How Stem Cells Contribute to Aging and Age-Related Diseases with Rob Signer
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- Опубліковано 10 чер 2024
- What challenges does aging pose to both individuals and society at large? What causes aging at the cellular and molecular level? Stem cell research is be key to finding solutions that increase our healthspan and change how we think about aging. Robert A.J. Signer, Ph.D., shares what is on the horizon. [10/2022] [Show ID: 38215]
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0:00 Introduction
2:39 Aging is an Emerging Global Public Health Issue
4:06 Aging is Fundamentally Changing the Economy
8:26 Stem Cell Superpowers: Self-Renewal & Multilineage Differentiation
10:03 Aging Causes Stem Cells to Malfunction Leading to Degenerative Diseases
11:17 Aging of Blood-Forming Stem Cells Leads to Blood & Immune Disorders
16:49 Reducing Protein Synthesis Alleviates Stress
20:44 HSF1: An Alarm System for Misfolded Proteins
21:54 Aging Stem Cells Sound the Stress Alarm
22:55 Aging Stem Cells Accumulate Aggregated Proteins
23:24 A Double-Edged Sword: HSF1 Also Protects Cancer Cells from Stress
24:23 Keeping Our Aging Stem Fells Fit Increases the Risk of Cancer
25:26 Limiting Misfolded Proteins to Keep Stem Cells Fit & Prevent Cancer
26:05 Strategy: Make Protein Synthesis Less Error-Prone
27:40 Keeping Stem Cells Fit to Extend Human Healthspan Aging is a primary risk factor for disease & death
Excellent video .i am a 56 year old man from the usa that had mesenchymal stemcells done in my shoulder a general iv and a pee shot . I got the stemcell therapy done in a different country and clinic, but it was incredible and quite affordable i am like a new man.. Thank you so much stemcells are incredible
Pee shot?
Which country?
Can you disclose this information please ? Which organization? Which country ? How much ? Thank you so much.
Would like to know too
My biggest healthcare expenditure was from age 33 thru 45. Then I realized that our food system was poisoning me and started eating clean fresh food. Now at 73 years, two asthma inhalers and annual physical on medicare.
Seems like it’s only are people that speak up
Congratulations! Your work on Stem Cells is going to help middle aged and older people some hope for a better and productive future. Thank you.
It's probably to late for us older people to benefit from this. Also, the eventual pill will probably be so costly, only billionaires will be able to afford it.
No it's not too late! You can change your diet, do some fasting, lower carbs, exercise, sleep early, get some sunshine but protect your skin, take NMN+TMG+Apigenin+omega 3, vitamin D3+K2+magnesium, Quercetin, Fisetin, Resveratrol maybe if you can afford it. I'm not telling you what you should do, just saying this is what a lot of people do to make massive improvements in their biological age/health.
Only the rich one, Bill Gates and Schwab want depopulation.
This is so exciting and I appreciate you all so much! A breast cancer survivor , daughter to a leukemia victim and mother of 2 daughters and 2 grand daughters I pray you are supported$$ for a hopeful future.
Hey doc, I'm glad you mentioned AM leukemia. I had a client/patient come in to my office about 3yrs ago with AML. She had 3 days to live. Using an endogenous glutathione therapy we were able to disable those hsf1s. We achieved negative feedback inhibition in those cancer calls. She died 6 months later, but not from the cancer.
🤣🤣🤣🤣 show proof
My wife had a bone marrow transplant also known as stem transplant. She had AML Leukemia with Flt3 marker. The transplant donor was our son and he was a 95% match, the transplant was done at Johns Hopkins Baltimore on Oct 1, 2021. For 14 months she has been cancer free (RMD shows no Flt3) her oncologist gives her prognosis excellent. Stem cell are the key.
How does this apply to c9 ALS?
@@tikipharm5957 The near reduction of "intracellular glutathione" is implicated. There are some really good studies on this. The cell will be subjected to all manner of assault leading to neurodegenerative diseases and/or death of the host without the presence of requisite endogenous glutathione.
Let me guess how then... A shootout with Police? Drug deal gone wrong? Gang related activities ?
thank you 😊 ROBERT A.J. SIGNER
In summary, they found a way to induce mutation that slow cell aging in lab animals. They also found a marker to test drugs that can slow cell aging. Cheers.
