Seriously, I’ve been lifetime intermittent fasting and every new person, even bankers and doctors who have all my bio/med information routinely say I look 30-35 years younger. They all ask to see my gov ID, especially after repeated blood panels that test pristine.
Again Dr. Sinclair, your colleague is asking Excellent and Thorough questions , that cover all points a viewer such as me was thinking about- such as the growth hormone discrepancy, among many other questions. Thanks to both of you for putting forth such interesting and fascinating information.
Agree! if loosing our estrogen after the 1st half of our lives triggers a few serious diseases like alzheimers, can any of the mentioned treatments cover for that besides taking lifetime HRT?
I’m surprised you haven’t talked about one of the best things you can do for anti-aging. Donating blood should be on the top of your list. I would love to hear you talk about the benefits of donating blood.
Thank you for your time and content. As a blue collar know buddy, your work has kept me younger and fitter than I ever really expected possible. I've been following your work for years. So happy to have all this content in one place, cataloged, with such depth. ❤️ 🙏 truly grateful
My doc put me on sermoreline the precursor to hgh. He checked my blood level for HGH and it was low. He started me out on .2 ml injection nightly. Over the course of six months I’ve had my level checked several times. Now I am at .4 ML after six months, the sweet spot. It is safe. It is just telling your body to produce HGH if it needs it and it is in the healthy normal range now. Feeling great
It would be great to get Dr. Sinclair's take on menopause treatment HRT; loss of estrogen = loss of bone. How to improve and reverse bone loss. Increasing quality bone density ... can NMN Stimulates Bone Marrow Stem Cells to Form More Bone ... ? Thank you Dr. Sinclair for what you do!!! 🙏
I'm loving this channel! It's my favorite kind of content to nerd out to.🤓 I've been binge watching, like Netflix. We humans and our genetic and cellular makeup are so incredibly fascinating. Thanks 🧬🧫👩🔬
I am a peri-menopausal 51 year old woman. I would appreciate it if Dr Sinclair could talk abt the menopause & how we can help ourselves maintain good health. I am getting conflicting advice abt taking HRT & I am unsure abt what I should do/take.
I can tell you what works its simple...... Tretinoin at night spf every single day no sunbathing smoking or alcohol then nutritious food comes next...... food is medicine is my mantra 🙏
@@michelles2299 agree! I do all of that. Especially after having melanoma. His latest video discusses other things like peptides as well. I hope he does more on those!!!
I would like to hear about the new studies on resveratrol that show it has no positive effect. And even takes away some of the positive effects of exercising. Could you discuss it in one of the future episodes? Would be great!
Only over the past 5 to 10 years have I finally learned the importance of good rest and sleep to good health. This is an ongoing learning experience. Will report again in 3 years if I am still about.
Just finished listening to the entire episode on Spotify & Damn it started a war of neurones in my brain. Sure now I don’t need any pre-workout boost. Thank you once again for everything that you are putting out for all of us to be better. Can’t wait for the next episode.. Excited🤪
Please address the hormones that are dominant in women also. Women have issues with dipping testosterone, but estrogen and progesterone also have a huge impact on women as we age.
@@Q_QQ_QYes, I know that and am actually on TRT, but leaving out the glaring effects of loss of estrogen on aging is disappointing. Both have had drastic effects on me and others in my life.
@@heatherschramm yes that is true . if you like you can share your experience as well . I think Dr Sinclair is only telling stuff he knows from papers and people he knows or heard of having these therapies which are usually mostly men but women do it like you have mentioned . I saw a podcast where a couple was telling about having done these therapies , i don't remember their name atm .
@@Q_QQ_Q my sister and I have joked about the idea of starting a vlog about our experiences and bringing on friends to talk about their experiences. It’s crazy how much variety there is and that very few people talk about it besides hot flashes.
The TRT studies that I've seen, including the one you linked have been a wash for mortality relations. Testosterone levels in men has been at a steady decline for the past 50 years. With there being a positive benefit to cardiovascular health, muscle size (particularly in legs, as in the Marcelo Rodrigues dos Santos and Shalender Bhasin study you linked) also correlating to healthy TRT doses, makes me believe there may even be a correlation to longevity. TRT has been shown to increase patient's insulin sensitivity, and even decreases c-reap (Xue-yan Wu 2009). Hypogonadism, SHBG, hematacrit/hemoglobin, estrodial issues have all been shown to be an issue with administration frequency, rather than the drug itself. It is all alleviated with a more in line pulsatile injection frequency of daily, or every other day. Also, it should be noted that Asian men tend to have a 20-30% higher testosterone than Caucasians. Japanese men in particular tend to live 10-15% longer than Caucasians. There are thousands of different biomarkers to examine here, but the correlation is strong enough for me to grant its efficacy, or at least place it under further examination. That being said, low testosterone has been linked to numerous deleterious effects (terrible sleep, hypogonadism, lack of drive, sexual dysfunction, weak muscles, etc.), all of which are correlated with mortality. In my opinion, the benefits for this far outweigh the cons, and could even be correlated with positive effects.
I was gonna take BPC-157 (Body protective compounds) for joint inflammation, I found out they are really act like a HGH effect with Angiogenesis , which literally creates new blood vessels that will heal organs , etc. etc. but the risk of cancer goes up , because cancers grow and get destroyed , but if we ever were to get cancer , added blood vessels could add to tumor growth as well as other diseases
More plates more dates, check his stuff, highly into pharma for hair... personally I'd cycle eating times and meals per day, some days eat loads otherdays don't eat and some days do omad ect.. Next cycle in fasting for long periods (5-10 days) a few times a yr, then give your body signs of abundance by eating loads of meat, organs and fruit the rest of the yr... Understand that ketones boost stemcells. For your hair the above works but also stop using shampoo and conditioner it's poison, just was with warm water then cold after and stimulate blood in that area (massage) and break up calcium deposits
I really like to listen to the lifespan podcast, but as a woman I feel women data are invisible in most of the researches. Could you please Dr Sinclair apporach some topics from the aspects of women? Especially when you talk about hormones like in this episode? It would be fab to hear about more similarities and differencies if there are any between a female or male body in terms of ageing! Thank you and congrats! And by the way, I’m Hungarian too as your grandma😊
Yep. So frustrating when they both say "people" when they mean men. Even rat research is largely on male rats. Grrrr.... Had a conversation with a researcher at the Salk Institute and he said "Well, womens' hormones are so complicated. It is like you are a different person every day." Lousy excuse for ignoring 50% of the population.
