You are the reason m getting good grade in biology, m a veterinary doctor and currently pursuing master degree, i have read many notes from different sources but the most simplified form of understanding came from ur lecture sir. Thank you
Can't thank you enough for speeding up the drawing! Helps me make connections without losing my train of thought from watching someone draw a picture for 30 seconds at a time
You have just saved me from days of avoiding revising this because the text books are so confusing. Thank you so much!!!!!!!!! You're so brilliant at explaining with your talent!!!!
The calcium that binds to Troponin-C comes from the Ryanadine receptor (Ca Release Channel) which is located on the Sarcoplasmic Reticulum (Ca is stored in the Terminal Cisternae of the SR).
Great job explaining. Best one I've seen yet. Keep it up man you're gonna help a lot of people get A's on those Anat/Phys tests. Especially the muscular unit exam I have tomorrow morning...
I Just want to let you know your Video has basically saved me on my anatomy final! thank you so much for putting this in "Layman's Terms" this is so wonderful and I'm so incredibly thankful!!!!!
I think you might have the role of ATP slightly wrong, ATP is required to release the myosin-actin cross bridge. Like rigor mortis - upon death Ca2+ flows into cells which allows the myosin-actin binding, however since there's no ATP muscles remain tense. Other than that though it was a good video.
She's actually correct, check any physiology textbook. In a muscle contraction it is a very very brief stage of the tight attachment, then ATP binds and myosin is able to release the actin. In rigor mortis, as there is no ATP, it remains attached, hence the rigor. @@sarahmueller335
Want to thank you very much for your time and effort into not only editing and making this video, but drawing everything out and explaining it. Really do appreciate it. Personally. Thank you.
So looking forward to the "Sliding Filament Theory"!! Bless you,@armandohasudungan- you're an amazing human being both for your artistic style and your simplified prose. look forward to the SFT
Wow, bravo on your skeletal muscle contraction video! We totally needed to hear about calcium binding to troponin about 47 times - because, you know, once just wouldn’t cut it for our poor, struggling brains. Your relentless repetition really hammered home the point that troponin moves tropomyosin, as if we were auditioning for a role in "Dumb and Dumber: Anatomy Edition." Maybe next time, try explaining it in Morse code or interpretive dance, just to keep it fresh. Thanks for the overkill - you truly have a gift for turning a simple concept into a marathon of monotony.
bro you are a genius! they say if you cant explain something simply then you dont understand it enough! this goes for 90% of people teaching physiology and 90% of the you tube videos! all your videos so far have been incredible best source i have seen yet!!!! please make more of these brillant clips as i (and many others) are keen to learn! (ps can u do the sliding filament theory one b4 next thursday as i have an exam lol cheers!)
Amazing the creativity of drawing and explaining makes your work so much easier to understand. Honestly i learn more on this channel than i do in school.......and im a medical student. So thank you. P.S new subscriber :)
Great videos and combination of fantastic artwork and clear explanations. I will be using these throughout nursing school. Thank you so much for making these.
Omg please tell me you have a video about how the smooth muscle works, not just the introduction to it! Eeek! You are AMAZING by the way and once I found your videos I shared them with my entire phys and anatomy class :)
just a small correction idk if i am correct or not but the ATP at the end (5:13) should be ADP plus a seperated phosphate group because the muscles need ADP for the power stroke and for contracting the muscle but need ATP to relax the muscle and disassociate myosin from actin.
+Karna priya yes you're right. BTW ATP is not needed for muscle contraction, Ca is and in smooth muscle the addition of phosphate. ATP only causes the myosin to unbind from the actin aka relaxation. This is what causes rigor mortis, the lack of ATP.
+Ishwar Raghu Thanks for the troll, btw I agreed with him and gave the clarification in case anyone needed it; however maybe you've been using google translate because you did exactly what I did. Without ATP the muscle will stay contracted until the muscle fibers deteriorate. Thanks for adding nothing to this conversation
+Ishwar Raghu I said ATP only cause myosin to unbind from the actin aka relaxation. This is what cuases rigo mortis, the lack of ATP...therefore the muscle is always tight because it cannot relax no ATP. Whatever I don't care any more. As for your question, myosin after it is relaxed hydrolyzes the ATP and returns to its cocked or excited state. That means that once Ca binds to tropinin C to move tropomycin out the way mysin can bind to actin and pull. Think of it like cocking your arm back before you through a ball. Myosin bound to ADP and Pi is waiting to bind and have that power stroke or throw the ball. I hope that makes sense
if I may add, actin is a dimer. We called it "fake helix". It's not a monomer that combine together to become a double helix. It's different. You can do more research for your video about "actin formation". And you'll find out.
