Coagulation Cascade | Part 1/12
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- Опубліковано 29 вер 2024
- #drnajeeb #medicines #pharmacology #physiology #coagulation
Coagulation Cascade | Part 1/12
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Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin.
Coagulation begins almost instantly after an injury to the endothelium lining a blood vessel. Exposure of blood to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial tissue factor to plasma factor VII, which ultimately leads to cross-linked fibrin formation. Platelets immediately form a plug at the site of injury; this is called primary hemostasis. Secondary hemostasis occurs simultaneously: additional coagulation (clotting) factors beyond factor VII respond in a cascade to form fibrin strands, which strengthen the platelet plug.
Disorders of coagulation are disease states which can result in problems with hemorrhage, bruising, or thrombosis.
Coagulation is highly conserved throughout biology. In all mammals, coagulation involves both a cellular (platelet) and a protein (coagulation factor) component. The system in humans has been the most extensively researched and is the best understood.
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I have never understood completely the Coagulation process. It seemed complicated and not that logic. But thanks to you, doctor Najeeb, I took a ten today at Physiopathology. Thank you so much, you're a fantastic teacher! :)
isn't it "pathophysiology"?
@@zakirehman9023 yes of course
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WOW Dr Najeeb. You are excellent. When I was in med school had to read this stuff in a pictureless text book. Now students can learn this same material on youtube. You really made the coagulation cascade much more clearer.
Hy
now if you can teach at my university as well that will be great
In short..
Coagulation is a serious of cascade reactions that ultimately produce fibrinogen that produces fibrin fibers that are for clots.
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