How about that theory out there about how glyphosate is very similar to the amino acid glycine and substitutes for glycine in protein synthesis. Glyphosate is bigger than glycine so it causes the protein to misfold. One solution would be to eliminate glyphosate from the diet (eat organic).
Glyphosate equals job security at many levels for big pharma and health system
Take a glycine supplement in your morning coffee (it tastes mildly sweet) or eat a lot of joint, skin and collagenous tissue. You will get large amounts of glycine this way.
Thanks so much...the presentation is enlightening...
Thank you so much for the lecture!
Good lecture. Thank you
Absolutely Brilliant
There's hope on the horizon. Your research explains what's happening in my body with a new technology I've had the privilege of experiencing. At 73, I'm looking forward to continuing dancing, backpacking and teaching for many more young years. This stem cell revitalizing technology was just published in the Journal of Biosciences and Medicines, 2022, 10, 164-172. FDA acceptance dates and numbers are printed in the article. I'm looking forward to the product of your research going into my body as well. The whole human race is in such desperate need for revitalized stem cells right now.
Run , baby , run ! Die healthy !
great lecture
Brilliant on a genius level
Verry informative health discussion with UCTV California. ♥️🎉
Best presentation I've seen on stem cells. Really nice work! Dr. Signer packed a lot of info into this short presentation. There is a big leap here from misfolded proteins to let's fix the problem with therapeutic genetic intervention to reduce misfolding. Some other big questions are unanswered here: Because the thesis of stressing stem cells and doing almost anything that causes stem cells to increase protein production is bad, I'd like to know what is the role of endurance exercise, HIIT exercise, weight lifting, hot sauna, calorie restriction, mindfulness approaches, yoga, etc? Any or all of these (increased or decreased) would be much more accessible to us right now as a behavioral modification.
Great minds Think Alike - I was just thinking the same thing - Perusing the comments to see if any one has any incite into these questions.
@@RobtJude did you guys get jabbed? any issues?
@@MK-ih6wp I never got jabbed
Yes, and what about the elephant in the room, diet. For the last 50 or so years the pyramid diet was deemed to be the healthiest. It is not. Now we have vegetarians, vegans, keto, ketovore, and carnivore, fasting, OMAD, etc. What role does a truly healthy diet play in keeping aging stem cells vital and what does a truly healthy diet look like? And as to the dinosaur in the room what about glyphosates, GMOs, pesticides, fluoride, heavy metals and on and on and on. Certainly those place unnecessary and mega stresses on stem cells as well as contributing directly to cancer, which is proven. I say until we address these issues, I am not willing to be a human pin cushion for injecting something else in my body that will supposedly keep my stem cells vital. Let's not overthink this. Lastly, how much funding are these studies provided vs how much funding is provided to solving the elephant and the dinosaur in the room. Ignoring the obvious to hunt for the needle in the haystack is not logical.
Based on the theory of homeostasis, the right amount but healthy stress is good for the body since this stress activates healthy and protective responses to enhance health. Exercise, caloric restriction without nutrition inadequacy, ice bath and sauna etc are all under this category. On the other hand, Too much stress (smoking, breathing toxic air and mold, poor diet etc.) cause cell damage beyond repair which in turn cause cells to malfunction, inflame, and even commit suicide (apotosis) when this safety process go correctly. So we have to differentiate what kind and what dose of stress we should take (e.g. exercise), and what to void (e.g. smoking).
The key is eating in moderation. Check your uric acid level. Uric acid can act as antioxidant, but more of it is harmful.
Thanks for your info.
Excellent. Thank you. 🌻
your ideas on reversing aging and less protien hypothosis idea is startling facinating im dron to this
Wow what a great talk so interesting i wish i learned alot more in my younger days
Key practical take away: Proteins are made of amino acids. Lessen your amino acid intake, and you will lessen the speed of protein production. This means (1) eating less meat and more vegetables (2) lessen your mental stress and increase physical stress-- this will distribute the (limited) amino acids to more production points, slowing the protein production speed even more . (3) reduce sugar intake to lessen cellular metabolism and production speed of proteins.
Regardless of diet, our bodies break down about 300 grams of protein from muscle each day.
You can’t lessen protein turn over.
Eat MORE meat to help your body recycle the amino acids it’s breaks down. Meat has the best balance of amino acid, and it’s nutrient dense and much easier on digestion.
