Cellular Respiration 3 - TCA Cycle (Krebs Cycle)

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  • Опубліковано 28 вер 2024
  • www.handwritten... - This tutorial is the third in the Cellular Respiration series. This tutorial provides an overview of the TCA Cycle (also known as the Krebs Cycle) with a particular focus on the carbon balance throughout the cycle and the enzymes involved in each step. For more entirely FREE tutorials and the accompanying PDFs visit www.handwritten...

КОМЕНТАРІ • 164

  • @zebzbebz
    @zebzbebz 10 років тому +33

    Amazing! I have a biology exam in a few hours and before watching this video I did not understand a single thing about Krebs Cycle.
    Watched it twice and now I feel fully prepared.
    Thankyou so much! :D

    • @castadesann5731
      @castadesann5731 10 років тому

      hahaha... I am you right now!

    • @NicoUnken
      @NicoUnken 10 років тому +1

      Casta Desann
      And I'm both of right now!

    • @bonbonpony
      @bonbonpony 9 років тому +3

      Zeba Fariha People should consider giving their money to this guy instead of to these bad teachers who didn't teach them a thing, then. They don't deserve the money, contrary to this guy. We should support great people, not bad people. Vote with your wallet.

    • @zebzbebz
      @zebzbebz 9 років тому +1

      Totally agree with you! I wish I could help him financially, we don't have paypal in our country and I don't have a visa card yet. However I am soon going to get one, and hopefully will be able to support him.

  • @monikkiify
    @monikkiify 8 років тому +36

    the broad marker is oddly satisfying...okayyy..back to studyinggggg

    • @zannatul23
      @zannatul23 7 років тому +1

      its arousing loool

  • @Deputydelhon
    @Deputydelhon 8 років тому +13

    Acetyl-CoA is not a two carbon molecule, but rather the acetyl functional group has two carbons. That's what the video meant, but I wanted to clarify!

  • @Betterbye
    @Betterbye 9 років тому +6

    You, sir, are an inspiration. Thank you for existing.

  • @harpinmartin
    @harpinmartin  11 років тому

    @christian honey All the PDFs are available on the website.

  • @CarlosRodriguez-ny7vf
    @CarlosRodriguez-ny7vf 10 років тому +3

    This is the best explanation by a long shot. Thank you!

  • @aakashbadhawan
    @aakashbadhawan 11 років тому

    I rarely comment on videos, but your effort is too good to be left unappreciated. Cheers!!

  • @fancydreaming
    @fancydreaming 11 років тому

    Can we expect the Electron Transport Chain video? Really love all of them.

  • @erickacruto6670
    @erickacruto6670 9 років тому +4

    Thank you so much this is really a big help, please continue making tutorials sir and may God bless you more.

  • @maryjanehugo6439
    @maryjanehugo6439 9 років тому +2

    I'm a student in Phillipine Normal University.. Thank you so much for this. It is really a great help in my report :)

  • @smitashinde7053
    @smitashinde7053 5 років тому +1

    Your videos are so helpful.
    Please make one on light reactions and dark reactions of photosynthesis , too.
    Please it's a request .

  • @felonymelany10
    @felonymelany10 8 років тому +2

    SO. FREAKING. AWESOME. And so easy to follow and understand!! Thank you so much!

  • @mdavis7143
    @mdavis7143 9 років тому +1

    that was an absolutely beautiful and clear explanation of the tca cycle--awesome work! thank you!

  • @aakankshajohare1932
    @aakankshajohare1932 7 років тому

    This is the best tutorial video I have ever seen.

  • @eightstreams
    @eightstreams 10 років тому

    Finally an explanation that makes sense. Thanks you so much. God bless you.

  • @fbah123
    @fbah123 9 років тому +108

    Now...how to memorize this overnight?...