THOUSANDS of THANKS So Much for Dr DAVID SINCLAIR + Mr MATT LaPLANTE * for your Unlimited + Immense + Continuous contributions to Humanity Prosperity. Those Valuable TIMESTAMPs are extremely useful.
Thank you Dr David Sinclair! Athletic Green is just delivered to my house now. Appreciate your videos it’s so helpful. Thank you! You look great in that blue sweater.❤️
Yamanaka factors have come so far way faster than I expected when I was first reading his research I thought it was going to be 10 or twenty years to make any real progress because of cancer.
I am a G I surgeon but I take particular interest in chronic diseases and old age . It would be super interesting to see if we could really wipe out old age related chronic debilitating diseases in future.
@@jeffreysorensen5298 yea but can u make a pill for that so we can profit off it? We know how to end chronic disease already. Are actually some powerful tools available but people have to want to do it. Something like 90% of all health improvements are realized simply by losing weight. Regardless of the diet.
@@theresaho9696 you are absolutely correct. Most people realize that obesity is the number comorbidity for a poor outcome of Covid but few realize that number 2 is fear and anxiety.
I have been on hormone replacement therapy for decades. I'm 80 now and do not look my age. Most think I look about 60. Hormone replacement therapy has been my life saver ....
I am following these podcasts with high interest... as I am 64 and on TRT, do intermittent fasting, weight train and take NMN and other supplements... (will be adding resveratrol). One issue that was not taken in consideration with regards to aging and testosterone is the fact that life is more than just time. How do you ballance adding life to your time vs adding time to your life. Quite frankly, TRT gave me my life back. My level of energy, motivation and general mood are way up with testosterone.... I would not live like I was before... The added estrogen that comes with TRT is actually cardio protective and has cured my joint pain... Maybe you should stay away of subjects you don't know well or you are biased against... Testosterone can actually be protective against prostate cancer and high levels of testosterone is actually being studies to treat certain forms of prostate cancer... I think your view is a little outdated... The biggest issue I have with all this longevity talk is the fact, it seems, that you have to choose between being vibrant, energetic but short lived or be starving, cold and low energy and live longer... Darn... Everything that makes me feel good seems bad (Mtor activation as I like my meat... testosterone as I enjoy being energetic and productive... ) ... Maybe I am looking for optimization and you are talking about absolute lifespan... Don't get me wrong, I love the podcast... great info to integrate into what I think will be a middle way for me... Cheers
I am with you - started TRT when I was 64 - now 68 - and I have experienced many benefits. I think that what Sinclair misses about TRT is that he has a “theory” that it may send the wrong signals to your body to “grow”. What is interesting is that, although Testosterone is anabolic, it is focused mainly on helping muscle and bone strength. Consequently, you can consume less protein (which too much can create issues) than someone who has low T. I think the bottom line is that the studies are pretty consistent that TRT reduces all-cause mortality while improving quality of life. Big Pharm and the medical industry in general do not like TRT because it cannot be patented and it takes a lot of a doctor’s time to get you dialed in. My understanding is that Sinclair is working on patenting concoctions out of his lab to sell as longevity drugs. Hence, TRT could be considered “competition” in spite of its efficacy.
Serge, you are right on all counts. Sinclair is still very much of a newbie to the testosterone space; one can tell this by listening to him. He will probably acquire better knowledge, with time. Meanwhile, don't deny yourself the benefits of testostereone just because he is still relatively ignorant! Also true that there is a balance between strength and vigor, and longevity. More of one, less of the other, or so it seems. Maybe someone will figure a way around that, eventually, but for now it seems you must choose.
@@AncestralFuel You are correct also. Testosterone's anabolic effects are such that you can recover from workouts and maintain strength on much lower protein intake; this is a grossly-neglected fact in the longevity space (Sinclair, Attia, and many others). They also neglect -- are probably ignorant of -- the literature describing the benefits that you mention such as reduced ACM, better QOL, etc. They are perhaps ignorant, and/or perhaps tend to dismiss because of prejudice against hormone therapy, especially hormones related to anabolic steroids. Also correct that TRT is non-patentable and involves a lot of old-fashioned patient-focused medical ARTISTRY (what you call "dialling in", which is beyond the science, beyond EBM), and as such will tend to be ignored and dismissed by commercial and some other entities. TRT cannot be successfully practiced by idiots following EBM cookbooks; therefore it will tend to be less popular. Also, yeah Sinclair might have a bias against things that he cannot sell. IDK, but that is the way things go, too often.
What would happen if you cycled on and off trt and hgh so that you get the short term benefits, but then stopped those and go into a longevity mode where you do minimal mtor generation and lots of sleep etc..... so cycling between abundance memetics and adversity memetics... so you get gains during abundance mode and then maintenance mode during adversity mode, then cycle back into abundance mode and do it all over again.
This podcast on anti-aging along with the research on CRSPR and gene editing/disrupting really is amazing. The only thing better than this would be a way to transplant consciousness into an already younger version of oneself. I watch this on UA-cam then I listen to it again on the podcast
Most definitely! I have found that in my city (Pittsburgh, PA), which is primarily a traditional medicine community, the majority of physicians are very hesitant to prescribe HRT and claim beyond a certain age, your risk to develop cancer is very high. I know this isn’t supported by current research. Also, there are few functional medicine practitioners who also have MDs - a background I am seeking so I can receive advisement from both perspectives. My DO wouldn’t even consider prescribing bio identical HRT and told me I should find a gynecologist who would. Even these practitioners are very hesitant and keep referring to older research in their explanations. This is SO very frustrating, and leaves many women struggling to find care that could prevent many downstream problems.
I love you David, i can‘t wait to put my hands on your book ( Lifespan) i already apply most of your advices, but i take it slowly, currently eating 2 meals a day instead 3…
@@quantitradersignalservice5735 curently i stopped eating 3 meals a day, i eat only 2. breakfast at 13:00 and dinner at 18:30-19:00, i do exercise 5-6 times a week, aerobic running, and i train in the gym for strength. i want also to start taking a supplement which it contains more or less the same ingredients which Profesor David Sinclair recommends : NAD + Cell Regenerator and Resveratrol 300 mg from life extension. Good Luck!
