Oxygen Hemoglobin Dissociation Curve - Comprehensive and Clear Explanation!

The Oxygen Hemoglobin Dissociation Curve, also known as the Oxyhemoglobin Dissociation Curve, is a critical concept. Understanding this provides a foundation for a number of pathophysiologic processes key in the understanding of physiology.
In this video, we dive into these concepts. We start by discussing what makes up oxygen content in the blood and how that differs between the arterial system and venous system. We discuss gas exchange of oxygen and carbon dioxide at the capillary level. We then define key concepts like oxygen content (with the equation), dissolved oxygen (PaO2), oxygen saturation (SaO2, SpO2). We dive into red blood cells, hemoglobin (subunits), oxygen binding capacity of hemoglobin, tense vs relaxed states, tissue-lung interface, and more. After that, we use all of these concepts to establish what the normal oxyhemoglobin dissociation curve is before discussing abnormal including left shifts, right shifts, Bohr's Law, and more!
Introduction to Capillary Gas Exchange, Arterial vs Venous Systems, Oxygen Content: 0:00 - 6:11
Defining Oxygen Content, Oxygen Saturation (SaO2, SpO2), Dissolved Oxygen (PaO2): 6:12 - 12:48
Red Blood Cells, Hemoglobin Structure (subunits), Oxygen Binding Capacity, Tense vs Relaxed, Lung Tissue Interface: 12:49 - 20:01
Relationship Between SaO2 (SpO2) and PaO2 or Oxygen Saturation and Dissolved Oxygen: 20:02 - 24:17
Normal Oxyhemoglobin Dissociation Curve: 24:18 - 28:54
Right Shift, Left Shift, Bohr's Law, Bringing it all Together: 28:55 - 37:35
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[@pinschrunner]

We LOVE @Whiteboard Medicine
Good morning 🌄

[@WhiteboardMedicine]

Good morning! We appreciate you!

[@debigdogk9563]

Waoooooo!!!!!! This my friend is the best video explaining this concept. I am really glad i found your video. God bless you for teaching and sharing ❤❤❤❤❤

[@WhiteboardMedicine]

Always our pleasure! Thanks for the kind words!

[@m_c_8656]

Thank you, Whiteboard!

[@WhiteboardMedicine]

Always our pleasure! Thanks for checking out the video and for commenting!

[@GumriRN]

My questions are, why hasn’t any physician named the exchange segment between the O2 capillaries & the CO2 venules? Or have they?
The value at that point in circulation
could be another good indication of how O2 is effectively being used.
And 2nd question w Carbon Monoxide Poisoning are they Right Shifted ergo, CO2 poisoning makes mucus membranes Ultra Red because Cells are holding on to hemoglobin & they’re saturated & can’t release it? Maybe I’m confused. 🤔 😊

[@WhiteboardMedicine]

Great questions across the board! Both the O2 and CO2 exchange happens in the capillary. The capillary is fed by the arterioles (oxygenated blood) and are drained by the venues (deoxygenated and CO2 rich blood) if that makes sense!
As for the second question, interestingly that cherry red blood sometimes quoted with carbon monoxide poisoning is from the hemoglobin molecules being saturated with CO! We are considering putting out a video on carbon monoxide poisoning in the future!