I really appreciate the pedagogical character of these vids. Most biochemistry videos will just go from point to point like it's obvious. Dr.Mike regularly explains and repeats every last detail and isn't trying to squeeze it all in 3min.
I don't have enough words to describe how amazing Dr. Mike's teachings are. As disorienting as anatomy and physiology is (especially to people like me with social science background) his teaching makes it easy and organized to digest. I can't thank you enough for what you do. May God bless you beyond measures!!
Nah, it`s perfect in terms of "simplification". While reading great volumes of scientific papers is often hard to synthesize or even understand basic, essential concepts. The video is just enough. For further details, we can always open the book. The important thing is to understannd the systems and the following connections. Thank you! Namaste!
I had my A&P2 final yesterday. Thank you so much Dr. Mike for your videos and support during the semester. And with all respect, "the easy on the eye" it is a bonus. 🙃
i was enlightened by this as i am always confused with gluconeogenesis and glycogenolysis. I got it now the difference. thanks for this informative video. great help! you made it so simple yet very understandable.
Your teaching is awesome! How much dedicated you are! Dr. Mike, you make physiology so interesting for a non medical student. Much gratitude. Lots of Love. I'm your fan.
I was eating every hour before and was sent to emergency 🚨 at 33 almost died. Now i am doing low carb, high fiber keto with intermittent fasting. From 210/140 blood pressure down to 117/77.
This video is an excellent presentation of metabolism. It is a guide for studying more details and to understand their part in the big picture of metabolism.
I better understand it when i just listened to it and not watching the video. Thanks, because this was already explained in si many videos i watched and now in a slower phase and i fully absorbed it. I have some good take away on this.
true i stumbled there also in 16:25 over the word glycerol(fats) because theres so much, glu, gly etc hahaha. by the way im a medical student. thanks for your video, highly appreciated it, Dr Mike!
Awesome! I'm going to watch this one a few more times to let it sink in. Nailed my Cranial Nerves and Cardiac testing thanks to your other videos! Thank you!
Wonderfully explained about the metabolism of Proteins, glucose, glycerol and fatty acids. Very easy to understand the Kreb cycle and pyruvate mechanism. Tks for sharing this excellent video. 👍👍👍👍👌
Love your vibe man! Thanks for sharing your knowledge. I am finding it incredibly helpful and insightful! Sending you energies of support and appreciation!
I love your videos :D however, id love to add that we have essential fatty acids we need to obtain from the diet, because the body cant make them its self and/or not in sufficient amounts. Thanks for your videos
What the 🤭!!! Where has this channel been?😂Your bloody-brilliant! Had my lecturers explained it like this id be ok😂 Thank goodness I found your channel. You've made everything crystal clear and connected the dot! Thank you!
Training to be a Paramedic and find these vids so so helpful. Just one (maybe two) questions (maybe three). Do you have a vid where you explain exactly what ATP is? Which bit of this process going wrong leads to diabetes? and/or obesity? Thanks again
I get the idea and the function, great explanation. Anyone got a better diagram though? Like a more structured and easily understandable one? Reply if you got one.
When does body breaks muscle for ATP versus FAT¿ Also, is the glycogen coming from muscle or liver? Can you make a video on when body decides to break muscle or how it builds muscle and breaks fat?
Thank you for this material! Very helpful :) So regarding ketones you are saying that w low carb diet is not good as it creates acid? But as I understand fats are essential and carbohydrates are not. And also, why then so many people feel better when switching to a ketogenic diet? Regards :)
I am diagnosed with a endocrine disorder. I have thyroid cancer and a swollen tumor in my throat. I also am diagnosed with a enlarged uterus and multiple fibroids. How are these illnesses related to metabolism and catabolism?
How can lipids avoid going through the liver via the lymph, doesn't this give an opportunity for toxic lipids to get into the bloodstream? Does the lymph system also filter somehow?
