Chronic Myeloid Leukemia (CML) | Pathogenesis, Symptoms and Treatment

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  • Опубліковано 16 гру 2024

КОМЕНТАРІ • 80

  • @Greanestbean
    @Greanestbean 11 місяців тому +6

    Thanks for the video! I think another important point to mention for board exams is differentiating CML from leukemoid reaction using the leukocyte alkaline phosphatase test. The test will be normal to elevated in leukemoid react and decreased in CML.

  • @ajjackson9229
    @ajjackson9229 2 роки тому +11

    I was diagnosed with CML in 2020 and my wbc has always stayed high. Yeah weeks ago I went and had my blood work done and I was at 247,000. I’m on Tasigna.

  • @allahhuakbar7362
    @allahhuakbar7362 2 роки тому +3

    This is one of the best channel

  • @jenniferakin7203
    @jenniferakin7203 2 роки тому +20

    i was diagnosed with cml around the first of june, 2022. they put me on bosilif 400mg daily. now my white count is normal and my red blood cells are starting to increase too. i go to my cancer dr every three weeks.

    • @malikdesilva6574
      @malikdesilva6574 Рік тому

      its under myeloproliferative syndrome--->increse RBC

    • @lqqlkqlq6271
      @lqqlkqlq6271 Рік тому

      ​@@malikdesilva6574No, you'd expect to see low RBC in CML because the blasts in the bone marrow start to suppress erythropoiesis which leads to splenomegali
      Her RBC is getting higher because she is responding to treatment

    • @mahnoorarshad6284
      @mahnoorarshad6284 Рік тому +1

      Allah pak shifa de aap ko

    • @thomasmohamed6218
      @thomasmohamed6218 Місяць тому +1

      Thanks for sharing my dear.

    • @jayeshaw5705
      @jayeshaw5705 26 днів тому

      I was diagnosed with cml also in 2022. Was put on dasatinib however the diarrhea was to severe so now my Dr is switching me to bosulif. Have you had any diarrhea with this drug?

  • @clinmedunder1036
    @clinmedunder1036 4 роки тому +10

    Thanks for a simple explanation of the pathogenesis of CML! Great video!

  • @janetuwakwe3745
    @janetuwakwe3745 Рік тому +1

    Thank you so much for this video. It just saved me.
    I'm about writing a hematology exam and CML is one of the major topics.
    Thank you once again,I'm definitely subscribing to your channel 😃😃

  • @alaek3853
    @alaek3853 4 роки тому +5

    Mature neutrophils are the multi lobed nuclei cells not the big immature things you point to...those look more blastic

  • @theawesomenava
    @theawesomenava 11 місяців тому +1

    thank you! I was confused on why it was called chronic CML

  • @EDWINMATTHEWJACOB
    @EDWINMATTHEWJACOB 9 місяців тому

    According to Rodak's Hematology, Platelets are actually Normal to Increased. This actually makes sense because thrombocytosis reflects the myeloproliferative nature of the disease

  • @kasunjay5383
    @kasunjay5383 9 місяців тому

    Hello please upload a video of acute leukemias too

  • @komalgaikwad8934
    @komalgaikwad8934 3 роки тому +2

    Plz upload more videos on medicine

  • @vittoriacraviolo4395
    @vittoriacraviolo4395 4 роки тому +10

    Thank you for the video. i just can not understand why there can be either anemia or erytrocytosis in CML. How is it possible to have both conditions together ? I thought that the increase in RBC was due to increase in myeloid progenitors that will also give rise to RBC. But on the other side II understand that anemia is due to “lack of space” in the bone marrow. So that the cells need to be produce by the spleen and the liver. Thank you

    • @annariehaasbroek7540
      @annariehaasbroek7540 2 роки тому +1

      Sometimes life just can't be explained. I know how you feel!!
      I have cml and Budd chiari syndrome. I also have anemia and Sydenham chorea. Sometimes we get screwed.
      Best wishes for your health

    • @shereehi5539
      @shereehi5539 2 роки тому

      The blood cells probably die very fast so the production goes super high?

