?
This drug may also quickly reduce the size of a person's savings
its covered by my Insurance $25 co pay
My copay is $42 per month.
In UK I get all prescriptions/ medical procedures free of charge.
Thank God for insurance!
What’s the cost of staying obese? I guarantee it’s far more.
It is a lifesaver. Mine is Mounjaro instead of Semaglutide. It is a great adjunct therapy to bariatric surgery. After losing 120 lbs with Bariatric surgery, I took some other medications that brought the return of my gut wrenching hunger. I still couldn’t eat much, but I would get hungry too often. I gained half of my weight back, and with Mounjaro, I am below my low weight with surgery.
The benefit won't last indefinitely - I see no sign of that. But you could use this time to change to a more healthy diet which would reduce your need for so much insulin.
@@eileenfb1948 I am actually not insulin resistant. I do suffer from biological obesity, Lipedema, Dercum’s disease, and Ehler’s Danlos. I have had good habits for years. I simply have painful hunger that must be caused by a hormone imbalance. In fact, the research shows the effects do last for most who stay on the medication even at a maintenance dose. The small number of people who can go off the medication appear to be those who have only been obese for a shorter period of time. That is what clinicians are reporting. Those of use who have suffered from obesity for much of our lives are in a different boat. Until I took the meds that caused my hunger to return, I maintained my weight loss from Bariatric Surgery for three years. I had previously lost most of my weight through diet and exercise six times, but as the research shows, the body fights against this, and I could never maintain for more than six months even starving myself.
You will find these drugs also cause significant muscle loss
@@eileenfb1948not sure where she says she's on insulin or hasn't made adjustments to her diet? Having made the latter is actually implied, given that she's had bariatric surgery.
@@moergb I know two people who had bariatric surgery and they put on a lot of weight. Both were buying sweets, etc and not eating well. Quite likely you are correct, I hope so.
Brillant I realy enjoyed listening to Bob all bout this thankyou
A very interesting episode. It was noticeable that the term 'weight loss' was used rather than 'body fat loss', and the negative effects on muscle mass and bone density not mentioned at all. That said, the potential is great, and hopefully subsequent versions may improve.
I’ve heard thyroid tumours are a rare side effect. Others include nausea, diarrhoea and headache.
I also read this
Thyroid tumours are a side effect in rats, who have GLP1 receptors in their thyroid cells. My understanding is that most humans do not have GLP1 receptors in their thyroid cells, and that as such most people are not at risk of thyroid cancer from GLP1 agonists.
Only if you're predisposed with thyroid issues and that's a suggestion. My side effects have been close to nothing
Rare side effects are actually gallbladder stones (1 of 100), direct pancreatitis (rare, but pretty dangerous), paralysis of intestines and other digestive problems. I have not heard of any registered thyroid cancer cases. There have been some pancreatic cancer cases in the USA - they are still trying to prove the connection in courts and scientific community. You can check the medications on the official sites of producers. There is a whole list of them: Ozempic (Wegovy), Trulicity, Saxenda etc... There are also a lot of such medicines for diabetes used daily.
Talking to people age 70 plus has helped. Age, genetics and family history seems to be important. I am happy.
I am 72, and I took it for 7 months, and I was able to reduce my A1C to 4.9, eliminate all blood pressure meds, loose 42 pounds, and my BMI is know 26. This is after a lifetime of obesity. I have been off Mounjaro for a month, and maintaining all these stats.
Type 1 Diabetes, and Type two Diabetes, should be given different names, as they are not the SAME disease, and should not be confused by giving them the same name.
When I checked online, the cost of the drug is about $1000 per weekly shot. How can that be a game changer? $1000 per week is approaching the median household income in the United States. I suppose if people spend all of their income on the drug, they won't have any money for food, and they could lose weight that way. But seriously, by following the advice on Zoe and other UA-cam channels, in less than a year (the same period as the trial Dr. Kushner conducted), I lost fully 30% of my body weight, by walking, intermittent fasting and reducing but not eliminating carbs. I also lost 20% body fat and went form obese to a normal BMI. And I saved $1000/week over buying this drug, not to mention the doctors' fees, etc. that I also didn't spend money on. This was 3 years ago and I have not regained the weight. To be honest, without being critical, it feels a bit like extortion.
