I started Wegovy after weight gain from quetiapine, which I must take for a mental health diagnosis. I have the side effect “insatiable appetite.” I would eat “perfectly” all day and then take seriously and eat everything… anyway my psychiatrist prescribed the Wegovy. I’ve lost 45lbs, started strength training, A1C is now 4.9 LDL 79 and feel so hopeful now for my future. 😊
Don't be misled this year 2023... because the only channel on UA-cam where you can get the perfect solution to cure your herpes permanently is @ THE SEVEN DAYS FAST CURE FOR HERPES 1&2. Herbalist Doctor Kingsley who's the owner of the channel on UA-cam @ THE SEVEN DAYS FAST CURE FOR HERPES 1&2 has the total cure for herpes.
My dude, some psycho active meds do cause that famished feeling like Zyprexa and some do not like Abilify Please have your doctor switch you from one to another until you find what works for you. Read all side effects before agreeing to any med
Ozempic costs here in Finland, when used not for diabetes so it's not goverment-comped, 115 Euros /month. It would be cheaper to fly from America to Finland once a month than pay the American prices out-of-pocet.
My MD wanted me in these meds asap. I said ‘no’, started the carnivore diet in January. My weight, BP, A1c, blood glucose, triglycerides, asthma, depression, and anxiety are all down and/or gone!
That’s literally how it works! It slows down your digestive system. All the information that comes in the box says so. That’s why (good) doctors also prescribe Zofran for nausea. Take your probiotics, take enzymes with your food, and eat some type of fermented food every day (kefir, sauerkraut, kimchi).
It makes me so sad that ignorance guides most inflamed conversations about those that are using Semaglutide for weight loss appetite control reasons instead of diabetes. Diabetes is serious but so is a life long battle with compulsive overeating disorders. I’ve seen first hand the massive positive impact that Ozempic has had on a loved one that has no ability to control their appetite or compulsion to eat and binge. This drug needs to be prescribed to this alternative group of people that are just as at risk of complications and death as chronic eating disorders ruin lives and health too
Yes I agree with you. Why would diabetics be more deserving of this drug than people who suffer from obesity? Both are dangerous chronic diseases where people suffer greatly. Diabetics have other options the market is flooded with diabetic drugs, that’s not the case for effective obesity drugs. Diabetics are mad because they also want to lose weight, therefore they feel they should be first in line because the drug was originally marketed for diabetes. That argument is a bunch of horse manure. Obese patients are just as at risk as diabetics.
Umm they are at risk but not just as much as diabetics. The risk for heart attacks, strokes is 10 to 15 fold. Plus if the A1C has been elevated for years kidney disease and retinopathy are a ticking time bomb. They need to be first in line. Just my opinion.
@@genalora841 that’s so amazing 💙There are Bulimic patients that aren’t overweight because they purge all excess food consumed. They don’t qualify for Semaglutide yet no one would argue that their mortality rates are significant too
I get my script filled via a Compounding pharmacy … about $100 per month for .5 weekly semaglutide - zero insurance,zero problems. I lift heavy 3 days a week, 2 cardio, 2 recovery days. I track my food like a hawk. I am barely dropping 4 pounds a month.. But I am seeing positive body recomp. This is NOT a magic bullet - I lost 90 on keto and a 2plus hour per day exercise regime. Now working on these next 70 - for me its a tool -
Rebelsus is the pill, I’m diabetic… but have a fear of the side effects. I don’t consider the weight loss a side effect, because I believe this is a sign that it is actually doing what it is supposed to do with your carbs. But thyroid cancer? Pancreatitis? Why would these things happen? That is what I’m trying to find out. Have not been able to find an answer.
The short answer is because the medication has effects in your body on the thyroid and pancreas. In some people, instead of beneficial effects, the medication can cause an unwanted side effect, such as pancreatitis. You should talk to the person who prescribes Rybelsus for you about these questions, not us.
@@ResearchSci2024 please don’t misunderstand. I’m not asking for advice. Those were rhetorical questions. I would never follow anyone’s advise on UA-cam. I too hope that no one else is doing that without consulting their doctor.
With respect to pancreatitis and gallbladder bladder problems I believe it has to do with really slowing down the passage of food in some parts of the digestive tract. I wish I could remember the podcast I listened to so I could include a link here.
There are GLP-1 receptors in the Pancreas. For some people this can cause pancreatitis. I had done several shots of Semaglutide and I started feeling mild pain on my left side under my rib cage. This pain came and went and it was mild. Kind of an annoyance. I believe it was after my 4th shot that I started to feel pain that also went around to my back. This was not intense pain. But annoying. If I took Advil the pain would be gone in 30 minutes and I would not feel anything for hours. I had my Pancreas Lipase tested and it was 111, which is higher than normal but not too concerning to my doctor. But he told me to stop taking Semaglutide, which I did. Frankly I was going to wait a few weeks and go back on to see if the pain would come back but I ended up cutting my food intake without it and now I am in that state where I don't need to eat a lot, so I guess why use Semaglutide if I can accomplish what I want without it.
I’m a NP and work at a weight loss clinic and have a masters in nutrition. These can range up to like $1400 a month and with insurance $500. Mounjaro has seemed to be the golden one, comparatively. Ppl are obsessed with these😐 BUT they have helped so many ppl lose weight who have been doing all the correct ways like proper nutrition and exercise. Insulin resistance is extremely under-diagnosed. This also aligns with PCOS. Hormones (especially with women) are a huge factor too. It’s an exciting med but I’m always skeptical and we don’t know long term impacts. So many ppl worry about the number on the scale and not the composition, so aggravating!🙄
@@Garret_bruh_homey Incorrect - it's a mass equation. The calorie is not a valid measure of the energy we derive from food. Ref: When you lose weight, where does the fat go? Most of the mass is breathed out as carbon dioxide, study shows Ref: The Calorie Myth
@@gribbler1695 Energy is stored in chemical bonds. Nutrients like carbohydrates and fats are oxidized to liberate energy, which is stored in ATP, and eventually used for work. CO2 is an end product of oxidation - just like when wood or gasoline are burnt. Also, calories are always a unit of energy. You can use joules or calories, but energy is energy. Its forms change, but the units do not.
@@Garret_bruh_homey Counting calories for fat loss is complete nonsense; it is far too simplistic for what actually happens in the body. The food industry wants to maintain the charade, so that ultra-processed foods seem 'healthy' if they fit your macros, rather than pushing quality whole foods. Ref: Why Everything You’ve Been Told About Food Is Wrong | Tim Spector
Came straight to the comments, and let me tell you, they did not disappoint! Very educational, interesting and enlightening. Worth the read in my opinion, if you’re interested in this topic (which I am).
The gastro side effects of oral semaglutide are apparently more unpleasant. I did not enjoy them at all. You also need bigger doses to get the same effects. But it wasn't *that* expensive here in Japan. It's about $90 a month.
@@Jlk6532there's always an ass in every group, huh. =you lol just messin with you. You are correct in that, however there are people out there that can't get to a gym.
Certainly don't need to go to the gym, per se. There are many other ways to workout, walking, biking get a few weights and bands for at home. even working out working around yard to start. @@alfenner3309
I was prescribed monjourno for weight loss. I was able to get 12 weeks for $50. With a coupon. I could only take 4 weeks' worth of injections, I had internal jitters and shakes so bad. I called my doc and he said, "Keep taking it, it will go away " I couldn't stand it. So, I just stopped. I did lose 5 lds. I gained 15 lbs after about 3 months after stopping monjourno. I still have jitters and shakiness. I still have the injections in my fridge. I found out shortly after I stopped that there is a shortage of this medication for people who really need it. I feel so bad.