Careful... I would argue that lactic acid makes NADH+ (not ATP) and it is this NADH+ which can be used to make ATP. Also, your image of the mitochondria gives the impression that "hydrogen" (not a hydrogen ion (proton)) is used and the outer membrane is involved in the ATPase Pump when it is the inner membrane involved in the electron transport chain - the outer membrane is not. These are important differences. Pictures speak a thousand words... you need the correct image for the correct words.
Thank you Doctor. What you don't mention is the pathway for all this hepatic cell ATP production. Does that then get sent to tissue cells everywhere as an energy source? If so, I don't understand why you said the brain needs glucose. Doesn't it need ATP (produced from glucose)?
It also goes to prove that humans do not ever need to consume a single gram of carbohydrates. Its the sugar....glucose in our diet that is responsible for so many health problems this world is facing. The keto diet is the answer. Studies have consistently shown that insulin resistance is the culprit and that metabolic disease is the real epidemic. As the clever doc pointed out....glucose is the main driving force for triglyceride formation. In fact its a great bio marker along with HbAc1 and small LDLs to test for metabolic disease. Insulin is our fat storage hormone. Consuming lots of saturated fat...cocounut oil...butter..lard..tallow..eggs..avos and all non seed oils are great sources of fats and HIGHLY recommended plus consuming beef...chicken...pork...mackeral..sardines.....and eggs including cheese for protein. If the worlds population completely stopped consuming all simple and complex carbs including bread..rice and pasta..including fruit..yes fruit.. ...alcohol and stopped smoking...the worlds health would drastically improve and one would have a weight issue. So many do not understand that glucose is the real reason why LDL has such a bad name...its actually healthy to have BUT its the sugars in particular fructose which damage the LDLs because it affects the apo b100 marker.. the science is clear about this. You will lead a long life if you dont smoke..dont drink alcohol...stop eating all carbs...exercise...sleep..and consume high fats and moderate protein.
It is very simplistic to turn one macronutrient into the main villain of the health story. Sure, excess sugar is bad, but it is not the complete story. Low-carb is not the answer to health.
@@metalmusi it is the main problem. You need to learn more. Carbs are not needed at all by humans not a single gram. You dont eat what a body doesnt need. Its this that gets us into trouble especially when the randle cycle is activated.
Hi - great video. Thanks for sharing - 4.45 min in to the video you mention and draw the big square. What do you call it? Hepatic??? Difficult to hear. Please help
In the anaerobic case, what is the purpose of going from pyruvate to lactic acid to ATP when I can already go from pyruvate to acetyl coA to ATP? And when I am missing glucose, why produce ketones when I could go from glycerol/amino acids to pyruvate to glucose, and run the Kreb's cycle normally?
I kinda have the same thought with you for ur second idea. For the first one, i think when the aerobic pathway does not produce sufficient energy for the intense activity that we do, the anaerobic pathway would come in the picture to help out and both pathways would be used at the same time.
@@543sam210 Looking at en.wikipedia.org/wiki/Cori_cycle, it seems that the anaerobic pathway actually net consumes ATP, but uses ATP preferentially from the liver rather than from muscles. This seems to shift the calculus away my original thoughts about solely maximizing ATP output. As for the second case, en.wikipedia.org/wiki/Ketogenesis suggests to me that ketogenesis only ramps up on simultaneous deprivation of glucose and Krebs cycle intermediates such as oxaloacetate. What causes a shortage in Krebs cycle intermediates and the degree to which glucose and Krebs cycle intermediate shortages correlate is unclear to me.
So if weight lifting creates lactic acid (which is then used for energy), and the lactic acid builds up in the muscle being stressed, is the lactic acid being produced in the muscle or is it being produced in the liver and merely used by the muscle?
As much I remember, while weight lifting (which is an extensive exercise) the glycolysis produces two end products - pyruvate (aerobic) and lactate (anaerobic). This lactate gets stored in the muscles.
