The single food high in most of those nutrients is...egg yolks! High in EPA, Vit E, choline, lutein, zeaxanthin. Also remember the more orange the yolk, the higher the lutein content. Most crappy mass produced eggs has light yellow yolks, low in lutein. You want dark orange, high in lutein. Egg yolks are literally a super food.
I'm tired of seeing people falsly claim eggs are high in EPA. They're not. They're very low in EPA and DHA. Just compare 100g of them with a can of sardines, anchovies or 100g of salmon to see the difference. Eggs are nice but they're nutritionally inferior to beef liver, sardines and anchovies
@@Y-JA Agree, but that does not imply that egg yolk, especially those that come from free-range hens with natural feeding and especially fertile eggs, are abundant in essential nutrients.
Fasting, intermittent or periodic, is also a powerful, and inexpensive, mean to fight brain aging , as it translates into significant production of BDNFs which are actually fertilizers for the brain.
Hey Michael 👋 I wonder, considering all this, what would be the ideal amounts of Walnuts, Almonds, Peanuts and Pistachios ? I already eat them regularly but it's completely at random, a handful here, a handful there... It'd be nice to have an idea of an optimized amount for each. Knowing this, I'd probably start preparing a bunch of those optmized nuts snack in advance. Convenience is king to keep these efforts going after all. Thanks again for all you do !
@@conqueragingordietrying1797 In Prof Ornish diet, he recommends just 1 walnut head, a good starting point until a blood biomarkers testing is available.
I wonder if astaxanthin could replace lutein and zeaxanthin... Very enlightening video, thank you Michael! I guess it wasn't a bad idea to add peanut butter to my diet..
It would be cool to combine your diet measurements with standardized brain function measurements. Maybe with something like braingauge from corticolmetrics or the brain games on e.g. brainhq.
Thanks for the heads up on the 2x video post-I have no idea how that happened (I didn't upload it twice!) Definitely, but even better would be a MRI-assessed brain age, which is commercially available...
@@conqueragingordietrying1797 I don't know too much about the MRI brain age's as they aren't available where I am. I was thinking those other ones because you can measure frequently and they have reasonable evidence that if you improve in some area it actually translates to daily living.
I think this topic is very interesting, and you're doing great work. But I have to point out that comparing the simple average of the various nutrient markers between 2023 and 2024 isn't particularly useful, especially since octedeconic acid and choline values are a 1 to 2 orders of magnitude larger than the others. You should take a weighted average if you wish to make comparisons between these collectively.
There is mounting evidence that just like the gut microbiome determines physical health there is a brain microbiome that determines brain health. Your markers are just that not determinants since correlations like this do not prove causation. There is stronger evidence that insulin resistance, mitochondrial function and degree of senescence are the key factors as in other cells.
Great in-depth analysis, as usual! Among fatty acids, pentadecanoic acid (C15:0) is quite hyped lately due to its potential anti-ferroptotic effects, and some even suggest it should be classified as an essential fatty acid. Might be interesting to see how it affects brain function. Maybe iollo will consider adding C15:0 in its panel. Any news regarding the addition of ergothioneine in iollo's panel? Have you received the results from them?
Thanks @stefan-cosmin.ionescu807. I wish I could say that iollo will add C15:0, but I'm unfortunately skeptical-I've been (gently) pushing them to add other interesting, longevity-related metabolites including ergothioneine and quinolinate for about a year, with no success... Someone will quantify C15:0-if anyone knows where, please share! I'm still waiting on a 5/28 sample for results, which is good news for them (more business!), but bad for me (slow news)...
Definitely a shame, indeed. Nevertheless, looking forward for the ergothioneine results! I think eating gray oyster mushrooms in conjunction with supplemental ergothioneine (in case L. reuteri strains are mostly absent) may be a better strategy than just supplementing with ergothioneine alone, as in this way one can reap the benefits of both protein and spermidine intake, but also lowering LDL cholesterol via monacolin K (lovastatin).