In Europe it's about £140 a MONTH when bought privately. And everyone in the supply chain is making profit at that price. How you get to these ludicrous costs in the USA is a question you might want to ask your politicians, because the drugs simply don't cost anywhere near that.
The whole thing sounds like problem disguise instead of problem solving.
@@RaveyDavey The politicians can't hear such questions because of the money stuffed in their ears from big Pharma.
If you are in the US and do not have insurance then the cost is about $1,000 per month, not per week. Many insurance plans cover these drugs, and they pay far less than cash paying patients. My cost to take Mounjaro was $42 per month.
Wegovy with no insurance is between 1200 to 1500 a month. With approval by insurance $25, compound pharmacy semaglutide $250 a month it's do-able. Not for everyone but many can make this work
An all-time high of 205 million people across 45 countries don’t have enough food to eat, according to the UN’s latest Hunger Hotspots report.
That quite tragic with the price of internet.
My first fast food in uk was in the 80s when kfc opened up. I also got food poisoning from it too with short hospital stay but that's another story!
Fast food has exploded in uk. You can't go shopping, work, leisure without passing a food outlet. Maybe there should be more local laws on how many food outlets are allowed
Great interview. Very informative!
Great video. Very informative. It has changed my mind about using the drug now though as who can afford to stay on it for life. Unless you stop eating altogether.
Very difficult to hear the good Dr. as the miking is terrible. I want to hear him. Do you have his words in text? That would help tremendously.
They are managing the symptoms, but not the cause
How does the medication work for type 2 diabetes? Is it meant to lower blood sugar. How is this different to to people taking it for losing weight ?
This describes how it works ua-cam.com/video/QHmRIEOWrHk/v-deo.html
The drug is made by a Danish based company, Novo Nordisk. The drugs are NOT allowed to be used for weight loss in Europe.
This doesn't sound great. If people still need to take a drug after losing weight that is failure because the problem is 90% because of processed foods.
If people need to take a drug for the rest of their life after a kidney transplant is the transplant a failure?
No- obviously the answer is no.
Thank you for this information
Thank you for this very informative podcast. From this video, I understand that Semaglotide (I hope I have the correct spelling) is a hormone produced in the guts. What I’d like to know is how does a healthy body creates it? Is there a natural way to help your guts into producing enough of it to avoid obesity totally? What do we know about the hormone in healthy individuals who may just be fighting with maintaining their weight despite a healthy lifestyle? Would diabetic people be prone to lack this hormone? When one has an impaired endocrine system, like polyglandular autoimmune syndrome type 2, could they be prone to semaglotide hormone deficiency?
Yes there is, cut out processed carbs and sugar - increase protein fibre and good fats
I have been using Ozempic for 4 weeks now at .25 and just upped to .5 have never experienced more nausea and vomiting in my life (i am from canada and my healthcare OHIP coveres my perscription entirely)
Hollywood director Paul Schrader posted extensively about the horrible side-effects he has been experiencing from this drug. It is sad to see ZOE turning into a drug-pushing enterprise.
I agree. We thought we could trust Zoe - in the pocket of drug company means I don't know if I can believe the information they have been given by the company
To be fair, the drugs have helped some celebrities like Mindy Kaling, etc. And Dr. Robert Kushner has mentioned a list of side effect at 23:53. Although, I'm not sure whether the list is complete or not.
Edit: I don't think Zoe tried to cash in from this session. They invited Dr. Will B. into the conversation to bring the scepticism about the drugs. And he did! He brought up "concern" about pancreatitis and thyroid which had not previously included in the list of risks mentioned by Dr. Robert Kushner. I think the problem is neither the drugs nor the clinical trials have been used or performed long enough to show any long-term serious risks.