I started to feel tingling and burning sensation in feet n hands. After each injection. The higher the dose the longer the sensation lasted. They said its not related to MJ
Prescribed Metformin by my internist my request due to insurance not approving ozempic, with that been said Metformin strained my energy stores I took myself OFF feeling like myself again 😊
But what if ya dont have a food issue? I fast 16-20hrs a day and eating high protein low sugar. My glucose number has never been over 4.5 in years! Still can’t get my weight under 80kg. I’m 52 just gone into menopause. I’m so tempted to take this medication but just don’t wanna mess with my hormones anymore than they’re changing now.
Thyroid FULLY tested? Not just TSH. On other meds like a statins? One could go to a trained doctor, and look into hormones that are Bio-Identical, not synthetic… but done correctly.
My doctor took me off of semeglutide for three months because my liver enzymes and pancreatic enzymes were slightly elevated, I hope those levels go down so I can get back on it
This is a known issue and I am not sure if in the end it is a problem. I believe it was 1/3 of Semaglutide users experienced 25% to 38% increases in their Pancreatic Lipase values. I don't have the study off hand but you could probably find it by googling it. My AST values have been slightly out of the high normal range for years. I told my doctor I was looking at supplements that might decrease my AST. He told me that my AST being slightly out of the normal range was nothing to worry about, especially when it consistently the same. My ALT values are right in the middle of the normal range.
Not sure if you drink alcohol at all, but I heard this could be the reason for the spike. Even a glass of wine 2x week could increase your levels while on this drug. It’s not being talked about, unfortunately.
It is addictive and you can only stay on it for 12 weeks max. Because it is an amphetamine-type of drug, it does not get at the "root" of the issue such as this class of medications. Besides, branded Wegovy and Mounjaro do not need to be that expensive. The peptides themselves can't be patented. We all have them in our body.
It is a short-term solution. I take Adderall for ADD. When people first start out they have issues sleeping and they have not appetite. But once you are on it for a while your body adapts. Trust me, I had no problem ballooning to 285lbs when I should be under 200lbs. Many, many years ago I was prescribed phenteramine and it did absolutely nothing because I was on Adderall, which is already stimulating the same pathways. Probably more so than Phenteramine. Semaglutide is completely different animal. I used for a short period of time and it reduced my hunger and made me feel full when I didn't eat that much. I had some issues that may or may not have been related to using Semaglutide, so I stopped and just ended up dieting without it and it has been working out so far.
If getting proper nutrition was required then there wouldn't be a need for you to hop on a drugs to lose weight. You would be achieving that with the proper nutrition.
Wouldn’t an appetite suppressant work as well for non diabetic people for weight loss? Is there an appetite suppressant on the market in the form of drug or supplement?
stimulant medications like vyvanse, then injections like wegovy, and saxena are your weight loss meds. the issue with the stimulant adhd pills that remove appetite is that when they wear off at night you cant sleep are are starving so many end up gaining on those. i did. so now im on daily saxena shots
@@Brainjoy01 I spray Garcinia Cambodia… works good for me. But I’m not an emotional eater or anything like that. I love food… but if my hunger is not there, I won’t overeat. So the spray works great for me.
I'm phasing out of liraglutide after about a year- prescribed for obesity. I wasn't satisfied with weight loss benefits although a1c went from 5.7 to 5. I noticed the increase in rhe and have had a big hit to exercise tolerance that hasn't fully bounced back. Agree on protien- appetite was way down and what I wanted to eat really shifted to fruit when I wasn't a big fruit person before.
Dr. Attia,how do you feel about diabetics getting run over by rich people, who want to lose weight and can pay full price for these drugs, that are making them not available for diabetics that the drugs were developed for, and that the drugs are a crucial part of our therapy who can no longer get them because of shortages? I would love to see at least one or two of the many UA-cam doctors who are talking about these drugs, and spinning up the demand for them, talk a bit about all the off label prescribing that is making diabetics have to chase these drugs from pharmacy to pharmacy, and frequently change dosages or completely change drugs or go completely without any because people are getting these drugs that should not. There is only one of these meds that is approved for weight loss.
I'll tell you why. It's the antiintechrins. It's the same reason why we originally didn't understand why diabetics with roux en ys went into immediate remission.
I have some Pendulum GLP-1 Probiotic in my Amazon cart. It is supposed to have bacterial strains that help your body produce more GLP-1. I gained 50 lbs during covid and my lifetime slim self is having trouble with enough deficit to take it off...Still :-( I feel like I have a healthy diet with mostly whole foods and pretty clean. Don't love counting calories. Do you have any thoughts on a product like that?
Dear Peter I started loving you since listen to your Ted Talk and interview with RIP Sara Hulberg. As 57 years old male with 27 years and chang T2D I have tried everything under sky. My diabetes got worse every year until November 2021. I was 236 lbs A1C 9 on 7 meds In very dark place mentally. Now I am 188 with A1C 5.4 with no meds. Walking 6.5 miles per day in average. I did all with elimination and reduction on food with pay close attention to my glucose feedback. I’m using CGM. I am wondering but I am not lost. I think there are lots organizations unfortunately with healthcare professionals whom take advantage of lost and desperate people. I have feeling marketing Glp1 drugs is part of this scam or as close as legally they can scam people.
The fact that one of these drugs was recently cleared for kids as young as 12 tells the whole story. Seriously….does a drug company actually want people to get better and not use their products, or is the dream scenario to start an infant on as many drugs as possible that they take for life….and have them live for as many years possible in order to extract the most $$$$$$. Some people need drugs put of necessity. Many others don’t or wouldn’t……but like any other company, more revenue streams are sought out….
I don’t have name for what I started almost 18 months ago. Here what I did 1- I got myself a CGM and I observed how f***d up I was at that time which didn’t surprised me. 2 - I started no NOT eating as much as I could tolerate. And eat as least as I could. 3- eliminated everything spiked my blood sugar fast. This goal eliminated all simple carbs and sugar. Including rice pizza and potatoes. 4- after while I started to decrease my meds and get rid of insulins injections. Follow by BP meds and using CPAP. 5 - recently I added some berries and leafy salad to my daily intake. 6 - my daily activity increased latter after I lost first 3 lbs. now I am walking twice a day or bike and enjoying hiking anytime I could. 7. I avoid eating out as much as it is possible. I hope it helps.
So we know from earlier podcast that Peter cut back on Metformin and only took it in the evening. Is Peter still taking Metformin at all now? Sounds like most of Peters comments end up trashing most anti ageing products. other then eating properly and fasting, what exactly does peter even recommend as an anti aging drug or Supplement.
Peters rule on drugs, supplements and food: don’t brag about doing anything’s, until your exercise house is in order. And he’s quit fasting because it caused muscle wasting.
Sooo many medications mess with hormones.. often I take Tropirimate for acute migraines and EVERYTIME I start I drop weight rapidly- 5-7kg in a few weeks! Noticed in my bloods it rapidly reduced my oestrogen so my hair thinned also & period stops. However I loose my short term memory super fast and so my thyroid also drops. So I go on and off it. So hard trying to take medication that won’t mess with hormones in menopause.
This isn't true. Wegovy is branded for weight loss however it is semaglutide and called ozempic for diabetes. Mounjaro has shown weight loss benefits clinically and currently undergoing trials to have authorization for weight loss in the near future.
Mounjaro is being certified for obesity. Your NP needs to do a better job of keeping up to date. In fact tirzepatide was a molecule that Eli Lilly had shelved, but when they saw how much money semaglutide was making with obese patients they took it back off the shelf to get it certified by the FDA for obesity. Diabetics would never even have mounjaro otherwise. The money is with the obese patients.
I wouldn’t take it, as it is a black box drug, which has serious side effect: Pancreatitis Gallbladder disease Kidney damage Thyroid Cancer …Among others and once you stop, weight regain is massive. Very expensive.