Yes, there's a lot of noise in popular media regarding C15:0. Most studies on it have been conducted by Venn-Watson's lab, which has declared conflict of interest having tested their own product. However, there is a review done by Jenkins et al. (2015) which suggested that there could be preliminary evidence for C15:0 being associated with better metabolical outcomes, and lower risk of multiple sclerosis (Holman et al. 1995), but correlation doesn't imply causation, so I remain skeptical myself. :)
It's interesting, but it's really hard to draw conclusions from the study, and it's even more difficult to know how to take action to improve oneself based upon plasma samples. They're looking at snapshots that might change throughout the day, and plasma may not tell you anything about the condition of the brain itself or what the nutrition was prior to the study. The blood/brain barrier is an issue, but also that some nutrients are stored or incorporated into the brain itself and aren't going to be flowing in your plasma throughout the day - just like vitamin D will be in fat tissue or other organs, and a plasma reading may not tell you anything about what's stored or used where. Like a calcium plasma test that tells you nothing about how much calcium is in your body or whether it's in bones or in arterial plaque, these tests give us a hint at things, but perhaps not enough to be actionable - especially if the tests aren't taken at the same time daily with roughly the same time frame after eating similar meals. I think we can safely say EPA, VitD, and choline supplements would be beneficial to stave off aging, but others, we'd really need biopsies to see composition, and it'd be great to screen candidates for structural issues w/ MRI or other to limit cognitive issues to normal aging and not anything genetic, chronic alcohol use, or injury. How do we know patients in the worse group weren't all pro football, soccer, and/or hockey athletes with head injuries? How do we know if many were alcoholics or drug users? There's just too many factors that aren't addressed, and the difference between the two groups was only 5 years on average. We need more info imho to understand the significance of the potential benefits of nutritional supplements.
Bacon fat has a lot of eicosadine acid (0.44 mg). Do I understand you correctly that this could imply that bacon fat (in moderation) could possibly be part of a good longevity diet?
Dietary intake is one side of the equation for plasma levels of these metabolites-the only way to know would be to test, in conjunction with other biomarkers, to evaluate whether bacon fat would be a net positive, neutral, or potentially detrimental for health.
@@sgill4833 The idea that peanuts is a rich source of oxalates isn't true. 100 calories of peanuts = 20 mg of oxalate. Almonds do have higher levels for 100 cal, 81 mg, but there's another variable in the oxalate story which is never discussed (unless it's here, as I have videos on it!), which is calcium intake. Calcium binds 1:1 to oxalate, so if calcium intake is relatively higher, then dietary oxalate shouldn't be an issue. When factoring in calcium levels (calcium minus oxalate) for peanuts and almonds, peanuts have 5 mg, whereas almonds have 33 mg of bioavailable oxalate that can be absorbed. These are very small amounts... In contrast, only 30g of spinach (7 calories!) yields 313 mg of bioavailable oxalate.
@@conqueragingordietrying1797 Thanks for these numbers! What about the risks of ingesting too much calcium by eating kale in an effort to avoid oxalates though? Hypercalcemia and calcified tissues is scary too. Feels like kale isn't any safer than spinach 😢
I think lecithin is considered a food, though it is also a supplement. It is very high in choline and naturally balanced with things related to choline. When used as a food, it is an ingredient rather than consumed on its own, generally. You can buy it as granules, as a liquid, or in softgells to swallow. I just buy the soy softgells. You can get sunflower seed based lecithin instead. My body loves soy. Never believed the attack on soy. I have used the granules. I made a candy of sorts to help me during chess tournaments. And it worked. It has been a while, I don't remember what else I had in it. Oh, it had walnuts, and honey. Don't know what else. This was way before my low AGEs diet. I doubt it complies. It melts quickly, and then you remove it from the heat. It is very sticky, so you have to put it on wax paper or something. Ah, it had molasses as well as honey (at the time I thought there were valuable compounds concentrated in molasses...now I suspect there are too many toxins likely concentrated in there, as well, and thus not worth the risk). My memory is slow. But it was 20 years ago. I might have had just a little cayenne pepper. If I were making it today, I would try cayenne and salt. Maybe throw in some chopped raw peanuts, and oats. I have taken lecithin almost every day for at least three decades. It can cause muscle tension, but in another light that is called muscle tone. Whatever you choose to call it, it burns more calories, because the muscles are constantly working against other muscles. Possibly it was a factor in not losing any muscle as I lost 60 lb in the last year.