    • @fbah123
      @fbah123 9 років тому

      *****​ good luck ;)

    • @bonbonpony
      @bonbonpony 9 років тому +31

      Faatimah B Notice that the enzymes are usually named after the molecule they produce or decompose, or a molecule they modify somehow. So knowing the molecules, you have half the work done. Just attach the names of the *functions* of these enzymes ("kinase" if it moves around the phosphates to/from ATP/GTP, "isomerase" or "mutase" if it modifies the molecule, "synthase" if it synthesizes a new molecule from two smaller molecules, "dehydrogenase" if it moves hydrogens by reducing NAD+ to NADH or FAD into FADH2, or simply add the "-ase" ending to the name of the molecule which is being decomposed).
      Harder thing is to memorize the names of the molecules. But since they have similar endings, you can try making a poem or a song out of them, or use some associations (e.g. I use a picture of a lemon to represent citrate, a big "A" to represent the CoA coenzyme etc.), and I try to remember where do they fit in the picture of the cycle.

    • @fbah123
      @fbah123 9 років тому +2

      Bon Bon​ thanks a whole lot for your explanation! Yeah I guess your ideas will make everything much easier.

    • @AASSAF-qy3dq
      @AASSAF-qy3dq 9 років тому +1

      Bon Bon ur great really thank u alot easiar this way

    • @bonbonpony
      @bonbonpony 8 років тому +1

      ***** Yes, but it only helps you to remember the order of these molecules, not their actual names. And it is the names that people find the most difficult to remember. In your mnemonic, you still need to know what these first letters stand for in the first place, so it has the same problem that most misused mnemonics have.

  • @DuranUE
    @DuranUE 10 років тому

    WOW very very helpful! This made more sense than anything else I have looked at. Thank you so much!

  • @carrielizotte3814
    @carrielizotte3814 7 років тому +1

    This made so much more sense thank you so much!!!

  • @assefadawit73
    @assefadawit73 10 років тому

    This is just what I needed thank you Y'all keep up the good work .

  • @namraali9138
    @namraali9138 9 років тому

    WOW! You made it so much easier, thank you!

  • @modelaircraft12
    @modelaircraft12 8 років тому

    great lecture Mate! Greetings form Sydney!

  • @shrishtipatley2753
    @shrishtipatley2753 7 років тому

    awesome!! now I can finally understand Krebs cycle thanks a lot 😊

  • @顾孙晟
    @顾孙晟 11 років тому

    great video, but you did not explain how GTP forms ATP by giving it's phosphate group to ADP

  • @andrewpetts3953
    @andrewpetts3953 8 років тому +4

    Thank you this was explained brilliantly! For anyone that missed the comment below by Ashley Hermes!:
    Remember this
    "Citrate Is Kreb's Starting Substrate For Making Oxaloacetate."
    The first letter of each word in the above sentence corresponds to the first letter of each molecule as you progress through the cycle. (Cirtrate, Isocitrate, Ketoglutarate, Succinyl-CoA, Succinate, Fumerate, Malate, Oxaloacetate)

  • @oglow100
    @oglow100 11 років тому

    Thanks. I just have one question, Why can't citric acid be converted directly to isocitrate? Are there any enzymes that can coordinate that process?

  • @hassanadel3905
    @hassanadel3905 8 років тому

    this video is simple and amazing ! Easy to understand it :D thanks a lot

  • @bhavindangar223
    @bhavindangar223 7 років тому +1

    plz make video on inflammation

  • @Nicholath
    @Nicholath 9 років тому +1

    This is beautiful

  • @indiansubbu
    @indiansubbu 8 років тому

    you missed the oxalosuccinate after the isocitrate molecule?

  • @alexamcguinness1762
    @alexamcguinness1762 4 роки тому

    This is so helpful! Thank you so much.

  • @saikanthreddy9515
    @saikanthreddy9515 9 років тому

    its really a big help!!! easy understanding nd learning a lot , thank u prof :)

  • @lizash8821
    @lizash8821 9 років тому

    Hi, thanks for the video.It gives a lovely review without the extra waffle.
    With the link reaction, isn't the enzyme a pyruvate decarboxylase complex?

  • @wuveralfred2920
    @wuveralfred2920 11 років тому

    great explanation

  • @disha6301
    @disha6301 6 років тому +1

    this vedio really helped me alott...thnx

  • @BigBangGDbabyyy
    @BigBangGDbabyyy 11 років тому

    you drew such a perfect circle *_*

  • @tomscott1163
    @tomscott1163 9 років тому +1

    So hummmmm,,,,Question? Which Fruits and Vegetables would you have to eat to get the right enzymes to produce the ATP in the Creb Cycle ???

