Infective Endocarditis, Animation
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- Опубліковано 10 січ 2025
- (USMLE topics) Endocarditis: causes, risk factors, pathophysiology, signs and symptoms, diagnosis and treatment.
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Voice by : Marty Henne
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Infective endocarditis is infection of the endocardium - the inner lining of heart chambers and the covering of heart valves. Infection is caused by microorganisms, mainly bacteria, that have managed to enter the bloodstream.
Except for rare cases caused by massive blood infections or highly virulent organisms, a healthy heart is usually resistant to infection. This is because bacteria do not easily adhere to the surface of an intact endocardium; constant flow of blood also helps prevent bacterial attachment; and the bacteria are usually destroyed by the immune system before they can cause infection. An abnormality of the endocardium is typically required for endocarditis to occur. Major risk factors include having prosthetic valves or other intra-cardiac devices, congenital heart defects, heart valve disorders, hypertrophic cardiomyopathy, and previous endocarditis.
Endothelial injury allows for either direct colonization by virulent organisms, or the formation of blood clots, which then become the attachment site for bacteria. Infection of the endocardium occurs most often on the left side of the heart.
Organisms that cause endocarditis may come from distant infected sites, such as skin abscesses or urinary tract infections; or they may enter the body through a contaminated central line or injection. Bacteria of the normal flora of the mouth can also infect the endocardium if they get into the bloodstream, such as during invasive dental procedures. Causative organisms vary depending on the source of infection, but streptococci and staphylococci are responsible for the majority of cases.
Vegetations formed by bacterial growth may cause heart valve dysfunction, which can be heard as murmurs, and may lead to congestive heart failure.
Myocardial abscesses and tissue destruction may lead to cardiac conduction problems.
Pieces of bacterial vegetation may break free, forming so-called emboli. Emboli travel in the bloodstream and may block arteries. Right-sided infections produce emboli that travel to the lungs, causing pulmonary infarction and respiratory symptoms. Left-sided infections can send emboli to any other organs, including the brain, kidney, spleen, and the heart itself. Tiny emboli may also travel to the skin and eyes, producing small red streaks under fingernails, on fingers, toes, and the whites of eyes.
Other symptoms include fever, chills, fatigue and fast heart rates. Symptoms can develop abruptly or gradually depending on the type of endocarditis.
Endocarditis must be suspected when fever is combined with a heart valve disorder, especially when characteristic symptoms, such as reddish spots on fingers or the whites of the eyes, are present. But diagnosis usually requires evidence of blood infection, and imaging studies such as echocardiography, to show vegetations on heart valves or damage to the heart tissues.
Treatment consists of several weeks of intravenous antimicrobial therapy. Identification of the causative organism by blood culture is vital to determine appropriate antibiotic regimens. Empiric antibiotic therapy before organism identification may be necessary in seriously ill patients. Some cases may require surgeries to repair or replace heart valves. Potential source of infection must be removed.
BEST MEDICAL VIDEO EVER!!! SIMPLE, SPECIFIC, AND CONCISE!!!
In the hospital now with endocarditis, waiting for cultures to come back. Thanks for this very informative video
Good luck!
How'd it go?
How do you get it?
@@Onlarryy
Abscess from testosterone injection
I Love this channel , their videos is all I need to know and kind of overview. thank you so much !!❤️
You are so welcome!
My internal medicine exam after 15 days....thanks for help may Allah blessed u ♡.
I am worried about my father, a month ago my father diagnosed with pumonary edema after staying a week at hospital they discharged us, few days later my father couldn’t breathe properly and we took him to hospital after blood culture test , gram positive cocci found in chains and treatment started with antibiotics, 24 ampicillin injection and 8 exidill injection in a day . had to continue these injections for 6 weeks, I cry every time when I see my father in pain , I couldn’t sleep at night . Hoping my father recover from infective endocarditis 😥 Pray for my father 😢
In my case, I had a fever of unknown origin. Seemed to get better with antibiotics. Cough persisted. Follow up found mild dehydration, and "yep, that's a cough". The cough got to the point where I'd end up retching. As though my body was trying to reach deep down to expel something. Then, one night at work, my left leg felt like I'd pulled/torn something. Just a sprain? Got worse. Dragged myself to the ER. They found vegetation on my aortic valve, mri of the leg showed infection (visual exam showed edema), later they found evidence of a stroke (that to date hasn't resulted in debility *thank God* ). So, now I have a loud heart that constantly remind me of enterococcus faecalis, and a run of bad luck.
I know how u feel.
Did the cough ever go away? I have been trying to find research on curing this cough and cannot find a thing. I was on vancomycin for 5 weeks and it stopped but they changed the antibiotic due to causing kidney damage. I hope you are doing better!