As a child, I was growth hormone deficient and underwent GH therapy for most of my adolescence. Aside from catching up growth and development, people who are growth hormone deficient (whether as children or adults) take GH because being deficient puts us at higher risk for lots of major health issues and risk factors including visceral fat, high cholesterol, osteoporosis, cardiovascular issues, etc. So I was surprised to hear Dr. Sinclair say that populations with lower GH have fewer health problems. I'm also curious now: I understand his point about those who take GH recreationally or as a "body hack", but for those of us for whom it was/is medically necessary, what effect does the later-but-accelerated development have on us in terms of overall longevity? I was a late bloomer but developed pretty quickly when I did. I'm 40 now and am usually told I look much younger which seems like a good sign, but I'm wondering what effect the GH deficiency and treatment might have had on things. Has there even been any research on this? I feel like whenever GH is discussed even among scientists it's always in the context of recreational/elective use and it's hard to find information relevant to my situation. (I previously left this comment on your appearance on the Huberman Lab podcast but never got a response so I'm leaving it again here!)
@@kaylabryson1932 my past has it's ""shady"" aspects. But you know what?.. i am actually a good guy (the type who knows how an orphanage looks from inside, not from the news) , really trying to understand me and surroundings . Reality , if it's not too cocky . While someone saying NEVER trust X sounds like a really bad guy, a guy who does not even understand relativity (and we have more than 100 years to digest it). More, there is nothing to ""trust" , because this is science. It might bring contradictions, it might bring arguments, but it's not about ""trust"" . Always go for more than one source if it is as important as aging. But don't take ""never"" in your arms, it is limiting. Just saying. PS. Sorry for my poor english, started late with this, while already speaking 4 other languages and became lazy. Good luck.
I have heard David say you should keep your testosterone levels up in a different interview (can't recall which one at the moment). This certainly contradicts that statement. I think if your levels are low, you need to keep them in the normal range.
This was a very interesting episode! I like this topic as it has not been repeated before in other interviews. I hope one day we can just take a pill that's gonna make us younger haha.
Good morning, Matt. You have a John Heilemann-esque vibe. Take it as a compliment. I think you do a great job of co-hosting, asking enlightening questions and keeping the conversation flowing. David is pretty good, too. Signed, Matt's mom
As always, interesting to watch and learn about the cutting edge in anti-ageing. Thanks David and Matthew! Dr. Sinclair is looking younger than usual lately - any recent changes in the protocol?
@52 min on thymus regeneration: See research of Janet Lor which showed that older (65 to 80) who cycled alot over many years preserved their thymus output of T cells and had immune function of people decades younger. It's also known from other research that exercise increases NAD+ and modulates other metabolic factors towards younger states.
Okay, so episode 6 hopefully will be on hair (re)growth too. This is a big issue for me right now. Perhaps for many other women too. I will keep in mind about GHK Copper (I hope I spelled that right). It was mentioned halfway through this episode (and the warning about peptides and their negative side-effects). Thank you! 🙏
one reason for hair loss is ( in men ) is increase in DHT on face and head . on face DHT increases hair like beard or face hair . on head high DHT results in hair loss . it can be something similar in women too but idk .
I hear you, it's a huge issue for me as well, I've been losing a lot of hair due to the hormonal imbalance for the last 6 years and it's still so heartbreaking...also I can't find a treatment that really works and keeps this under control
The HGH discussion skipped over the TRIM and TRIMX trials done by Greg Fahy, and showing age reversal with epigenetic clocks. Shame - I really wanted to hear Davids view on that work
guys! when are you going to speak about the skin and hair part of all this?!?! you guys mentioned that you'll go into detail with it! please and thanks
@@Dr_Dieta you are brave, indeed. Messing around with a potassium channel opener is, currently, not a good idea. In those neurn we have 3 different types of potassium channels, and symptoms gt relieved if the SK channels get BLOCKED. There is absolutely NO consensus about how to handle them. If you mess around with potassium channels systemically you quickly age to terminal age.
Hi David, I studied your book and have been using NMN, etc since Feb 2021. My stem cells have been banked and I have 1.4Billons of my cells IV'ed and IN'ed in my body since 2020.
I wish I had seen this podcast earlier, I had been using peptides to deal with an injury that got worse and to boot, I now have arthritis in my hip and big toe.
Are you referring to peptides that were made in Russia and now available here? These are said to heal the heart,liver, brain and other organs. What do you think? They are said to extend lifespan by 30%, but I think that means expected lifespan of an already ill person. They are made from animals or synthesized.
Wow I was wondering if they offered a discount. 25 % is great. I'm just about to get back on Resv, Berberine and NMN. I've been using senolytics sparodically, and during pre and post vaccine. After a year off, feeling like crap tbh 😆, so thanks for making feel human and hearing you did the same at some point. I do remember how fabulous I felt a year ago. This time I want to do full bloods, and track properly not just anecdotally. Thank you 😊 ✌️❤️🇭🇲
First time I’m seeing he looks healthy and skin is glowing only little inflammation on left shoulder and little on left side and front of the elbow. well done I can respect you now. If you’re advocating for your job or what you believe in show the evidence in your body.
Okay, I have watched all the videos thus far, but have heard almost nothing on the accumulation of intercellular junk, and just a bit about junk inside the cell, and what can be done about it. Because it looks to me like this is a major player in the current limits of human lifespan. There is more than one kind of heart disease, and the one killing the 100+ crowd is often Wild-type transthyretin amyloid (WTTA), where transthyretin amyloid builds up in the heart and some other tissues making the tissue stiff, and it becomes very tiring to even stand. 25% of men over 80 already show signs of this beginning. And this is just one of 25 or 30 proteins that can misfold and accumulate in the body. Then there is glucosepane. This Advanced Glycation End Product can't be removed by the kidneys, even if they are healthy, even if the other AGEs can be. This also builds up stiffening tissues and is implicated in a number of aging diseases. And what about lipofuscin? Maybe that will be covered when skin is the topic, but this crud is also in the brain, muscles, the heart and other internal organs. Then there are the studies about the intentional conjoined mice, where they saw the health of the older mouse improve, and the younger mouse go downhill. And after a series of studies they determined that it was chemicals in the blood of the older mouse that was the problem, and by plasmaphereses they could restore the older mice to health. That to me suggests that there are accumulations not just in tissue but in the blood. I don't know if healthy kidneys is the answer to that or if there are things the kidneys can't do anything about, like that glucosepane, which needs periodically removed. Then there is scar tissue. There are injuries within the body from infections and whatnot, and the body chooses speed over accuracy during repair, but if you live long enough, these sloppy repairs will also accumulate. We also accumulate infections that the body can't ever completely eliminate. Older people have much more of these than younger people. Things like toxoplasmoses, and cytomegalovirus. Ultimately, I don't think these things are benign. It is likely they wear down defenses, or promote diseases we haven't yet tracked down to them. I sure would like this accumulation topic discussed.