@@jasonc247 Thanks for the reply. I'm not worried about cholesterol causing CVD; I think most know that it is caused by inflammation and sugar, not high cholesterol. However, high LDL *is* associated with decreased cognition in the elderly for those with APOE4, and too many eggs significantly increase in my LDL, along with saturated fat.
@@ChessMasterNate Yes, lecithin is a great source. I've been putting about 1 tsp of sunflower lecithin powder in my daily oatmeal. I think this provides about 100mg of choline, according to Cronometer.
Taking the sum of those acids, and choline without weighting is very weird. They are on such different scales that the variance of the octadecenoic acid by itself overshadows any of the other 4 markers.
thanks for the video. a bit confused about the 5 first checkmarked nutrients, where do you get them, or are they produced in the body? I know EPA and Choline are found in supplements and food
More directly, in future iterations of this video I can calculate correlations with diet, to see which foods may impact them, which may/may not translate to others, though...
Sesame seeds are a good source of tocotrienols, which are a group of Vitamin E metabolites, but also have gamma-tocopherol, which was on the list in the video. They don't contain alpha-tocopherol, though.
@@conqueragingordietrying1797 The highest sources of alpha-tocopherol in nuts and seeds are sunflower seeds, almonds/almond butter, hazelnuts, and pine nuts.
@@conqueragingordietrying1797I’m allergic to dairy, so you think egg shell calcium capsules would substitute in here to balance out the reasonably high oxalates im getting from a high greens diet?
@@conqueragingordietrying1797if you had to nail down two things you have done (supplementary or lifestyle) that has improved your deep/slow wave sleep, what would you choose? Thanks!
@@conqueragingordietrying1797 no if it hardens them or if on the contrary it promotes vasodilation or some vascular growth process such as angiogenesis
I don’t take astaxanthim it may be good but it crashed my dht levels so bad I lost my sex drive . Much like finasteride - so I’m sensitive to dht inhibitors
Did they compare ldl , a1c or cholesterol in the two groups? Dean Ornish did a recent study demonstrating reversal of progression ofAlzheimer's dementia with life style changes and a whole food low fat vegan diet. Its the same nutrition used in his coronary artery disease reversal study. The hypothesis is that cognitive impairment is a vascular problem maybe small vessel disease.
They're not recommendations, they're the top food sources for those nutrients. If the top sources included steak, I'd include it, too. For ex., plasma choline could be a marker of egg intake.
@conqueragingordietrying1797 yes there are studies. Choi, Miyeon, et al. “Ketamine Induces Brain-Derived Neurotrophic Factor Expression via Phosphorylation of Histone Deacetylase 5 in Rats.” Biochemical and Biophysical Research Communications, vol. 489, no. 4, 2017, pp. 420-425., doi:10.1016/j.bbrc.2017.05.157. Lepack, A. E., et al. “BDNF Release Is Required for the Behavioral Actions of Ketamine.” International Journal of Neuropsychopharmacology, vol. 18, no. 1, 2014, doi:10.1093/ijnp/pyu033. Réus, Gislaine, et al. “Ketamine Treatment Partly Reverses Alterations in Brain Derived- Neurotrophic Factor, Oxidative Stress and Energy Metabolism Parameters Induced by an Animal Model of Depression.” Current Neurovascular Research, vol. 12, no. 1, 2015, pp. 73-84., doi:10.2174/1567202612666150122122924.
![The BIG Magnesium MISTAKE 50%+ People Are Making! [+4 BIG SECRETS]](http://i.ytimg.com/vi/5DzSw8Ynhpo/mqdefault.jpg)
The single food high in most of those nutrients is...egg yolks! High in EPA, Vit E, choline, lutein, zeaxanthin. Also remember the more orange the yolk, the higher the lutein content. Most crappy mass produced eggs has light yellow yolks, low in lutein. You want dark orange, high in lutein. Egg yolks are literally a super food.
Yep, that could be true
Does it matter whether the yolk is runny or not?
