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- Опубліковано 18 чер 2019
- Rexulti improves symptoms of schizophrenia but is principally advertised as an add-on therapy for lingering symptoms of depression not satisfactorily improved with ongoing antidepressants. Rexulti appears to be a successor to Abilify - another similar atypical antipsychotic drug.
Questions exist regarding the wisdom of prescribing atypical antipsychotic drugs for treatment resistant depression. Weighing the potential benefits against the very real risks of significant harm leads some to doubt any advantage of Rexulti. The drug causes tardive dyskinesia - a movement disorder that typically persists long after discontinuing the drug. It also leads to weight gain, diabetes, increased cholesterol, falls and impulsive behaviors. Both fatal and non-fatal stroke may occur.
The Canadian health authorities appear unimpressed with Rexulti and recommend against its use in typical depression. Similarly a Veterans Administration study demonstrated relatively equivalent results with adding another antidepressant or switching to a different antidepressant.
The cash price for Rexulti exceeds $1100.00 a month compared to less than $25 for the generic versions of Abilify, Zyprexa, Resperdal or Seroquel.
Idec what side effects rexulti MAY cause. I'm still gonna take it cause as someone with bipolar disorder, this is honest to God the only medicine that's really helped me and I've been on almost everything
jennifer Palumbo it’s an amazing drug
Same
Any side effects? I'm bp2
@@Just_vi2weight gain, makes you tired as well. (My experience)
Wow, my doctor gave this to me to take with Cymbalta which was prescribed for Fibromyalgia. I started getting depressed because I lost my job due to slow recovery from obstructive sleep apnea and fibromyalgia. He said that if the depression wasn’t manageable to take rexulti. He gave me a starter pack. I’m glad I saw your video before taking it.
You're the best doc.I love to watch your videos :D
Many thanks for the thorough video.
Helped me with intrusive thoughts of suicide and self harm. First time in 12 years since I was diagnosed.
Still help?
Fantastic video. thank you!
Glad you liked it!
Tried it with SSRI. Overheating body temperature binge eating insomnia
Thank you! I
Been on this a month it’s an amazing medication however for me it is fairly sedating ( 1mg dose)
Graeme Nunes I love being sedated 👌🏻
I was on it for 2 years for Schizoaffective disorder. I loved it because it was the only anti-psychotic I've been on that didn't have any side effects on me. But unfortunately it stopped working after a couple years. Now I take Invega, which has it's pros and cons. Do you by chance have a video on Invega?
It is interesting that you had a severe akathisia reaction while on Abilify and 2yrs on Rexulti no such reaction although it is supposedly the same chemical formula. What if this drug gives its specific positives only to a subset of patients (like all APs), but who would otherwise have a bad reaction on Abilify (1 in 4 patients on 15mg Abilify ends up in emergency for akathisia). Maybe only those patients are the target for Rexulti: try Abilify first, but severe reaction => try Rexulti.
While on Rexulti for 2yrs, what was your LDL, HDL, Total, Triglycerides, HbA1c (ideal HbA1c level is 48mmol/mol (6.5%) or below. If you're at risk of developing type 2 diabetes, your target HbA1c level should be below 42mmol/mol (6%)) at the end of 2yr period?
@@Burevestnik9M730 Yeah that is a good possibility.
@@corymodzeleski7191 When it stopped working, did you increase the dosage or you were already on the highest dosage?
I experienced fairly significant impulse control issues while on Rexulti and needed to stop the medication. What is the underlying mechanism of this as I know it is an adverse side effect of its close cousin, abilify
Not sure if you're still interested in this, but it's because of the activation that the Dopamine D2 receptor, we'll just heavily involved in pleasure seeking and enjoying activities. Abilify and Rexulti both act as Partial Agonists at this site, unlike almost every other antipsychotic which are D2 antagonists. Antagonists bind to and fully block the action at a receptor site. Agonists Will bind to and stimulate action at receptors similar to the way free floating dopamine well touch that detail receptor and give you the "feel goods".
These medications have the Goldilocks Effect because they are partial agonists meaning that they can theoretically lift low dopamine levels and reduce overabundant dopamine levels.
They bind to the site and in the presence of low dopamine transmission (depression), will boost dopamine activity in their own right. In high concentrations of free androgenous dopamine floating in the synapse (schizophrenia), you are still getting some activation because the medication is sitting on the receptor and causing some sort of intrinsic activity, but still blocking/reducing levels overall.
All that being said, typically it tends to be very balancing for many, but for those sensitive to the acts of dopamine and dopaminergic transmission, in both control and dopaminergic transmission, impulsivity and hedonistic activity can increase.
Hope that helps! :)
rexulti was a good drug no cap
Getting to know how much Rexulti costs in the US is shocking. In Brazil I pay less than 50 USD for a month of the medication.
Você ainda está em tratamento com rexulti? Está gostando?
@@ilaVLira Eu gostei bastante, foi muito mais eficiente do que risperidona, mas tive que parar por causa do preço. Agora estou com risperidona, escitalopram e ritalina, após ter o diagnóstico te TDAH + TOC e TAG. Está sendo incrível, me sinto vivo, motivado e feliz pela primeira.