So these things will almost certainly require input from my doctor, as you mentioned, but I'm unclear as to which ones are currently available to me for treatment now.
I know they have to tread lightly and not recommend actually doing some of these promising new treatments and taking non-FDA approved supplements and drugs. But not all people have the time to wait, so it seems there is kind of a sliding scale of risk vs reward for each individual to decide what they want to try. My other concern is that once we have all the scientific confirmations of efficacy and safety, once there is FDA approval and the drug companies get their patents some of these treatments may be out of reach for many people who don't have a lot of money. Is my pessimism over exaggerated?
I would like to learn more about how the Yamanaka factors work, their relationships with sirtuins and how they are used in regressing adult cells into stem cells.
I am still wondering... when the cheap test is coming ? Last year you said : at the end of this year. I'm on the wait list but impatient. Have been using a great deal of money for several years and it's all on faith.
I am loving this series. Currently I am on my second regimen of Fiesitn (hit and run method) I know ysaid it's still experimental however I have been scathing of Damage and repairing for agent orange poisoning for decades. Doing rather well at it. So I have some savy and knowledge. About what I am doing.
Dr. Sinclair, we are SO grateful for the work you are doing and sharing! Would you consider discussing how far off we are from being able to grow heart valves using a person's own stem cells? My husband was born with a bicuspid valve (and so was his father). He will eventually need a valve replacement, but because his immune system is so strong, we are concerned that his body will reject a mechanical or animal valve (as his father did). Can you refer us to someone who is doing work in this field?
I am a cardiologist. In 20 years I have never seen rejection of a mechanical or biological valve. A mechanical valve has no antigens so will not stimulate the immune system. Biological valves are not living tissue and are treated. It is living tissue transplanted that stimulates the immune system. A bicuspid aortic valve is the most common congenital heart anomaly in the country. If you have children they should screened. I hope that puts your mind at ease.
not everybody wants to live longer as in past the avg life expectancy, they just want superior quality while they are here. you also leave out that there are ways to counter some of those side effects
are people who are non-diabetic having success in getting metformin prescription? I did a telehealth doctor thing and after the session he says, "we don't do that", despite me informing ahead of time that was the reason for the appointment.
I have been following Dr. Sinclair since I was 25.
I am 22 now.
Best comment on this thread..🤣🤣
Seriously, I’ve been lifetime intermittent fasting and every new person, even bankers and doctors who have all my bio/med information routinely say I look 30-35 years younger. They all ask to see my gov ID, especially after repeated blood panels that test pristine.
HAHAHAH thank you for this
Lmaoooo 😂
shrieking
Man, Mathew is truly superb in slowing it down and also not loosing any threads. Thank you Sir!
Again Dr. Sinclair, your colleague is asking Excellent and Thorough questions , that cover all points a viewer such as me was thinking about- such as the growth hormone discrepancy, among many other questions. Thanks to both of you for putting forth such interesting and fascinating information.
A discussion on menopause and HRT/TRT would be brilliant!
Yes !!! Definitely
@@lauramakin834 Totally!!!!!!!!!!!!
Yes please do.
@@quantitradersignalservice5735 Haha
Agree! if loosing our estrogen after the 1st half of our lives triggers a few serious diseases like alzheimers, can any of the mentioned treatments cover for that besides taking lifetime HRT?
I’m surprised you haven’t talked about one of the best things you can do for anti-aging. Donating blood should be on the top of your list. I would love to hear you talk about the benefits of donating blood.
They did mention that on another podcast when they were talking about iron.
Thank you for your time and content. As a blue collar know buddy, your work has kept me younger and fitter than I ever really expected possible. I've been following your work for years. So happy to have all this content in one place, cataloged, with such depth. ❤️ 🙏 truly grateful
All of this is fascinating to me as someone in my early 30s. I’m really hoping this keeps going in the right direction and quickly.
What about menopausal women and HRT? Would be interesting to hear about menopause and aging, maybe specific advice for pre and post menopausal women.
Yes, yes, yes!
My doc put me on sermoreline the precursor to hgh. He checked my blood level for HGH and it was low. He started me out on .2 ml injection nightly. Over the course of six months I’ve had my level checked several times. Now I am at .4 ML after six months, the sweet spot. It is safe. It is just telling your body to produce HGH if it needs it and it is in the healthy normal range now. Feeling great
It would be great to get Dr. Sinclair's take on menopause treatment HRT; loss of estrogen = loss of bone. How to improve and reverse bone loss. Increasing quality bone density ... can NMN Stimulates Bone Marrow Stem Cells to Form More Bone ... ? Thank you Dr. Sinclair for what you do!!! 🙏
Who cares about meopausal women?
@@starfox300 It is always lovely to know that there are people who care about their mothers and the future of their girlfriends and wives. :)
I'm loving this channel! It's my favorite kind of content to nerd out to.🤓 I've been binge watching, like Netflix. We humans and our genetic and cellular makeup are so incredibly fascinating. Thanks 🧬🧫👩🔬
I am a peri-menopausal 51 year old woman. I would appreciate it if Dr Sinclair could talk abt the menopause & how we can help ourselves maintain good health. I am getting conflicting advice abt taking HRT & I am unsure abt what I should do/take.
Love it! Skin aging is what I've been waiting for!!! Can't wait to hear what you have to say on the next podcast🙌🙌🙌❤
I can tell you what works its simple...... Tretinoin at night spf every single day no sunbathing smoking or alcohol then nutritious food comes next...... food is medicine is my mantra 🙏
@@michelles2299 agree! I do all of that. Especially after having melanoma. His latest video discusses other things like peptides as well. I hope he does more on those!!!
