Acid Base Balance, Animation.

Acid base regulation basics, pulmonary regulation and renal handling of acid-base balance.
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©Alila Medical Media. All rights reserved. Voice by Sue Stern.
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pH is an indicator of acidity. The body’s blood pH is strictly regulated within a narrow range between 7.35 and 7.45. This is because even a minor change in acidity may have devastating effects on protein stability and biochemical processes.
Normal cellular metabolism constantly produces and excretes carbon dioxide into the blood. Carbon dioxide combines with water to make carbonic acid which dissociates into hydrogen ions and bicarbonate. This equilibrium is central to understand acid-base regulation. CONTINUED carbon dioxide production by all cells of the body drives the equilibrium to the right to generate more hydrogen ions. Because pH is basically a function of hydrogen ion concentration, more hydrogen means higher acidity and lower pH. Normal metabolism, therefore, constantly makes the blood more acidic. The body must react to keep the blood pH within the normal limits. This is achieved by 2 mechanisms:
- Elimination of carbon dioxide through exhalation. The amount of carbon dioxide exhaled by the lungs is regulated in response to changes in acidity. A decrease in pH is sensed by central or arterial chemoreceptors and leads to deeper, faster breathing; more carbon dioxide is exhaled, less hydrogen is made, blood acidity decreases and blood pH returns to normal. Pulmonary regulation is fast, usually effective within minutes to hours.
- Excretion of hydrogen ions and reabsorption of bicarbonate through the kidneys. The kidneys control blood pH by adjusting the amount of excreted acids and reabsorbed bicarbonate. Renal regulation is slower; it usually takes days to respond to pH disturbances.
Pathologic changes may cause acid-base disturbances. Acidosis refers to a process that causes increased acidity, while alkalosis refers to one that causes increased alkalinity. It’s not uncommon for a patient to have several processes going on at once, some of them in opposite directions. The resulting plasma pH may be normal; too acidic, called acidemia; or too basic, called alkalemia.
Acidosis may result from inadequate function of the lungs which causes arterial carbon dioxide to accumulate. This is RESPIRATORY acidosis. On the other hand, METABOLIC acidosis may result from excessive production of metabolic acids, decreased ability of the kidneys to excrete acids, ingestion of acids, or loss of alkali. Metabolic acidosis is characterized by primary decrease in plasma bicarbonate.

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[@dee8168]

i've been having a hard time understanding this lesson on my physiology class but you explained it in just 5:44 minutes. amazing. thank you!

[@Venice1917]

Sue Stern does an incredibly good job at speaking. Her speed, clarity and intonation is just perfect for me. Thanks, Sue!

[@KarthikKarthik-db9zc]

Under rated UA-cam channel. Simple n crystal clear explanations. 😍😍

[@prags9819]

Thank you so much team, this topic was troubling me for months... Heartfelt thanks to all of your sincere efforts!!!! In making knowledge worthy videos, can't express my gratitude to you guys, kudos!!!, with love!!!

[@adekunleemmanuel1305]

P

[@johnnyapple5772]

I take ap chemistry and im so surprised and happy to understand this video lol

[@Apeekinmylife]

please make detailed video on lung mechanics and also CNS
P.S I LOVE YOUR VIDEOS

[@MariaJose-or1sb]

Could you consider doing more videos about metabolic acidosis, alkalosis, and respiratory acidosis/alkalosis? Your videos are so good, thank you for making them!

[@samma-brook7851]

Hi there if I may suggest some topics to talk about like :
Genetic disorders
Endocrine abnormalities
Autistic spectrum disorder

[@emilyparks8635]

Thank goodness for this video. Everything I've been learning in my Physiology class finally made sense after watching this. Such an important concept for homeostasis!

[@brunoarekhandia4722]

Same here!

[@-VP-696]

For many years I have tried to learn this topic, and I have never really understood it, until now! So easy! At last :) Thank you very much! Great presentation

[@nerd3390]

the cell In acidosis there will be expelling of H+ or entering of HCO3- into the cell
the cell In alkalosis is opposed by expelling of HCO3- via the anion exchanger.

