Understanding the properties of amino acid residues in the ligand binding pocket is very important to structure-based drug design (SBDD). SBDD is using the knowledge of the three-dimension space of the binding pocket to optimize the interaction between the drug and the biomolecule target.
Thank you for posting this! Something I'm a little confused about: you stated around 1:04 that a peptide bond is formed via "a dehydrogenation or condensation reaction". Isn't dehydrogenation the removal of JUST hydrogen? So, it wouldn't actually be a dehydrogenation reaction in the case of a peptide bond forming?
Understanding the properties of amino acid residues in the ligand binding pocket is very important to structure-based drug design (SBDD). SBDD is using the knowledge of the three-dimension space of the binding pocket to optimize the interaction between the drug and the biomolecule target.
Thank u
Thx
Thank you for posting this!
Something I'm a little confused about: you stated around 1:04 that a peptide bond is formed via "a dehydrogenation or condensation reaction". Isn't dehydrogenation the removal of JUST hydrogen? So, it wouldn't actually be a dehydrogenation reaction in the case of a peptide bond forming?