I'm in my 5th year doing my renal rotation and omg, I spent like one hour almost tearing up with this concept cause I used to understand it very well in my 2nd year in physiology but I don't get it that much now. And suddenly your notification appeared. So thank you, really. All medical students all over the world owe you so much. جزاك الله عنا كل خير
1st question : 2 mOsm/L 2 mOsm/L 18 mOsm/L 2nd question: I am not sure if we need to make all the units the same before we calculate because dl =1/10 liter But I think we do not need to the serum osmolality gap is 30 so it is more than 25 this a medical emergency for a toxic alcohol poisoning we put the pet on the 1- 1- so we make sure the pet is well ventilated (I think we give atropine ) 2- we put give on IV fluids 3- and vasopressors (I think the atropine will do the job but may give epi for more if we need to ) first of all thank you so much for your GREET job and really you are my main motivator every time I see one of your videos I get more energy to study because you make me remember the beauty of medicine please corrects me if I am wrong and go easy on me I did not take pharma yet this is what I know from physio
Awesome explanation. I work in life science as an equipment tech/engineer, and nobody understands those damn machines!!! I’m sharing this to the team…..
I learned so much WHILE getting roasted! Thank you!! Couldn’t understand Osmolality/ larity for the life of me but i finally do! Appreciate you so much!
Hi medicosis, could potassium level affect plasma osmolality if the blood is contaminated by EDTA during blood collection step? (K+ could be up to ~40 mmol/L if it is EDTA contaminated while normally K+ should be at a relative low level in blood) Thank you!
You can measure blood potassium in the sample, if it’s around the reference range, then it’s unlikely. If you found that potassium is triple or quadruple the normal value, then it’s likely.
Hyperosmolar: Increase number of osmoles in the blood. (Serum osmolality > 300 mOsm/Kg). Hypertonicity: increased number of EFFECTIVE osmoles in the blood. (Serum osmolality > 300 mOsm/Kg). Vasopressin (via V1 receptor) contracts smooth muscles in vessel wall -> vasoconstriction.
I am sorry I didn't understand your question. V1 receptor is in every arteriole --> vasoconstriction. V3 receptor is in the kidney's afferent arteriole --> vasodilation.
@@MedicosisPerfectionalis Does hypertonocity mean serum *effective* osmolality greater than 300 unlike hyperosmolar where just serum osmolality greater than 300..what the difference between both osmolality and how can we differentiate since both have same value..
@@MedicosisPerfectionalis I mean what happen when arteiole is constricted and its physiological effect just like when vasopressin v1 acts on kidney it constrict the blood vessels and *there is decrease in blood supply and hence less gfr..*
Osmolality deals with the number of particles, not the mass. Sodium chloride will ionize in water and dissociate into Na and Cl (2 osmoles). Glucose does NOT dissociate in water into hydrogens and carbons.
🧪🥵😰Acid-Base Course: www.medicosisperfectionalis.com/products/p/acid-base-disturbances-course/
I realize Im pretty randomly asking but do anyone know a good site to watch new movies online?
@Noe Blaze try Flixzone. Just search on google for it =)
I appreciate the author's sense of humor and depth of knowledge. Thank you.
You’re very welcome 😊
I appreciate you too!
I'm in my 5th year doing my renal rotation and omg, I spent like one hour almost tearing up with this concept cause I used to understand it very well in my 2nd year in physiology but I don't get it that much now. And suddenly your notification appeared. So thank you, really. All medical students all over the world owe you so much. جزاك الله عنا كل خير
Thank you so much, dear :)
I appreciate you!
1st question :
2 mOsm/L
2 mOsm/L
18 mOsm/L
2nd question:
I am not sure if we need to make all the units the same before we calculate because dl =1/10 liter But I think we do not need to
the serum osmolality gap is 30 so it is more than 25 this a medical emergency for a toxic alcohol poisoning we put the pet on the 1- 1- so we make sure the pet is well ventilated (I think we give atropine )
2- we put give on IV fluids
3- and vasopressors (I think the atropine will do the job but may give epi for more if we need to )
first of all thank you so much for your GREET job and really you are my main motivator every time I see one of your videos I get more energy to study because you make me remember the beauty of medicine
please corrects me if I am wrong and go easy on me I did not take pharma yet this is what I know from physio
Awesome explanation. I work in life science as an equipment tech/engineer, and nobody understands those damn machines!!! I’m sharing this to the team…..
Osmolarity calculated 290mOsm/L
Osmolar gap= 30 mOsm/L, meaning there are some other ions in the ECF which are not supposed to be there
The way u teach can never let me fall asleep between lectures 🤓🤓
Wow!