I really appreciate the pedagogical character of these vids. Most biochemistry videos will just go from point to point like it's obvious. Dr.Mike regularly explains and repeats every last detail and isn't trying to squeeze it all in 3min.
pedagogical ? maybe someone has a little had too much education :p
I don't have enough words to describe how amazing Dr. Mike's teachings are. As disorienting as anatomy and physiology is (especially to people like me with social science background) his teaching makes it easy and organized to digest. I can't thank you enough for what you do. May God bless you beyond measures!!
Nah, it`s perfect in terms of "simplification". While reading great volumes of scientific papers is often hard to synthesize or even understand basic, essential concepts. The video is just enough. For further details, we can always open the book. The important thing is to understannd the systems and the following connections. Thank you! Namaste!
I had my A&P2 final yesterday. Thank you so much Dr. Mike for your videos and support during the semester. And with all respect, "the easy on the eye" it is a bonus. 🙃
Better than the Khan Academy videos. Thanks for this!
i was enlightened by this as i am always confused with gluconeogenesis and glycogenolysis. I got it now the difference. thanks for this informative video. great help! you made it so simple yet very understandable.
Respect. I am a big fan of those videos. Complicated things made simple. Thank you.
I agree.
Your teaching is awesome! How much dedicated you are! Dr. Mike, you make physiology so interesting for a non medical student. Much gratitude. Lots of Love. I'm your fan.
I learned one thing today - I eat every four hours so I am continuously in an absorptive phase.
I was eating every hour before and was sent to emergency 🚨 at 33 almost died. Now i am doing low carb, high fiber keto with intermittent fasting. From 210/140 blood pressure down to 117/77.
I really don't know what to say but thank you for this simple, very important Metabolism overview, I'm really impressed
Made much easier to understand than high school biology covering this topic.
This video is an excellent presentation of metabolism. It is a guide for studying more details and to understand their part in the big picture of metabolism.
Thank a lot. This provide just enough for non medical laymen.
I want to confirm that we need only essential fatty acid, says EPA , DHA.
🤔
Yes that is right
I better understand it when i just listened to it and not watching the video. Thanks, because this was already explained in si many videos i watched and now in a slower phase and i fully absorbed it. I have some good take away on this.
Thanks Dr Mike. I appreciate your videos and how you explain these topics. You 've made getting through biochem a little easier.
true i stumbled there also in 16:25 over the word glycerol(fats) because theres so much, glu, gly etc hahaha. by the way im a medical student. thanks for your video, highly appreciated it, Dr Mike!
Dude this just saved me...thank you so much for this video..It will now make sense when I study more into detail.
Finally, I found someone explaining the pathway to Ketones.... Thanks, A lot!!!!
Awesome! I'm going to watch this one a few more times to let it sink in. Nailed my Cranial Nerves and Cardiac testing thanks to your other videos! Thank you!
Just discovered your channel and absolutely love the simplicity in your explanations! Thank you!
Wonderfully explained about the metabolism of Proteins, glucose, glycerol and fatty acids. Very easy to understand the Kreb cycle and pyruvate mechanism. Tks for sharing this excellent video. 👍👍👍👍👌
You are a excellent teacher..
Love your podcast
God bless you Dr.Mike. I’m gonna rock my nutrition biochem grad level yay 🙌🙌🙌🫶🙏
Love your vibe man! Thanks for sharing your knowledge. I am finding it incredibly helpful and insightful!
Sending you energies of support and appreciation!
Thanks sir for making such a good video, it really helped me to understand how food is metabolize in our body , and you have a nice physique.
Greatest machine ever built ...
This is so helpful to just get an overview and understanding, Thank you!
Your teaching is awesome , it makes it easier to understand
A good way to learn from your videos you upload .much Thanks
Thank you l learned a lot and good to know this information because l am on my second week of a carnivore diet for good health.
Thank you for this insightful overview, very helpful
I love these videos. He is such an excellent teacher.