I'm tired of seeing people falsly claim eggs are high in EPA. They're not. They're very low in EPA and DHA. Just compare 100g of them with a can of sardines, anchovies or 100g of salmon to see the difference.
Eggs are nice but they're nutritionally inferior to beef liver, sardines and anchovies
@@Y-JA Agree, but that does not imply that egg yolk, especially those that come from free-range hens with natural feeding and especially fertile eggs, are abundant in essential nutrients.
Try salmon eggs
Fasting, intermittent or periodic, is also a powerful, and inexpensive, mean to fight brain aging , as it translates into significant production of BDNFs which are actually fertilizers for the brain.
Yep, thanks Abdelilah-the study looked at metabolites, not proteins, which is why BNDF isn't on the list.
@@conqueragingordietrying1797 what you think about creatine now for blood vessel? is good?
Hey Michael 👋 I wonder, considering all this, what would be the ideal amounts of Walnuts, Almonds, Peanuts and Pistachios ? I already eat them regularly but it's completely at random, a handful here, a handful there... It'd be nice to have an idea of an optimized amount for each. Knowing this, I'd probably start preparing a bunch of those optmized nuts snack in advance. Convenience is king to keep these efforts going after all.
Thanks again for all you do !
Hi @DumbBirb and thanks. The only way to know is with regular blood (and other) biomarker testing. Everything else is a guess...
@@conqueragingordietrying1797 In Prof Ornish diet, he recommends just 1 walnut head, a good starting point until a blood biomarkers testing is available.
I wonder if astaxanthin could replace lutein and zeaxanthin... Very enlightening video, thank you Michael! I guess it wasn't a bad idea to add peanut butter to my diet..
It would be cool to combine your diet measurements with standardized brain function measurements. Maybe with something like braingauge from corticolmetrics or the brain games on e.g. brainhq.
Thanks for the heads up on the 2x video post-I have no idea how that happened (I didn't upload it twice!)
Definitely, but even better would be a MRI-assessed brain age, which is commercially available...
@@conqueragingordietrying1797 I don't know too much about the MRI brain age's as they aren't available where I am. I was thinking those other ones because you can measure frequently and they have reasonable evidence that if you improve in some area it actually translates to daily living.
Yet another informative video of excellent quality . Thanks for your work
Thanks @jeanvoeux7062!
I think this topic is very interesting, and you're doing great work. But I have to point out that comparing the simple average of the various nutrient markers between 2023 and 2024 isn't particularly useful, especially since octedeconic acid and choline values are a 1 to 2 orders of magnitude larger than the others. You should take a weighted average if you wish to make comparisons between these collectively.
Thanks @BartTrojanowski, someone else suggested that, I might give it a try.
There is mounting evidence that just like the gut microbiome determines physical health there is a brain microbiome that determines brain health. Your markers are just that not determinants since correlations like this do not prove causation. There is stronger evidence that insulin resistance, mitochondrial function and degree of senescence are the key factors as in other cells.
Great in-depth analysis, as usual! Among fatty acids, pentadecanoic acid (C15:0) is quite hyped lately due to its potential anti-ferroptotic effects, and some even suggest it should be classified as an essential fatty acid. Might be interesting to see how it affects brain function. Maybe iollo will consider adding C15:0 in its panel. Any news regarding the addition of ergothioneine in iollo's panel? Have you received the results from them?
Thanks @stefan-cosmin.ionescu807. I wish I could say that iollo will add C15:0, but I'm unfortunately skeptical-I've been (gently) pushing them to add other interesting, longevity-related metabolites including ergothioneine and quinolinate for about a year, with no success...
Someone will quantify C15:0-if anyone knows where, please share!
I'm still waiting on a 5/28 sample for results, which is good news for them (more business!), but bad for me (slow news)...
Definitely a shame, indeed. Nevertheless, looking forward for the ergothioneine results! I think eating gray oyster mushrooms in conjunction with supplemental ergothioneine (in case L. reuteri strains are mostly absent) may be a better strategy than just supplementing with ergothioneine alone, as in this way one can reap the benefits of both protein and spermidine intake, but also lowering LDL cholesterol via monacolin K (lovastatin).