I can confirm, as a non-diabetic who just started taking semaglutide *on a keto diet * (so, no carb intake to begin with), I definitely got hit with hypoglycemia. Numbers so low my CGM didn’t even display it (I’ll see it in the 40’s, but then it’ll just say “LOW” instead of digits). Got shakes & sweats, almost passed out. I first tried to corrected this with some crackers & a Nugo bar, which barely brought myself back into the 60’s, then a tablespoon of honey finally helped me hover around 80). I didn’t get hypoglycemic on keto before semaglutide. Long story short: YES GLP-1 can potentially lead to hypoglycemia in non-diabetics, especially if you don’t tailor your diet accordingly
@@Wealth-and-Wellbeing $100 per month without insurance is ridiculously inexpensive for an on patent drug . I pay more than that for some medications with insurance coverage
I’m a NP and work at a weight loss clinic and have a masters in nutrition. These can range up to like $1400 a month and with insurance $500. Mounjaro has seemed to be the golden one, comparatively. Ppl are obsessed with these😐 BUT they have helped so many ppl lose weight who have been doing all the correct ways like proper nutrition and exercise. Insulin resistance is extremely under-diagnosed. This also aligns with PCOS. Hormones (especially with women) are a huge factor too. It’s an exciting med but I’m always skeptical and we don’t know long term impacts. So many ppl worry about the number on the scale and not what the composition, so aggravating!🙄
A suggestion for Dr Attia: since you are probably crushing APOB in many of your patients (n=1000?), it should be easy to see a signal (no ASCVD) in your patient data over a 10-20-year period, given the immense incidence. Is APOB truly necessary for the disease? Hello, Nobel Prize!
if you stain a plaque from a coronary artery that killed someone via a heart attack you can identify BOTH apoB48 and apoB100. the numbers indicate the number of amino acids. liver makes the 100 and intestine makes the 48. they do the same thing in that apoB binds to receptors so the lipoproteins can be re-uptaken by the liver. every atherogenic particle (non-HDL) has one apo B protein on it's surface so it is a surrogate marker for number of atherogenic particles.
@@joken8028 ua-cam.com/video/t_z6E7OXEeY/v-deo.html It was the New England Journal of medicine dated 3/18/21. It was a 68 week study with placebo group and with patients taking 2.4MG. They lost on average 15% of their weight. However, they only did dexa scans on like 40 patients and the results were 60% fat loss, very little viceral fat loss and 40% fat loss.
The elephant in the room has always been appetite. If you've got a big appetite, you've got a big problem when it comes to trying to lose weight end of story.
Nonsense. Metformin is a mitchondrial poison. It cannot be good for longevity. There are better ways to avoid "overheating" the mitochondria like avoiding sugar and cabohydrates, excercising, eating saturated fat (with no sugar)...
Unfortunately, yet another search for cheatcodes instead of addressing the cause: the IR, intramyocellular/intrahepatic/intrapancreatic lipids... all of which is lifestyle mediated. And same as metformin is now clear not to be the fancy magic pill, so the GLP1A won't be in years to come. Training food habits, moderation, optimizing nutrition - is the key. Love Peter and all his work regardless 🙏❤️
"Training food habits, moderation, optimizing nutrition". Yes, you are right. At the same time, we are human beings, not robots and not for every human being is as easy as it sounds to do/be "Training food habits, moderation, optimizing nutrition." I think there is much more than that to be taken care of, specially from the Psychological aspect. It is a much, much, more complex issue than just "Training food habits, moderation, optimizing nutrition". And I think the "failure" to treat this issue is because the "jogging/diet" is the solution and underestimate the many factors around the failure.
@@jeanniej8296 Totally agree. More than that: if changing lifestyle or behaviours was easy, there would be little market to most chronic disease drugs. Well, people's search for magic pills that will keep them healthy without addressing the cause (lifestyle and behaviours) marries perfectly to the intelligence and greed of big pharma. Unfortunately, such marriage is only benefitting one of the partners. Luckily, there are ways and robust frameworks to transform lifestyle and behaviours. But the first step to unlock them for oneself is to realize that cheatcodes will not work in the long run - without excuses, self-pacifying explanations and so on. Otherwise the quest for the holy grail of magic pills will continue, bringing further epidemic of chronic disease and disappointment, irrespective of advances in tech and medicine... which is what we see now.
@@Tod_oMal Nothing worth doing or having is easy. It’s also a vicious cycle, people’s eating/drinking habits and lack of exercise, social media use, fresh air and sunshine lead to obesity, depression, anxiety. I’m in my late 59s, and none of these poison foods and drugs and technology were around-hence none of the problems of today’s society.
Yeah when you are in serious need to lose weight ..it’s a personal decision between you and your Dr…. Period. Also, much more is being known about genetics of obesity …it’s long overdue.
If metformin has negative impacts on mitochondria and skeletal muscle, then does it make sense to use metformin when resistance exercising to minimize sarcopenia?
To heck with all these drugs... It's so simple it's unbelievable: eat no processed foods and sugar, do fasting, get sleep, and exercise... Great Dr's, like Jamnadas, aren't quick to prescribe those bandaids. Ugh...
Just doesn’t work. When your hormones are so out of whack post menopausal, it’s very difficult to lose weight. Your GL1hormone may not work as in my case. I exercise five days a week(3x hiit) walk daily , I don’t eat processed foods or added sugars. I haven’t been able to lose any weight in eight months. It’s extremely frustrated. I’ve been on this medication and slowly increasing my dosage for three weeks. I haven’t lost any weight but I feel like my appetite is diminishing. I’m hopeful.
@@lindanewman8710 What is your fasting insulin? C-peptide? Fasting glucose? Free T3? Reverse T3? Free T4? TSH? Thyroid Antibodies? Vitamin D test? B12 level? Iron panel? Triglyceride:HDL ratio? CAC score? Taking a statin? Causes lots of problems Example of what types of foods eaten daily? Snack between meals? Amount of grams of total carbohydrates? Amount of animal protein in grams? Amount of grams of healthy animal fats? Avoid processed seed oils? Some good information to learn for yourself.
Not for everyone. I've done all these things for years, and my body prefers being enough "overweight" that I have a spare tire. That said I'm quite fit (the ability to perform) and athletic. I hike weekly and aggressively, day hikes in the 15 mile, 3000 ft range. Barbell train 3 times a week, etc. The novelty of low carb has worn off on my system. I could go zero carb for a week and nothing. I have to do a multiday fast (3-5 days) to see any fat loss movement.
Take this. No idea why it works but trust us it's safe, honest. Oh, and by the way, keep eating too many carbs to preserve our revenue streams, pretty please.
The book is ok and only because Peter like everyone in his field shrinks when asked about actual weight loss. The best he does is a cyclist example and what amounts to the system is broken for weight loss. There is a transport problem in what seems to start in the muscles. So, if this is a illness then why not just push this into an illness that is covered by medication or banning of substances that cost so much we are all better of by not having to UPF because it’s terrible for us. He’s not going out on a limb. He’s just monetizing his platform. He does give out good information and it’s the best we can manage in this economic environment. I’ll still subscribe but Attia is not your friend. You pay for it and you should not expect a benevolent being in him or anybody else.
If type-2 diabetes is a glucose metabolism problem they why are there several interventional studies showing reversal of type 2 diabetes when given a bread and white sugar diet?
If you ask me, people these days are using drugs and other medical interventions as an excuse to not make the changes they need to in order to truly fix the problem(s). If these things were not available, I’m willing to bet people would be far more motivated to make lifestyle changes.
