Aaaaaaand I FINALLY freaking understand it now!!!! Your videos should be required lectures for our A&P/ biology/ science classes. Better than any other “teaching” method in my classes. Thank you! 🙏
I have watched many videos to learn about Krebs cycle. This is the far best video one can come across!! Thank you so much for such a clear explanation!
This is acutally the best explanation ive seen, students shouldnt be scared to watch longer explanation videos, becuase these kinds of videos are hidden gems
Generally, books are incomplete and teachers teach incompletely and this video clarified many obscure parts of this cycle for me. Thank you very muchhh🤍🤍🙌🏻
@@misterthemonkeykingARE U --- respectfully NO ONE SAID IT SHOULDNT BE USED AS A RESOURCE FOR LEARNING bbbbbbb please read a comment completely before criticising someone else thankyou very much
We like to do that since 2020 and coronavirus ,,and it seems that you do that too ,,, also we rely on videos that teachers from your country do ,, so i think that we owe you guys 😊
How in the world did the scientists figure all this stuff out? It's truly marvelous. Thanks for the B-complex heads-up! Maybe I'm missing something here, but are the phosphates lost or depleted in this process?
Wow, you explained the krebs cycle so beautifully. Our cells' adaptability to producing energy even when there is noy glucose is amazing. Everytime that there is a lack of something in the body, it substitutes another substance for it. Jehovah God designs are wonderfully!
Thank you for explaining the kreb cycle. I have mercury poisoning and figured out because I had no more citric acid in me my body goes into a metabolic acidosis and citric acid reversed this but now I am needing a lot of sugar to function which explains the glucose process in the krebs cycle.
I am obliged to thank you from the core of my heart for your teaching and efforts. I can't thank you enough but still... Thanks a lot my dearest sir. ❤️🥰
This is great. Now I can whistle glycolysis (632) and the Krebs cycle (66544444). If I use sharps for CoA then it's (63#2) and (665#44444). You can even interleave them so it's (63#2) (665#44444) (665#44444) and repeat to represent a glycolysis causing two turns of the TCA cycle. The Music of Life!
Hi... thank you so much for your videos...words can't explain how much they help me in med school but I have a question about this.... Since the succinate, fumarate and malate are all 4 carbon molecules, why isn't an isomerase enzyme used?
Great, informative and charming video presentation. Much appreciated. I will check (and subscribe to) all your other video presentations, as well.. Thank you.
Thanks for your explanations We study this subject in the school but unfortunately it's almost censored in our school books and i had to get back to the reference and check it correctly. Thank you so much ❤
Super helpful video (as are the others you've done about cellular respiration). Thanks! One question, though. My textbook says that "*after* moving into the mitochondrial matrix, the pyruvic acid (or pyruvate) is converted into a 2-carbon compound called Acetyl coenzyme A (Acetyl CoA)." Most other sources I'm finding say the same. However, if I understand correctly, this video is saying that this happens *before* moving into the mitochondria, and that the pyruvate molecule actually needs CoA to be able to cross the mitochondria membrane. I'm curious about this difference. Thanks.
The idea of CoA helping pyruvate cross the membrane isn't accurate. Instead, pyruvate enters the mitochondria through specific transport proteins called pyruvate translocase in the inner mitochondrial membrane. Once inside, the enzyme pyruvate dehydrogenase catalyzes the conversion of pyruvate to Acetyl CoA. So, in short, the conversion to Acetyl CoA happens after pyruvate has crossed into the mitochondria.
Yes, you are right, I think he made an mistake here. Pyruvate enter the matrix of mitochondria with MPC1 and MPC2 and is then converted into a 2-carbon Compound called Acetyl CoA.
I would like to suggest a small correction in the 3rd reaction where iso-citrate should convert into oxalo succinate before alpha-ketoglutarate dehydrogenase
I was burnt out and your video helped me feel passionate about the sciences again. Thank you.
Your arms did it for me.
Are you kidding?
This explanation is so clear and a great level of detail for students - not too little, not too much.
ur the most jacked biology teacher I love it
Aaaaaaand I FINALLY freaking understand it now!!!!
Your videos should be required lectures for our A&P/ biology/ science classes.
Better than any other “teaching” method in my classes. Thank you! 🙏
Coming back to this video for the 1000th time cause i always forget and watch it again
My mind is completely blown. This is the best explanation of the krebs cycle I've seen. Thank you!
Studying for MCAT and this video was more helpful than the explanation during my biochem class. Much appreciated.
me too
I have watched many videos to learn about Krebs cycle. This is the far best video one can come across!! Thank you so much for such a clear explanation!
