29:36 Vomiting generally causes metabolic *ALKALOSIS* (unless the vomiting is so deep/strong) and you vomit bicarbonate from the duodenum and it could rarely cause metabolic acidosis. But for purposes of all exams, go with metabolic alkalosis. I wrote it correct on the third bullet on this slide, but it was 3am when I recorded this and was tired and didn’t edit it. My apologies. Edit: Also for base I meant to say 7.01-14 (7 is neutral)
Thank you for not giving too much information at a fast pace. Sometimes these videos move too fast and I can't follow all this new information. You explained everything in a calm logical way and I learned a lot.
Here from 2017 I'm about to take my A&P2 test .I'm watching this video and I'm smiling ,because I finally understand the bicarbonate buffer system. I could never understand the way my teacher teaches; therefore thank you for this video.
Excellent video presentation that explained most confusing and important topic of medicine in a simple and easily understandable way. Keep up your good work. Many doctors and medical students will be benefitted by your great job.
Wow! One intelligent Doctor, Thank You !👍♥️I knew it was my Lungs Causing my Heart problems Years ago ! You nailed it 100% , But unfortunately plumary Dr.s in my Area and Heart Drs don't know this , Your Knowledge is Above their understanding. Again Thank You.
Sure, I just had my exam on cardiovascular and respiratory system yesterday. Now I can work on making this video on the renal system as a physiological buffer. I agree it is a bit confusing but I will do my best to break it down for you. Should hopefully have it done by tomorrow (wed. the 17th).
Thank you Prof. Roofs for all your classes and videos.... it's helps us a lot, even in the other side of the world..... in this case; thank you from Spain. Your examples and your drawings are perfects. When I was a child, there were a tv program called "Il etait une fois.... la vie". Your videos and explanations remember me that; the owners of the rights should think about contact with you to create a new version for the students in the Univesity. : ) Thank you so much Professor
Absolutely wonderful video! Thank you for your knowledge! I was confused by one thing about vomiting. You mentioned that it causes alkalosis but then later on state it causes acidosis. Can u please elaborate on that? Thank you again for the very helpful video!
18:07--I think the bicarbonate is written incorrectly. Shouldn't bicarb be HCO3 ^ -? (With the 3 as a subscript, and a negative 1 charge as a superscript)
Yes, I apologize. I wrote it correctly on the 3rd bullet point on that screen, but wrote it wrong below. When you vomit all those protons out you are left with a basic environment. Thank you for catching that.
Hey, I would need it a couple of days before the 26th of October, because than I have an exam in med school myself. This is a subject I have to study for it. Don't know if you will be able to produce it before the 26th, but thanks anyway!!
Hello, I could but I don't know if I would produce it in time for you. I have an exam in med school this Monday. Let me know when you would need it by.
thank you very much for the lecture. been very educative. there is something that has always confused me in the reaction below CO2 + H20 - H2CO3 - H+ + HCO3- why do we always say the foward reaction leads to formation of acid and yet the equation shows formation of base (HCO3-) and acid(H+) in equal proportion?
@@yathishbl3757 What, SPECIFICALLY has that got to do with it? I've also been looking for an answer to this question for years, but nobody ever explains it clearly. Can't SOMEONE somewhere in the whole damn world do that?
@@tomterific390 dude it's really complicated but ill simplify it as much as possible You see after H+ and HCO3- is formed,both are excreted into bowman's capsule and later reabsorbed in PCT of the kidneys and however the HCO3- is more absorbed than H+ So you'll essentially retain more HCO3- than H+
@@yathishbl3757 Thanks, but you're not addressing my question. 1) This has nothing to do with renal handling but just the damn buffer equation--what's happening in the couple of days BEFORE the kidneys start ramping up bicarb reabsorption--they don't work instantaneously--so to talk about that is going off into the wrong direction. 2) You don't have the renal part quite right--H+ is NOT reabsorbed--it combines with HCO3- to form H2CO3. C.A. splits that to CO2 & water, those get taken up and all that reverses in the tubular cell--the HCO3- is what then gets reabsorbed, but the H+ just gets spit back out into the lumen via H+/Na+ exchange--no net H+ reabsorption or excretion is going on at all--just bicarbonate trapping; the H+ is just being recycled. What happens with THIS in respiratory acidosis: CO2 + H2O --> H2CO3 --> H+ + HCO3-? Everybody talks about H+ going up, but for every mole of that you are making here, you're also making a mole of HCO3-! In every description of respiratory acidosis, everybody just ignores the bicarb. But it's right there in the chemistry. There has to be something going on that renders it irrelevant here, but what the hell is it? Is there nobody who even thinks about this? Is it just that it just reforms carbonic on buffering the acid, and as long as PCO2 stays high you end up with NO net buffering, and you gradually run out of bicarb UNTIL the kidney kicks in?