@@DeniseCumminsi agree! We have people that do NOT exercise nor eat healthy and yet they are not overweight. To all the people that exercise and eat a healthy diet then loose weight…they have found a solution that works. Yay for them. Then there are those that do exercise, do eat extremely healthy yet their weight does not budge. I am such a person. However I also don’t have a functioning thyroid so I need thyroid meds. Even when I trained with a professional bodybuilder who provided my food type and quantity and my fitness routine - he could not help me loose all the weight and keep it off. He said that I was his best client. I followed his instructions and was consistent. I lost an initial 15 pounds, (needed to lose 30-40) but at the 5th month in my body started putting on weight and no it was not muscle. Did the Dutch test and that showed that I all my hormones were depleted and my Cortisol was all over the place. My body was messed up - healthy food and an exercise routine should equal health but it doesn’t always work out that way. So for me, maybe this kind of drug would level the playing field to match all you who do lose weight when you clean up your lifestyle.
@@DeniseCummins Standard diet is the problem… WAY too high in carbohydrates. Most stores are so loaded with processed carbohydrates, that never existed before the last 30-50 years. Fruit is 2-3x the size, grown to be sweeter. Foods are now available all year long instead of being seasonal. People drink pop, juice, sugary drinks, that are liquid fasting acting fructose and sugars. There are 75+ names for sugar, so it fools people to think a food is sugar free. Claims on front on products can claim “no added sugar” but still be high in carbohydrates which convert to sugar in the body. People were lied to about meat and eggs, and butter, which turn out to be healthiest. Veganism is not healthy like people assume; it just leaves one deficient in critical nutrients, and often gaunt. There are no Essential carbohydrates. But we require Essential Amino Acids and Essential Fatty Acids. Thyroid health can slow weight loss; TSH testing is not enough. If you are hungry always, Insulin Resistance is probably high. Doctors rarely test for it.
The med doesn't allow someone to not do the things needed to be healthier. The drug allows them to do what is necessary to be healthier. If you eat how you've always eaten, and move how you've always moved ..you're not going to lose weight. Our brains are wired for us to eat enough for our body to hit it's set point. Once someone gains weight and keeps it on for a few months, then that setpoint is moved higher. This is why even after bariatric surgery, after a few years many people gain it back. These drugs help counter the cravings that the brain triggers, to gain it back.
Discipline? Do you mean willpower? It is actually carbohydrate addiction. Reduce carbohydrates to nearly nothing, or none, and carb cravings over a month disappears.
@@HeyYall398 You ask for evidence? Sure, what about the evidence showed by basic Chemistry when studying the properties of food? That's enough scientific evidence I think. Carbs are sugars, not proteins... So, I am afraid Marlene is right.
WTF???? Why do you need drugs for weightloss??? Get your head straight AND FAST FFS....all it takes is push....AWAY FROM THE TABLE!!!! STOP LOOKING FOR THE EASY WAY OUT ALL THE TIME....do some research on fasting and save your own life
There is a whole lot more to body mass regulation than just simply "fast and eat less". Sure, that has a significant place in weight loss for most, but there is a whole lot more at play in the body that shouldn't be ignorantly ignored
Peter Attia doesn't seem to understand that his approach of using small molecules to try to make his patients' bodies to mimick the metabolome and proteinome of Centenarians cannot work and will not work. I explained to him exactly why in like 20 paragraphs of text, but it didn't work. He is just too much of a medical establishment guy . I look at Peter Attia and the first two words that comes to my mind is: "Establishment"
Couldn't agree more. More and more he continues to diminish any benefits of most longevity drugs or supplements. Thats what the Medical industry does so they can push their higher cost crappy drugs that do nothing to help with wellness or longevity.
I started Wegovy after weight gain from quetiapine, which I must take for a mental health diagnosis. I have the side effect “insatiable appetite.” I would eat “perfectly” all day and then take seriously and eat everything… anyway my psychiatrist prescribed the Wegovy. I’ve lost 45lbs, started strength training, A1C is now 4.9 LDL 79 and feel so hopeful now for my future. 😊
All the best on your journey back to full health 😊
❤️
Don't be misled this year 2023... because the only channel on UA-cam where you can get the perfect solution to cure your herpes permanently is @ THE SEVEN DAYS FAST CURE FOR HERPES 1&2. Herbalist Doctor Kingsley who's the owner of the channel on UA-cam @ THE SEVEN DAYS FAST CURE FOR HERPES 1&2 has the total cure for herpes.
Just say no to drugs, weight training and diet would have worked more than likely.
My dude, some psycho active meds do cause that famished feeling like Zyprexa and some do not like Abilify
Please have your doctor switch you from one to another until you find what works for you. Read all side effects before agreeing to any med
Ozempic costs here in Finland, when used not for diabetes so it's not goverment-comped, 115 Euros /month. It would be cheaper to fly from America to Finland once a month than pay the American prices out-of-pocet.
My MD wanted me in these meds asap. I said ‘no’, started the carnivore diet in January. My weight, BP, A1c, blood glucose, triglycerides, asthma, depression, and anxiety are all down and/or gone!
Take your pseudoscientific nonsense and shove it. Not a place to discuss it.
Congrats 🎉🎈🍾 on your health
That’s literally how it works! It slows down your digestive system. All the information that comes in the box says so. That’s why (good) doctors also prescribe Zofran for nausea. Take your probiotics, take enzymes with your food, and eat some type of fermented food every day (kefir, sauerkraut, kimchi).
Tirzepatide appears to be so much more effective for weight loss than semaglutide based on my many friends & recent research.
It makes me so sad that ignorance guides most inflamed conversations about those that are using Semaglutide for weight loss appetite control reasons instead of diabetes. Diabetes is serious but so is a life long battle with compulsive overeating disorders. I’ve seen first hand the massive positive impact that Ozempic has had on a loved one that has no ability to control their appetite or compulsion to eat and binge. This drug needs to be prescribed to this alternative group of people that are just as at risk of complications and death as chronic eating disorders ruin lives and health too
Yes I agree with you. Why would diabetics be more deserving of this drug than people who suffer from obesity? Both are dangerous chronic diseases where people suffer greatly.
Diabetics have other options the market is flooded with diabetic drugs, that’s not the case for effective obesity drugs. Diabetics are mad because they also want to lose weight, therefore they feel they should be first in line because the drug was originally marketed for diabetes. That argument is a bunch of horse manure. Obese patients are just as at risk as diabetics.
Umm they are at risk but not just as much as diabetics. The risk for heart attacks, strokes is 10 to 15 fold. Plus if the A1C has been elevated for years kidney disease and retinopathy are a ticking time bomb. They need to be first in line. Just my opinion.
💯💯💯
life long compulsive over eater 60 over weight and I am getting relief from semiglutide. There is finally hope for the future.
@@genalora841 that’s so amazing 💙There are Bulimic patients that aren’t overweight because they purge all excess food consumed. They don’t qualify for Semaglutide yet no one would argue that their mortality rates are significant too
I get my script filled via a Compounding pharmacy … about $100 per month for .5 weekly semaglutide - zero insurance,zero problems. I lift heavy 3 days a week, 2 cardio, 2 recovery days. I track my food like a hawk. I am barely dropping 4 pounds a month.. But I am seeing positive body recomp. This is NOT a magic bullet - I lost 90 on keto and a 2plus hour per day exercise regime. Now working on these next 70 - for me its a tool -
what is your pharmacy?
@@milaurban yes please help us out
Seems like you have a liver issue. Doesn't seem like it's metabolising fat for energy properly
Rebelsus is the pill, I’m diabetic… but have a fear of the side effects. I don’t consider the weight loss a side effect, because I believe this is a sign that it is actually doing what it is supposed to do with your carbs. But thyroid cancer? Pancreatitis? Why would these things happen? That is what I’m trying to find out. Have not been able to find an answer.
The short answer is because the medication has effects in your body on the thyroid and pancreas. In some people, instead of beneficial effects, the medication can cause an unwanted side effect, such as pancreatitis. You should talk to the person who prescribes Rybelsus for you about these questions, not us.