[@richardikpegbu2558]

Thank you soo much, it was really helpful. Can you do one on fatty acid metabolism ?

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I agree

[@jacob476]

thank God, someone finally said it.

[@viveksinghchauhan7496]

Very good way of spreading knowledge . Well done guys !

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I would love to see a video like that on Alpha 1 Antitrypsin, its structure, role in the body on a cellular level as well as its synthesis and how an acquired A1AT deficiency happens.

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Thanks a lot... I understood the topic so easily in 5 min.... Its troubling me... 🙏🙏🙏

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I love your channel, it's so great. Thank you so much

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excellent video

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This some true Top G content fr. Appreciate you brotha, doin good work out here changin lives ong!

[@LEARNERSTECHBLOG]

Please can you talk about the compensatory mechanism of acidosis and alkalosis

[@rebeccayiru4781]

no one has EVER explained this to me as well as you have - thank you so much!

[@ahmedalezzani6663]

so nice thank you so much 🌹🌹🌹🌹

[@nicolegavigan8450]

This was amazing. Super helpful thank you!

[@amaranathanpalaniappan4408]

I am a chemistry graduate .so I am easily understood the ph balance and body 's functions.

[@lubnakalsoom6198]

Yes it's a great effort that you have made for students as well as teacher good way of presenting the ideas

[@luceromausolff6997]

Well explained video, and easy to understand this complex processes

[@neelahuja9420]

Hi, very nicely explained, i would like you to make a video on: what happens inside, during box breathing, how hold in this technique helps

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Amazing so advanced feed back closed circuit systems.

[@whyknot5527]

thanks for simple but complete explanation of this theme

[@BNLandim]

in the case of an extra-renal acidosis, are the blood levels of Phosphates and Calcium Ions elevated or decreased?

[@necronomician]

The third mechanism, hydrogen - potassium exchange in cells, is also worth to mention

[@jigarthakker1880]

After the kidney part it kept me complicated, shall I go through some renal video and get back to watch this ?
If so which video shall be precursor to this ?
TIA 🙏🏻

[@Alilamedicalmedia]

Try this one: ua-cam.com/video/6HJfr00CIqM/v-deo.html

[@jigarthakker1880]

Alila Medical Media thank you 🙏🏻

[@arasissa1201]

Please translat to Arabic language

[@on10Line]

By far this is the best explanation on UA-cam.

[@MachotMabiorgarang-me4mw]

You made it understandable but what are the causes of pH lead to illness or death

[@Zckwarriar2009zi]

Brilliant explanation. Thank you.

[@katrinapuguan1449]

Thank you so much. Please dont delete your videos and keep on creating more in the future. They are awesome!

[@angelsaidferreira5193]

that balance around 7 it’s ideal for h.pylori bacteria

[@nethmiranasinghe291]

Thank you so much for describing a this complicating topic. Can you explain how these are compensated within the body in a next video. Thank you.

[@Alilamedicalmedia]

Look for alkalosis and acidosis videos on our channel!

[@JaiKumar-pr6hu]

U made my life easy, I have my exam next week, this was very helpful !!!! Tysm

[@changeyourlife9664]

How much time does it generally takes to recover from high ph. Is there any formula to calculate. I have taken duretics 5mg for 1 month. Resulting in high ph

[@angelsaidferreira5193]

why google say the ideal PH is like 7-7.5… It’s not suppose to be acid? lower than 5? 🤔

[@Bluebee9761]

Normal blood pH range is between 7.35-7.45, actually it’s slightly alkaline! 7 is neutral. A solution with a pH lower than 7 is acidic whereas a solution higher than that is basic.

[@LilliHerveau]

Would the consumption of acids (like sodas... which are not alkaline like baking soda... weird.) lead to an increase in the metabolic pH, requiring the lungs to expel CO2? Also, where does the carbon atom come from?