Your body can’t process fiber- bacteria that live in your gut do. And they make short chain fatty acids from the indigestible material.
Or whatever. Don’t eat meat. But have the information.
Peace to you.
And fast to increase autophagy' and lessen the clutter and debris in the stem cell
🎉
Thank you for the summary 👍
none of these practical take aways were mentioned by the presenter
Ageing is nothing to do with how old are you...is got to do with the body ability to repear it self..resist training make your muscle young even if you have 80yo
However resistance training also increases stress
Keep up the great research and work.........i did not know my mother because of leukemia......she passed when i was three.......
Hey doc, thx for the presentation, but glutathione can also produce/clone cells. There's lots of research on glutathione creating monoclonal expansion of cd4/cd8 cells, thus reversing many cancers and immune dysfunction.
Love it 🔥
This man is going to conquer the time ! Hallelujah
I would have shared if you mentioned preventive steps.
Nice lecture. I wont think of aging and covid by 2050.
Curious, is the Lifewave X39 patches which claims that they can reverse aging by waking up dormant Stem Cells a scam or true? Good presentation!
Interesting presentation. I have more questions than answers. How do we explain death and existence of degenerative diseases in young children?
Maybe parents had problems we aren’t paying attention to
Children inherit their mother's acidic and toxic colons, liver, kidneys, and lymph system. You can see it in the eyes according to iridology. Also, poor diet can start on day one including toxic chemical baby formulas that have heavy metals in them. The mother can also pass down parasites, fungi, bad bacteria, and viruses in utero. These can steal nutrients and latch to the nervous system. Viruses will latch onto proteins, as they are protein splitters, and this can cause deficiencies and cell degeneration from day one. Children who do not see the sunrise and sunset. Just like adults, and get to much blue screen time....just like adults...can also have damaged mitochondria in their cells. Children can have cellular issues from lifestyle, stress at home, and processed food from day -270 aka -9 months.
What do you think about Dr Joy Kong and her protocol ... several videos on UA-cam ... great reviews ...with donated placenta stem cells.... in California .....thanks I'm seriously thinking about doing that protocol...❤️
Hello Robert.Thank you for the wonderful information you blessed us with.I have a great interest in adult stem cells.May I ask you will a diet of very low plant protein from mostly fruit and nuts increase our adult stem calls and slow aging?
intermittent fasting and lowprotein low sugar diet ,3 veg meal per day can be helpful for reducing protein synthesis speed as per my idea.i followed lecture of walter longo.thank you Sir for your research information sharing with common people directly .
Preach, baby, preach
Interesting 😊
When will people get this medication?
Are u selling the products
What would be the cause of the stress at cellular level? Can it be minimised by changing ones' way of living?
University.Yeah, best editing.
Can we control HSLF 1 , level through external activities?
Does reducing protien intake in general reduce the chances of protien misfolding? And if so does this tie into the idea of mtor which is the sensing pathway for protien and that one would obviously want to reduce that pathway to sort of increase healthspan. Or is it a separate mechenism which it appears to be
You asked my question, let's wait....
Can HSLV 1 , level can change through external activities
excellent presentation but I was under the impression that we no longer call them stem cells and in vivo, they cannot dedifferentiate because the cells which most refer to as MSCs - (mesenchymal signal cells) have no stemness in vivo and are adult, fully differentiated , tissue specific pericytes. They have superpowers but becoming other types of cells is not one of their superpowers at least in vivo.
What about MSC stem cells from donors that are more potent and available abroad?
how stem cell mulfunction
Low protein synthesis in stem cell is key! Thank you so much for the lecture!
Myth
He stopped at the point of explaining how to achieve that
@@BlackMamba-lt8oe How is that a myth? Research link pls!
@@snowbird6855 There are lots of ways to reduce that stress and even cell death. You simply need a few very good antioxidants: endogenous glutathione, and oligomeric proanthocyanadins in therapeutic amounts.
@@nsudatta-roy8154 what research nothing is proved
Great presentation. What role does epigenetic and mind activities contribute to cell degeneration?
It is a lot . Epigenetic is epi above the genes. Epigentics is environmental variables. Genes like loaded gun with good and bad genes. Environmental variables pull the triggers. Good express good genes, bad toxic environment express bad genes. We all have good and bad genes but our environment make the difference. Take care.