Literally the best and most comprehensive video I have seen and I’m 4 mins in. It’s clearer without all the excessive illustrations.
Very kind! 😊
Thanks!
Thank you!
This is acutally the best explanation ive seen, students shouldnt be scared to watch longer explanation videos, becuase these kinds of videos are hidden gems
Generally, books are incomplete and teachers teach incompletely and this video clarified many obscure parts of this cycle for me. Thank you very muchhh🤍🤍🙌🏻
I understood this 18 min video compared to the hour lecture my Professor tried explaining it, you are a life saver
I learned this better in less than 18 minutes than I have in several semesters of college level bio. Ferris Bueller, you're my hero.
Adding in the carbon diagram changes my understanding of the cycle completely. How simple yet effective!
This explanation was so comprehensive and easy to understand that i want to be asked about it in the exam now
Thank you so much Doctor Mike
"Everyone's favorite...." It wasn't until after I watched this video. Thank You, Dr. Mike! I am inspired to be like you someday
I'm having an exam tomorrow and I must say this has raised my confidence to a new level
First video that made things click for me. Was feeling like I was never going to get it, but this saved me. Thank you!!!!
Just what i needed back to back! glycolysis and kreb cycle💪🏼🙌🏼
subscribed
I'll come back again 👏👏👏
the MOST helpful explanation of the the kreb's cycle! The explanation using the carbon atoms made this finally make sense for me! Thank you :)
im from india and it's so crazy how students from all over the world r relying on yt videos😭😭
Reading is nice and all, but visual diagrams coupled with verbal explanation is nice
😮😮 Osh ya
But it's just a video in the internet, why shouldn't it be used as a resource to facilitate learning?
@@misterthemonkeykingARE U --- respectfully NO ONE SAID IT SHOULDNT BE USED AS A RESOURCE FOR LEARNING bbbbbbb please read a comment completely before criticising someone else thankyou very much
We like to do that since 2020 and coronavirus ,,and it seems that you do that too ,,, also we rely on videos that teachers from your country do ,, so i think that we owe you guys 😊
Great lecture Mike👍Any thoughts on reverse Krebs cycle that takes place in cancer cells ? thanks
You saved me, it was so understandable and explained in a fun way, love it!
I've never understood the concept of the Krebs cycle this fast, thank you so much!
Beautiful explanation of Krebs cycle ..i have never experienced ever before ❤❤
only God can reward you Dr. The best explanation ❤
Best expalantion of the acid citric cycle I have ever seen.
Awesome teacher make difficult topics so easy to understand.
your videos are the best on yt for medical study. kind regards!
How in the world did the scientists figure all this stuff out? It's truly marvelous. Thanks for the B-complex heads-up! Maybe I'm missing something here, but are the phosphates lost or depleted in this process?
Wow, you explained the krebs cycle so beautifully. Our cells' adaptability to producing energy even when there is noy glucose is amazing. Everytime that there is a lack of something in the body, it substitutes another substance for it. Jehovah God designs are wonderfully!
Thanks sir, ur videos didn't just helped me a lot academically ,it also makes my day!! You're voice just sounds so cheerful & relaxing
You earned my Respect my, a Masters in Biotechnology student here🙌
Your lectures make me so happy, because I am sure that will understand the topic , thank you sir
every time I watch this it makes more and more sense. Such a great explanation
This really helped me for my organic chem exam!!!
Thank you for explaining the kreb cycle. I have mercury poisoning and figured out because I had no more citric acid in me my body goes into a metabolic acidosis and citric acid reversed this but now I am needing a lot of sugar to function which explains the glucose process in the krebs cycle.
Thank you so much for being such amazing teachers on here as well as your podcast! Would you consider doing a whole video on the PDH complex?
Love that you also included info about how B vitamins fit in and fatty acids/ketones! Thank you!
I am obliged to thank you from the core of my heart for your teaching and efforts. I can't thank you enough but still... Thanks a lot my dearest sir. ❤️🥰
Thank you for teaching this! This is really going to help me in my bio chem next sem!
THANK YOU SO MUCH FOR MAKING THESE!!!
Thank y so much as complicated as it somewhat seemed I have a better understanding now ❤❤❤thank u sir
WOW! Thank you so much for this. It really made my cramming easier...😓
THANK YOU SIR AWESOME EXPLANATION SIR NO WORDS TO SAY
THANK YOU THANK YOU THANK YOU SO MUCH SIR
I didn't attend my class last time, this is so helpful😭
This is great. Now I can whistle glycolysis (632) and the Krebs cycle (66544444). If I use sharps for CoA then it's (63#2) and (665#44444).