Nice video, but unfortunately the role of ATP is stated a little differently than what research is saying at the moment. ATP is needed to RELEASE the myosin from the actin and it has to be ADP+Pi to be able to extend to bind again in the next round.
OMG !!!! ,, This is the most outstanding teaching performance that I've ever witnessed in my entire Fucking life. thank you so much and you are a true hero indeed.
dude, Youd made an excellent video about the parts of a muscle and the contraction of the muscle. Bro, would you make a video about the sliding filament theory soon?
Wow! Wonderful teaching, bro!! Though I've never met any UA-cam lecturer who begs for shares, and likes as much as you do. I just feel guilty not to share! *Shares video on Google+, Twitter, Facebook, Pinterest, WhatsApp, BBM, MySpace, Viber, TrueCaller, uTorrent, etc. hehe!*
Please, if you cannot appreciate somebody's effort at least do not criticize it. he might have an intention of reaching to those students who are struggling to understand these topics but do not know about it. very few people can explain things they way he does. Come out of the closet of stereotyping, please.
DANG IT :( Studying for my finals and your videos were helping so much and one on the sliding filament theory would have been so amazing! But thank you. You're so great at explaining.
📌MAKE THIS LECTURE STICK: FREE PRACTICE QUESTIONS HERE! 🎓
youmakr.ai/test-playground/questionnaire/673d5236859b9c170836f28b
I was here 4 years ago when I started vet school, here I am now watching this again as I prepare of my licensure exam.
same, for RPN and now for RN
It must feel nostalgic
Here for DPT. Figure I’ll be back for the licensure exam as well
Here now studying for a physiology exam while also working on VMCAS :')
You are the reason m getting good grade in biology, m a veterinary doctor and currently pursuing master degree, i have read many notes from different sources but the most simplified form of understanding came from ur lecture sir. Thank you
Can't thank you enough for speeding up the drawing! Helps me make connections without losing my train of thought from watching someone draw a picture for 30 seconds at a time
You have just saved me from days of avoiding revising this because the text books are so confusing. Thank you so much!!!!!!!!!
You're so brilliant at explaining with your talent!!!!
The calcium that binds to Troponin-C comes from the Ryanadine receptor (Ca Release Channel) which is located on the Sarcoplasmic Reticulum (Ca is stored in the Terminal Cisternae of the SR).
Great job explaining. Best one I've seen yet. Keep it up man you're gonna help a lot of people get A's on those Anat/Phys tests. Especially the muscular unit exam I have tomorrow morning...
what grade did u get
I Just want to let you know your Video has basically saved me on my anatomy final! thank you so much for putting this in "Layman's Terms" this is so wonderful and I'm so incredibly thankful!!!!!
you became a part of the curriculum! :D my Anatomy teacher makes us take notes of two of your videos. :D
I think you might have the role of ATP slightly wrong, ATP is required to release the myosin-actin cross bridge. Like rigor mortis - upon death Ca2+ flows into cells which allows the myosin-actin binding, however since there's no ATP muscles remain tense. Other than that though it was a good video.
Nope, you are confusing two total different situations: rigor mortise and voluntary muscle contractions.
She's actually correct, check any physiology textbook. In a muscle contraction it is a very very brief stage of the tight attachment, then ATP binds and myosin is able to release the actin. In rigor mortis, as there is no ATP, it remains attached, hence the rigor. @@sarahmueller335
@@sarahmueller335 She is correct, ATP is used to release myosin head from actin, not to bind
My teacher introduced me to your videos and I love them. Thank you so much for helping me understand anatomy better.
Cristine401 this is not anatomy lol
Want to thank you very much for your time and effort into not only editing and making this video, but drawing everything out and explaining it. Really do appreciate it. Personally. Thank you.
So looking forward to the "Sliding Filament Theory"!! Bless you,@armandohasudungan- you're an amazing human being both for your artistic style and your simplified prose. look forward to the SFT
Great video, Armando. And I'm not being sacrastic.
KnowJesusKnowPeace Good one.