I love your videos :D however, id love to add that we have essential fatty acids we need to obtain from the diet, because the body cant make them its self and/or not in sufficient amounts. Thanks for your videos
The comments are true you’re great at what you do
What the 🤭!!! Where has this channel been?😂Your bloody-brilliant! Had my lecturers explained it like this id be ok😂 Thank goodness I found your channel. You've made everything crystal clear and connected the dot! Thank you!
Longest portion of small intestine is ilium not jejunum..... Rest of the video is just exceptional, connecting all scattered dots and MAKING A SENSE
Thank you Dr Mike
Great video...
Good job Dr Mike
It was magnificent super doctor, thanks so much for the amazing explanation ....
it makes a lot of sense
Sir it really helped alot!!! Thank you so much sir
Easy to understand even for a non-doctor like me. Thanks so much!
This refreshes me..👏👏👏❤❤❤
thank you Dr. mike this was very helpful
THIS IS SO HELPFUL. Thank you!
Doc, this is an awesome video. Thanks!
Sir you make every topic so easy to understand .. THANKS 🥰
Training to be a Paramedic and find these vids so so helpful. Just one (maybe two) questions (maybe three). Do you have a vid where you explain exactly what ATP is? Which bit of this process going wrong leads to diabetes? and/or obesity?
Thanks again
Simply, splendid. ..!!
Thank you for this video- a higher quality microphone would aide the listener-
Thankyou for the wonderful explanation, really interesting👍
Interesting...tqsm sir..may allah blss uu😊🖤
It was a very useful video for me. Thank you sir
Sir very very useful videos
you are a great teacher
Amazing explanation! Thank you...
You didn't mention the essential fatty acids EPA and DHA that our bodies cannot synthesise
This is amazing. Amazing. Thank you so much!!
Interesting. More please
Great Video
super helpful, thank your for simplifying this for me :)
thank you so much for teaching us
Wow you explained like bomb 💣thanks
Wonderful. Thank you!!
Awesome!
Thanks, you are my hero teacher ❤
wow finally got it !!! thanks
Salute sir
Respect. Great explanations🙌👍
Bless you Doc
someone get this man an eraser 😭😭😭
I get the idea and the function, great explanation. Anyone got a better diagram though? Like a more structured and easily understandable one? Reply if you got one.
Your videos are so helpful. Thanks a lot! :)
Amazing ❤❤❤
Awesome!!
When does body breaks muscle for ATP versus FAT¿ Also, is the glycogen coming from muscle or liver? Can you make a video on when body decides to break muscle or how it builds muscle and breaks fat?
I love your videos
Amazing
❤❤❤you’re the best thank you!!!!!
Doc, what happened to Oxaloacetate in the Krebs cycle ?
Oxaloacetate being the flame to burn fats.
Thank you for this material! Very helpful :) So regarding ketones you are saying that w low carb diet is not good as it creates acid? But as I understand fats are essential and carbohydrates are not. And also, why then so many people feel better when switching to a ketogenic diet? Regards :)
You are AWESOME :) thank you thank you thank you
Can you make a video on Gaba and digestion
The question is how does it get screwed up, and how to fix it after it gets screwed up.
I am diagnosed with a endocrine disorder. I have thyroid cancer and a swollen tumor in my throat. I also am diagnosed with a enlarged uterus and multiple fibroids. How are these illnesses related to metabolism and catabolism?
What decided whether fats go direct to the portal vein of the lymphatic path
The best
Good
How can lipids avoid going through the liver via the lymph, doesn't this give an opportunity for toxic lipids to get into the bloodstream? Does the lymph system also filter somehow?
Thanksssss
Careful... I would argue that lactic acid makes NADH+ (not ATP) and it is this NADH+ which can be used to make ATP. Also, your image of the mitochondria gives the impression that "hydrogen" (not a hydrogen ion (proton)) is used and the outer membrane is involved in the ATPase Pump when it is the inner membrane involved in the electron transport chain - the outer membrane is not. These are important differences. Pictures speak a thousand words... you need the correct image for the correct words.