[@alejandramunozbuleje7421]

Nunca existen videos como estos en español. Amazing video!!

[@lailayasser3686]

Great content thanks alot and apericate it!

[@pavan2512]

in respiratory acidosis topic ...when co2 accululates....h+ and hco3 both increase right??so how come acidosis occurs when bicarbonate levels also rise?

[@viveksinghchauhan7496]

Tu bohot confused atma lgg rha hai . bhai basics clear krr

[@viveksinghchauhan7496]

Bhai carbon dioxide (acid) hoti hai . Aur HCO3 (base)
toh jyada co2 mtlab jyada acidosis

[@pavan2512]

Bhai...do you know why you called co2 'acid'? That is because it reacts with water to form h+ and hco3- ....because it produces h+ ...you called it acid.....now read my question again before you spit rubbish

[@missionjupiter1946]

Thank you for the video. Please update with Fluid and electrolyte disturbances topic.

[@johnz7167]

Ngl the pct part is hard as fck - MLS Student

[@mutturajkichcha2537]

Explaination is very good try to explain with 3D animation it will be more effective thank you for your superb creativity

[@medishine044]

Thank you so much, please explain how does lung surfactants work.

[@monamundada66]

Very well explained... Can respiratory and renal regulation of Acid base balance be explained in more details

[@sandeshp934]

I want a video on what happens when the acidity of blood increase how it affects the body if this decrease in ph goes unchecked beacuse of disease, and what happens when blood ph increases what are there effects.

[@hismajesty40]

Excellent presentation! Thank you for such a great tutorial

[@haticha1]

I really liked your explanation of acid-base, Can you please explain about endocrine and renal topics? Thank you so much

[@joshuaogutu156]

Thanks for the teaching may we do ventilation perfusion ratio

[@mtashambazibwa]

Please explain reproduction system

[@sheenareblando6443]

Kindly make a video about mechanical ventilation. Thank you

[@sindhupolukonda3571]

Superb explanation

[@InTheNewCovenant]

we can regulate our Ph buy breathing fast or slow?

[@drcssundaram1976]

Very clear illustration !

[@WarwickJames007]

Your narration need to slow down a little bit plzz...good content

[@ivanmelo6870]

Excellent graphics, congrats!

[@srikrishnan4643]

Saved me from stress of studying books without understanding

[@abdumalik_choriyev]

Thanks great explanation

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Perfect explanation

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The water mark is obstructing almost 50% of the screen and makes it hard to concentrate. A very stupid act. You could have just located your logo on one of the corners and made it easier for the viewer to follow the info.

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thanks so much Alila, I really love u people

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Great job!!!! Loved the visuals. Please do more!

[@chinmayvaidya9634]

Very informative video and hats off to the channel

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Thanks so greatly your lessons àre fantastic

[@yoditaga8381]

Waww very useful😮 thank you

[@Alilamedicalmedia]

My pleasure 😊

[@waheguruwaheguru9176]

V nicely explained 🌋🚿

[@annettewright202]

Acid base compensated vs uncompensated

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i realy loved your video thank you so much

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Jazakallah

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Excellent

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Thanks alot 💖💖💖

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thank you so much for this video. Finally, i got it

[@Alilamedicalmedia]

You're welcome!

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Great video. I think I’m starting to grasp it. Thanks!

[@Alilamedicalmedia]

Great to hear!

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Thank you it saved my time ❤️

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Love this! Thank you so much.

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GREAT VIDEO! thanks!

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please add english subtitle in screen

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I like the vedio

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Constructive

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Well that's it's

[@learningneurology9201]

can you please make a video about Cryoglobinemia.

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thank you sm

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Stress urinary incontinence

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How to take care of metabolic type

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Very helpful. Thanks

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thank you

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CAH please

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Thanks, great lecture

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How to treat uric acid formation

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Great 😊

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Nice👍👍

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Thanks

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great video and visuals!