@@tomterific390 thanks for correcting me .....its been long since i studied for entrance exams so got the H+ and HCO3- confused there Yeah its true that PCT spits out H+ and reabsorbs HCO3- in PCT but there's one thing you got wrong there... You see the respiratory system and renal system in interlinked and the link is the buffer system and other tissues which use bicarbonate 1) Rs produces equal amount of H+ and HCO3- 2) the HCO3- is used up in the blood due to buffering of weak acids 3) HCO3- is further used up by the duodenum to make a bicarbonate barrier to protect from the acidic bolus from the stomach... 3) of course H+ is used up in HCl of stomach and excreted in the PCT in form of H2CO3 and NH4Cl 4) however the rate of loss of H+ is nowhere near the usage of HCO3- because as you know that the HCO3- is the most abundant buffer in the blood and any mild acids the tissue produces is buffered by the HCO3- so essentially the arterial blood has high H+ and the HCO3- is used up in arterial blood(comparatively acidic ph of 7.35) Later after passing through tissues, the H+ is used up and after passing through kidney the HCO3- is is reabsorbed in the pct which then passes through the Liver which also needs buffering because of its acidic secretions and after all this the venous blood going to lungs will have low H+ and HCO3-( ph of 7.45)and will be acidified there
I'm glad I could help. I could type out the answer here but I think I might be better if you go watch my video titled, "Compensation of Respiratory and Metabolic Acidosis and Alkalosis" and start the video @ 27 minutes to learn about renal compensation. If that does not help, then let me know.
athletes constantly hyper ventilate.. what should they eat/drink to keep balance and not enter in alkalosis? what tests should I do to find out if I am in respiratory or metabolic alkalosis?
Comment on the video or inbox me and let me know if it helps or if it is garbage (you won't hurt my feelings, I'll survive). But in all honesty let me know if there is something you want me to explain a little more. I did not know how in-depth you wanted to know. Make sure you sleep with some of those hours!
Prof. Roofs, MD it was amazing ,I finally understood alkalosis and acidosis first time in my life,plz explain how hyperkalemia causes cardiac arrest..thanks a lot your teaching skills wow
![Lp. Сердце Вселенной #60 РОЖДЕНИЕ ЛОЛОЛОШКИ [Финал] • Майнкрафт](http://i.ytimg.com/vi/YoR0pAV9FVQ/mqdefault.jpg)
29:36 Vomiting generally causes metabolic *ALKALOSIS* (unless the vomiting is so deep/strong) and you vomit bicarbonate from the duodenum and it could rarely cause metabolic acidosis. But for purposes of all exams, go with metabolic alkalosis. I wrote it correct on the third bullet on this slide, but it was 3am when I recorded this and was tired and didn’t edit it. My apologies.
Edit: Also for base I meant to say 7.01-14 (7 is neutral)
Prof. Roofs, MD just perfect..Wow
@@letshavefunwithayyanshah3571 Thank you!
Mesmerized...💖love you...
Qss
Trying to sabotage me for Monday got nervous 😂
After numerous views of my professor's power points and still no understanding, I FINALLY understand it with 1 view of your video! Thank you!
3 years on and your video is still helping students. Thank you for your time in creating this video. Helped me so much!
Iyam Canadian And I hope it always helps! You’re welcome
Thank you for not giving too much information at a fast pace. Sometimes these videos move too fast and I can't follow all this new information. You explained everything in a calm logical way and I learned a lot.
