Insights about berberine (AMA #3)
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- Опубліковано 22 січ 2020
- Original release date: 10/29/18
This AMA Clip is a segment pulled from an "Ask Me Anything" episode of The Drive titled: #26 - AMA #3: supplements, women’s health, patient care, and more
Show notes page: peterattiamd.com/ama03/
About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 10 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is the founder of Attia Medical, PC, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity. The practice applies nutritional biochemistry, exercise physiology, sleep physiology, techniques to increase distress tolerance, lipidology, pharmacology, and four-system endocrinology to increase lifespan (delaying the onset of chronic disease), while simultaneously improving healthspan (quality of life).
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![Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent [AMA 45 sneak peek]](http://i.ytimg.com/vi/GCCHOBLTiCk/mqdefault.jpg)
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I started taking Berberine this passed July, and it has literally changed my life. No blood sugar based mood swings anymore.
What brand do you take?
It has changed my life too! I was able to reverse diabetes in one week.
@@talawoods25 I buy the Toniq brand on Amazon. It’s the purest highest concentration for a price you can’t beat.
Where did you get urs from
Monica, I read that it can cause constipation. Was this true in your experience? I have had bad issues with constipation in the past but doing better now, but I don't want to try anything that may help my blood sugar issues but cause me to be constipated. Can you share your experience with me please. Thanks for your comment.
Thought the title read “Insights about barbecue”
It’s been a long day forgive me
If you barbecue - u might have other issues
😂
🤣🤣🤣🤣🤣 I love BBQ too! FOUR-GIVENNN!!!
I would love to see that podcast lol
Dr Attia, you are a rockstar, thank you and the interviewer 👍. This, gold nugget, information saved me hours of searching google 😂, thanks again👍!
Thank you for this video. I first watched it about 7 months ago and decided to start taking berberine. My TC dropped from 326 to 224, LDL dropped from 232 to 121, Triglycerides dropped from 90 to 67, and HDL rose from 78 to 90. It actually does seem miraculous.
what dosage did you use?
@@unclegeorge4629 I take 1000 mg a day, 500 after each meal.
@@unclegeorge4629 I use Paradise Herbs berberine 500mg twice per day.
Wow! I guess I better try this stuff. I'm wondering how long it takes to work.
@@njsongwriter My tests were 120 days apart. I started berberine 20 days after first test.
I see a decrease in hunger. I’m able easily to fast for 16-18 hours. Before berberine it was a struggle, now will power, of which I’m in short supply, doesn’t have to be used.
I think medical professionals ascribe the appetite suppressive impact of Berberine to the placebo effect. I know it has quelled a raging hunger that I feel post swim workout- - (along w/giving me potty trots). It does NOT enhance my athletic performance but it does help me get into a deeper restorative sleep cycle. Simply put, I know when I am not using it.
Metformin is a synthetic based on a natural compound. Many side effects to speak of. Berberine is just as or more effective in my experience and no side effect for me at least. As for cost, it is just a bit more expensive. Assuming a good quality product, I prefer the Berberine and I have switched after 15 years on the Met.
Have you tried dihydroberberine? It's even better. Almost no side effects. Regular berberine gives me bad stomach ache. Dihydroberberine, I only get mild stomach cramps-but only now and then.
@@toddrowland2081 Never even heard of it. So I looked it up, it's hard to find and expensive. Reviews are mixed. I get no side effects from the regular version and it's working even better than the metformin. It brings my numbers down a bit more.
@@gguerra3 Really? Where did you look? It’s on Amzazon, not hard to find-at all. I purchase a bottle of 60 pills for $29. Now, compared to Berberine, it’s a little more pricey, but it’s worth the cost for me. Berberine tears up my stomach, dihydroberberine is easy on my stomach. Works great. If regular berberine works for you, by all means- continue to use it, bc, ultimately you’re getting the intended result. Dihydroberberine has a better absorption rate. 🙏🏻
Took metformin for nearly 10years in the end id be talking to someone ie the checkout girl and a series of loud uncontrollable gag reflexes would start and after that happening for a while id take it and would feel sick so that was the end of that.