Mind , thought, relationships are all part of environment and our perception. Keep asking and having an open mind . It our duty to educate our selves ( Emmanuel Kant , famous German Philosopher).
@@dr.samierasadoonalhassani2669
The fundamental question about why is it that research into age-related stress hasn’t looked at the psychological reality in terms of fact V non-facts or fragmented thought V non-fragmented thoughts? It goes like this: psychological facts are unchangeable input to the brain’s cells and are not factored in memory in the way that non-facts are registered. Why is that important? Fact is complete in and of itself whereas non-fact is incomplete and therefore enters the brain’s illusory time structure because something is missing and necessitates further input in the hope of reaching completion. The brain cells are overwhelmed by catching, holding and remembering all these impressions that are self images within the psyche and reinvigorated over time in a futile attempt to solve its self-created problems. In so-doing it is reactivating the ashes of the past unfinished memories in a simulated manner that is a process of wasting energy.
The question of what will remove waste products from clogging up the brain’s biological structure is the only real psychological problem facing mankind and it is directly attributable to the incorrect belief that each living person is a uniquely individual consciousness. Unless conscious processes are understood holistically, the problem of distress will remain as a serious factor for the ageing process.
I had learnt about role of Telemere in health span . It's shortening corresponds to aging & age related disability & diseases.
If Telemere's shortening can be slowed down health span will increase.
How ? Is it the right ( Nature friendly) lifestyle, diet, exercise, yoga , meditation and stress management ?
So, what practical steps can I take now to slow down aging? Not get elected President? Anything else?
Cardio and weight training, wear sunscreen, eat mostly plants, only eat red meat when your lifting a shit ton of heavy weights. And stay tf away from sugar. Just these things will add 15 years of healthy life
@@Parkourmattstrong Avoid Blue Light and No sunscreen very toxic ---replace that with correct Light-Style as taught by Neurosurgeon and Health Educator, Dr. Jack Kruse MD.
Reduce your mTor1 activity to lower down intra cellular protein synthesis. That can be done thru lifestyle choices/food and supplements…too early to talk about gene therapy for humans for sure
@@Always-xl9db what food and supplements do you suggest? thanks!
There is so much on this topic...example of diet change is to avoid certain amino acids and limit animal proteins, supplements would be Metformin(prescription) or Berberine (over the counter). Great podcast to get overall idea of what to do, specifically, is Lifespan by David Sinclair. He is a Harvard Professor and works in that field.
As lecture goes, good. But what good is all that among toxic societties. You made your research, what help did your discoveries bring to day to day struggeling people?
What about food.
Estaré suspendido?
Of course, to make impact on health, Intermittent Fasting is the opportunity to clean our cells and primote apoptosis too.
I had the intuition that denatured enzymes (proteins ) is responsible for all kinds of diseases .
Could you put this into layman’s terms? Thank you
He thinks the key to aging well is to make protein synthesis less error prone. How to do it? Mess with your DNA. Yes, mutate one of your base pairs. Sounds good? This is a google years away from having any impact on human life but it was a good lecture.
@@jpintero6330 yikes…. Well I’m 60 & in tip top health & strength & I want to stay this way 👍
Then eat a keto diet, stay active and never submit to gene therapy, @@kimdavis7812.
@@jpintero6330 is this an mrna vaccine use case? or different kind of technology/treatments?
15:47 Less protein production (slowed down) = longer life
Well at least it makes sense. When you workout, you destroy muscle for it to regenerate stronger, so, putting stress on the muscle. So if stress equals more workout, will this mean that working out is actually bad for us?
no
Yes
Hell no. Work keeps you alive.
Natural movements.
So is does a low protein diet slow down aging?
Unlikely. The digestion of proteins and the synthesis of proteins are _totally_ different.
Mice have been shown to live longer and more robust on a low protein diet vs regular diet.
Did the studies control for calories, @@spoudaois4535? I think low caloric diets are known to extend life. If proteins are reduced as part of an overall reduction it's probably not the reduction in proteins that are giving the benefit.
@@KenJackson_US no lower protein same calories. There is a protein myth. More is not better and as one ages animal protein byproducts are toxic because the kidneys cannot clear them fast enough as one ages.
Do you follow Dr.Ken D. Berry at all, @@spoudaois4535? He recently specifically addressed the claim that protein is bad for your kidneys and says the research shows it's not true.