This subject is usually badly explained, this video is the exception. Well Done! I finally get it!
Explained with basics and in simplest way. Thankyou
कमला देवी वर्मा you’re welcome
Here from 2017 I'm about to take my A&P2 test .I'm watching this video and I'm smiling ,because I finally understand the bicarbonate buffer system. I could never understand the way my teacher teaches; therefore thank you for this video.
Annie lee you’re very welcome
I have been strugling to know this. But, I know it in a simple video like this. Thank you so much Sir. You are really a good professor!
Excellent video presentation that explained most confusing and important topic of medicine in a simple and easily understandable way. Keep up your good work. Many doctors and medical students will be benefitted by your great job.
Glad it helped. I apologize for the tired voice. I made this video during my office hours on a 10-hour teaching day.
What a nice explanation, calm word by word and repetition of important things, just perfect 👌 lecture
Awesome work 👌 sir. Thanks a lot.
Nimrah Ishtiaq you’re welcome!
Ok, stayed up all night finishing the video, hope it is not too late. It is uploading now.
What should I say, really speechless thank you from the bottom of my heart
This is so useful! Thanks for explaining it in such simple terms.
Wow! One intelligent Doctor, Thank You !👍♥️I knew it was my Lungs Causing my Heart problems Years ago ! You nailed it 100% , But unfortunately plumary Dr.s in my Area and Heart Drs don't know this , Your Knowledge is Above their understanding. Again Thank You.
You are welcome. I hope all goes well with your studies and best of luck on exams!
Thanks for the video ! Small correction: 29:35 vomiting causes metabolic ALKALOSIS
Sure, I just had my exam on cardiovascular and respiratory system yesterday. Now I can work on making this video on the renal system as a physiological buffer. I agree it is a bit confusing but I will do my best to break it down for you. Should hopefully have it done by tomorrow (wed. the 17th).
so awesome ! thanks so much ! you really explained everything in a very clear, concise way that really helped me understand the material
WOW! You explain way better than our chem instructor! Thanks! :) I hope you continue making videos like this. Really helpful.
I am really appreciate your efforts , many thanks
Thank you Prof. Roofs for all your classes and videos.... it's helps us a lot, even in the other side of the world..... in this case; thank you from Spain.
Your examples and your drawings are perfects. When I was a child, there were a tv program called "Il etait une fois.... la vie". Your videos and explanations remember me that; the owners of the rights should think about contact with you to create a new version for the students in the Univesity. : )
Thank you so much Professor
Professor Thanks a lot. You are a true educator. I'm very glad you made this video. THANKS !!!!
awesome video! Saved me sooo much trouble! Explained it so clearly that I completely understand it now!
You are a wonderful teacher, thank you so much for your effort!
Mai El-Refa'ey you’re very welcome and shokran شكرًا
Great lecture sir!!!
Every bit was understandable.!!
Thnks a lot!!!
Make such amazing videos a lot pls!!!
this helped me understand the buffering system and alkolisis and acidosos so much more thank you!!!
Divya Pallivathucal you’re welcome! :)
Absolutely wonderful video! Thank you for your knowledge!
I was confused by one thing about vomiting. You mentioned that it causes alkalosis but then later on state it causes acidosis. Can u please elaborate on that?
Thank you again for the very helpful video!
Thanks you rock....best explanation out of many Ive looked at......
Sir, I have a presentation about this topic tmw and your videos really helped me out!
Rawan saleh How did your presentation go?
It was an amazing vedio ......my concepts are clear now thank you so much sir ❤❤
Sapna Parkash you’re very welcome 😊
Finally i got it...thank you thank you soon much prof ..💖so much of love
Very good presentation. Most informative and extremely helpful. Thanks!
His voice is so smooth and easy to follow. :D
Which there were more teachers like you!!!! V E R Y helpful!!
+Crystal Bland *Wish
This was helpful.Thanx! I used it to study for nursing school.
Awesome presentation!! thank you!! it made have a better understanding on this matter!!! Thank you sooo much
amazing sir🤗.... explain with example 😇
You're welcome. I will do my best.