    • @shereehi5539
      @shereehi5539 2 роки тому

      I am guessing. All I know is blood cells can have low oxygen in sickle cell anemia.😞

    • @lqqlkqlq6271
      @lqqlkqlq6271 Рік тому

      Who says there can be erythrocytes in CML, I've never heard of it

  • @krutisundar6685
    @krutisundar6685 4 роки тому +2

    Excellent lecture sir....

  • @sarojraut330
    @sarojraut330 4 роки тому +3

    Beautifully ❤️ and explained.. Thanks

  • @pratheekshayadav
    @pratheekshayadav 27 днів тому

    Thanks for the video learnt alot

  • @mejustme1357
    @mejustme1357 3 роки тому +1

    Can you please upload videos of AML and ALL

  • @superciliousguy
    @superciliousguy Рік тому +2

    Hi , could you please help me “ why in CML we have only WBCs high initially and later low RBCs and PLTs but never high RBC or PLTs considering the defect to be in either Hematopoietic stem cell or Myeloid stem cell”

    • @superciliousguy
      @superciliousguy Рік тому

      And if you see in Polycythemia Vera the defect is in Myeloid stem cell with high tyrosine kinase activity leading to high RBCs (predominately) but high WBC and PLTs as well

    • @superciliousguy
      @superciliousguy Рік тому

      Your help would be much appreciated ,Thank you ❤

  • @rukiee.b.ovwigho5709
    @rukiee.b.ovwigho5709 2 роки тому +1

    Wonderful video. I love the use of outlines. Simple and straight to the point. Exam based 👏👏👏

  • @jovinkomba2908
    @jovinkomba2908 Рік тому

    Very Good Presentation but i have noticed there is an error in Mature cell , Matured cell have small Nucleus to Cytoplasmic Ratio meaning the Cytoplasm occupies large space than Nucleus

  • @N8pr0x
    @N8pr0x 4 роки тому +2

    The way I was diagnosed was due to blood splotches in my eyes kept increasing, I finally got a Whole blood test. My WBC was 150.

    • @N8pr0x
      @N8pr0x 4 роки тому +2

      Well I've been on Imatinib Mesylate 800 mg. My Hematologist. So my WBC are around 8, still fighting, living, breathing, & walking.

    • @anandanu8698
      @anandanu8698 4 роки тому

      𝘔𝘺 𝘸𝘣𝘤 190 𝘢𝘺𝘶𝘳𝘷𝘦𝘥𝘢 𝘵𝘳𝘦𝘢𝘵𝘮𝘦𝘯𝘵 15𝘥𝘢𝘺𝘴 𝘸𝘣𝘤 15.6

    • @sheikh1988
      @sheikh1988 3 роки тому

      @@anandanu8698 i m also cml patient where u consulted ayurveda

    • @alexjohnson5075
      @alexjohnson5075 5 місяців тому

      My wbc was at >440 when I was diagnosed. After infusions, it as rapidly decreased. Within a week I was down to 150. Still kicking it. Was just diagnosed about two weeks ago. So learning all I can about cml

  • @aaliyaansari8140
    @aaliyaansari8140 9 місяців тому

    Wonderful lecture 😍Thank you sir❤

  • @Ilililsss
    @Ilililsss 10 місяців тому

    Thanks - one question. For CML is it normal to have low platelet? I thought it is more common to have high platelet (unlike other leukemia types)?

  • @U2FanSanFran
    @U2FanSanFran 9 місяців тому +1

    I’m a 47 year old male, After getting a bone marrow biopsy procedure I was diagnosed with CML and put on a medication called Sprycel. Is CML réversible or is this for life? Also will this eventually turn into Leukemia or will this medication prevent that? Thanks

    • @Root1502
      @Root1502 5 місяців тому

      I too have CML and take Sprycel daily. From what my hematologist told me is that it is something that stays with you for life. He told me it’s manageable and I can expect to live a normal life with treatment. I went into full remission less than a year taking Sprycel.