The drugs might be useful to ease people into clean eating, carb reduction, & fasting. After your body get used to all that, you can reduce the drugs little by little.
I have no connections to Zoe. I can't even join their program because of my country of residence.
I don't see how anyone who listened to the entire episode could accuse Zoe of being "in the pockets of the drug industry." This was a balanced discussion about the pros and cons of using this medication as one tool to combat a public health crisis.
The accusation that Zoe is a "drug pushing enterprise" is ludicrous, since Zoe does not sell the medication. Indeed, if this medication becomes widely administered for obesity, it could reduce demand for Zoe's services.
Zoe is giving me an alternative to the medicine. I don't see why you say this?
@@eileenfb1948If people like Zoe don’t talk about about what is being heralded as the greatest breakthrough in obesity then all I’m left with is information I really don’t trust.
I find his presentation somehow that something is being hidden.. or not disclosed. I find Will more helpful in his approach to weight loss.
so it turns out NICE (in the UK) have recommended this stuff for a *maximum* of 2 years. Which according to the discussion about what happens when you stop (from about 39:23), makes it basically pointless and set up to fail. Right?
Yep. NICE sometimes make their recommendations based on the cost of a treatment or the number of healthcare professionals available to give that care, rather than on the amount of care needed to give benifit.
Yeah I have been on semaglutide for about 3 years now. I never really feel hunger anymore and find I eat out if habits and seems to have bad habits that are out of control. It was the weight management service that put me on it and talking to my diabetic nurse or GPs, they don't want to take me off until my weight is lower. Hearing about it should be closely monitored does concern me, no one has ever reviewed things (at least I don't believe they have)
Taking you off the meds will make you regain the weight, There is no endpoint to weight loss if your weight loss depends on the "medication". I don't get your healthcare team's reasoning.
@@myggggeneration I think the drugs meant to ease obese people into a healthier lifestyle. If they change their eating habits by lowering carbs consumption, eliminating ultra processed food, and fasting regularly, the weight will be kept off although they stop taking the drugs.
Thanks for the education ❤
Education? Mad Scientist and a hunger for money! That is what this is about.
Can you take any other natural diet supplements with this Yes or No please?…
Normalizing use of a hormonal drug makes me very wary. My mother's terminal cancer may well have resulted from many years of hormonal replacement treatment (HRT) for a hysterectomy. I think I'll stick to a whole foods plant based diet...it's working and I'm down 14 lbs so far.
Any pharmaceutical drug has side effects.
Yep! Tylenol.. Ibuprofen.. you name it.
Went to see my endo doctor just the other day. I have had thyroid cancer. My diabetes is in remission, blood pressure is regulated, not on statins anymore. My weight was 267 I have managed to get it down to 187. I found it strange that I was given literature on this product when I asked about my concerns I was told I would get skinny. Then I asked about the lifetime injections and weight coming back and was told that it would be my fault if I stopped and gained it back. Was also told that my insurance would not approve cause I had lost so much weight. Was given a info where I could call and possibly negotiate a price. I just think there maybe some good but it seems like its not for me. I went through injections for what I thought was PSA and it was not. Think I am gonna work my way down and continue to heal my body.
It is disappointing to hear in this channel, which I thought its main purpose was to promote health by improving diet and living style, what seems to be now a promotion of a drug.
I take this for diabetes… no weight loss but i only take 0.25 per week….
Y
I'm slightly alarmed by the complete medicalisation of obesity demonstrated by this doctor. It very much reminds me of how depression is looked at now: it's a chemical imbalance...here is a pill. My brother take anti-depressants. They seem to help a bit. However, why is he depressed? Well maybe it has something to do with his destructive behaviour patterns and beliefs that have damaged his life over the last 30 years! Of course he's depressed. I would be too. Chemical imbalance? Maybe but why? I know, it's bloody obvious LOL.