@@toddrowland2081 ive been taking berberine for about 2 months with absolutely no side effects too! I think u really beed a quality brand of berberine as its side effe are u heard of
Berberine brought my a1c from 10.2 to 6.3
Are you still taking it Butter Robot? Thanks for your comment.
How long did it take
@@detroitslight it can take 1-2 days to start seeing the effects
How much did you take per day? Brand you took?
@@CocoChanelle-1
I take 1500mg daily. (Morning, noon, night). Thorne is a trusted brand.
I’m surprised you don’t mention the amazing way Berberine lowers high blood pressure to normal overnight
Thanks Edward. Did it cause you any upset stomach or constipation? How much do you take?
@@boomerang6130 no stomach upset although a friend of mine in Canada told me she couldn’t take it because of the constipation . I take 500 mg at bedtime and another 500 in the morning with breakfast.
@@edwardthrall8397 Ok Edward, thanks for writing back friend.
@@edwardthrall8397
We should take it with probiotics
It has ACE inhibition properties
This is what I keep telling people, not everything they take is going to work in every way for everybody.
Are there any drug interactions such as blood pressure beta blockers thyroid medications
can I use berberine as a way to have a once-twice a week afternoon cheat/carb meal or snack on keto/carnivore?
Exactly how much lower will glucose go down/stay down on average? Like, if I eat a bowl of yogurt and it spikes X amount, what will 500 mg of Berberine do to the same amount of yogurt? X-20 points? or just X-2 ?
found the answer, ish ua-cam.com/video/rSSSObL0vIM/v-deo.html
Metformin raises Lipoprotein(a)? Hard to find data on this.
Do to have to take Berberine everyday! Or can you do it for a month?
When I tried Berberine, it made me vomit after a few hours. Why? Is this a normal side effect and is this temporary?
Thank You for your work
Metformin killed my stomach. I just discovered barberine and in 4 days my bs levels dropped. I feel like a rock star!!!🎵🎶
It's killing my stomach as well. You are giving me some hope. I'm gonna switch and see if it's tolerable!
@@amandabousheley3189 How are you doing? Are you on it now?
@@boomerang6130 yes, it's been amazing! I did develop diverticulitis but don't think it was related but took it while treating infection and since and have seen no negative side effects!
@@amandabousheley3189 are you still taking berberine? If so, what do you think about taking time off occasionally? Is it necessary?
@@reecemorris9820 I am. I have went off it for a week here and there. The only thing I noticed being off it was a slightly less stable mood (so not terrible though). I really believe it helps and haven't seen any negative side effects at all personally.
This is the most luke warm assessment of berberine I have seen on the net. I'm not saying he's wrong; I'm just saying that either he is understating its value or everyone else is overstating it.
Apparently he didn't prepare for the interview. He couldn't even remember the dosing...
Will berberine cause any bad issue to our liver or organ?
But is it still a decent enough alternative to Metformin? I got displaced by the Almeda fire here in Oregon and I can't get my medication, even in an emergency situation, but I can get berberine.
Yes it can be. It's just not absorbed that well. So take as much as needed in order to level down your glucose levels
Is this supplement something that would directly counteract the poor effects weight-wise of antipsychotics (Slowed BMR, Glucose metabolism, insulin resistance) in someone? If so is this more or less a long term fix or would it be something you would have to do indefinitely provided the person stopped taking the medicines causing said effects (slowed bmr, glucose metabolism hinderance, increased insulin resistance).
Yes to your first question. Yes you stop.
@@shaunthebaptist "yes you stop" can you help me understand what you meant by this? Yes if you stop taking berberine that the effects of it would go away? So you would have to take it for the rest of your life basically?
Is Berberine hard on the kidneys though? Hearing that from some other forum's..Hmm..
Is berberine better in combination with anything like exercise or other foods/supplements? Also is the effets on the insulin resistance and glucose metabolism lasting if those things were damaged in the first place? Thanks
At least in mouse studies berberin causes muscular atrophy, so maybe it's not that beneficial.
Try milk thistle.
@@AngelPopov that's in extremely high doses that are unstained by oral ingestion
i think exercise gets everything activated and moving as it should. metabolism would be greatly improved and you would live up to your genetic potential more so than not working out; when taking supplements, its working with your body and its important to also do our part in getting the cells moving.