@@stefan-cosmin.ionescu807 I agree, and good plan
I didn't see any scientific studies on c15 other than marketing material and claims from a seller. No data was provided, just opinions.
Yes, there's a lot of noise in popular media regarding C15:0. Most studies on it have been conducted by Venn-Watson's lab, which has declared conflict of interest having tested their own product. However, there is a review done by Jenkins et al. (2015) which suggested that there could be preliminary evidence for C15:0 being associated with better metabolical outcomes, and lower risk of multiple sclerosis (Holman et al. 1995), but correlation doesn't imply causation, so I remain skeptical myself. :)
Good to know.
Which Nutrients Are Associated With A Younger Brain Age? Captain Crunch, Count Chocula, and jello!
1) Good summary, thanks.
2) Re: Lutein and zeaxanthan, the most bioavailable source, in my understanding, is egg yolks.
Thanks Nils-while that could be true, the only way to know would be to measure plasma levels.
It's interesting, but it's really hard to draw conclusions from the study, and it's even more difficult to know how to take action to improve oneself based upon plasma samples. They're looking at snapshots that might change throughout the day, and plasma may not tell you anything about the condition of the brain itself or what the nutrition was prior to the study. The blood/brain barrier is an issue, but also that some nutrients are stored or incorporated into the brain itself and aren't going to be flowing in your plasma throughout the day - just like vitamin D will be in fat tissue or other organs, and a plasma reading may not tell you anything about what's stored or used where. Like a calcium plasma test that tells you nothing about how much calcium is in your body or whether it's in bones or in arterial plaque, these tests give us a hint at things, but perhaps not enough to be actionable - especially if the tests aren't taken at the same time daily with roughly the same time frame after eating similar meals.
I think we can safely say EPA, VitD, and choline supplements would be beneficial to stave off aging, but others, we'd really need biopsies to see composition, and it'd be great to screen candidates for structural issues w/ MRI or other to limit cognitive issues to normal aging and not anything genetic, chronic alcohol use, or injury. How do we know patients in the worse group weren't all pro football, soccer, and/or hockey athletes with head injuries? How do we know if many were alcoholics or drug users? There's just too many factors that aren't addressed, and the difference between the two groups was only 5 years on average. We need more info imho to understand the significance of the potential benefits of nutritional supplements.
Bacon fat has a lot of eicosadine acid (0.44 mg). Do I understand you correctly that this could imply that bacon fat (in moderation) could possibly be part of a good longevity diet?
Dietary intake is one side of the equation for plasma levels of these metabolites-the only way to know would be to test, in conjunction with other biomarkers, to evaluate whether bacon fat would be a net positive, neutral, or potentially detrimental for health.
Err.... Seems that I have to rethink my diet.
Fortunately I really like peanuts and pistachios.
Who knows about causation, but I prefer to cover as many bases as possible, just in case...
Hmm, I quit eating peanuts because of oxalates, and Omega 6 content. Any other source of vaccenic acid.
Same with almonds.
@@sgill4833 The idea that peanuts is a rich source of oxalates isn't true. 100 calories of peanuts = 20 mg of oxalate.
Almonds do have higher levels for 100 cal, 81 mg, but there's another variable in the oxalate story which is never discussed (unless it's here, as I have videos on it!), which is calcium intake.
Calcium binds 1:1 to oxalate, so if calcium intake is relatively higher, then dietary oxalate shouldn't be an issue.
When factoring in calcium levels (calcium minus oxalate) for peanuts and almonds, peanuts have 5 mg, whereas almonds have 33 mg of bioavailable oxalate that can be absorbed. These are very small amounts...
In contrast, only 30g of spinach (7 calories!) yields 313 mg of bioavailable oxalate.
@@conqueragingordietrying1797 Thanks for these numbers! What about the risks of ingesting too much calcium by eating kale in an effort to avoid oxalates though? Hypercalcemia and calcified tissues is scary too. Feels like kale isn't any safer than spinach 😢
What food sources do you use to get choline? I know egg yolks are a very good source, but due to my APOE4 gene I need to limit my intake.
Eggs likely caused the high recent test-collard greens are otherwise my top source (160 mg/d, ~12 mg choline/oz collards) .