I know these videos are a little older, but they have been a great help to understand my A&P class better. Thank you
Wow, bravo on your skeletal muscle contraction video! We totally needed to hear about calcium binding to troponin about 47 times - because, you know, once just wouldn’t cut it for our poor, struggling brains. Your relentless repetition really hammered home the point that troponin moves tropomyosin, as if we were auditioning for a role in "Dumb and Dumber: Anatomy Edition." Maybe next time, try explaining it in Morse code or interpretive dance, just to keep it fresh. Thanks for the overkill - you truly have a gift for turning a simple concept into a marathon of monotony.
This is soooo helpful! My professor gave the same lecture today but you are far more clear and concise.
Shoutout to your actin and myosin drawing for these amazing videos
I have an anatomy exam in two days. thank you for saving my life with these videos!
bro you are a genius! they say if you cant explain something simply then you dont understand it enough! this goes for 90% of people teaching physiology and 90% of the you tube videos! all your videos so far have been incredible best source i have seen yet!!!! please make more of these brillant clips as i (and many others) are keen to learn! (ps can u do the sliding filament theory one b4 next thursday as i have an exam lol cheers!)
Amazing the creativity of drawing and explaining makes your work so much easier to understand. Honestly i learn more on this channel than i do in school.......and im a medical student. So thank you. P.S new subscriber :)
sARCOmere... its killing me
Best videos though, thank you!
why? i don't get it
oh, i see, he says the whole time sacromere...
I am mindblown over how good this actually was! U my man, are THA bomb!
where is the link for sliding filament theory ??
This is the sliding filament theory
Sorry bro, havent made one yet, hopefully soon
Wow! This video is great! What I didn't learn in an hour in class I learned in a 6:15min video. Thanks!
Helps a lot to actually watch it being explained than just reading it from the textbook. Thanks
Thanks for wonder video. A sarcomere (Greek σάρξ sarx "flesh", μέρος meros "part") is the smallest functional unit of striated muscle tissue.
Great videos and combination of fantastic artwork and clear explanations. I will be using these throughout nursing school. Thank you so much for making these.
This video is soo amazing!What took me months to understand was summarized in 6 minutes!
Thank you soo much :)
this is the most amazing way u in which can serve youngsters do better and learn better .. ! i m in love with the way u work ! thanku so much sir :)
thank you so much. you have no idea how clear this topic is now
I have never seen any one to explain in this amazing way and unforgettable. ..well done wish you success
Just wanted to thank you. You were my time saver during my DAT studying period. Thanks! :)
how did your DAT go? i have my MCAT in 4 days :(
I haven't done it yet! Its near!!! :(
.
Omg please tell me you have a video about how the smooth muscle works, not just the introduction to it! Eeek! You are AMAZING by the way and once I found your videos I shared them with my entire phys and anatomy class :)
Thank you very much. Universities should give you an Honorary Doctorates Degree for your work!
I was here 6 years ago when I started Dental School and am again preparing for my licensure.
just a small correction idk if i am correct or not but the ATP at the end (5:13) should be ADP plus a seperated phosphate group because the muscles need ADP for the power stroke and for contracting the muscle but need ATP to relax the muscle and disassociate myosin from actin.
+Karna priya yes you're right. BTW ATP is not needed for muscle contraction, Ca is and in smooth muscle the addition of phosphate. ATP only causes the myosin to unbind from the actin aka relaxation. This is what causes rigor mortis, the lack of ATP.
+Ishwar Raghu Thanks for the troll, btw I agreed with him and gave the clarification in case anyone needed it; however maybe you've been using google translate because you did exactly what I did. Without ATP the muscle will stay contracted until the muscle fibers deteriorate. Thanks for adding nothing to this conversation
+Ishwar Raghu I said ATP only cause myosin to unbind from the actin aka relaxation. This is what cuases rigo mortis, the lack of ATP...therefore the muscle is always tight because it cannot relax no ATP. Whatever I don't care any more. As for your question, myosin after it is relaxed hydrolyzes the ATP and returns to its cocked or excited state. That means that once Ca binds to tropinin C to move tropomycin out the way mysin can bind to actin and pull. Think of it like cocking your arm back before you through a ball. Myosin bound to ADP and Pi is waiting to bind and have that power stroke or throw the ball. I hope that makes sense
thanx
THANK YOU SO MUCH !! this made skeletal muscle physiology much easier for me .
Armando, thank you for these videos! It's interesting so much to see it! You are very talanted!
Thank you for existing man!