Very clear explanations. Thanks!
Great video, and great pace
29:37 i think threre's been a mistake
easy to understand. this video was helpful for me!
Thanks man, this helps a lot. Quality tutorial.
Hi dear I'm very excited to listen this video, really it is very attractive way of presentation so keep it up. Thank you very much!!!!
Thanks for this! Could you just explain something more about the kidneys as physiologic buffer?
the H2O is from carbohydrate catabolism right? (glucose breakdown) to produce 6CO2 and 6H2O.
💜👍 thanks alot ...struggled to understand why co2 is increased in resp acidosis ... Afr watching dis video finally understood 😀
18:07--I think the bicarbonate is written incorrectly. Shouldn't bicarb be HCO3 ^ -? (With the 3 as a subscript, and a negative 1 charge as a superscript)
yes i noticed that too, the chemistry grad in me was very confused
U r an awesome teacher..
Well explained man thank you so much
I understood so well. Thanks.
Thanks alot professor for such an amazing video!
Yes, I apologize. I wrote it correctly on the 3rd bullet point on that screen, but wrote it wrong below. When you vomit all those protons out you are left with a basic environment. Thank you for catching that.
Love u bro awsome work I am glad and appreciate your work bro love from india
Very well done. Helped alot
Prof roof could help me how to study physiology and concepts like you
wouldn't ph for base start at 7.1, just above neutral?
I may be in love with this man.
Thank you. It is very helpful.
Hey, I would need it a couple of days before the 26th of October, because than I have an exam in med school myself. This is a subject I have to study for it. Don't know if you will be able to produce it before the 26th, but thanks anyway!!
I think pH of base should be more than 7 not 6.99
Vomiting causes metabolic alkalosis not metabolic acidosis
Thank you for totally breaking this down!!!!!!!
Do You make video lectures on Anatomy too?
Its my first year in medical school, and I am facing a lot of problems in Anatomy.
Ariba Qamar Hello! I teach Anatomy as well but I haven’t produced Anatomy videos yet. It is on my todo list 😊
@@ProfRoofs me too brother
Thank you!
You’re welcome
Hello, I could but I don't know if I would produce it in time for you. I have an exam in med school this Monday. Let me know when you would need it by.
thank you very much for the lecture. been very educative. there is something that has always confused me
in the reaction below
CO2 + H20 - H2CO3 - H+ + HCO3- why do we always say the foward reaction leads to formation of acid and yet the equation shows formation of base (HCO3-) and acid(H+) in equal proportion?
Thats got to do with movements of hco3- inside the cells by ion channels and h+ in the blood
@@yathishbl3757 What, SPECIFICALLY has that got to do with it? I've also been looking for an answer to this question for years, but nobody ever explains it clearly. Can't SOMEONE somewhere in the whole damn world do that?
@@tomterific390 dude it's really complicated but ill simplify it as much as possible
You see after H+ and HCO3- is formed,both are excreted into bowman's capsule and later reabsorbed in PCT of the kidneys and however the HCO3- is more absorbed than H+
So you'll essentially retain more HCO3- than H+
@@yathishbl3757 Thanks, but you're not addressing my question. 1) This has nothing to
do with renal handling but just the damn buffer equation--what's
happening in the couple of days BEFORE the kidneys start ramping up
bicarb reabsorption--they don't work instantaneously--so to talk about
that is going off into the wrong direction. 2) You don't have the renal
part quite right--H+ is NOT reabsorbed--it combines with HCO3- to form
H2CO3. C.A. splits that to CO2 & water, those get taken up and all
that reverses in the tubular cell--the HCO3- is what then gets
reabsorbed, but the H+ just gets spit back out into the lumen via H+/Na+
exchange--no net H+ reabsorption or excretion is going on at all--just
bicarbonate trapping; the H+ is just being recycled. What happens with
THIS in respiratory acidosis: CO2 + H2O --> H2CO3 --> H+ + HCO3-?