    • @bonbonpony
      @bonbonpony 9 років тому

      Tom Scott Good question. I'd like to know the answer too. Especially for the Coenzyme A, which seems to be key to metabolism of fatty acids (in other words, it doesn't let you become a fat ass :P ). My guess is that you need to eat stuff which contains some precursors to the CoA, such as pantothenic acid. Just take a look at the molecule and try to figure out its constituents. They will surely be needed in your diet to synthesize the CoA.

  • @sakshiojha9227
    @sakshiojha9227 8 років тому

    thank u very much . it's very helpful to me .....

  • @2032kaka
    @2032kaka 10 років тому

    this helped me alot! thankx!

  • @mohammadwaqar6415
    @mohammadwaqar6415 6 років тому

    Kindly help to draw a pain and its inhibition by pain killer....?

  • @abbeymorin3721
    @abbeymorin3721 8 років тому

    this is very helpful!!!! THANKYOU

  • @sarax9101
    @sarax9101 7 років тому

    Thank you!

  • @malakaldakhilallah6487
    @malakaldakhilallah6487 7 років тому +1

    I LOVED it 💕💕💕thanks

  • @keziahcyrapapas6941
    @keziahcyrapapas6941 11 років тому

    thank you! you are a big help!

  • @rayanaalo6022
    @rayanaalo6022 7 років тому

    Thank you this is really helpful 💜💜

  • @Gr4ceful4life
    @Gr4ceful4life 10 років тому

    thank you so much

  • @taltsarfaty9389
    @taltsarfaty9389 8 років тому

    Wow really helped me thank you

  • @misskittani
    @misskittani 10 років тому

    Very easy very helpful

  • @nandi018
    @nandi018 10 років тому

    this was amazinggg!

  • @ladysparkles4567
    @ladysparkles4567 10 років тому

    perfect. thank you

  • @daniablub
    @daniablub 9 років тому

    THANK YOU SO MUCH

  • @jezreelluna6311
    @jezreelluna6311 7 років тому

    finally I understand now!

  • @chiefpink29
    @chiefpink29 11 років тому

    GREAT VIDEO! VERY NICE HANDWRITING AND DRAWING. LOL

  • @nadadew473
    @nadadew473 8 років тому

    Thanks 👍

  • @malbasicka
    @malbasicka 11 років тому

    Hats Off !

  • @kalkidanberhanu7708
    @kalkidanberhanu7708 5 років тому

    Wow thanks!!

  • @Mishti25
    @Mishti25 8 місяців тому

    God bless youuuuuuuuu💗💗💗

  • @felixmboya8820
    @felixmboya8820 6 років тому

    Nice one

  • @gwaladrielle
    @gwaladrielle 11 років тому

    Dude You Rock!!! thanks!!!

  • @NhanNguyen-ip6gw
    @NhanNguyen-ip6gw 10 років тому +1

    I heard at 1m45s that you said "Acetyl CoA is a two-carbon molecules". Is it right? Because I search on Wikipedia, and they say Acetyl CoA is a big molecule? en.wikipedia.org/wiki/Acetyl-CoA .
    I'm not a native English speaker. So sorry.

    • @lih7542
      @lih7542 10 років тому +2

      Acetyl CoA =acetyl group"which has two carbon atoms" + co-enzyme A"which is a co-enzyme derived from pantothenic acid and has a complicated structure " ......so CoA is just a carrier for acetyl group and doesn't actually enter the cycle and what is meant by the two carbon molecule is the Acetyl (2C) that combine with oxaloacetate (4C) to form citrate(6C)

    • @NhanNguyen-ip6gw
      @NhanNguyen-ip6gw 10 років тому

      I want to say thank you very much. Now I got the idea :)

  • @skabuzar7863
    @skabuzar7863 7 років тому

    thanks sir

  • @StarLegend111
    @StarLegend111 11 років тому

    Very helpful
    Thanks a lot :)

  • @adada8450
    @adada8450 11 років тому +1

    it help me a lot. thanks

  • @tuqadada7506
    @tuqadada7506 8 років тому

    Thank you 👌🏻✨

  • @vydehi17
    @vydehi17 11 років тому

    super sir

  • @ssaaffaar
    @ssaaffaar 9 років тому

    thax

  • @krupalparmarbiology
    @krupalparmarbiology 6 років тому

    can you want to collaborate?

