How Digoxin acts as Cardiotonic in Heart Failure?

Digoxin increases force but decreases rate of contraction of heart. So it is specifically a cardiotonic with opposite action on the rate. It inhibits Na+/K+-ATPase pump thereby increases intracellular calcium levels which are responsible for increase in the force of contraction. The inhibitory effect on cardiac rate by Digoxin is due to its vagal activity.
#digoxin
#digoxinforafib
#digoxinandatrialfibrillation

[@santoshtuta4906]

THIS IS NOT A CARDIAC STIMULANT....THIS IS A CARDIOTONIC.........WAH SIR........SUCH A GREATFUL EXPLANATION .....no more confusions........tq u sir ji........

[@woshanimal]

Brilliant! A very difficult topic for me finally understood. Thank you!

[@abdussamad657]

Thanks alot for such a nice explanation

[@yudhisthirmudi1527]

Excellent Explanation Sir

[@Simplensweett]

Very clearly explained. U have made it very intresting and easy to understand.

[@drrubina6293]

Excellent explanation.

[@mohammedmehdi4318]

I couldnt understand when i read from tripathi . Katzung and even goodman gillman . But after seeing ur video . The concept is crystal clear . Thank u sir .

[@egpat]

Glad to hear that. Thank you and keep watching.

[@maazadnan9087]

This video is very helpful

[@nikitathakur5534]

Omg after 5 days I understood this concept... amazing video

[@egpat]

Glad it helped. Thanks for watching !!

[@babyshalini3857]

Very clear explanation.thank you sir

[@egpat]

You are welcome. Thanks for watching.

[@WHATHAPPENSIF5147]

Good explanation

[@musabawad8612]

Well done

[@richapandey3368]

A big thanks.. 🙏

[@nighatgull6116]

Great sir

[@dvvnmurthy2519]

Thank you sir...it is soo clear

[@mallavarapunandini9534]

thank you so much sir ....very interesting and informative

[@egpat]

Thank you. Keep watching.

[@sauravmishra1737]

I remember my college's Dean asked this question but no one had answered it 😅😅

[@vara98.]

Thankyou so much

[@aandbproductions999]

Uffff thanks... I now clearly understood

[@Rahulkirola]

Thank you 🙌♥️

[@egpat]

You are welcome

[@PrasannaKethupalli-fd5ye]

Superrr explanation 🎉💥

[@egpat]

Glad you liked it

[@shaikh3667]

Thanks ❤

[@egpat]

You're welcome

[@Asmaa-gk8yz]

Dr, can you explain the toxicity of digitalis?

[@radhikasudheer5144]

Very clear teaching🙏🙏

[@egpat]

You are welcome. Thanks for liking

[@tabithapynam4968]

Thank you

[@raeshaauliaz3909]

Your welcome

[@t.jeyanthi.5116]

Sir pls upload the video of structure of lurasidone

[@martaboros524]

❤

[@husnuljaseeda4233]

Tnk you sir

[@egpat]

You are welcome.

[@udayKumar-oq5bt]

Increase in which ion concentration causes digitalis toxicity sir?

[@egpat]

Digitalis toxicity can be increased by raised levels of calcium within the serum. With the elevated levels of these ions they more enter into the cardiac membrane and thereby raise intracellular sodium levels resulting in ventricular arrhythmias. That's why lidocaine can be used to treat these digitalis induced arrhythmias by blocking sodium channels. Similarly, hypokalemia can also increase digoxin toxicity.

[@Vmanmeme]

Sir the ion concentration maintain or restore of ion at minus 90 mv this is phase 4 or phase 3 ????
Sir I chose phase 4 .in phase 4 restoration ion take place at minus 90 mv .if it phase3 then why .please explain ??

[@WHATHAPPENSIF5147]

It's phase 4 brother . On phase 4 the memberane fully repolarized and became stable till the. Generating next action

[@egpat]

Phase 4 is mainly observed in pacemaker cells where membrane potential is around -55 to -60 mv which slowly reaches to -40 mv by opening of calcium and sodium channels within phase 4.

[@Vmanmeme]

@@egpat thank you sir