Everybody talks about H+ going up, but for every mole of that you are
making here, you're also making a mole of HCO3-! In every description
of respiratory acidosis, everybody just ignores the bicarb. But it's
right there in the chemistry. There has to be something going on that
renders it irrelevant here, but what the hell is it? Is there nobody
who even thinks about this? Is it just that it just reforms carbonic on
buffering the acid, and as long as PCO2 stays high you end up with NO
net buffering, and you gradually run out of bicarb UNTIL the kidney
kicks in?
@@tomterific390 thanks for correcting me .....its been long since i studied for entrance exams so got the H+ and HCO3- confused there
Yeah its true that PCT spits out H+ and reabsorbs HCO3- in PCT but there's one thing you got wrong there...
You see the respiratory system and renal system in interlinked and the link is the buffer system and other tissues which use bicarbonate
1) Rs produces equal amount of H+ and HCO3-
2) the HCO3- is used up in the blood due to buffering of weak acids
3) HCO3- is further used up by the duodenum to make a bicarbonate barrier to protect from the acidic bolus from the stomach...
3) of course H+ is used up in HCl of stomach and excreted in the PCT in form of H2CO3 and NH4Cl
4) however the rate of loss of H+ is nowhere near the usage of HCO3- because as you know that the HCO3- is the most abundant buffer in the blood and any mild acids the tissue produces is buffered by the HCO3- so essentially the arterial blood has high H+ and the HCO3- is used up in arterial blood(comparatively acidic ph of 7.35)
Later after passing through tissues, the H+ is used up and after passing through kidney the HCO3- is is reabsorbed in the pct which then passes through the Liver which also needs buffering because of its acidic secretions and after all this the venous blood going to lungs will have low H+ and HCO3-( ph of 7.45)and will be acidified there
Good Job. Nice explanation.
How is nursing school going where what school? Just interested to know where I can help.
Great video.
This video was so helpful! Thank you so much!
29.36 you have written vomiting causes metabolic acidosis. Dont you mean alkalosis?
Ok read your typo!
Yes and he's clarified it by saying Acidosis
thank you very much..!! good luck doctor..!! thnxx again,,,!! this video saved my time..
I'm glad I could help. I could type out the answer here but I think I might be better if you go watch my video titled, "Compensation of Respiratory and Metabolic Acidosis and Alkalosis" and start the video @ 27 minutes to learn about renal compensation. If that does not help, then let me know.
athletes constantly hyper ventilate.. what should they eat/drink to keep balance and not enter in alkalosis?
what tests should I do to find out if I am in respiratory or metabolic alkalosis?
AMAZING VIDEO!! Thanks so much!
Great video! Thanks!
it finally makes sense now!
WOW..THT WAS JUST SUPERB..THNKS ALOT FOR THE VIDEO...
best explanation ever
i'm from yemen. thanks very match .great video
Hello pro. Please you said the vomiting cause metabolic acidosis but it’s cause metabolic alkalosis. Thanks
Hvs Hde correct 👍🏽
First of all video is very good sir..but you havent explained renal mechanism so please add it
Thanks it helps me a lot. Keep it up.
This was wonderful. Thank you!
Great 👌
Very good, thank you Sir.
very excellent
EXCELLENT VID!!! :) Thank you sosooso much sir.
Thank you 💖
Great video 👍👍👍👍
great work thank you
why would Nitrogen take on an extra H+ when it already has three bonds?
At 29:34 it says vomiting causes metabolic acidosis, when shouldn't it say metabolic alkalosis?
Comment on the video or inbox me and let me know if it helps or if it is garbage (you won't hurt my feelings, I'll survive). But in all honesty let me know if there is something you want me to explain a little more. I did not know how in-depth you wanted to know. Make sure you sleep with some of those hours!
Prof. Roofs, MD it was amazing ,I finally understood alkalosis and acidosis first time in my life,plz explain how hyperkalemia causes cardiac arrest..thanks a lot your teaching skills wow
Awesome helps a lot
This was a great video!!!!!!!
Thank you very much for help
I understand well but not renal (kidneys) in this video, please, add it. Thank you
You are amazing!! Thank you so much :) feel like i actually understand this now!