@@PeppaPicky que bom, Pedro. Não sei meu diagnóstico ainda. Talvez seja distimia com ansiedade. Comecei pela primeira vez um tratamento medicamentoso há 25 dias: 10mg de escitalopram e 50mg de quetiapina.
Não sei se estou melhorando. Estou pesquisando opções. Acho que o Rexulti pode potencializar o antidepressivo.
@@PeppaPicky você teve algum efeito colateral?
@@ilaVLira Que bom que você começou o tratamento, Ila! Minha adaptação ao escitalopram foi muito difícil, piorou muito a ansiedade, mas depois de três meses cheguei na dose adequada para mim e agora tô ótimo.
Meu marido tem distimia e respondeu muito rápido ao tratamento (Venlafaxina e Bup).
Desejo uma melhora rápida no seu quadro. Nunca desista. A psiquiatria é muito artesanal e é baseada em tentativa e erro, mas quando bem feita ela muda a vida da gente.
Lord... I appreciate the time and effort you took to try to explain this new compound, but the structure and the linearity of your explanation is anti psychotic prescription-worthy.
I have peptic ulcers is this viable to use
I stopped it about 6 weeks ago reducing over about two months. I was on Latuda for many years then brexpiprazole for about 6 months. I started getting some blepharospasm and the was one of the reasons I went off of it. I am still getting blepharospasm. Can withdrawal from brexpiprazole cause this?
Help, I just just 0.5mg for the first time (prescribed by a psychiatrist) and I CANNOT stop crying! I am just in a frenzy now, I flushed the rest of the pills down the toilet, I don't know what to do, this is scary
How long did you take it for?
Damn it Dr. Landow. Just got prescribed Rexalti today and am scared to take it now.
same, any update for us lol
This medication caused uncommon events of rage. I stopped it after about 2-4 weeks.
@Anthony Supar I experienced feelings of anger and rage on a level that was not customary to my personality while taking this medication. I responded to people around me more aggressively and just overall felt more angry than usual. Also my anger was more difficult to control. This wasn't the intended purpose for the medication so I called my doctor and stopped taking it.
@Anthony Supar In my case, it was prescribed as a mood stablizer in conjuction with an antidepressant, but it didn't work well for me at all.
@Anthony Supar It was crazy! lol It was a bad fit for me it may be different for you. Talk with your doctor right away about any concerns you have. Good luck.
Can you do a video on trileptal?
I use this for schizoaffectice disorder. Does anyone have any opinions on Rexulti?
I don’t know about the accuracy of what you’re saying but the depth and detail with such fluent delivery gives me have faith in your knowledge.
Thank you for such an elaborate explanation and quality video.
*Consider having the microphone closer to your mouth*
I just started it, my anxiety is spiking. I'm stopping
Thank you. Have you done a video on Latuda?
Lutruda did me no good plus you have to eat with it just saying
Latuda I meant
Latuda is the best for me
ua-cam.com/video/gnwDG2Af764/v-deo.html
Made me feel like uncomfortable and had negative impacts on my eyesight
I love his voice tone, looks like professor McGonagall
I was prescribed this for the low price of $1400 a month. I said hell no.
My husband's taking 40mg of this. It's been working for him so far. There was an adjustment period though. With our insurance, we pay $15 for a month's supply.
Rex Benten 40 mg ?! 😳 I’m on 1mg and get it from my doctor for free
@@rexbenten8309 don't you mean 4mg no 40mg?
Pobably @@tagaway6173
This intro "music" is really irritating. How about attenuate it and then whoever longs for it, he can increase the volume?
Rexulti is not Abilify, use Rexulti not Abilify for less side effects. College of Pharmacy UICC, Chicagoland.
per month Rexulti costs. 1480-dollars 1700 at Walgreens
Bad drug in my opinion.
Wow way to scare people from trying this drug….guess it’s better to just stay depressed 😮
Add weed to it. Might as well go all the way. Glory to meds.
Terrible drug!!!!! Made me figety, made anxiety worse! Headache since i started taking it. I had to stop it. Just remember everyone is different
Did your symptoms go away?
why would you claim it is a terrible drug if you acknowledge that everyone reacts differently?
Sounds like side effects
Me, too. After two doses, too!
It's just a waste of time and money.
This is all complete insanity. Just stay with the depression, sit with it, and see it. Take your time and you can overcome.
That’s like saying Just simply sit with being diabetic, you can overcome.
This is simply stupid.
I used to be this ignorant as well. Now I'm 32 and was just diagnosed bi-polar after trying to just "deal with it" for 17+ years.
@@jordandahm9586 Trying to help here ok? Do you have any idea what could be causing the bipolar with the up and down mood if that’s what you’re experiencing?
@@TheYogimind they’re literally telling you it’s chemical. Just because you don’t have clinical depression or mood swings that deal with hormonal imbalances doesn’t mean they don’t. I’m glad you were able to work out whatever life events that were causing your depression but other people may not be in the same boat and choosing to ignore it because it’s not your experience is ignorant my guy.