Thank you Doctor. What you don't mention is the pathway for all this hepatic cell ATP production. Does that then get sent to tissue cells everywhere as an energy source? If so, I don't understand why you said the brain needs glucose. Doesn't it need ATP (produced from glucose)?
why is nobody talking about this man's bodyyyyyyy. like damnn he's fit.
It also goes to prove that humans do not ever need to consume a single gram of carbohydrates. Its the sugar....glucose in our diet that is responsible for so many health problems this world is facing. The keto diet is the answer. Studies have consistently shown that insulin resistance is the culprit and that metabolic disease is the real epidemic. As the clever doc pointed out....glucose is the main driving force for triglyceride formation. In fact its a great bio marker along with HbAc1 and small LDLs to test for metabolic disease. Insulin is our fat storage hormone. Consuming lots of saturated fat...cocounut oil...butter..lard..tallow..eggs..avos and all non seed oils are great sources of fats and HIGHLY recommended plus consuming beef...chicken...pork...mackeral..sardines.....and eggs including cheese for protein. If the worlds population completely stopped consuming all simple and complex carbs including bread..rice and pasta..including fruit..yes fruit.. ...alcohol and stopped smoking...the worlds health would drastically improve and one would have a weight issue. So many do not understand that glucose is the real reason why LDL has such a bad name...its actually healthy to have BUT its the sugars in particular fructose which damage the LDLs because it affects the apo b100 marker.. the science is clear about this. You will lead a long life if you dont smoke..dont drink alcohol...stop eating all carbs...exercise...sleep..and consume high fats and moderate protein.
It is very simplistic to turn one macronutrient into the main villain of the health story. Sure, excess sugar is bad, but it is not the complete story. Low-carb is not the answer to health.
@@metalmusi it is the main problem. You need to learn more. Carbs are not needed at all by humans not a single gram. You dont eat what a body doesnt need. Its this that gets us into trouble especially when the randle cycle is activated.
What is the name of the enzyme that needs glucose available for the Krebs?
Hi - great video. Thanks for sharing - 4.45 min in to the video you mention and draw the big square. What do you call it? Hepatic??? Difficult to hear.
Please help
Hepatocyte
NMN OR TRU Nagen?
In the anaerobic case, what is the purpose of going from pyruvate to lactic acid to ATP when I can already go from pyruvate to acetyl coA to ATP?
And when I am missing glucose, why produce ketones when I could go from glycerol/amino acids to pyruvate to glucose, and run the Kreb's cycle normally?
I kinda have the same thought with you for ur second idea. For the first one, i think when the aerobic pathway does not produce sufficient energy for the intense activity that we do, the anaerobic pathway would come in the picture to help out and both pathways would be used at the same time.
@@543sam210 Looking at en.wikipedia.org/wiki/Cori_cycle, it seems that the anaerobic pathway actually net consumes ATP, but uses ATP preferentially from the liver rather than from muscles. This seems to shift the calculus away my original thoughts about solely maximizing ATP output. As for the second case, en.wikipedia.org/wiki/Ketogenesis suggests to me that ketogenesis only ramps up on simultaneous deprivation of glucose and Krebs cycle intermediates such as oxaloacetate. What causes a shortage in Krebs cycle intermediates and the degree to which glucose and Krebs cycle intermediate shortages correlate is unclear to me.
So if weight lifting creates lactic acid (which is then used for energy), and the lactic acid builds up in the muscle being stressed, is the lactic acid being produced in the muscle or is it being produced in the liver and merely used by the muscle?
As much I remember, while weight lifting (which is an extensive exercise) the glycolysis produces two end products - pyruvate (aerobic) and lactate (anaerobic). This lactate gets stored in the muscles.