It's the best simple way to explain complex mechanisms. 👍👍👍
Thank you!
👨🏫 Nephrology Playlist: ua-cam.com/play/PLYcLrRDaR8_d7bEi4DvucO73N4N_1vvPk.html
Teacher from another world🤯🤯
Thank you ☺️
Thank goodness I found your yt channel!
Welcome!
Superb... Great explanation.. Thank you so much sir
My pleasure 😇
This was so entertaining and so funny. Also, educational (obviously). Much love.
Thank you 🙏
I learned so much WHILE getting roasted! Thank you!! Couldn’t understand Osmolality/ larity for the life of me but i finally do! Appreciate you so much!
Glad it was helpful!
We need clinical instructor like this! 😂
Thank you!
This video is superb….could you share pdf of your notes please?
Long live my love 🥰🥰 you are indeed a life saver
Thank you 🙏
Hi medicosis, could potassium level affect plasma osmolality if the blood is contaminated by EDTA during blood collection step?
(K+ could be up to ~40 mmol/L if it is EDTA contaminated while normally K+ should be at a relative low level in blood)
Thank you!
You can measure blood potassium in the sample, if it’s around the reference range, then it’s unlikely. If you found that potassium is triple or quadruple the normal value, then it’s likely.
Thank you Medicosis!!
My pleasure 😇
Ya are my hero ❤
Thank you so much!
thank you, God bless you for all you effort. wonderful video. well explained
Thank you so much, dear!
Do you have videos on ecg???
Not yet
@@MedicosisPerfectionalis please make videos on cardiology. It's very difficult 🥺
I'm lucky to have come across this video thank u
I am honored!
Thank you! Enjoy your videos. Very helpful!
My pleasure 😇
Osmolar gap 29.5
320-290.5=29.5
Greater than 10 so significant!
Doesn't sodium crosses lipid membrane then how does it contribute to tonicity.Plz explain
You have to open a channel for the sodium to enter. Otherwise, it will not diffuse.
Thanks sir!
My pleasure 😇
Plz if u could explain what is hyperosmolar hypertonocity..and what is the effect of vasopreesin on Arteriole and smooth muscle..
Hyperosmolar: Increase number of osmoles in the blood. (Serum osmolality > 300 mOsm/Kg).
Hypertonicity: increased number of EFFECTIVE osmoles in the blood. (Serum osmolality > 300 mOsm/Kg).
Vasopressin (via V1 receptor) contracts smooth muscles in vessel wall -> vasoconstriction.
@@MedicosisPerfectionalis in kidney v1 constrict vessel so decrease urine formation ,so what the effect in arteriole physiologically and smooth muscle
I am sorry I didn't understand your question.
V1 receptor is in every arteriole --> vasoconstriction.
V3 receptor is in the kidney's afferent arteriole --> vasodilation.
@@MedicosisPerfectionalis Does hypertonocity mean serum *effective* osmolality greater than 300 unlike hyperosmolar where just serum osmolality greater than 300..what the difference between both osmolality and how can we differentiate since both have same value..
@@MedicosisPerfectionalis I mean what happen when arteiole is constricted and its physiological effect just like when vasopressin v1 acts on kidney it constrict the blood vessels and *there is decrease in blood supply and hence less gfr..*
Does tonicity and osmolality refers to just solute not water..
What do you mean?
They refer to the number of osmotically active particles (of the solute) in water.
Doesn't glucose c6h12o6 have more moles instead calculating as single mole..
Osmolality deals with the number of particles, not the mass.
Sodium chloride will ionize in water and dissociate into Na and Cl (2 osmoles).
Glucose does NOT dissociate in water into hydrogens and carbons.
Dr, hyperosmolar result in hyperglycemia , right? But does it occure in hypo or hyper tonicity? And why and how? Please i am confused a little bit
Hyperglycemia can cause hyperosmolarity (and hypertonicity).
@@MedicosisPerfectionalis that means the sugar will be all out of the cell hence coma, right?
Where did you explain hagma, lagma, respiratory acidosis....etc
God bless you
Thank you
You’re very welcome 😊
What is plasma osmolality
What if it is 262.96?
That can be a really good rap song 16:06
too early to check my answers from the comments but too unsure to post them myself xD
😂😂😂
What if it is 275 ?
What are you referring to by “it”?
Serum osmolality?
@@MedicosisPerfectionalis blood serum mine is 275 is this ok . Or should I be worried 😦
@@MedicosisPerfectionalis yes
As a lab tech. I'm offended 🤨
I was joking 🙃
First.
Thank you 🙏