HSP-70 / HSP-40 Chaperone Protein Folding

#hussainbiology #hsp70 # apbiology
In this video we have discussed the HSP 70 chaperone system which includes the help from co chaperone called the HSP 40. The HSP 70 cannot work alone and needs HSP 40 for the regulation of ATPase activity. The Unfolded protein is recruited by HSP 40 towards the HSP 70 cavity and mediates the folding.
HSP-60 or Gro EL ES : • Mechanism of Chaperone...

[@dontperceiveme3025]

Thank you! Very good illustration and narration. It was very helpful to me.

[@AnjaliSingh-ug7il]

amazing explanation thankyou!

[@faixankhan1231]

Very helpful video

[@deepameenakshipokala1448]

Thank you Hussain! This clarified a few gaps I had about this mechanism from my Cell Bio class :)

[@werwer65]

Всё ясно и понятно!

[@bhanu289]

Please make a video on KLa value regarding bioreactor and how we can calculate in scale up of cell culture.

[@hussainbiology]

Seriously Brother , i have never encountered this question yet and it is not in CSIR syllabus which fails the audience here who are waiting for the CSIR and AP biology topics.

[@bhanu289]

Ok sir.

[@LACERENZANUTRITION]

👍🏼👑💪🏾

[@unlockbiofactsjyoti]

I have one doubt
hsp-70 prevent protein folding
is it right?

[@Olivia-tw3nm]

your diagrams are really nice and easy to follow~

[@hussainbiology]

thanks Olivia for appreciation....Glad to know that it helps

[@madi9660]

Thank you so much for this helpful viedeo. But ist there any literature you can suggest which proofs the information in the video. I need it for a course🙈🙈

[@hussainbiology]

Yes , the reference is :
1.Molecular Cell Biology by Lodish ( Chapter 3 )

[@madi9660]

@@hussainbiology thank you so much, really appreciate it 🥳

[@hussainbiology]

@@madi9660 You are most welcome 👍

[@nourlahrichi590]

Very helpful video thank you !!!!

[@hussainbiology]

thanks for appreciation..
Glad it helps.✌️

[@salonimewara195]

Thank you sir your explanation was simple and easy to understand 🙏

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@myfaith4995]

The video really helped

[@hafizmuhammadrehan074]

Like before watching 😍😍😍😍😍😍😍😍😍

[@hussainbiology]

Thanks brother for appreciation..

[@ultracraft1997]

Please sir explain in hindi 🙏🙏🙏

[@chalsuu]

Hi sir what book can you recommend me to read about these chaperones? Thank you so much for making this lecture it helped me a lot

[@hussainbiology]

Albert's Molecular Biology

[@chalsuu]

Hussain Biology thank you sir

[@Siyaraghuvar_kripa]

Please make a video on maternal inheritance also. Thank you

[@hussainbiology]

Yeah Surely i will be making a video on that too very soon.... thanks

[@shatabdisarkar3998]

Very helpful. Made my preparations for csir easier.

[@hussainbiology]

thanks for appreciation...Glad to know that it helps ✌️

[@wellwhatsgoingonhere]

That's not true. The protein folding occurs due to continuous binding and unbinding of Hsp70 + Hsp40 complex with the substrate. The folding does not occur inside the Hsp70. You're thinking of Hsp60 chaperonin.

[@egs8545]

Great video thank you for making this!

[@hussainbiology]

Thanks Emma for appreciation...Glad to know that it helps

[@amindelna5863]

what an explanation man... U deserve one subscriber, one thumbs up and one comment ..

[@hussainbiology]

thank you so much for ur kind words....This kind of appreciation brings smile on my face...

[@robertmurray4236]

Does Hsp40 not dissociate immediately after delivering the substrate polypeptide to Hsp70? and then after it dissociates, ATP hydrolysis occurs?