@@ResearchSci2024 please don’t misunderstand. I’m not asking for advice. Those were rhetorical questions. I would never follow anyone’s advise on UA-cam. I too hope that no one else is doing that without consulting their doctor.
With respect to pancreatitis and gallbladder bladder problems I believe it has to do with really slowing down the passage of food in some parts of the digestive tract. I wish I could remember the podcast I listened to so I could include a link here.
There are GLP-1 receptors in the Pancreas. For some people this can cause pancreatitis. I had done several shots of Semaglutide and I started feeling mild pain on my left side under my rib cage. This pain came and went and it was mild. Kind of an annoyance. I believe it was after my 4th shot that I started to feel pain that also went around to my back. This was not intense pain. But annoying. If I took Advil the pain would be gone in 30 minutes and I would not feel anything for hours. I had my Pancreas Lipase tested and it was 111, which is higher than normal but not too concerning to my doctor. But he told me to stop taking Semaglutide, which I did. Frankly I was going to wait a few weeks and go back on to see if the pain would come back but I ended up cutting my food intake without it and now I am in that state where I don't need to eat a lot, so I guess why use Semaglutide if I can accomplish what I want without it.
Food stays too long in your system and the drug messed with your hormones.
I’m a NP and work at a weight loss clinic and have a masters in nutrition. These can range up to like $1400 a month and with insurance $500. Mounjaro has seemed to be the golden one, comparatively. Ppl are obsessed with these😐 BUT they have helped so many ppl lose weight who have been doing all the correct ways like proper nutrition and exercise. Insulin resistance is extremely under-diagnosed. This also aligns with PCOS. Hormones (especially with women) are a huge factor too. It’s an exciting med but I’m always skeptical and we don’t know long term impacts. So many ppl worry about the number on the scale and not the composition, so aggravating!🙄
Why do nutritionist seem to reject Keto rather than conventional calories in calories out mantra? The conventional approach does not work…
@@betha8021 All fat loss is about energy balance. When ketogenic diets work, it’s because of the energy deficit.
@@Garret_bruh_homey Incorrect - it's a mass equation. The calorie is not a valid measure of the energy we derive from food.
Ref: When you lose weight, where does the fat go? Most of the mass is breathed out as carbon dioxide, study shows
Ref: The Calorie Myth
@@gribbler1695 Energy is stored in chemical bonds. Nutrients like carbohydrates and fats are oxidized to liberate energy, which is stored in ATP, and eventually used for work. CO2 is an end product of oxidation - just like when wood or gasoline are burnt.
Also, calories are always a unit of energy. You can use joules or calories, but energy is energy. Its forms change, but the units do not.
@@Garret_bruh_homey Counting calories for fat loss is complete nonsense; it is far too simplistic for what actually happens in the body.
The food industry wants to maintain the charade, so that ultra-processed foods seem 'healthy' if they fit your macros, rather than pushing quality whole foods.
Ref: Why Everything You’ve Been Told About Food Is Wrong | Tim Spector
Came straight to the comments, and let me tell you, they did not disappoint! Very educational, interesting and enlightening. Worth the read in my opinion, if you’re interested in this topic (which I am).
I used restraint. Waited till 10:00 mark😅
The gastro side effects of oral semaglutide are apparently more unpleasant. I did not enjoy them at all. You also need bigger doses to get the same effects. But it wasn't *that* expensive here in Japan. It's about $90 a month.
My doctors prescribed Vitamin B6 + B12 to avoid the gastro side effects of semaglutide. I started a week ago and had no side effects whatsoever.
@@olgamelo5227let me know you you do in a month...
A gym membership is cheaper
@@Jlk6532there's always an ass in every group, huh. =you lol just messin with you. You are correct in that, however there are people out there that can't get to a gym.
Certainly don't need to go to the gym, per se. There are many other ways to workout, walking, biking get a few weights and bands for at home. even working out working around yard to start. @@alfenner3309
Can you update this video, there’s a lot more information available now that wasn’t when this was made
I was prescribed monjourno for weight loss. I was able to get 12 weeks for $50. With a coupon. I could only take 4 weeks' worth of injections, I had internal jitters and shakes so bad. I called my doc and he said, "Keep taking it, it will go away " I couldn't stand it. So, I just stopped. I did lose 5 lds. I gained 15 lbs after about 3 months after stopping monjourno. I still have jitters and shakiness. I still have the injections in my fridge. I found out shortly after I stopped that there is a shortage of this medication for people who really need it. I feel so bad.
I started to feel tingling and burning sensation in feet n hands. After each injection. The higher the dose the longer the sensation lasted. They said its not related to MJ
I believe the shortage is the pens, not the medicine itself.
16:44 0.25mg - you can actually dial this to 0.125mg or smaller if needed
Metformin depletes several vitamins and minerals from the body. For example, magnesium and B12. Look it up.
Prescribed Metformin by my internist my request due to insurance not approving ozempic, with that been said Metformin strained my energy stores I took myself OFF feeling like myself again 😊
@@andreastone8629 Try Berberine
Are you in the medical field
@@paigewilson7893 I do medical research, not a practitioner.
@@justbabes2685 how does the Berberine affect your appetite? I am diabetic.. trying to figure all this out.
The pill is called RYBELSUS.
But what if ya dont have a food issue? I fast 16-20hrs a day and eating high protein low sugar. My glucose number has never been over 4.5 in years! Still can’t get my weight under 80kg. I’m 52 just gone into menopause. I’m so tempted to take this medication but just don’t wanna mess with my hormones anymore than they’re changing now.
Thyroid FULLY tested?
Not just TSH.
On other meds like a statins?
One could go to a trained doctor, and look into hormones that are Bio-Identical, not synthetic… but done correctly.
Fasting is likely killing your thyroid which is already sluggish due to meno. Have full thyroid incl rt3
Clearly fasting isn't an effective strategy for you. Have you tried working with a Registered Dietician?
@@marlenegold280 synthetic hormones ARE bioidentical and are much safer than compounded hormones
Are you weight training? Try that if you aren't.
My doctor took me off of semeglutide for three months because my liver enzymes and pancreatic enzymes were slightly elevated, I hope those levels go down so I can get back on it
I know of 2 people that that also happened to, your fortunate your did your liver enzymes testing as sadly many Dr's don't. All the best
This is a known issue and I am not sure if in the end it is a problem. I believe it was 1/3 of Semaglutide users experienced 25% to 38% increases in their Pancreatic Lipase values. I don't have the study off hand but you could probably find it by googling it. My AST values have been slightly out of the high normal range for years. I told my doctor I was looking at supplements that might decrease my AST. He told me that my AST being slightly out of the normal range was nothing to worry about, especially when it consistently the same. My ALT values are right in the middle of the normal range.
Not worth it.
Not sure if you drink alcohol at all, but I heard this could be the reason for the spike. Even a glass of wine 2x week could increase your levels while on this drug. It’s not being talked about, unfortunately.
There is also phenteramine for weight loss. Apparently it’s been around for a long time and it is far more affordable than ozembique
It is addictive and you can only stay on it for 12 weeks max. Because it is an amphetamine-type of drug, it does not get at the "root" of the issue such as this class of medications. Besides, branded Wegovy and Mounjaro do not need to be that expensive. The peptides themselves can't be patented. We all have them in our body.
Not if you’re hypertensive.
Horrible med. I don’t sleep on it and become so depressed.