  • @newnew9048
    @newnew9048 3 роки тому +1

    Doc in CML if WBC n NEUTROPHIL is Low How to increase them..pls Respond thankyou

  • @azizaxonkarimova70
    @azizaxonkarimova70 6 місяців тому

    Thank you for a wonderful video 👍👍👍

  • @anupamtiwari31
    @anupamtiwari31 Рік тому

    Under what case a patient with blast cells

  • @emanyaqoub7626
    @emanyaqoub7626 4 роки тому +2

    Excellent, thank you

  • @somie4639
    @somie4639 2 роки тому +1

    Thank you!

  • @semsem8801
    @semsem8801 3 роки тому +1

    Thank you

  • @shivalikarmali8105
    @shivalikarmali8105 2 роки тому +1

    Thank you sir

  • @Ezekiel728
    @Ezekiel728 3 роки тому +1

    Thanks man

  • @prasenlade9034
    @prasenlade9034 4 роки тому +1

    Awesome... 👍

  • @030bhumikadas5
    @030bhumikadas5 4 роки тому +3

    Awesome! Make more videos!

  • @Tony.250
    @Tony.250 Рік тому

    Tnx❤

  • @adarshkumar8563
    @adarshkumar8563 4 роки тому +1

    If WBC is 142000 and hemoglobin 8.5
    The CML is curable or not

    • @sheikh1988
      @sheikh1988 3 роки тому

      Hopefully it will cure, i m suffering with the same

    • @Pats.
      @Pats. 3 роки тому

      I remember having my WBC around more than 200,000. Thankfully im doing amazing

    • @Pats.
      @Pats. 3 роки тому

      @@sheikh1988 Same

  • @erayylmazer2673
    @erayylmazer2673 7 днів тому

    Dude this rocks

  • @prudhvirajpampana3339
    @prudhvirajpampana3339 3 роки тому

    3:49 accelerated phase

  • @thankusimon5451
    @thankusimon5451 2 роки тому

    Sir, pls explain why this is happening for 30 years in young people

  • @marcegarcia2466
    @marcegarcia2466 4 роки тому +1

    I got a wbc count a little higher than normal now i saw i was getting testing for bcr abl what does that mean 🥺🥺🥺

    • @iramsshah
      @iramsshah 3 роки тому +1

      That is done to differentiate between CML and a leukaemoid reaction, and bcr abl is positive only in CML.

    • @lqqlkqlq6271
      @lqqlkqlq6271 Рік тому

      Hi how did results come

  • @jimfaust6342
    @jimfaust6342 2 роки тому +1

    Roman Reigns has this . Or had it.

  • @monicaayrton7639
    @monicaayrton7639 3 місяці тому

    Thompson David Walker Kevin Rodriguez Jessica

  • @MdFaruk-rj1lo
    @MdFaruk-rj1lo 3 роки тому

    Cml rugi koruna tika dite parbe kina

  • @MariaThomas-j1y
    @MariaThomas-j1y 2 місяці тому

    Lewis Nancy Garcia Paul Moore Eric

  • @rimourimoi4101
    @rimourimoi4101 5 років тому +1

    Who van see by high quality

  • @AbdulBarek-p3q
    @AbdulBarek-p3q 3 місяці тому

    Young Angela Allen Margaret Lewis Sarah

  • @MariaThomas-j1y
    @MariaThomas-j1y 2 місяці тому

    Thompson Amy Williams William Taylor Betty

  • @GusCarol-j2f
    @GusCarol-j2f 3 місяці тому

    Luettgen Centers

  • @misbahumar4577
    @misbahumar4577 2 роки тому

    👍👍👍

  • @3lies
    @3lies 3 роки тому +1

    Cash Money Lavish D

  • @ManojchutiaManojchutia
    @ManojchutiaManojchutia 7 місяців тому

    Eas

  • @shaidasabah2606
    @shaidasabah2606 2 роки тому

    THANK YOU