You can even interleave them so it's (63#2) (665#44444) (665#44444) and repeat to represent a glycolysis causing two turns of the TCA cycle. The Music of Life!
Amazing video just made the topic so easy to understand thank you somuch ❤❤😊 God bless you always
Thanks as always you make difficult thing sound easy all the way from Zambia Africa salute you Dr mike🎉🎉
Thank you! 😊
I like that you simplified it .................... really clear !
Your videos are such a big help🥺❤
❤ Thanks, can you explain how to retain all needed elements and how to add them to the body
Dr Mike you're the goat for saving me in ap bio . cheers 🙌
Fantastic! Thank you for sharing this complex process is detail. I will return to it later for reference. Subscribed!
Great lecture
4 NADH = 24. ( 2X4)= 8×3=24+ 4(2FADH)+ 2ATP...total 30 + 8 glycolysis = 38
THIS IS SO COOL AND SO INFORMATIVE !!!🙌🙌🙌🙌
Best krebs cycle explanation
Thank you so much, Sir.
Thank you very much!
Very detailed and informative video, God Bless You
Hi... thank you so much for your videos...words can't explain how much they help me in med school but I have a question about this....
Since the succinate, fumarate and malate are all 4 carbon molecules, why isn't an isomerase enzyme used?
Great, informative and charming video presentation. Much appreciated. I will check (and subscribe to) all your other video presentations, as well.. Thank you.
Thanks for your explanations
We study this subject in the school but unfortunately it's almost censored in our school books and i had to get back to the reference and check it correctly.
Thank you so much ❤
I hope it helps! 😊
Really amazing job with this explanation!
Thank you! 😃
Most handsome Biology tutor to ever exist 🍁🌷
Thank you Dr. Mike!!
My pleasure! 😊
You are amazing dr mike love you
wonderful i love your lectures
Mind blown! thank you!!
Super helpful video (as are the others you've done about cellular respiration). Thanks! One question, though. My textbook says that "*after* moving into the mitochondrial matrix, the pyruvic acid (or pyruvate) is converted into a 2-carbon compound called Acetyl coenzyme A (Acetyl CoA)." Most other sources I'm finding say the same. However, if I understand correctly, this video is saying that this happens *before* moving into the mitochondria, and that the pyruvate molecule actually needs CoA to be able to cross the mitochondria membrane. I'm curious about this difference. Thanks.
The idea of CoA helping pyruvate cross the membrane isn't accurate. Instead, pyruvate enters the mitochondria through specific transport proteins called pyruvate translocase in the inner mitochondrial membrane. Once inside, the enzyme pyruvate dehydrogenase catalyzes the conversion of pyruvate to Acetyl CoA.
So, in short, the conversion to Acetyl CoA happens after pyruvate has crossed into the mitochondria.
Yes, you are right, I think he made an mistake here. Pyruvate enter the matrix of mitochondria with MPC1 and MPC2 and is then converted into a 2-carbon Compound called Acetyl CoA.
Amazing thank you Doc!
No way this man is soo good😂.
Fantastic work!!!! It helped a ton!
I love the aside! Can you show how Methylene Blue would work in this cycle, since it has the ability to donate electrons.
Man I like your videos. They are great
Your video definitely helped! I have an exam next week, so hopefully I can ace it now lol
Midterm tomorrow, must learn
Thank you! I enjoyed the video very much! ✨
I am just watching to comprehend everything because today's lecture I was if I am watching news
Thank you so much for this doc!!
Perfect! Thank you!
You're welcome!
Thanks for this amazing video
is ionic aluminum and arsenic a required trace element in the Krebs cycle?
well explained!
Thank you u real made biochem easy for me 🙏
That was a great video-good progressive explanation which I will forget in about 5 minutes
Where do pyruvate oxidation actually takes place in matrix or outside motochondrial membrane?
This video helped me a lot thank u
I appreciate the last bit on ketones
Well done on the explanation 😊😊😊
thank you doctor mike!
Mike
I need your workout routine too!
💪🏽 😂
I hope you guys will have more videos about biochemistry!
Like a piece of cake. Thanks.
I wish you have had a free online MCAT prep course which covers improtant topics
I would like to suggest a small correction in the 3rd reaction where iso-citrate should convert into oxalo succinate before alpha-ketoglutarate dehydrogenase
Wow thank you Dr Mike, thank you so much.
I was just about to tear my hair out because yoh!!!!
You are so welcome 🤗
You did not mention the transporter when it enters the mitochondria
Bro never quits arm day
Another great video. Thanks.