We were not fat here in the UK until really the late 70s early 80s when the obesity crisis started to kick in. Our bodies didn't change but the food environment and work/life behaviours sure did through the 80s and beyond. THAT is why we're a nation of fat people. But have we got the guts to change it? It would seem not.
You have all the obvious answers that these expert doctors failed to give. Like diabetes another big moneymaker for big pharma.
My first fast food in uk was in the 80s when kfc opened up. I also got food poisoning from it too with short hospital stay but that's another story!
Fast food has exploded in uk. You can't go shopping, work, leisure without passing a food outlet. Maybe there should be more local laws on how many food outlets are allowed
This is a big deal. I know someone who this has worked for. Regaining weight back is something I have seen time and again on conventional diets. The person I know has never eaten well nutritionally and still eats poorly. Just less of it. I also know a person who has no appetite because if she gets stressed she can't eat and also does not eat for nutritional reasons.
Purchase Dr B's book and try that first. 10 bucks instead of thousands.
I’d try a lot of things before this. It did bring to light some interesting knowledge about biochemistry and eating. Sometimes we just need patience and certainly we need to believe in protocol. The body systems are complex.
At the end of the diet when you aren't losing weight, if you keep eating the same and drop volume of excercise, you will start to build muscle and fat will remain the same. Increase food as muscle gain stops. In no time you will need more energy than before the diet started. You can increase your energy requirements more, or return to the diet once all metabolic adaptation is reversed
You do need to train harder
look at how the types of food we eat now has changed in tbe last 50 years
Any known risk /interaction for people with Hashimoto’s autoimmune hypothyroiditis using levothyroxin?
ua-cam.com/video/QHmRIEOWrHk/v-deo.html
How does this compare to other glp1-ra drugs? Same class, different drug maker
How about a video on the biology and math regarding calories burned by the body. Eg can you divide your bmr by 24 to determine calories burned per hour? What are other factors?
Giving 'it' back to them is a bit misleading as it is artificial so how can you be giving it back. What happens in the blood with this product is the same as giving them even more insulin? How does insulin resistance fit in with this product when it looks like it will make it worse?
I know people who are around BMI of 30 and they tell me that they eat too much and they eat when they are not hungry. Others say it is because they eat fast food. Another has had surgery but buys sweets made of sugar and keeps putting weight on. Others eat to help them cope with their emotions.
I am appalled that Zoe is giving air time to promote this product.
I don't think it's a promotion. Zoe was trying to tackle the current hot issue which currently trending on the society, health-wise. They invited Dr. Will B. to bring sceptcism to the conversation, and he did. The problem is the both the clinical trials and the use of the drugs have not been long enough to really prove there is no serious side effect.
I think Zoe is simply sharing the science of this drug with their audience so they can make their own mind up about using it or not. Some may consider taking it and want to know what the science says about it, whether it is safe and to hear why they should not take it.
Possibly safer than a stomach surgery such as gastric bypass?
The drug sound very awful. 😅 It is really for patients who have no choice. However, isn't we should be asking why are we obese in the first place, solve the problem from it's core please.
My experience of loosing weight is first few weeks feel difficult but after that healthy low calorie type dieting simply feel like the new normal.
Eyeroll......
Sounds like all the drugs pushed on giving up smoking too. People invariably go back to smoking.
There needs to be a non drug way of supporting people to eat healthier to loose and keep a healthy weight.
True, however, in the UK prescriptions are mostly free, those who have to pay are charged under £10. The cost of healthy eating is huge, so for many, the drug will be viewed as a weight and budget friendly fix. It may not encourage a healthy diet
Big pharma makes money out of all the aides given for quitting smoking, patches, logenges, gum etc. And almost all return to smoking within a year. Allen Carr's book and methods work but have not received funding to research his methods as there is no profit. Yet his approach works. It did for me. Looking at our mental blocks and not preachy.