I would like to hear about the new studies on resveratrol that show it has no positive effect. And even takes away some of the positive effects of exercising. Could you discuss it in one of the future episodes? Would be great!
Every Wednesday now is like xmass morning! Running to check what gifts I got!!! Amazing!
Only over the past 5 to 10 years have I finally learned the importance of good rest and sleep to good health. This is an ongoing learning experience. Will report again in 3 years if I am still about.
Just finished listening to the entire episode on Spotify & Damn it started a war of neurones in my brain. Sure now I don’t need any pre-workout boost. Thank you once again for everything that you are putting out for all of us to be better.
Can’t wait for the next episode.. Excited🤪
Bhai yeh banda top class hai also Dr.Huberman sir
@@Junaid_x01 it’s Dr. Andrew Huberman
@@callofthedark yeah

Please address the hormones that are dominant in women also. Women have issues with dipping testosterone, but estrogen and progesterone also have a huge impact on women as we age.
check buck institution, Dr. Jennifer garrison's OVA
THT therapy is for women too . for exact info you may check it with clinics or certified doctors .
@@Q_QQ_QYes, I know that and am actually on TRT, but leaving out the glaring effects of loss of estrogen on aging is disappointing. Both have had drastic effects on me and others in my life.
@@heatherschramm yes that is true . if you like you can share your experience as well . I think Dr Sinclair is only telling stuff he knows from papers and people he knows or heard of having these therapies which are usually mostly men but women do it like you have mentioned . I saw a podcast where a couple was telling about having done these therapies , i don't remember their name atm .
@@Q_QQ_Q my sister and I have joked about the idea of starting a vlog about our experiences and bringing on friends to talk about their experiences. It’s crazy how much variety there is and that very few people talk about it besides hot flashes.
The TRT studies that I've seen, including the one you linked have been a wash for mortality relations. Testosterone levels in men has been at a steady decline for the past 50 years. With there being a positive benefit to cardiovascular health, muscle size (particularly in legs, as in the Marcelo Rodrigues dos Santos and Shalender Bhasin study you linked) also correlating to healthy TRT doses, makes me believe there may even be a correlation to longevity.
TRT has been shown to increase patient's insulin sensitivity, and even decreases c-reap (Xue-yan Wu 2009).
Hypogonadism, SHBG, hematacrit/hemoglobin, estrodial issues have all been shown to be an issue with administration frequency, rather than the drug itself. It is all alleviated with a more in line pulsatile injection frequency of daily, or every other day.
Also, it should be noted that Asian men tend to have a 20-30% higher testosterone than Caucasians. Japanese men in particular tend to live 10-15% longer than Caucasians. There are thousands of different biomarkers to examine here, but the correlation is strong enough for me to grant its efficacy, or at least place it under further examination.
That being said, low testosterone has been linked to numerous deleterious effects (terrible sleep, hypogonadism, lack of drive, sexual dysfunction, weak muscles, etc.), all of which are correlated with mortality.
In my opinion, the benefits for this far outweigh the cons, and could even be correlated with positive effects.
David's smile at 42:23 after Matthew's statement is one of great satisfaction! love it
I was gonna take BPC-157 (Body protective compounds) for joint inflammation, I found out they are really act like a HGH effect with Angiogenesis , which literally creates new blood vessels that will heal organs , etc. etc. but the risk of cancer goes up , because cancers grow and get destroyed , but if we ever were to get cancer , added blood vessels could add to tumor growth as well as other diseases
Can you talk about hair? Male pattern balding and grey hair? And also talk about Finasteride use and its long term effects.
More plates more dates, check his stuff, highly into pharma for hair... personally I'd cycle eating times and meals per day, some days eat loads otherdays don't eat and some days do omad ect.. Next cycle in fasting for long periods (5-10 days) a few times a yr, then give your body signs of abundance by eating loads of meat, organs and fruit the rest of the yr... Understand that ketones boost stemcells.
For your hair the above works but also stop using shampoo and conditioner it's poison, just was with warm water then cold after and stimulate blood in that area (massage) and break up calcium deposits
Thank you for widening the boarder of understanding ageing 🙏
Thank you for your personality and work you put in yourself. Deepest respect🙏
I really like to listen to the lifespan podcast, but as a woman I feel women data are invisible in most of the researches. Could you please Dr Sinclair apporach some topics from the aspects of women? Especially when you talk about hormones like in this episode? It would be fab to hear about more similarities and differencies if there are any between a female or male body in terms of ageing! Thank you and congrats! And by the way, I’m Hungarian too as your grandma😊
Yep. So frustrating when they both say "people" when they mean men. Even rat research is largely on male rats. Grrrr.... Had a conversation with a researcher at the Salk Institute and he said "Well, womens' hormones are so complicated. It is like you are a different person every day." Lousy excuse for ignoring 50% of the population.
THOUSANDS of THANKS So Much for Dr DAVID SINCLAIR +
Mr MATT LaPLANTE * for your Unlimited + Immense + Continuous
contributions to Humanity Prosperity.
Those Valuable TIMESTAMPs are extremely useful.
Thank you Dr David Sinclair! Athletic Green is just delivered to my house now. Appreciate your videos it’s so helpful. Thank you! You look great in that blue sweater.❤️
Yamanaka factors have come so far way faster than I expected when I was first reading his research I thought it was going to be 10 or twenty years to make any real progress because of cancer.
I am a G I surgeon but I take particular interest in chronic diseases and old age . It would be super interesting to see if we could really wipe out old age related chronic debilitating diseases in future.
We mostly can it’s called diet and life style
@@jeffreysorensen5298 yea but can u make a pill for that so we can profit off it? We know how to end chronic disease already. Are actually some powerful tools available but people have to want to do it. Something like 90% of all health improvements are realized simply by losing weight. Regardless of the diet.
@@jeffreysorensen5298 may I add optimism besides diet, lifestyle?
@@theresaho9696 you are absolutely correct. Most people realize that obesity is the number comorbidity for a poor outcome of Covid but few realize that number 2 is fear and anxiety.