[@shashios1236]

Y we need another Atp molecule by NEF ....as we already hydrolyzed the atp to adp.... earlier??? Plz explain

[@toddmarks581]

Very important question I have. Can heat shock proteins help beta galactosidase disease? This is a lysosomal storage disease.

[@claires.8249]

YOU ARE A LIFESAVER!!!! I think I might actually pass this class now!!!

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@wretched00]

থ্যাঙ্কিউ,

[@saurabhkrjha5299]

Explained good... But try to teach slowly

[@magathzen524]

I watch his vids in 0.75 speed

[@santro1112]

wonderful explanation, brother

[@hussainbiology]

thanks for appreciation..Glad it helps....✌️

[@afrizalnurkadirrpg2189]

Sorry, can we know about your refferance that you use?

[@hussainbiology]

The Alberts Molecular Biology , NCBI and Science direct are the sources.
U see the video , research on it , read paper and then u will yourself get to know is it right or wrong.....

[@anupampandey7335]

Wau that is really good presentation..thank you

[@hussainbiology]

Thanks Anupam for appreciation...

[@ezgi3174]

Really helpful with nice drawings

[@hussainbiology]

thanks for appreciation..Glad to know that it helps

[@sandunigunarathne3264]

so clear video.Thank you

[@hussainbiology]

thanks for appreciation..Glad to know that it helps

[@doctorofmedicine1113]

Comment and like b4 watching
Wonderful video

[@hussainbiology]

Thanks brother,,,,,

[@doctorofmedicine1113]

Yes dear ...also i used to watch his lecture in ist course of my MBBS ...that was too useful...and I know Dr Hussain personally as well ..

[@doctorofmedicine1113]

[phone] is my Watts app no...i think i know u that is y... Don't take otherwise ..

[@desmonddilo]

I enjoyed the story. thank you

[@hussainbiology]

thanks

[@anjalisaini6656]

Sir life sciences ke Sare topics par vedio bana loo please

[@hussainbiology]

Haan g pakka .... Trying to make imp topics first.

[@mnproduction5290]

Thanks.i was worried about this topic.i searched it many times but can't understand.Now ,by seeing this I understand fully in easy way.

[@hussainbiology]

You are most welcome

[@Celtokee]

Quite well done, sir.

[@hussainbiology]

thanks for appreciation..Glad to know that it helps

[@lindsayadams7386]

Thank you so much Hussain! This video was extremely helpful for my biochemistry course. :)

[@hussainbiology]

thanks Lindsay for appreciation.....Glad to know that it helps.😊

[@salonimewara195]

Ya same i am also from biochemistry field

[@owaisriyazbhat9922]

Keep it up bro

[@hussainbiology]

Shukriya boi..

[@sunidhim.ghatikar3625]

Thanks sir!!

[@hussainbiology]

Thanks Sunidhi for appreciation...

[@kalkidanberhanu7708]

amazing rundown! thank youu :D

[@hussainbiology]

thanks

[@ayeshafatima-lq1qp]

Thank you sir

[@hussainbiology]

Thanks Fatima for appreciation......Keep sharing and supporting

[@ayeshafatima-lq1qp]

@@hussainbiology welcome, sir,please make videos on animal physiology,bcoz I'm from botany background

[@hussainbiology]

@@ayeshafatima-lq1qp I am starting a series on PLANT Development videos but will consider making Animal Physiology videos too.

[@ayeshafatima-lq1qp]

@@hussainbiology ok sir

[@hussainbiology]

The upcoming videos will be for Physiology
Erythroblastosis fetalis ( Rh Disease )

[@TeresaEstrella-bw4xi]

I don’t know why...but I don’t understand a word you’re saying...I’m the only one?🤔Anyways, thanks for everything👍

[@hussainbiology]

I'm sorry

[@TeresaEstrella-bw4xi]

@@hussainbiology No no, it's okay you don't have to apologize. I'm sorry for saying those things to you, after all, you seem like a nice guy. Besides, I don't have a level ten in English. Please dont say sorry🫂