Hello
How are you doing now
I have a similar story…fever and headache originally diagnosed as a sinus infection. Was given several rounds of antibiotics which helped a little, but then symptoms would get worse. Night sweats, poor coordination, 24/7 headache…this went on for two months. Finally my doctor sent me for an MRI for my headaches. Went the results came back, he sent me to the emergency room because it appeared that I was having mini strokes. After a week in the hospital and MANY tests, they finally diagnosed endocarditis. Surgery gave me a mechanical aortic valve (LOUD!), a new aortic root, a patch on my heart wall and a whole new appreciation for life!
that part when the image shows the little emboli showing spots on hands, and ur immediate reaction is to look for spots on ur hands XD
Good explanation sir directly we can write it after watching this video
سبحان الله قبل ساعتين بحثت عنو ف القناه دي
Marty Henne, you got a very nice voice. Awesome video too 🌈
i like alila MM 🥰🥰🥰🥰🥰🥰From Ethiopia😍 keep it up
Thankyou sm. Great video!!! ❤
Wish it has uploaded 1 week ago, before my Cardiovascular System exam, but it's a great video anyway 😊
Oops, Sorry!
@@Alilamedicalmedia No problem, I passed it already 😇 Your videos are very useful to learn and even our lecturers attach your videos' links in our slides 😄
@@dr.dorukerdem o doc are you serious, is your lecture that we were teach come from this video?
@@soliyanadenekew480 😄 not exactly. I am medical practitioner right now, but if I do a cardiology expertise, then maybe
@@dr.dorukerdem o thanks for reply to me , I don't even expect
I’m watching this because a friend of mine got strep infection and got heart problems . And in my place LVAD has been common . take care of your body guys . Don’t do @drugs “ and check yourself from strep
In my case ASO titre values are increasing month by month, Does this have anything to do with Strep infection???
I had a thrombus the size of Texas in my left ventricle around Christmas 2019. I had a heart attack a week before and just thought it was BAD indigestion. It damaged my heart which caused a giant thrombus to form. Emboli showered to my brain and I had a massive stroke, I would have never known otherwise and would have likely died very soon. I had to have open heart surgery to remove the thrombus and have a bypass, it was terrifying. If you want to see an ultrasound of that thrombus it's on my UA-cam channel, it's unbelievably large, I don't know how I survived
thank you so much for such a informative video in juss 4 mins👏👏
great video, very succinct summary. Thank you very much!
Great Alila Medical Media.
Thanks.
Smbat Arami.
Wonderful video ...
Thank you for making greatest video😄
Wow simple and understandable thank you 🙏
Tremendous video, thank you!
I love this channel so much
Thanks very much 🙏
It is very useful video 😇😍😍
Very good explanation Tq sir ❤
Wow... Nicely explained
2:21 Right sided vs Left sided. right side is systemic and left side is pulmonary.
Did anyone else notice or ...? if I'm wrong please help and correct me.
keep it up, love such videoes
I had severe endocarditis this past summer. I fell into a coma for 57 days in June. I infected myself through intravenous drug use. I also contracted pneumonia and a severe dermal staphylococcus infection. Ironically, I've only ever overdosed once in my life, yet dope nearly killed me in a much worse way.
Edit: Also, the doctors had to put a central line in my neck. That was a wildly unpleasant surprise to wake up to.
@Lyndsey 79 thank you so much. I am getting better. It's slow, but it's better than the alternative. Again, thank you so much. I truly appreciate your kind words.
glad to know that you are doing better take care dear
@@kondareddykondareddy7482
Thank you very much. I appreciate that. The pneumonia is still a pain. But, otherwise, things are going well.
Wow, I hope you're doing better brother! Did you have to have open heart surgery?
@@JoeyNTasha Luckily, no. I opted in to being a guinea pig for an experimental antibiotic that cleared up the bacteria. It didn't help with the pneumonia or dermal infection, however. I'm doing better now. Thank you so much for asking. I really appreciate it. ✌🏻
Tqsmmm sir 🥰🥰
Can this be diagnosed with a heart MRI with Contrast? Also if the cause is an infected tooth, when should the tooth be removed? (After the treatment of Endocarditis or before/as soon as posible?
have u figured out the answer yet?
Tq 👍so helpful
Thank you so much sir
This will be help full
Thank u so much.
Thank youuuu❤
Great 🤍
good job
So if the patient had rheumatic carditis in childhood and now he is having fever chills murmur and positive culture for g+ org is that rhd or infective endocarditis
Thank u sir
Arent most cases of endocarditis from IV drug use? I feel like thats a major cause, especially nowadays with the opioid epidemic and this video barely even lists it as a cause.
It does list it as a cause if you see it correctly
That's how I ended up with it....
My labs are pending now and I have never used IV drugs. 44y.o. female with minimal history.
Mine was caused by being immuno compromised from my medications to treat my auto immune disorders. Never used IV drugs in my life
I was a very healthy, active person (although with a bicuspid aortic valve) who contracted endocarditis…the bacteria that caused my infection is one normally found in your mouth, but there was no obvious answer to how it got into my bloodstream and “attacked” my heart.
NICE
I have a bacteria on my valve on the big one l'haorte du coeur ! 6 antibios per days for 2 months
I had skin disorders with this. Painful
I'm 25 with this shit why me 😔
Is it because of strep? Like my friend got one . So check every time you have sore throat . Because it might cause heart problems
Hello
How are you now
Are u alright mate
I am first viewer
عظيمم
🙏🏻🙏🏻🙏🏻🙄🙏🏻🙏🏻💐
💕
👍
Sase
So am gonna die
Are you convinced you are going to go.
@@deborahhanrahanu won’t treatment is good
Don’t worry, its fatal if not treated but if it is treated, theres a big chance you’ll survive! :)
Anyways u okay now?