Quality of life trumps everything
I have been on hormone replacement therapy for decades. I'm 80 now and do not look my age. Most think I look about 60. Hormone replacement therapy has been my life saver ....
We're in a golden age of podcasts between this and Andrew Huberman podcast
I am following these podcasts with high interest... as I am 64 and on TRT, do intermittent fasting, weight train and take NMN and other supplements... (will be adding resveratrol). One issue that was not taken in consideration with regards to aging and testosterone is the fact that life is more than just time. How do you ballance adding life to your time vs adding time to your life. Quite frankly, TRT gave me my life back. My level of energy, motivation and general mood are way up with testosterone.... I would not live like I was before... The added estrogen that comes with TRT is actually cardio protective and has cured my joint pain... Maybe you should stay away of subjects you don't know well or you are biased against... Testosterone can actually be protective against prostate cancer and high levels of testosterone is actually being studies to treat certain forms of prostate cancer... I think your view is a little outdated...
The biggest issue I have with all this longevity talk is the fact, it seems, that you have to choose between being vibrant, energetic but short lived or be starving, cold and low energy and live longer... Darn... Everything that makes me feel good seems bad (Mtor activation as I like my meat... testosterone as I enjoy being energetic and productive... ) ...
Maybe I am looking for optimization and you are talking about absolute lifespan...
Don't get me wrong, I love the podcast... great info to integrate into what I think will be a middle way for me... Cheers
I am with you - started TRT when I was 64 - now 68 - and I have experienced many benefits. I think that what Sinclair misses about TRT is that he has a “theory” that it may send the wrong signals to your body to “grow”. What is interesting is that, although Testosterone is anabolic, it is focused mainly on helping muscle and bone strength. Consequently, you can consume less protein (which too much can create issues) than someone who has low T. I think the bottom line is that the studies are pretty consistent that TRT reduces all-cause mortality while improving quality of life. Big Pharm and the medical industry in general do not like TRT because it cannot be patented and it takes a lot of a doctor’s time to get you dialed in. My understanding is that Sinclair is working on patenting concoctions out of his lab to sell as longevity drugs. Hence, TRT could be considered “competition” in spite of its efficacy.
Serge, you are right on all counts. Sinclair is still very much of a newbie to the testosterone space; one can tell this by listening to him. He will probably acquire better knowledge, with time. Meanwhile, don't deny yourself the benefits of testostereone just because he is still relatively ignorant!
Also true that there is a balance between strength and vigor, and longevity. More of one, less of the other, or so it seems. Maybe someone will figure a way around that, eventually, but for now it seems you must choose.
@@AncestralFuel You are correct also. Testosterone's anabolic effects are such that you can recover from workouts and maintain strength on much lower protein intake; this is a grossly-neglected fact in the longevity space (Sinclair, Attia, and many others). They also neglect -- are probably ignorant of -- the literature describing the benefits that you mention such as reduced ACM, better QOL, etc. They are perhaps ignorant, and/or perhaps tend to dismiss because of prejudice against hormone therapy, especially hormones related to anabolic steroids.
Also correct that TRT is non-patentable and involves a lot of old-fashioned patient-focused medical ARTISTRY (what you call "dialling in", which is beyond the science, beyond EBM), and as such will tend to be ignored and dismissed by commercial and some other entities. TRT cannot be successfully practiced by idiots following EBM cookbooks; therefore it will tend to be less popular.
Also, yeah Sinclair might have a bias against things that he cannot sell. IDK, but that is the way things go, too often.
What would happen if you cycled on and off trt and hgh so that you get the short term benefits, but then stopped those and go into a longevity mode where you do minimal mtor generation and lots of sleep etc..... so cycling between abundance memetics and adversity memetics... so you get gains during abundance mode and then maintenance mode during adversity mode, then cycle back into abundance mode and do it all over again.
This podcast on anti-aging along with the research on CRSPR and gene editing/disrupting really is amazing. The only thing better than this would be a way to transplant consciousness into an already younger version of oneself. I watch this on UA-cam then I listen to it again on the podcast
Can’t tell you how many people I’ve recommended the book Lifespan too it was great. Very excited to see how well we can Amplify these Sirtuin genes
Fastest longevity channel to 100K. Congrats!
Most definitely! I have found that in my city (Pittsburgh, PA), which is primarily a traditional medicine community, the majority of physicians are very hesitant to prescribe HRT and claim beyond a certain age, your risk to develop cancer is very high. I know this isn’t supported by current research. Also, there are few functional medicine practitioners who also have MDs - a background I am seeking so I can receive advisement from both perspectives. My DO wouldn’t even consider prescribing bio identical HRT and told me I should find a gynecologist who would. Even these practitioners are very hesitant and keep referring to older research in their explanations. This is SO very frustrating, and leaves many women struggling to find care that could prevent many downstream problems.
I love you David, i can‘t wait to put my hands on your book ( Lifespan) i already apply most of your advices, but i take it slowly, currently eating 2 meals a day instead 3…
What protocols have you started because of Sinclairs' podcast? I have too and would like to compare.
@@quantitradersignalservice5735 curently i stopped eating 3 meals a day, i eat only 2. breakfast at 13:00 and dinner at 18:30-19:00, i do exercise 5-6 times a week, aerobic running, and i train in the gym for strength. i want also to start taking a supplement which it contains more or less the same ingredients which Profesor David Sinclair recommends : NAD + Cell Regenerator and Resveratrol 300 mg from life extension. Good Luck!
So wish that there is subtitle. It would be immensely helpful for so many of us. We are constantly pausing and rewinding.😢
As a child, I was growth hormone deficient and underwent GH therapy for most of my adolescence. Aside from catching up growth and development, people who are growth hormone deficient (whether as children or adults) take GH because being deficient puts us at higher risk for lots of major health issues and risk factors including visceral fat, high cholesterol, osteoporosis, cardiovascular issues, etc. So I was surprised to hear Dr. Sinclair say that populations with lower GH have fewer health problems. I'm also curious now: I understand his point about those who take GH recreationally or as a "body hack", but for those of us for whom it was/is medically necessary, what effect does the later-but-accelerated development have on us in terms of overall longevity? I was a late bloomer but developed pretty quickly when I did. I'm 40 now and am usually told I look much younger which seems like a good sign, but I'm wondering what effect the GH deficiency and treatment might have had on things. Has there even been any research on this? I feel like whenever GH is discussed even among scientists it's always in the context of recreational/elective use and it's hard to find information relevant to my situation.