Wonderful method and diagram
I never saw a method like this
Keep it up sir 💕💕💕💕💕
Sliding filament theory was basically explained. Calcium comes from an action potential ie. nerve conduction on to muscle. Hope that helps x
Omggg thank uuu so muchh for thiss,my teacher literally explained this in 2 hours
if I may add, actin is a dimer. We called it "fake helix". It's not a monomer that combine together to become a double helix. It's different. You can do more research for your video about "actin formation". And you'll find out.
you are amazing at this way better than any of the famous stuff even better than khan academy! You should start your own thing like that
He is a doctor
it is explained very well!!!
Amazing. Beautiful illustrations make the concepts very clear.
Thank goodness for Armando. !!!
Your videos on skeletal muscle contraction are very well done. Thanks for helping me study!
I love it .. please upload cardiac muscle and smooth muscle full description
nice u cleared all my confusions abt this theory .ur diagrams are so neat and clear
Thank you! You've made that sooo much easier than reading a text book!
I LOVE U MAN SRSLY!!! 2 HOURS OF LECTURE EXPLAINED IN 6 MINUTES!!
Sir your way of explaining with diagrams is amazing 👍please Keep it up
Your videos are the best for understanding the details. Thank you
This makes so much sense, I am so happy I found these video’s before my exam!
same here siso
you are wonderful, I'm so glad I came across your videos. A&P is kicking my butt!
Nice video, but unfortunately the role of ATP is stated a little differently than what research is saying at the moment. ATP is needed to RELEASE the myosin from the actin and it has to be ADP+Pi to be able to extend to bind again in the next round.
excellent explanation and awesome diagrams!
Thank you so so so much for your time and contribution for doing this excellent video for us!
OMG !!!! ,, This is the most outstanding teaching performance that I've ever witnessed in my entire Fucking life. thank you so much and you are a true hero indeed.
this is outstanding explanation of SLIDING FILAMENT THEORY..Amazing..
thank you, one of the best video on the net
dude, Youd made an excellent video about the parts of a muscle and the contraction of the muscle. Bro, would you make a video about the sliding filament theory soon?
Truly great stuff. Keep it up, man! I'm sure you've saved many students from the arduous task of learning this from a badly worded textbook ;)
Brilliant videos! You make the tough stuff much easier to tolerate.
you are the greatest man ..much love
Wow! Wonderful teaching, bro!!
Though I've never met any UA-cam lecturer who begs for shares, and likes as much as you do. I just feel guilty not to share!
*Shares video on Google+, Twitter, Facebook, Pinterest, WhatsApp, BBM, MySpace, Viber, TrueCaller, uTorrent, etc. hehe!*
Please, if you cannot appreciate somebody's effort at least do not criticize it. he might have an intention of reaching to those students who are struggling to understand these topics but do not know about it. very few people can explain things they way he does. Come out of the closet of stereotyping, please.
Congratulations!!!Your amazing explanation helped me a lot .
dude this is very helpful! I've seen this video 3 times.
Thanks a lot
Hi. Great video. I cannot find your sliding filament theory video. Can you please direct me to it? Thank you in advance.
Excellent video and straight to the point
Big bros
thanks, you always make things so easy to understand
honestly i have to comment again, the video is excellent
thank you g
Your drawings are so good!
You're so awesome!! thanks for sharing! It was a great idea to draw it out and explain it. I was able to understand it.
just for you guys to know, i think the atp binding site of myosin is the same as the nucleotide binding site, since my textbook calls it that!
ATP is a nucleotide. it;s generic name is nicleotide.
GREAT!!!!!!! Keep doing that, because you are doing an extraordinary job!
Very helpful. Thank you! Studying for my PT Recert and NASM doesn't quite go into depth like this.
wow, i have never heard a better explanation of this process. thank you!
You're amazing! I love your lectures. thank you!!!
Excellent video!
Wish there was a download link for this one too. truly awesome videos thank you
DANG IT :( Studying for my finals and your videos were helping so much and one on the sliding filament theory would have been so amazing! But thank you. You're so great at explaining.
Amazing work bro ... Keep it coming ❤️
such a clear and well explained video. extremely helpful.
Oh my god !!
Your drawing skills are dope
Thankyou sir☺
There's an annotation at the start regarding that.
You are my favorite teacher!
realy
Where is the sliding filament theory? Ur video is great btw!
your videos are helping me a lot!!! thank you thank you thank you !!
Extremely helpful. Well done! 👍
You are so incredible with the knowledge u explain with art 💞
THANK YOU!
really nice work there!
You are doing good job sir...thak u so much..love from kashmir
Great job pal
So useful thanks Armando
very good video and well explained,
Where is the filament theory