I have been taking Berberin, DIM, Milk Thistle and Ashwagardha for a month. I normally have horrible migraine right before and after my periods. Apparently I suffer from hormonal imbalances which make it difficult for me to loose weight no matter what I try and gives me horrible migraines. This month I haven’t had the horrible migraines. I feel it starting but then just dissolves after a short while. Another thing is with the weight. I have lost 2 Kg in the last month without changing anything. I eat junk and do no exercise. Normally my weight would balloon with no stop but I believe these are helping me to maintain my weight and loosing a little. Eating healthy is my wish but very difficult for me. So if these supplements can make me loose 2 kg per Month without changing my eating habits, am good with that
Did u loose more weight?
@@aoifewest I have lost 3 Kg. I am not doing any exercise and am eating everything except sugar. I also sleep very well thanks to Ashwagardha
Can you share the dosages? x
Vitex chasteberry balances female hormones.
Thank you
I am a neurologist and have learned so much from your channel. My question to the doctor or anyone in this community: can berberine cause a low B12 level like MetFormin? Can taking MCT oil such as coconut oil before consuming berberine increase by availability? Thank you very much
Get the NOW brand, his has it with MTC oil in gel caps
Get the NOW brand, his has it with MTC oil in gel caps
Did you ever find out the answer to your B12 question? I am already low B12 even with supplementation.
@@DoggieFosters no.. but if your B12 levels are low, supplement with either intramuscular or subcutaneous forms. I just don’t completely trust the oral forms..
I started taking berberine 3x a day at 1500mg total and I’m very bloated with higher water retention. Have you seen this before ?
I agree with the bloating whenever I take it twice in a day. Let your body get used to it to once per day then gradually increase it a few days after I guess. Now for me 2 is ok.
500mg 3x a day seems a bit too much, try taking lower dosage a day to let your body get used to it.
Bergeron combines with blood pressure meds? yes? no?
But does berberine have the side effects like metformin? B12 deficiency? Cloudy mind?
It made me vomit
none for me. and no on B12.
good info + Ayrton Senna cameo, I like
Does berberine affect the rate of muscle growth in humans ? I can’t find any definitive answers online .
No it doesn’t
According to my research so far, its activation of AMPK does inhibit muscle protein synthesis. So if you're an athlete or looking to build muscle, it might be better to seek a solution that works via a different pathway.
I’ve seen the concern with metformin, but there’s nuance in that it doesn’t effect ampk in skeletal muscle, ergo not necessarily catabolic for athletes. Not to mention athletes using metformin are also using insulin anyway. I would suspect the sale is true of Berberine, or the effect is overshadowed by other factors
@@krane15 if so the amount would be microscopic. Oral berberine is very poorly absorbed and retained. In fact you only retain less than half a percent of the original dose
Absolutely. mTOR pathway is inhibited by Metformin.
I'm going to start taking it with dinner but I'm concerned about malabsorption of the nutrients I would be getting from my food in the gut.
Al Keegan can i suggest taking it an hour before dinner.
i take it and it’s more effective earlier rather than later
@@beautifulmess2023 Which brand of berberine you're taking if you don't mind me asking. I see that's is also good a few things that can help me like inflammation in arthritis, tumors etc. Thanks an advance...
Take it on empty stomach preferably before a meal
I've watched many videos she's read all about Berberine and they say it helps your gut microbiome
stack it with something like Kutaja herb to improve nutrient absorption and to totally prevent the chance of diarrhea & upset stomach that can happen to some people with berberine.
So how can normal humans who arent obese get a subscription for metformin??? Its all well and good for doctors to have access for personal use but how about us mere mortals 😩
Exactly my thoughts.....they really don't realize who listens to their podcasts
Do mean wear baseball caps when their hair starts thinning? These caps are really good looking and compliment these guys' appearances.
I am taking berberine to lower my LDL but I feel so dehydrated when I take it
Drink more water
Check your electrolytes!!
Take taurine and drink more water.
Why would you want to lower your LDL?
Great info, Thanks!!