(I previously left this comment on your appearance on the Huberman Lab podcast but never got a response so I'm leaving it again here!)
I would never trust David SInclair. His past is definitely shady
@@kaylabryson1932 my past has it's ""shady"" aspects. But you know what?.. i am actually a good guy (the type who knows how an orphanage looks from inside, not from the news) , really trying to understand me and surroundings . Reality , if it's not too cocky . While someone saying NEVER trust X sounds like a really bad guy, a guy who does not even understand relativity (and we have more than 100 years to digest it). More, there is nothing to ""trust" , because this is science. It might bring contradictions, it might bring arguments, but it's not about ""trust"" . Always go for more than one source if it is as important as aging. But don't take ""never"" in your arms, it is limiting. Just saying. PS. Sorry for my poor english, started late with this, while already speaking 4 other languages and became lazy. Good luck.
@@kaylabryson1932 Yet here you are, listening/following the great Dr. David Sinclair. Perhaps you're just a "perfect" human being, but I digress.
I have heard David say you should keep your testosterone levels up in a different interview (can't recall which one at the moment). This certainly contradicts that statement. I think if your levels are low, you need to keep them in the normal range.
@@shawnshawn7477 Too low kills you quicker - try getting lutenising hormones for prostate cancer - I know... heart attack highway :D
Thank you very much! Looking forward to the next episode!
This was a very interesting episode! I like this topic as it has not been repeated before in other interviews. I hope one day we can just take a pill that's gonna make us younger haha.
Great discussion!!! Been a fan since your Rogan interview. Ready your Lifespan book 3 times, Can't get enough of Mr. DS
Good morning, Matt. You have a John Heilemann-esque vibe. Take it as a compliment. I think you do a great job of co-hosting, asking enlightening questions and keeping the conversation flowing. David is pretty good, too. Signed, Matt's mom
The idea from the book that "aging is a disease and a treatable one" opened my eyes to the possibilities and I'm fascinated since.
You both are lovely! Lol 😆 thank you for telling us what doctors don't- please do one on menopause!
Yes I'd love one on perimenopause and menopause.
i'm hoping that Dr. Sinclair reads these posts because if he does he'll get the idea we would love to hear his thoughts on woman's helath.
As always, interesting to watch and learn about the cutting edge in anti-ageing. Thanks David and Matthew! Dr. Sinclair is looking younger than usual lately - any recent changes in the protocol?
Hair colour definitely helps
I think they are using a soft focus filter on their videos.
@52 min on thymus regeneration: See research of Janet Lor which showed that older (65 to 80) who cycled alot over many years preserved their thymus output of T cells and had immune function of people decades younger. It's also known from other research that exercise increases NAD+ and modulates other metabolic factors towards younger states.
exercise and diet is best .
Okay, so episode 6 hopefully will be on hair (re)growth too. This is a big issue for me right now. Perhaps for many other women too. I will keep in mind about GHK Copper (I hope I spelled that right). It was mentioned halfway through this episode (and the warning about peptides and their negative side-effects). Thank you! 🙏
Micro needling, minoxidil, and oral Castor oil will regrow hair... Do your own research and make an Informed decision before doing it
one reason for hair loss is ( in men ) is increase in DHT on face and head . on face DHT increases hair like beard or face hair . on head high DHT results in hair loss . it can be something similar in women too but idk .
I hear you, it's a huge issue for me as well, I've been losing a lot of hair due to the hormonal imbalance for the last 6 years and it's still so heartbreaking...also I can't find a treatment that really works and keeps this under control
Microneedling, topical minoxidil and oral Castor oil... It should solve the problem
Sylvester Stallone looks like he’s in great shape. He’s been taking growth hormone testosterone for 50 years or more.
I’m so excited for the weekly releases, I don’t put that kind of value into any other channel
The HGH discussion skipped over the TRIM and TRIMX trials done by Greg Fahy, and showing age reversal with epigenetic clocks. Shame - I really wanted to hear Davids view on that work
Matthew is an outstanding conductor
Another very interesting episode! I love this podcast! Can’t wait to know more about aging outside! ❤️❤️❤️
love your pod cast Im 56 and look and feel 36 Topics you cover so fascinating and your partner covers every detailed information
I would like to know David's testosterone levels, and what range would be considered optimal? At what point should you supplement?
I'm drinking athletic greens for 3 months. Great product
Great message at the end, thanks Matt and David for this episode
TRT leads to muscle growth and typically more food intake to support growth which is the opposite of caloric restriction
Yea makes me hungry after workouts gah lee
Thanks for making this video series!
David Sinclair just aged backward by a week while I aged forward waiting for another episode.
guys! when are you going to speak about the skin and hair part of all this?!?! you guys mentioned that you'll go into detail with it! please and thanks
These podcasts are absolutely amazing and life changing! Thank you so much.
Please take a look at Diazoxide neurological and antiaging benefits. 🙏 It's well studied
Do u think it would help Parkinson’s? I
@@debsarno2532 yes.
There are better ways to kill oneself doctor. Please ppl do not listen to that dude.
@@Dr_Dieta you are brave, indeed. Messing around with a potassium channel opener is, currently, not a good idea. In those neurn we have 3 different types of potassium channels, and symptoms gt relieved if the SK channels get BLOCKED. There is absolutely NO consensus about how to handle them.
If you mess around with potassium channels systemically you quickly age to terminal age.
Thank you David & Matthew, such awesome podcasts
I am just surprised why the FDA seems have never big problems with Glyphosate.
I would love to hear more about whether GLP-1 is similar to metformin or a good idea to increase health span
At 22:35 the text reads 'thymus and alpha one', it should be thymosin α (alpha) 1.
Hi David, I studied your book and have been using NMN, etc since Feb 2021. My stem cells have been banked and I have 1.4Billons of my cells IV'ed and IN'ed in my body since 2020.
What is NMN?
I wish I had seen this podcast earlier, I had been using peptides to deal with an injury that got worse and to boot, I now have arthritis in my hip and big toe.
Are you referring to peptides that were made in Russia and now available here? These are said to heal the heart,liver, brain and other organs. What do you think? They are said to extend lifespan by 30%, but I think that means expected lifespan of an already ill person. They are made from animals or synthesized.
