If we're not what we assume (LTD) we are but what we grow (LTP) to become, might there be room for mechanisms involved in neurodegeneration to reside outside of the brain?
Schizophrenia, yes; dysregulation of adolescent synaptic pruning (a function normally carried out by microglia) is a leading theory for the developmental mechanism of schizophrenia. I don't think it's as likely for depression, or at the very least it's not being as heavily looked into as a possibility. The predominant neurological theory for depression still centers around regulation of monoamine neurotransmitters.
@@gangstercomputergod9362 My personal sensation is that my depression is also a chronic state … with Prozac the high and low waves equalize somehow. But it seems to be a continuous pull towards “eliminate” those “positive” connections, therefore I wonder if it is a malfunction of microglia as well. Just a thought
@@germancavelier8434 There is a lot of converging evidence, and recently some more direct evidence, that microglia are playing a part in depression pathology. We know that synapse loss induced by chronic stress, particularly in the prefrontal cortex and hippocampus, is related to the manifestation of depression-like behavior. It is also well known (at least among those who study it) that inflammation in these brain regions generally occurs secondary to stress and can play a causal role in behavioral outcomes. If you’re interested in the microglia/depression story, a good place to start would be with recent reviews and work by Eric Wohleb’s group at the University of Cincinnati. Good luck!
My wife Carolyn loves your videos, which make a complicated subject so much easier to understand. Many thanks.
Most interesting finds! Thank you so much for this utterly educational video.
Essential information. Where can I learn more?
Are these processes involved by ion influx?
If we're not what we assume (LTD) we are but what we grow (LTP) to become, might there be room for mechanisms involved in neurodegeneration to reside outside of the brain?
Wonderful findings! How about depression? Has this been linked to depression or schizophrenia?
Schizophrenia, yes; dysregulation of adolescent synaptic pruning (a function normally carried out by microglia) is a leading theory for the developmental mechanism of schizophrenia.
I don't think it's as likely for depression, or at the very least it's not being as heavily looked into as a possibility. The predominant neurological theory for depression still centers around regulation of monoamine neurotransmitters.
@@gangstercomputergod9362 My personal sensation is that my depression is also a chronic state … with Prozac the high and low waves equalize somehow. But it seems to be a continuous pull towards “eliminate” those “positive” connections, therefore I wonder if it is a malfunction of microglia as well. Just a thought
@@germancavelier8434 There is a lot of converging evidence, and recently some more direct evidence, that microglia are playing a part in depression pathology. We know that synapse loss induced by chronic stress, particularly in the prefrontal cortex and hippocampus, is related to the manifestation of depression-like behavior. It is also well known (at least among those who study it) that inflammation in these brain regions generally occurs secondary to stress and can play a causal role in behavioral outcomes. If you’re interested in the microglia/depression story, a good place to start would be with recent reviews and work by Eric Wohleb’s group at the University of Cincinnati. Good luck!
Nice
After this talk, iBiology changed its style to shorter and shallower videos. What a pity!
Golgi stains from dead kids I take it? Damn
In 100 years we'll make progress in neurology. Until then it's pretty pics all the way down