  • @aryantyagi915
    @aryantyagi915 8 років тому

    valiuable........!!!!

  • @ToddAndersonD
    @ToddAndersonD 11 років тому

    10 ATP per cycle right?!

  • @SaulRodriguezshow
    @SaulRodriguezshow 9 років тому

    NICE

  • @19tez87
    @19tez87 9 років тому

    These might just save my ass for my uni exam tomorrow!!

  • @Mishti25
    @Mishti25 8 місяців тому

    Loveeeeeee ittt ❤❤❤

  • @FaceCol
    @FaceCol 11 років тому

    Muy bueno, gracias :)

  • @MrCheeseguy123
    @MrCheeseguy123 10 років тому +7

    fuking beautiful

  • @kelseymo2647
    @kelseymo2647 8 років тому +4

    i lost it once he said oxaloacate

  • @riadzeini7770
    @riadzeini7770 8 років тому +5

    And tomorrow, my IB externals......

  • @pranaysatdeve8173
    @pranaysatdeve8173 8 років тому

    it's not playing 😑

  • @dhirajmgr2006
    @dhirajmgr2006 8 років тому

    saved my time 😈😈😈

  • @fairymaheta
    @fairymaheta 7 років тому

    damn, it was sooooo f**king easy.

  • @Jojo-ug9gx
    @Jojo-ug9gx 8 років тому

    perfecttttttttttttttttttttt

  • @rawdonwaller
    @rawdonwaller 11 років тому

    Donate!!

  • @naisamehzabin7652
    @naisamehzabin7652 9 років тому

    fuck !!! why cant I watch it ?

  • @T-K4L
    @T-K4L 7 років тому

    aint no one gonna donate to you

  • @harpinmartin
    @harpinmartin  11 років тому +2

    Yeah thats right 3NADH = 7.5ATP, 1FADH=1.5ATP, 1GTP=1ATP, therefore 10ATP in total.

  • @yousuf5124
    @yousuf5124 8 років тому

    thanks.

  • @arohe4705
    @arohe4705 8 років тому +1

    i can give nice comment thanks love ur videos

  • @swadtheking8608
    @swadtheking8608 7 років тому +2

    you're australian am i right?

  • @MrAmmody07
    @MrAmmody07 10 років тому +1

    thanks prof
    you are a big help!

  • @mothman_slayer4217
    @mothman_slayer4217 6 років тому +1

    What about Pyruvate carboxylase?

  • @OsloThea
    @OsloThea 11 років тому

    In Marks Medical Biochemistry, it says 12 ATP, because 1 NADH would be oxidized to make 3 ATP, 1 FADH2 to 2 ATP and 1 GTP to 1 ATP, overall 9 + 2 + 1 = 12 ATP. Do you know whats right?

  • @daniboo2381
    @daniboo2381 7 років тому

    Isn’t this too complicated for A level bio? Just wanna know

  • @danieladeyinka
    @danieladeyinka 11 років тому

    this is the only krebs cycle vid that worked for me. thank you!

  • @markbriangazmin
    @markbriangazmin 11 років тому

    I'd like to buy you a drink man! You are such a big help....=)

  • @allen9845
    @allen9845 11 років тому

    awesome if only professors knew how to teach it this way....

  • @beckwilde
    @beckwilde 8 років тому

    your drawing is aesthetically pleasing. good job with the TCA cycle. clear and simple and fairly short

  • @alexmorrell3923
    @alexmorrell3923 11 років тому

    Great!!! Keep them coming :) UREA CYCLE pleeaseeeee :)

  • @OwnedBy619
    @OwnedBy619 11 років тому

    A cycle = A turn, or 2 turn to complete the cycle ?

  • @BSPUPM-
    @BSPUPM- 8 років тому

    thank a lot..your video help me to understand it well

  • @tharunreddy1104
    @tharunreddy1104 9 років тому

    thank u very much. it was greatly useful.

  • @mahomedkaise3446
    @mahomedkaise3446 8 років тому

    thnk u so much ur vedio gonna help my exams thnks