So let's use pharmaceutical products..lol
Instead of something naturals remedies
Doctor’s won’t prescribe Metformin unless you’re type 2 diabetic also Berberine is not cheap
Right now I'm using a supplement that works way better than the half dozen drugs I was prescribed by my doctor. Best part is, they're out of my system in a day, Not the two week it took me to kick the addition I have for my pharmaceutical, which just put me in a brain dead catatonic state. Never again.
@@krane15 Moringa power works well
@@traconiannation Thanks. The anti depressant and liver protection benefits sound promising. I'll check into it to and see if its right for me.
@@traconiannation powder
Any advise on Combination of metformin and berberine for PCOS and insulin resistance.? I can’t lose weight no matter what I do
The combination of the two could lead to dangerously low blood sugars, be careful.
@@jacobdebernardi4385 that isn't true at all. Berberine and Metformin do not cause any hypoglycemia
Yes you can combine them. They do not act as insulin so theres no risk of hypoglycemia
@@iLoveBoysandBerries I'm speaking from my personal experience in taking 3 grams berberine at once. What experience do you speak from?
Try a 3 day water fast. Also look at areas of your life which are causing you stress
Thanks a lot.
It’s a better version of metformin without all the side effects 😊
Do I need to see my GP before taking it?
It can be bought OTC
No
You may want to talk to your doctor if you're on blood thinners.
Metformin made my blood sugar go high and stay there. It NEVER helped me. It also make be feel like i was going to haver s heart attack and it made me bulk up.
Why take a pharmaceutical if you can take a natural product.
Except you don’t need a script so it’s not the poor man’s metformin
Metformin blew my friends mom's Kidneys.
Why would you want to decrease your LDL? 🤔
heart health
@@adamcraig1468 - that’s a myth. Most heart attacks occur in individuals with low LDL
@@jammin6816 I thought it was people with high dense LDL
@@adamcraig1468 - actually it’s oxidized LDL which causes inflammation, the result of metabolic syndrome, or too many carbs. The carbs trigger insulin which tries to store carbs as fat until there’s no more room in the cells. LDL is then turned loose into the blood stream as free radicals, becomes oxidized, or rusts, and can lead to an eruption in the endothelium (wall of the artery) resulting in occlusion. So in this respect you’re correct if you say oxidized LDL causes heart attacks. But overall LDL (non-oxidized low density lipoprotein) is very low in most patients who experience myocardial infarctions, or heart attacks.
@@jammin6816 No, that is wrong. The LDL is not really low in most HA victims.
If I wanted less vitamin B12... I'd take Metformin, too
We understand that metformin is a drug and as such we are not going down that road of side effects . You guess seem to be ignorance trying to sound intelligent. Fancy words don't freak me.. Peoples, please use berberine to help to keep your kidney and liver
🔥🔥🔥
Poor man’s version that costs more
Really? He prefers to use Metformin? A drug? The more you use drugs the more your body gets used to them. Before you know it, you’re taking more and more metformin and it’s less effective!
Ya let’s just use metformin. Good luck getting that script from your doctor.
Exactly!! He talks like you just go to your local GNC to get it.
Yay, let's throw vitamin b12 out of the window whilst we're at it then spend all day wondering why we have no energy
doctor touting big Pharma over herbs is concerning $$
You walk out into the yard and grab all of the plants and shove them into your mouth and see what happens
We see you bro ! Try a new schtick nobody's buying this one
Sounds like a physician that doesn’t listen to the patient when they come to see him
Dude literally contradicted himself😂
Dear Dr. Know It All. Metformin cancels out exercise effects. Berberine does not. There, you really do know it all now.
黄连素
Typical - dr promotes pharmacological over natural.
Berberine gives me diarrhea.
Same.
i started slow with about 200 for a couple days then 500 for a week then now i take 1200
Berber one is used for digestive and other toxic issues in China, for as long as Chinese medicine exists. It’s a common cabinet must for every Chinese household. This being said a diarrhea is really not suppose to happen. It could be with you take with it at the same period of time or dosage.
Ok thx finally a straight answer. And metformin is recalled. Nmn anyone?
Start slow increase the dosage
Consistent package like the vaccines were okay