Love this !!! Thank you dr David!!! You rock !!!
Dr Sinclair, Could you Please let me know the Name of the Sleeping Pills that you take. Thank You . Love listening to you.
Very very exciting times. 3 months for every 1 year lived right now…the near future is amazing.
Now I wonder how all this fits with Dr. Michal Levin''s research in "Bio-electricity" and "Morphospace" ?
Wow I was wondering if they offered a discount. 25 % is great. I'm just about to get back on Resv, Berberine and NMN. I've been using senolytics sparodically, and during pre and post vaccine. After a year off, feeling like crap tbh 😆, so thanks for making feel human and hearing you did the same at some point. I do remember how fabulous I felt a year ago. This time I want to do full bloods, and track properly not just anecdotally. Thank you 😊 ✌️❤️🇭🇲
First time I’m seeing he looks healthy and skin is glowing only little inflammation on left shoulder and little on left side and front of the elbow. well done I can respect you now. If you’re advocating for your job or what you believe in show the evidence in your body.
Please note that Levels is currently available in some American states only. I’m in New Zealand & desperately want it! 😂
Okay, I have watched all the videos thus far, but have heard almost nothing on the accumulation of intercellular junk, and just a bit about junk inside the cell, and what can be done about it. Because it looks to me like this is a major player in the current limits of human lifespan. There is more than one kind of heart disease, and the one killing the 100+ crowd is often Wild-type transthyretin amyloid (WTTA), where transthyretin amyloid builds up in the heart and some other tissues making the tissue stiff, and it becomes very tiring to even stand. 25% of men over 80 already show signs of this beginning. And this is just one of 25 or 30 proteins that can misfold and accumulate in the body. Then there is glucosepane. This Advanced Glycation End Product can't be removed by the kidneys, even if they are healthy, even if the other AGEs can be. This also builds up stiffening tissues and is implicated in a number of aging diseases. And what about lipofuscin? Maybe that will be covered when skin is the topic, but this crud is also in the brain, muscles, the heart and other internal organs.
Then there are the studies about the intentional conjoined mice, where they saw the health of the older mouse improve, and the younger mouse go downhill. And after a series of studies they determined that it was chemicals in the blood of the older mouse that was the problem, and by plasmaphereses they could restore the older mice to health. That to me suggests that there are accumulations not just in tissue but in the blood. I don't know if healthy kidneys is the answer to that or if there are things the kidneys can't do anything about, like that glucosepane, which needs periodically removed.
Then there is scar tissue. There are injuries within the body from infections and whatnot, and the body chooses speed over accuracy during repair, but if you live long enough, these sloppy repairs will also accumulate.
We also accumulate infections that the body can't ever completely eliminate. Older people have much more of these than younger people. Things like toxoplasmoses, and cytomegalovirus. Ultimately, I don't think these things are benign. It is likely they wear down defenses, or promote diseases we haven't yet tracked down to them.
I sure would like this accumulation topic discussed.
So these things will almost certainly require input from my doctor, as you mentioned, but I'm unclear as to which ones are currently available to me for treatment now.
Amazing and wonderful. Thank you!!
Oh Jesus!
I had to take a break after the mini human brain part!!
35:00
So excited to listen to this one. Thx Dr. Sinclair
I know they have to tread lightly and not recommend actually doing some of these promising new treatments and taking non-FDA approved supplements and drugs. But not all people have the time to wait, so it seems there is kind of a sliding scale of risk vs reward for each individual to decide what they want to try. My other concern is that once we have all the scientific confirmations of efficacy and safety, once there is FDA approval and the drug companies get their patents some of these treatments may be out of reach for many people who don't have a lot of money. Is my pessimism over exaggerated?
I would like to learn more about how the Yamanaka factors work, their relationships with sirtuins and how they are used in regressing adult cells into stem cells.
Awesome Channel and powerful data!!! Thank you !!! ✨💪🏽😎🤙🏽✨
Bonjour from Switzerland 🇨🇭! Je suis prête 😁
Brilliant!
I wish you could speak about other supplements that promote growth hormone like arginine,ornithine, niacin, choline, tryptophan, melatonin, etc.
You need to take B12 supplement along side Metformin, just a quick note.
I am still wondering... when the cheap test is coming ? Last year you said : at the end of this year. I'm on the wait list but impatient. Have been using a great deal of money for several years and it's all on faith.
I am loving this series. Currently I am on my second regimen of Fiesitn (hit and run method) I know ysaid it's still experimental however I have been scathing of Damage and repairing for agent orange poisoning for decades. Doing rather well at it. So I have some savy and knowledge. About what I am doing.
Thanks. Great Content
So thankful for great information and very interesting podcast
can you say something about how the fluorine in water affects us?
Dr. Sinclair, we are SO grateful for the work you are doing and sharing! Would you consider discussing how far off we are from being able to grow heart valves using a person's own stem cells? My husband was born with a bicuspid valve (and so was his father). He will eventually need a valve replacement, but because his immune system is so strong, we are concerned that his body will reject a mechanical or animal valve (as his father did). Can you refer us to someone who is doing work in this field?
I am a cardiologist. In 20 years I have never seen rejection of a mechanical or biological valve. A mechanical valve has no antigens so will not stimulate the immune system. Biological valves are not living tissue and are treated. It is living tissue transplanted that stimulates the immune system. A bicuspid aortic valve is the most common congenital heart anomaly in the country. If you have children they should screened. I hope that puts your mind at ease.
Podrías poner en Español ,por favor 🙏🏻 me gustaria😔que puedas hacerlo en español
Maybe any interest in discussion on microchimeric fetal-derived placental cells rejuvenation and effects of parity on longevity? Awesome work! :)
What is the name of the company/ which is the company for exosome diagnosis that you were mentioning?thank you so much 🙏 great podcast
not everybody wants to live longer as in past the avg life expectancy, they just want superior quality while they are here. you also leave out that there are ways to counter some of those side effects
are people who are non-diabetic having success in getting metformin prescription? I did a telehealth doctor thing and after the session he says, "we don't do that", despite me informing ahead of time that was the reason for the appointment.
How is the medical intervention for longevity studies going? I would love an update.
Thanks you guys! Blessings.