If you're worried about heart disease, a significant minority of researchers think the whole "animal fat bad" hypothesis is tragically wrong.
I think lecithin is considered a food, though it is also a supplement. It is very high in choline and naturally balanced with things related to choline. When used as a food, it is an ingredient rather than consumed on its own, generally. You can buy it as granules, as a liquid, or in softgells to swallow. I just buy the soy softgells. You can get sunflower seed based lecithin instead. My body loves soy. Never believed the attack on soy. I have used the granules. I made a candy of sorts to help me during chess tournaments. And it worked. It has been a while, I don't remember what else I had in it. Oh, it had walnuts, and honey. Don't know what else. This was way before my low AGEs diet. I doubt it complies. It melts quickly, and then you remove it from the heat. It is very sticky, so you have to put it on wax paper or something. Ah, it had molasses as well as honey (at the time I thought there were valuable compounds concentrated in molasses...now I suspect there are too many toxins likely concentrated in there, as well, and thus not worth the risk). My memory is slow. But it was 20 years ago. I might have had just a little cayenne pepper. If I were making it today, I would try cayenne and salt. Maybe throw in some chopped raw peanuts, and oats.
I have taken lecithin almost every day for at least three decades. It can cause muscle tension, but in another light that is called muscle tone. Whatever you choose to call it, it burns more calories, because the muscles are constantly working against other muscles. Possibly it was a factor in not losing any muscle as I lost 60 lb in the last year.
@@jasonc247 Thanks for the reply. I'm not worried about cholesterol causing CVD; I think most know that it is caused by inflammation and sugar, not high cholesterol. However, high LDL *is* associated with decreased cognition in the elderly for those with APOE4, and too many eggs significantly increase in my LDL, along with saturated fat.
@@ChessMasterNate Yes, lecithin is a great source. I've been putting about 1 tsp of sunflower lecithin powder in my daily oatmeal. I think this provides about 100mg of choline, according to Cronometer.
Foods High in Docosadienoic acid (per 100 g edible portion)
Ark shell (canned with seasoning)
33 mg
Topshell (canned with seasoning)
24 mg
Watermelon seed (roasted and salted)
19 mg
Short-necked clam, Canned product (with seasoning)
18 mg
Japanese abalone (raw)
9 mg
Pacific saury (canned product, with seasoning)
9 mg
Abalone (canned in brine)
8 mg
Southern black cod (raw)
7 mg
Atlantic salmon (cultured, baked)
6 mg
Pink salmon (canned in brine)
6 mg
Atlantic salmon (cultured, raw)
5 mg
Cattle, Beef product (corned beef, canned)
3 mg
Squid, Processed product (canned with seasoning)
3 mg
Pacific saury (canned product, kabayaki)
3 mg
Snow crab (canned in brine)
2 mg
Adductor muscle (canned in brine)
2 mg
Abalone (steamed and dried)
2 mg
Young bluefin tuna (raw)
2 mg
Mackerel (canned products, miso-ni)
2 mg
Chinook salmon (baked)
2 mg
Thanks @Icarianbrother, is there a reference?
@@conqueragingordietrying1797 You're welcome! Whole Food Catalog- Foods High in Docosadienoic acid
@@conqueragingordietrying1797 according to chatgpt, yellow mustard is also a good source of this docosadienoic acid (an omega 6?) with 11mg per 100g .
Hmm makes case for keeping in eggs and fish or fish oils
Taking the sum of those acids, and choline without weighting is very weird. They are on such different scales that the variance of the octadecenoic acid by itself overshadows any of the other 4 markers.
Thanks for the input, I may take the weighted average at some point.
thanks for the video. a bit confused about the 5 first checkmarked nutrients, where do you get them, or are they produced in the body? I know EPA and Choline are found in supplements and food
More directly, in future iterations of this video I can calculate correlations with diet, to see which foods may impact them, which may/may not translate to others, though...
@@conqueragingordietrying1797 Looking forward to it
so what ur saying is I should drink some eggs?
I think there's a mouse study floating around where sesame seeds significantly increased vitamin e activity. Not sure if you've seen it.