Wow, aren’t you a f*cking revolutionary. No one has ever suggested such a thing before. It’s not like fat people aren’t constantly demonized, villainized, and shamed by people to try and make us lose weight- if ONLY you could “find a way”. Now they come up with an actually effective medication that is helping people control the “food noise” in their heads that has plagued them for a lifetime and - “no we don’t want that, we still want you fatties to suffer and do it the hard way because you deserve any kind of actual help”
Get f*cked.
I used the drug Champix to give up cigarettes. The first time I gave up for 2 years then, after battling the flood in the UK in 2007 until 4am, I thought I would just have one. I went straight back on them. Second time I was wiser, I knew if I had just one cigarette I would be back on them again. That was 5 years ago and I haven't had one since. The drug 'made me' not want one and that was how I wanted to give up. I wanted to not want one. Horses for courses I guess.
I am type 2 diabetic and I had a horrible experience with Ozempic. I made a video on that if any body wants to watch. It's on my channel. I will NEVER take this drug again.
Terrible, must be getting kick back ,can not wait to see the law suits this ozempic
AVOID THIS LIKE THE PLAGUE - My wife was put on Dulagutide (the same medicine different name) for Diabeties, within a week she had severe abdomial pain. Our doctor said persevere and the pain will go away - IT DID NOT - After two months she had an ultra sound and had a mass on her pancreas and liver, she then had a scan booked but another 2 months ahead - they gave her an appointment with a Consultant another 2 months ahead. In the meanwhile she then investigated the drug and company and found 178 litigations against the company in the USA because of Cancer. She was eventually diagnosed with terminal Pancreatic cancer and died in March 2022. DO NOT take my word for it - you must check it out for yourself. I am sure this drug causes pancreatic cancer and I stand to be corrected. If you want to lose weight eat less and exercise it's as easy as that.
So sorry for your loss and certainly links with cancer need to be investigated. But you are wrong on your final point. If you listened to the science as explained on the podcast, it is clearly not "as easy as that". People who have been obese are fighting against hundreds of thousands of years of evolution and biology. Eating less is not easy when your body is ramping up appetite and cravings to force you to eat more. And your body will even reduce the energy burning impact of exercise to foil weight loss efforts.
So sorry for your loss
It sounds dangerous if given to people who dont want to change their lifestyle and diet. They do gradually regain weight unless they dollow a ketodiet abd intermittent fastibg.
I was put on Saxenda but my body couldn't tolerate the side effects.
How does semaglutide compare to sibutramine in its action?
Not even comparable. Subutramine has an action on fat and the liver, not hunger.
Weight Loss or Fat Loss, what is it?
I think they say people always talk about 'weight loss' when actually they should probably say they want to lose fat, so 'fat loss' is more accurate.
I am far from overweight, and am wondering about this for Fatty Liver. Anyone have any insight into that?
Sounds more like a fad drug. How do these drugs react with other medications?
No one mentioned Phentermine as opposed to semiglutide.
Because phentermine is just a stimulant and will cause your blood pressure and heart rate to sky rocket. No one mentioned meth either 🤷♀️
Do you get these weight loss injections from yr gp are they on NHS?
They will be on the NHS this year via referrals to obesity clinics.
Show me the science ,the studie on the side effects, must of us,not all just eat the sandard American diet .
I think you will find we do have famine
Every scientist you interview pushes a vegan/veggie diet.
Is that telling you something?
I wonder what will happen if I drink semagglutin and do not apply it to the muscle? will it have the same effect but much weaker or none at all? thank you (when applying to the muscle, I had extremely undesirable effects with 1 ml and I would need to carefully reduce the dose)
Ur not supposed to inject into muscle! Just under the skin ..