It is a short-term solution. I take Adderall for ADD. When people first start out they have issues sleeping and they have not appetite. But once you are on it for a while your body adapts. Trust me, I had no problem ballooning to 285lbs when I should be under 200lbs. Many, many years ago I was prescribed phenteramine and it did absolutely nothing because I was on Adderall, which is already stimulating the same pathways. Probably more so than Phenteramine. Semaglutide is completely different animal. I used for a short period of time and it reduced my hunger and made me feel full when I didn't eat that much. I had some issues that may or may not have been related to using Semaglutide, so I stopped and just ended up dieting without it and it has been working out so far.
I love your book Peter. Thank YOU!
When a GLP-1 is prescribed for weight loss, are patients monitored to ensure they’re getting proper nutrition?
Proper or Confounded 😅
Not usually.
No. And this is bad.
Look at what happened to Sharon Osborne and she is a celebrity
If getting proper nutrition was required then there wouldn't be a need for you to hop on a drugs to lose weight. You would be achieving that with the proper nutrition.
Rybelsus is the oral version of Ozempic and is supposed to be just as effective. The cost is comparable to Ozempic.
Wouldn’t an appetite suppressant work as well for non diabetic people for weight loss? Is there an appetite suppressant on the market in the form of drug or supplement?
stimulant medications like vyvanse, then injections like wegovy, and saxena are your weight loss meds. the issue with the stimulant adhd pills that remove appetite is that when they wear off at night you cant sleep are are starving so many end up gaining on those. i did. so now im on daily saxena shots
@@Brainjoy01 I spray Garcinia Cambodia… works good for me. But I’m not an emotional eater or anything like that. I love food… but if my hunger is not there, I won’t overeat. So the spray works great for me.
Unpleasant side effects on appetite suppressants that glp1 meds do not have. Night and day difference …
@@Tonia787 I use Konjac root… 1/4 tsp of the powder…no side effects.
Ozempic cuts your appetite but even small amount of food festers in your stomach and leads to terrible constipation. No weight loss for me.
I'm phasing out of liraglutide after about a year- prescribed for obesity. I wasn't satisfied with weight loss benefits although a1c went from 5.7 to 5.
I noticed the increase in rhe and have had a big hit to exercise tolerance that hasn't fully bounced back. Agree on protien- appetite was way down and what I wanted to eat really shifted to fruit when I wasn't a big fruit person before.
Dr. Attia,how do you feel about diabetics getting run over by rich people, who want to lose weight and can pay full price for these drugs, that are making them not available for diabetics that the drugs were developed for, and that the drugs are a crucial part of our therapy who can no longer get them because of shortages? I would love to see at least one or two of the many UA-cam doctors who are talking about these drugs, and spinning up the demand for them, talk a bit about all the off label prescribing that is making diabetics have to chase these drugs from pharmacy to pharmacy, and frequently change dosages or completely change drugs or go completely without any because people are getting these drugs that should not. There is only one of these meds that is approved for weight loss.
I'll tell you why. It's the antiintechrins. It's the same reason why we originally didn't understand why diabetics with roux en ys went into immediate remission.
insulin resistance is treated with more insulin ..and insulinotropic drugs for weight loss ! Am I the only one losing my mind here ?!!!🤨
Retatrutide will phase out all the prior GLP-1s.
Ive been waiting for this talk!
Rybelsus is the oral drug.
I have some Pendulum GLP-1 Probiotic in my Amazon cart. It is supposed to have bacterial strains that help your body produce more GLP-1. I gained 50 lbs during covid and my lifetime slim self is having trouble with enough deficit to take it off...Still :-( I feel like I have a healthy diet with mostly whole foods and pretty clean. Don't love counting calories. Do you have any thoughts on a product like that?
Grateful for the book 📖 Thank you for sticking it out! 🙏
Dear Peter I started loving you since listen to your Ted Talk and interview with RIP Sara Hulberg. As 57 years old male with 27 years and chang T2D I have tried everything under sky. My diabetes got worse every year until November 2021. I was 236 lbs A1C 9 on 7 meds In very dark place mentally. Now I am 188 with A1C 5.4 with no meds. Walking 6.5 miles per day in average. I did all with elimination and reduction on food with pay close attention to my glucose feedback. I’m using CGM. I am wondering but I am not lost. I think there are lots organizations unfortunately with healthcare professionals whom take advantage of lost and desperate people. I have feeling marketing Glp1 drugs is part of this scam or as close as legally they can scam people.
The fact that one of these drugs was recently cleared for kids as young as 12 tells the whole story. Seriously….does a drug company actually want people to get better and not use their products, or is the dream scenario to start an infant on as many drugs as possible that they take for life….and have them live for as many years possible in order to extract the most $$$$$$. Some people need drugs put of necessity. Many others don’t or wouldn’t……but like any other company, more revenue streams are sought out….
Majid congratulations on such a wonderful improvement in your health! How did you use diet to have such a great weight loss? Keto or some other?
I don’t have name for what I started almost 18 months ago. Here what I did 1- I got myself a CGM and I observed how f***d up I was at that time which didn’t surprised me. 2 - I started no NOT eating as much as I could tolerate. And eat as least as I could. 3- eliminated everything spiked my blood sugar fast. This goal eliminated all simple carbs and sugar. Including rice pizza and potatoes. 4- after while I started to decrease my meds and get rid of insulins injections. Follow by BP meds and using CPAP. 5 - recently I added some berries and leafy salad to my daily intake. 6 - my daily activity increased latter after I lost first 3 lbs. now I am walking twice a day or bike and enjoying hiking anytime I could. 7. I avoid eating out as much as it is possible. I hope it helps.
Man said "Dear Peter"
Is Trulicity included in this type of medication?
yes it’s a glp1 agonist
Yes, Trulicity is a GLP-1 agonist.
What do you think it would be the reason why semaglutide would not work on somebody
Because suger haves a lot to do with cycling 🚴♂️ will this shot interfere
So we know from earlier podcast that Peter cut back on Metformin and only took it in the evening. Is Peter still taking Metformin at all now? Sounds like most of Peters comments end up trashing most anti ageing products. other then eating properly and fasting, what exactly does peter even recommend as an anti aging drug or Supplement.
Rapamycin
Peters rule on drugs, supplements and food: don’t brag about doing anything’s, until your exercise house is in order.
And he’s quit fasting because it caused muscle wasting.
Sooo many medications mess with hormones.. often I take Tropirimate for acute migraines and EVERYTIME I start I drop weight rapidly- 5-7kg in a few weeks! Noticed in my bloods it rapidly reduced my oestrogen so my hair thinned also & period stops. However I loose my short term memory super fast and so my thyroid also drops. So I go on and off it.
So hard trying to take medication that won’t mess with hormones in menopause.
Last week, I heard from a NP that Mounjaro was going to be for type 2 diabetes only and Wegovy will be for weight loss.
This isn't true. Wegovy is branded for weight loss however it is semaglutide and called ozempic for diabetes. Mounjaro has shown weight loss benefits clinically and currently undergoing trials to have authorization for weight loss in the near future.
Mounjaro is being certified for obesity. Your NP needs to do a better job of keeping up to date.
In fact tirzepatide was a molecule that Eli Lilly had shelved, but when they saw how much money semaglutide was making with obese patients they took it back off the shelf to get it certified by the FDA for obesity. Diabetics would never even have mounjaro otherwise. The money is with the obese patients.
If a nondiabetic takes GLP-1 is there a risk of becoming Hypoglycemic?
I wouldn’t take it, as it is a black box drug, which has serious side effect:
Pancreatitis
Gallbladder disease
Kidney damage
Thyroid Cancer
…Among others
and once you stop, weight regain is massive.
Very expensive.
not at all! it only lowers blood glucose if it's too high.
I can confirm, as a non-diabetic who just started taking semaglutide *on a keto diet * (so, no carb intake to begin with), I definitely got hit with hypoglycemia. Numbers so low my CGM didn’t even display it (I’ll see it in the 40’s, but then it’ll just say “LOW” instead of digits). Got shakes & sweats, almost passed out. I first tried to corrected this with some crackers & a Nugo bar, which barely brought myself back into the 60’s, then a tablespoon of honey finally helped me hover around 80).
