Nuclear Receptors & Signaling Pathway

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Video Summary:
Nuclear receptors are located inside the cell. They bind with a lipophilic ligand molecule. They are transcription factors. They have a ligand-binding domain, DNA binding domain, and transactivation domain. Under resting state, glucocorticoid receptors are located in the cytoplasm and are bound with chaperone protein HSP-90 that prevents its activity. Binding of glucocorticoid causes release of chaperone protein, dimerization, entry into the nucleus, binding with coregulator, binding with DNA, and modulation of transcriptional activity. Because of the involvement of protein synthesis, their effects are slow to appear and slow to disappear.
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Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.

[@riyamittal4871]

Excellent explanation
Thanku for teaching basics from scratch which no one does

[@jessterdayoncemore7049]

Really great video! I understand this so much better, thank you!

[@ohmykk9629]

You described so clearly. Thank you very much💞

[@garry8935]

your quick summary is awesome

[@michaelfung4629]

Great explanation! Thank you!

[@neurosciencegirl]

Great video! Thanks so much for making this video - nailed it :)

[@nadaahmed8425]

Thanks it’s amazing description

[@md.tariqulislamtareq4357]

Precise and concise!

[@nikolina4803]

Thank you very much!

[@johntindell9591]

Thank you so much.

[@rajnandinisunagar6224]

Thank uh so much for such a clear n easy explanation 😊

[@dendrophile9385]

Nice explanation

[@Hend3077]

Amazing, thanks

[@graemelaubach3106]

Thanks homie

[@user-mr5fz8pl6w]

Great video

[@user-st3mx8ig3i]

Thanks a lot Sir❤

[@ghadaabdelrazik2239]

It is so easy! Thank you!

[@NonstopNeuron]

Welcome 😊

[@menakhalid1697]

A very helpful video , thank you so much

[@NonstopNeuron]

Glad it was helpful!

[@jillianlaw8600]

thank you so much !!!

[@NonstopNeuron]

You are welcome ☺️

[@shubhangiagrvl]

perfect

[@malabikaghosh2012]

Great video!! Tysm..

[@NonstopNeuron]

You're welcome!!

[@alimamstudying9462]

Thank u

[@rheachaudhary8567]

DAMNNNNN!!! CRYSAL CONCEPT😭

[@walaadabbas9354]

Tyyy

[@gagandubey9524]

How your concepts are so clear?? Plz share

[@NonstopNeuron]

I read a lot. I refer multiple books ranging from those targeted to newbies and those target to experts. And I love learning and sharing.

[@angieweathers7180]

Why don’t you say glucocorticoid receptor instead of glucocorticoid, you confused me in the middle of the lesson
Glycocorticoid hormone (the ligand) binds to glucocorticoid receptor inside the cell which provoque detachment of the charperone

[@harshmishra104]

best

[@elijahizere]

2:10 Didn't think I'd start thinking about Joe Rogan here

[@MingeTheAllKnowing]

Please why does that one receptor have a gun inside it

[@NonstopNeuron]

It represents kinase activity

[@NonstopNeuron]

It represents kinase activity

[@NonstopNeuron]

It represents kinase activity