@@Z8terfix thank you, yes I know. BUT that was not the answer to my question,)
@@n.p.8223 I don't think you should drink it personally as it's not formulated for that. Generally speaking drugs are formulated for different intake routes and cannot be administered interchangeably
With are you talking about lol, the muscle lol, you inject into a 1 inch squeezed bit of flesh 2 inches from your navel, and just go in the length of the tiny diabetic insulin needles. Unless you have the pen which is basically exactly the same instructions but you push in the button and the needle pops into your flesh and releases the meds for you. No it's not meant to be digested
Wow, lifetime medication (alarm bells ringing!) and some questions that were asked, had an answer of unknown as yet. He very quickly skimmed over the cancer question to the point of changing the subject to talk about other side effects. Definitely not for me! What is needed is something to get the patient started that can be continued on their own with follow up therapy maybe? Why is it injected and not a pill that can be gently reduced? I can see only the benefits for people who have reached the point of trying everything and a way of avoiding going under the knife (and to be fair, he did kind of own that point at the end). Does the NHS have access to this and if so, how much does it cost the NHS per person per year?
There are plenty of people who are on medications for a lifetime - diabetics on insulin, transplant patients on immune suppressants, obese people on cholesterol and/or blood pressure medication, HIV patients on antiretrovirals, etc. people who have spent a lifetime fighting a losing fight with their bodies don’t need your judgment about being relieved over there _finally_ being a medication to help them that actually *works* even if it means they have to take it forever to maintain as healthy weight.
No one is helped by your moralizing.
@@BoringTroublemakerthank you! These were exactly my thoughts!
$800+ per month!!
I guess confusing the body to think starvation is fine will work. How healthy do these people end up though. You can lose weight by eating before you are hungry, so you make better choices. Eat lots of low energy carbohydrate and a good blend of fat and protein with it, to make it filling before you get enough. Add pumping iron and the weight will fall off, slowly, without the need for drugs
None of that works when your hunger and satiety hormones are screaming at you all day long that you are starving. What is it about that people like you don’t understand? It isn’t a matter of willpower when your body is being signaled constantly that you need to eat - it is a biologically and hormonally driven need that can’t just be ignored no matter how often random people on the internet call you “weak willed” when they’ve literally never experienced it.
Instead of offering useless unsolicited advice that literally EVERY fat person has heard before, maybe you could try actually _listening_ for once.
@@BoringTroublemaker my waist was at 52 inches at one point
@@brucejensen3081 that changes nothing. Your experience isn’t the same as everyone else’s. Why is that so hard to understand? First, you’re a man and don’t have to deal with estrogen or menopause or constantly fluctuating hormones, so your experience is literally different than 50% of the population. But that aside, there are people is PCOS, people on steroids, people with lipedema, people with thyroid issues, people with depression, etc. YOU have no idea what someone else is going through by simply looking at them. If “pumping iron” and eating less was sustainable and worked for you, then you were one of the few lucky ones, but that’s clearly not the case for most people.
@@BoringTroublemaker I have hypothyroidism and bipolar, but I am not going to go out and find excuses
@@brucejensen3081 you’re acting as if losing weight is the easiest thing in the world while also claiming that you have a condition that causes weight gain, so either you’re pretending that it’s easy so you can smugly act superior to people who struggle, or you’re full of sh*t. Either way, I really don’t care.
Ummmm...I want some to eat lots of Candy bars,Doughnuts, Ice-Cream & see if you still lost weight on this Ozempic whne he said NO! No worries if take it...
Am I the only one who notices? The guy on the right claims that after stopping taking the drug people go back to their old weight. Bob points out that they gain weight but don't go back to their old weight but they may do if the study went on long enough. They can't both be right, isn't it Jonathon's role to sort this out, there shouldn't be conflicting claims. The guy on the right should be asked to give his evidence or apologise for making things up.
Later Bob says that gastric bands are one of the few ways a person can change the tendancy of people to return to their former weight. Guy on the right contradicts this. Again Jonathon needs to sort out the facts.
Either Zoe should endeavour to sort the fact from the fiction or it's just another psuedo-science, snake oil, fleece the overweight bunch of chancers.
I met my goals a month ago and I stopped taking Mounjaro. I am working hard to maintain and improve my health, and so far all is good.
These ppl need to discuss Andrew (bariatric surgeon’s) jenkinson’s book - why we eat (too much) - discusses all this and more much better based on current research)
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