Innovator Sir
100 year's, Possible to live?
We need stem cells now for our son with diabetes typ 1. He is 30 ., which country can us help?
Panama, Columbia, Mexico dreambody clinic in PV
What causes the stem cells to work faster? Can changing the life style help reduce the speed of synthesis ?
Eating more polyphenols in fruits and RAW veggies, taking enzymes to help clear the unmetabolized junk out, water fasts after youve replenished your body for the stem cell action, staring at the sun- sunrise and sunset- to repair mitochondria, not looking at blue light after the sun goes down, putting your feet or hands on the earth or ocean to get more electrons, taking magnesium to escort those electrons, taking a blood and hair mineral/vitamin test to see what you're deficient in, taking a self decode or Nebula test to see if you have any gene variations that inhibit you from methylation or conversions or detoxing, etc, so you can work around those in diet and supplementation, breathing deeply so you can exhale toxins, massaging your lymph toward your kidneys for better filtration, trying to get a lot of your hydration from fruits and leafy greens (structured hydration), filtering your water and structuring it, not drinking high ph water that actually destroys your stomach acid, doing liver and gallbladder and colon flushes with enzymes, bentonite clay, charcoal, psyllium husk, etc, green juices for the flavanoid boost to really suck all the acid out, eating as raw as possible to get the enzymes from live biophotonic food, getting pemf mats or scalar technology to combat emf that steals your electrons, making sure you use flourode free toothpaste and natural herbal toothpaste to kill bacteria and remineralize teeth (your teeth are connected to parts of your body on the Chinese meridian), taking binders like fulvic acid/shilajit and the ones I listed before in order to bind onto anything positively charged in your body i.e. parasites, metals, fungi including mold, mucoid plaque and pathogen biofilms that harbor them, taking cellcore or Microbe Formulas parasite cleanses that are binders and herbs, herbs for certain gland health. All of these things will create the right environment for stem cell activation. The water fast is the best way. But if you don't clear some stuff out first, then you will get herx symptoms because the toxins will float around. Sweat and bind them out. Your cells are bogged down with toxins right now. Get rid of them and you can look 10 or 20 years younger. Many health advocates do them a couple times a year at least. If you eat meat, dairy, and grains, you need to do them often. Take care.
Stress?
So, in developing countries, med tech will enable longer but less enriched lives. During a recent dr visit for the wife, I sat outside near the er intake. In 45 minutes at least 20 ambulances discharged patients. Every one of them looked to be a 75+ year old person. One can only hope they are living fulfilled lives. My mother is 86. Her life doesn't appear to be all that happy for her.
How does "reversing" aging automatically equate to living a good life? Are we postulating all pathologies nominally related to aging will be prevented thereby resulting in a higher quality of life? Further, are we equating this reversing of aging with longevity? Without the ability to sustain a human population that large, this appears shortsighted.
There is time to adjust.
Wow...What a let down. You could have talked about what causes stress in the stem cells. Is it lack of sleep? Could too much of something we eat do it? Environmental factors? Emotional stress with cortisol overload? How about you at least mention what causes the stress .It is not just aging time wise because I am 70 and have not been sick with anything and walk everyday.
Great Blue Water , my mom died wiith ovarian cancer / Cardia arrest 2yrs ago , since am over 63yrs now am more fucus on better health for myself now more than ever as l dont want to be sick to be a burden to anyone soon ; so am watching what l eat , drink & exercise , so l walks for 1 hr every morning despite some days l have a heavy schedule as l lives all by myself & maintains my yard , garden & house alone with God Almighty help
You are fortunate.⭐️
Rocket science! I don't understand what he said.
How do we keep protein healthy. Quality protein? How much protein should we consume? Is a high protein level dangerous?
More free range eggs?
Hmmm protein from eggs from young chickens with healthier stem cells?
I am confused! I started on a supplement called Perfect Aminos which dr. Minkoff made up and tested to be 99% used to produce protein (AAU) so doesnt require digestion to be assimilated. This is apparently compared to natural protein sources which must be broken down and utilized to construct human proteins so much lower AAUs. For example, whole eggs are said to be the highest AAU after breast milk but most of it is turned to sugar and consequently nitrogen needs to be discarded by the body. So the Perfect Aminos premise is we need MORE protein to maintain as we age. Now this talk SEEMS to me to indicate that vegan and lower protein is more protective of our stem cells? I would like to hear thoughts by someone knowledgeable that I might understand.