I didn’t get hypoglycemic on keto before semaglutide.
Long story short: YES GLP-1 can potentially lead to hypoglycemia in non-diabetics, especially if you don’t tailor your diet accordingly
@@Jtsui5308 I didn't get hypo on mounjaro on keto diet and didn't have high blood sugar to start with either.
What about all of the warnings on these drugs in regards to thyroid cancer cells in rats 👀
Can I water fast on these drugs? No one seems to be talking about this… (24 or 48s)…
For those trying these GLP-1/GIP agonist drugs -- what is the approximate cost per dose/perscription? Especially curious if paying out-of-pocket.
$1100 per month. Wegovy is sometimes covered by insurance for weight loss.
@@Wealth-and-Wellbeing $100 per month without insurance is ridiculously inexpensive for an on patent drug . I pay more than that for some medications with insurance coverage
@@dondajulah4168 eleven hundred, not one hundred.
I’m a NP and work at a weight loss clinic and have a masters in nutrition. These can range up to like $1400 a month and with insurance $500. Mounjaro has seemed to be the golden one, comparatively. Ppl are obsessed with these😐 BUT they have helped so many ppl lose weight who have been doing all the correct ways like proper nutrition and exercise. Insulin resistance is extremely under-diagnosed. This also aligns with PCOS. Hormones (especially with women) are a huge factor too. It’s an exciting med but I’m always skeptical and we don’t know long term impacts. So many ppl worry about the number on the scale and not what the composition, so aggravating!🙄
@@karenrogers9985 got it. My bad.
Is Ozempic the same as Victoza?
same group but Ozempic is more potent as it comes to weight lost.
A suggestion for Dr Attia: since you are probably crushing APOB in many of your patients (n=1000?), it should be easy to see a signal (no ASCVD) in your patient data over a 10-20-year period, given the immense incidence. Is APOB truly necessary for the disease? Hello, Nobel Prize!
if you stain a plaque from a coronary artery that killed someone via a heart attack you can identify BOTH apoB48 and apoB100. the numbers indicate the number of amino acids. liver makes the 100 and intestine makes the 48. they do the same thing in that apoB binds to receptors so the lipoproteins can be re-uptaken by the liver. every atherogenic particle (non-HDL) has one apo B protein on it's surface so it is a surrogate marker for number of atherogenic particles.
What is the Fat Loss to Muscle Mass percentage using these GLP1? I read a study that 40% of the weight loss is lean body mass. Is that true?
@Edgar please could you drop a link for the study about 40 % muscle mass. Would like to read up. Thanks
@@joken8028 ua-cam.com/video/t_z6E7OXEeY/v-deo.html It was the New England Journal of medicine dated 3/18/21. It was a 68 week study with placebo group and with patients taking 2.4MG. They lost on average 15% of their weight. However, they only did dexa scans on like 40 patients and the results were 60% fat loss, very little viceral fat loss and 40% fat loss.
This one goes more into the New England Journal Of Medicine study on weight loss results. ua-cam.com/video/JekNCSmmr1c/v-deo.html
True.
So if you stop these drugs you end up even more obese, because of weight re-gain, but also because of so much muscle loss.
OMO this is BS. THEY didn't take into consideration the person's diet. You need to eat your protein. So many go on this without changing their diet
It doesn’t make sense to me to give a person with extreme insulin resistance even more insulin.
Will this shot interfear with exercise bike
The elephant in the room has always been appetite. If you've got a big appetite, you've got a big problem when it comes to trying to lose weight end of story.
That’s partly why semaglutide and tirzepatide are effective, they just cut down the food noise to manageable levels.
PS This is like when fasting craze started. You tube filled with "Eating disorder" superwomen and men. Same with this GLP drugs and craze
@ 23:00 Rybelsus?
Metformin had shown so much potential for longevity with minimal side effects that it should at this point be part of anyone’s medications
Nonsense. Metformin is a mitchondrial poison. It cannot be good for longevity. There are better ways to avoid "overheating" the mitochondria like avoiding sugar and cabohydrates, excercising, eating saturated fat (with no sugar)...
Except it hadn't.
I’m gonna watch you take it, while I train and live naturally.
Good luck, peace
Just like aspirin 😭
My grandma lived to 102 and didn’t take metformin.
Unfortunately, yet another search for cheatcodes instead of addressing the cause: the IR, intramyocellular/intrahepatic/intrapancreatic lipids... all of which is lifestyle mediated.
And same as metformin is now clear not to be the fancy magic pill, so the GLP1A won't be in years to come.
Training food habits, moderation, optimizing nutrition - is the key.
Love Peter and all his work regardless 🙏❤️
"Training food habits, moderation, optimizing nutrition". Yes, you are right. At the same time, we are human beings, not robots and not for every human being is as easy as it sounds to do/be "Training food habits, moderation, optimizing nutrition." I think there is much more than that to be taken care of, specially from the Psychological aspect. It is a much, much, more complex issue than just "Training food habits, moderation, optimizing nutrition". And I think the "failure" to treat this issue is because the "jogging/diet" is the solution and underestimate the many factors around the failure.
❤
If changing lifestyle or behaviors were that easy there would be no market for this drug.
@@jeanniej8296 Totally agree. More than that: if changing lifestyle or behaviours was easy, there would be little market to most chronic disease drugs. Well, people's search for magic pills that will keep them healthy without addressing the cause (lifestyle and behaviours) marries perfectly to the intelligence and greed of big pharma. Unfortunately, such marriage is only benefitting one of the partners.
Luckily, there are ways and robust frameworks to transform lifestyle and behaviours. But the first step to unlock them for oneself is to realize that cheatcodes will not work in the long run - without excuses, self-pacifying explanations and so on. Otherwise the quest for the holy grail of magic pills will continue, bringing further epidemic of chronic disease and disappointment, irrespective of advances in tech and medicine... which is what we see now.
@@Tod_oMal Nothing worth doing or having is easy. It’s also a vicious cycle, people’s eating/drinking habits and lack of exercise, social media use, fresh air and sunshine lead to obesity, depression, anxiety. I’m in my late 59s, and none of these poison foods and drugs and technology were around-hence none of the problems of today’s society.
Yeah when you are in serious need to lose weight ..it’s a personal decision between you and your Dr…. Period. Also, much more is being known about genetics of obesity …it’s long overdue.
Jardiance is Ok
If metformin has negative impacts on mitochondria and skeletal muscle, then does it make sense to use metformin when resistance exercising to minimize sarcopenia?
For longevity avoid Metformin on workout days. See back episodes.
To heck with all these drugs... It's so simple it's unbelievable: eat no processed foods and sugar, do fasting, get sleep, and exercise...
Great Dr's, like Jamnadas, aren't quick to prescribe those bandaids.
Ugh...
Just doesn’t work. When your hormones are so out of whack post menopausal, it’s very difficult to lose weight. Your GL1hormone may not work as in my case. I exercise five days a week(3x hiit) walk daily , I don’t eat processed foods or added sugars. I haven’t been able to lose any weight in eight months. It’s extremely frustrated. I’ve been on this medication and slowly increasing my dosage for three weeks. I haven’t lost any weight but I feel like my appetite is diminishing. I’m hopeful.
@@lindanewman8710
What is your fasting insulin?
C-peptide?
Fasting glucose?
Free T3?
Reverse T3?
Free T4?
TSH?
Thyroid Antibodies?
Vitamin D test?
B12 level?
Iron panel?
Triglyceride:HDL ratio?
CAC score?
Taking a statin? Causes lots of problems
Example of what types of foods eaten daily?
Snack between meals?