Sesame seeds are a good source of tocotrienols, which are a group of Vitamin E metabolites, but also have gamma-tocopherol, which was on the list in the video. They don't contain alpha-tocopherol, though.
@@conqueragingordietrying1797 The highest sources of alpha-tocopherol in nuts and seeds are sunflower seeds, almonds/almond butter, hazelnuts, and pine nuts.
If you're concerned about the oxalates in greens you might want to look at almonds too.
Oxalates aren't a big deal if one eats plenty of calcium-rich foods.
@@conqueragingordietrying1797how about k2? Wouldn’t that help reduce that risk?
@@conqueragingordietrying1797I’m allergic to dairy, so you think egg shell calcium capsules would substitute in here to balance out the reasonably high oxalates im getting from a high greens diet?
Very great channel, can I ask how much hours do you get x night (more near 7 or 8) and how much of them in Rem and deep sleep? thank you
Thanks @pietroDestefani. Via WHOOP, 7.4h average, 1.9 and 2.0h each for REM, SWS since the 5/28/2024 blood test
@@conqueragingordietrying1797if you had to nail down two things you have done (supplementary or lifestyle) that has improved your deep/slow wave sleep, what would you choose? Thanks!
taurine, taurine taurine taurine taurine taurine and taurine
what you think about creatine now for blood vessel? is good?
If you mean blood vessel health, are you measuring blood pressure? If so, you could easily do that experiment...
@@conqueragingordietrying1797 no if it hardens them or if on the contrary it promotes vasodilation or some vascular growth process such as angiogenesis
I don’t take astaxanthim it may be good but it crashed my dht levels so bad I lost my sex drive . Much like finasteride - so I’m sensitive to dht inhibitors
idk, the accelerateed group has more subjects? almost twice as many
It's hard to say-some of the traces overlap
Did they compare ldl , a1c or cholesterol in the two groups? Dean Ornish did a recent study demonstrating reversal of progression ofAlzheimer's dementia with life style changes and a whole food low fat vegan diet. Its the same nutrition used in his coronary artery disease reversal study. The hypothesis is that cognitive impairment is a vascular problem maybe small vessel disease.
Nope, not included in the study
behenic acid seems to be found mostly in moringa seeds and mustard seeds.
Hmm, all the recommendations are vegetables and nuts. I wonder if my Ribeye Steak has those fatty acid micro nutrients.
They're not recommendations, they're the top food sources for those nutrients. If the top sources included steak, I'd include it, too. For ex., plasma choline could be a marker of egg intake.
@@conqueragingordietrying1797 Thank you
Algorithm support
Thanks @pursuingtruth13!
Would BDNF not help with brain aging?
The study looked at metabolites, not proteins (BNDF), but likely yes
@conqueragingordietrying1797 I'm thinking ketamine might be beneficial in that regard.
@@sgill4833 Is there published evidence that ketamine impacts the balance for neurogenesis vs neurodegeneration?
@conqueragingordietrying1797 yes there are studies.
Choi, Miyeon, et al. “Ketamine Induces Brain-Derived Neurotrophic Factor Expression via Phosphorylation of Histone Deacetylase 5 in Rats.” Biochemical and Biophysical Research Communications, vol. 489, no. 4, 2017, pp. 420-425., doi:10.1016/j.bbrc.2017.05.157.
Lepack, A. E., et al. “BDNF Release Is Required for the Behavioral Actions of Ketamine.” International Journal of Neuropsychopharmacology, vol. 18, no. 1, 2014, doi:10.1093/ijnp/pyu033.
Réus, Gislaine, et al. “Ketamine Treatment Partly Reverses Alterations in Brain Derived- Neurotrophic Factor, Oxidative Stress and Energy Metabolism Parameters Induced by an Animal Model of Depression.” Current Neurovascular Research, vol. 12, no. 1, 2015, pp. 73-84., doi:10.2174/1567202612666150122122924.
@conqueragingordietrying1797 also psilocybin is interesting as well. I know my vision drastically improves with psilocybin. But it's not long lasting.
Aging is so competitive it gives me chills.
Do you mean the aging process is competitive, or the field studying it?
A small channel dot is taking to me.
lol, I used to not show my face, as (imo) it distracts form the story.