H e h, third but I'm 82 still aging! But less than most
You didn't advise anything that we could do on a personal level to assist in health span..
16:00 low protein synthesis
I'm losing my eyesight 😢
And can one improve one’s number of stem cell by way of cells name Ngp stem cells may be in the form of eating aborted dead embryos???
Intermittent Rapamycin therapy to get rid of the old stem cells (senescent). Low protein diet.
🤣😸🤣🤣🤣
Take your zinc 😜 never eat after dark... Herbs fresh food sunlight exercise everyday 😘💗 to all
What role does zinc play in aging? Could you explain more on why you mentioned zinc? Thanks
@@prettyme3150 hello. Zinc helps fight infections prevent sun damage good for immune system. Zinc oxide on skin blocks harmful radiation.
Ok....so, i guess that what you are doing Is making a mutation that could slow down the metabolism in general. I guess that mouse which has that mutated gene will be lethargic or something like that.
"How do we increase health span? Easy: Eat less, eat better, move. Do until you get optimal results:
Men 15-75 yo might be: BMI 20-21, waist to hip 0.9, 10-14% fat, performance to pass US Army standards at a top 1/3 percentile.
Problem solved! But thats not really the problem. Its mostly a matter of inflammation avoidance and lifestyle. Simply, people are just too lazy to exercise and eat right, or maybe they really only care about asthetics eg watched too many movies and think they should look like Arnold to be fit.
Well done !
Health span no longevity.
The Longevity paradox book by Steven Gundry is helpful. I think avoiding sugar is a big thing and eat mostly plants. Get your gut in shape.
steve gundry is a greedy old man ! he knows nothing !
And isn’t this the problem with the jab? It is known to cause prion damage.
first
So?
千金買房
萬金買鄰
幹細胞在那個組織附近，就會產生該組織的細胞！
幹細胞具有無限的可能！
Bill gates will be happy to see his 120 anniversary, and we will be too when he accepts the first clinical trial, he always talks about African health aid
Bill Gates may be happy at but unless you have his money...you won't.
Rubbish
Make sure you get enough white sugar, bread, milk, steak and sausage, every day.
Lab animals on a low protein diet live longer than those on a normal diet. There is a by product of animal protein called TMAO that is inflammatory, cause arthritis, damages blood vessels and ages you.
Are you being sarcastic, as I don't indulge on those foods!
How far did Bush put us behind in stem cell research?
There is an entirely different approach and perspective on helping the body gain Health. The definition of health is: "𝙁𝙐𝙉𝘾𝙏𝙄𝙊𝙉," and a lot of what was discussed in this presentation does not touch on other factors. Are the Stem cells functioning as it is intended to function? Age has relatively less to do with the degeneration of stem cells than what was presented here. There are two major factors not discussed. 𝐓𝐫𝐚𝐮𝐦𝐚 and 𝐓𝐨𝐱𝐢𝐧𝐬 along with 𝙎𝙩𝙧𝙚𝙨𝙨 hindering function. If you eliminate those factors, the proper function of the stem cells will occur as God intended and there are No humanly created synthetic pharmaceutical substances needed to stimulate the production of a perfect form, a.k.a. structured protein created by the Stem cell. In other words, your lifestyle over time destroys the production. Not age. The genetics of a family is not really a factor either. It's just that you grew up adopting the bad habits of your family which causes the same condition that occurred within you that happened with an ancestor(s), / parents. Bad habits run in your family, not bad genes, and you have an opportunity to change all that regardless of your age. So, that's my opinion, take it or leave it. But be sure, there is a Whole Different Perspective out there you should investigate before trying to Mutate/modify your genetic code. The body is like a Swiss Watch with many gears. If you alter one gear, it will affect the entire watch's function.
It would seem that these western medical doctors would have learned their lesson with the introduction of the Gene therapeutic genetic mRNA and DNA vaccines that mutate the function of cells. But I digress.
Can you summarise in a Lay man’s pls
Kisi ki life s aap sab kya khub kheley business men ,or doctor bas kisi ki Gmail I'd ko hake kro or tum jasey logo ko kuch pata nahi hota