Amount of grams of total carbohydrates?
Amount of animal protein in grams?
Amount of grams of healthy animal fats?
Avoid processed seed oils?
Some good information to learn for yourself.
Not for everyone. I've done all these things for years, and my body prefers being enough "overweight" that I have a spare tire. That said I'm quite fit (the ability to perform) and athletic. I hike weekly and aggressively, day hikes in the 15 mile, 3000 ft range. Barbell train 3 times a week, etc. The novelty of low carb has worn off on my system. I could go zero carb for a week and nothing. I have to do a multiday fast (3-5 days) to see any fat loss movement.
Good one
Interesting
Is that a Ayrton Senna helmet?
Attia regards Senna as the greatest F1 driver
20:30 nice try Johnny Manjaro!
Wow 20 minutes in and no new information
20:59 should be Johnny Mounjaro - this drug is a miracle for some
Lots serious complications in this black box drug.
@@marlenegold280 huh?
Take this. No idea why it works but trust us it's safe, honest. Oh, and by the way, keep eating too many carbs to preserve our revenue streams, pretty please.
Except, that's not how it works.
Is that nose Plastic?
Ha ❤
It’s attached to the glasses
Ayrton Senna helmet?
23:30 Rybelsus
The book is ok and only because Peter like everyone in his field shrinks when asked about actual weight loss. The best he does is a cyclist example and what amounts to the system is broken for weight loss. There is a transport problem in what seems to start in the muscles. So, if this is a illness then why not just push this into an illness that is covered by medication or banning of substances that cost so much we are all better of by not having to UPF because it’s terrible for us. He’s not going out on a limb. He’s just monetizing his platform. He does give out good information and it’s the best we can manage in this economic environment. I’ll still subscribe but Attia is not your friend. You pay for it and you should not expect a benevolent being in him or anybody else.
Gotta love thin Hollywood celebrities who end up with an Rx for these drugs. 🙄
If type-2 diabetes is a glucose metabolism problem they why are there several interventional studies showing reversal of type 2 diabetes when given a bread and white sugar diet?
You’ll have to cite your sources; I’ve never seen anything like such a claim.
Why does the MC nose look fake?
This cover photo looks just like Dr. Evil
Must pay to listen to the rest. What ever. Unsubscribe
If you ask me, people these days are using drugs and other medical interventions as an excuse to not make the changes they need to in order to truly fix the problem(s).
If these things were not available, I’m willing to bet people would be far more motivated to make lifestyle changes.
That's because you (and no one you know) has suffered unexplained massive weight gain that is resistant to standard diet and exercise intervention
@@DeniseCumminsi agree!
We have people that do NOT exercise nor eat healthy and yet they are not overweight. To all the people that exercise and eat a healthy diet then loose weight…they have found a solution that works. Yay for them. Then there are those that do exercise, do eat extremely healthy yet their weight does not budge. I am such a person. However I also don’t have a functioning thyroid so I need thyroid meds. Even when I trained with a professional bodybuilder who provided my food type and quantity and my fitness routine - he could not help me loose all the weight and keep it off. He said that I was his best client. I followed his instructions and was consistent. I lost an initial 15 pounds, (needed to lose 30-40) but at the 5th month in my body started putting on weight and no it was not muscle. Did the Dutch test and that showed that I all my hormones were depleted and my Cortisol was all over the place. My body was messed up - healthy food and an exercise routine should equal health but it doesn’t always work out that way. So for me, maybe this kind of drug would level the playing field to match all you who do lose weight when you clean up your lifestyle.
@@DeniseCummins
Standard diet is the problem… WAY too high in carbohydrates.
Most stores are so loaded with processed carbohydrates, that never existed before the last 30-50 years.
Fruit is 2-3x the size, grown to be sweeter.
Foods are now available all year long instead of being seasonal.
People drink pop, juice, sugary drinks, that are liquid fasting acting fructose and sugars.
There are 75+ names for sugar, so it fools people to think a food is sugar free.
Claims on front on products can claim “no added sugar” but still be high in carbohydrates which convert to sugar in the body.
People were lied to about meat and eggs, and butter, which turn out to be healthiest.
Veganism is not healthy like people assume; it just leaves one deficient in critical nutrients, and often gaunt.
There are no Essential carbohydrates.
But we require Essential Amino Acids and Essential Fatty Acids.
Thyroid health can slow weight loss; TSH testing is not enough.
If you are hungry always, Insulin Resistance is probably high.
Doctors rarely test for it.
The med doesn't allow someone to not do the things needed to be healthier. The drug allows them to do what is necessary to be healthier.
If you eat how you've always eaten, and move how you've always moved
..you're not going to lose weight.
Our brains are wired for us to eat enough for our body to hit it's set point. Once someone gains weight and keeps it on for a few months, then that setpoint is moved higher. This is why even after bariatric surgery, after a few years many people gain it back.
These drugs help counter the cravings that the brain triggers, to gain it back.
Bigpicturegains - No one is asking you.
The Misadventures of Johnny Mounjaro.
What a horrible waste of time
Don’t waste time on this podcast clickbait
I seriously watch these to go to sleep... They gotta know how boring this is, maybe on purpose?
They are for smart people. You might not be the target population.
LMAOOO
I have lost all respect for you. Unless you are using peple like Dr. Grant tinsley your data is invalid.
It's meds. Danger ahead.
Skip this video, its a waste of time. There is nothing new and mostly vague talk
Is the other guy using a filter? Bro, stop it. Just stop it.
♿️
If it's a pharmaceutical, it's bad.
Lol
how about discipline?
You are talking about a Psychological aspect, which of course should be included in the whole treatment. Generally underestimated.Good point.
Discipline?
Do you mean willpower?
It is actually carbohydrate addiction.
Reduce carbohydrates to nearly nothing, or none, and carb cravings over a month disappears.
@@HeyYall398 You ask for evidence? Sure, what about the evidence showed by basic Chemistry when studying the properties of food? That's enough scientific evidence I think. Carbs are sugars, not proteins... So, I am afraid Marlene is right.
@@HeyYall398 Ok, no problem, good luck with that.
@@marlenegold280 that is dumb. carbohydrate is essential. if you have addiction go see therapist
A lot of bla bla. We're trying to live long, not waste time, please spare us the bla bla.
brilliant content - enchancing my education at UBC so i can understand why im learnign matters and what it actually means for the body
WTF???? Why do you need drugs for weightloss??? Get your head straight AND FAST FFS....all it takes is push....AWAY FROM THE TABLE!!!! STOP LOOKING FOR THE EASY WAY OUT ALL THE TIME....do some research on fasting and save your own life
This doesn’t work for everyone specially when women’s have their hormones involved.
There is a whole lot more to body mass regulation than just simply "fast and eat less". Sure, that has a significant place in weight loss for most, but there is a whole lot more at play in the body that shouldn't be ignorantly ignored
Peter Attia doesn't seem to understand that his approach of using small molecules to try to make his patients' bodies to mimick the metabolome and proteinome of Centenarians cannot work and will not work. I explained to him exactly why in like 20 paragraphs of text, but it didn't work. He is just too much of a medical establishment guy . I look at Peter Attia and the first two words that comes to my mind is:
"Establishment"
Well, its a "tool" that deserves conversation right? Plenty more of conversations where he pushes nutrition and exercise.
im just curious, could you sum up in a paragraph exactly why it wouldn't work?
Thank you 😊
Please elaborate. I am very interested.
Couldn't agree more. More and more he continues to diminish any benefits of most longevity drugs or supplements. Thats what the Medical industry does so they can push their higher cost crappy drugs that do nothing to help with wellness or longevity.
Now all of hollywood is on it! 🫣😏🙈
Ever noticed that Hollywooders look so gaunt? You can tell who's on it and who isn't.