What is the effect of thrombolytics like nattokinase on kidneys, notably the nephrons? Do all these dissolved clots end up passing through the kidneys and if so, why would that not show up in degraded kidney performance?
Thank you for uploading! After being a functional food(Natto) for over a thousand years it amazes me why more studies aren't done on Nattokinase? I shared here before how it helped me. The recommended 2000fu is way too low in my opinion. Store bought Natto comes in portion size of approx 2000fu. I didn't start seeing results until i increased the dosage to 5000-6000fu twice per day. Severe claudication and shortness of breath are a thing of the past. BP is near normal now. I also take Glynac at 7grams per day, 3.5g twice per day. I think this protocol should be mandatory for over 50's.
because western medicine intends to keep ppl sick, then treat them, not cure them. why would they do studies on a substance they cant patent that can cure and prevent their money making sicknesses? thats pretty simple to answer
_"After being a functional food(Natto) for over a thousand years it amazes me why more studies aren't done on Nattokinase?"_ Probably because nattokinase does not have oral bioavailability and thus there is no plausible mechanism for working.
Nicolas, I cannot thank you enough. I just got done listening to the full version over on, insiders. I had asked only a short time ago you review one study that was being promoted, I am sure many others appreciate your analysis and asked as well. Thank you for putting out all the free information that you do!
I would have loved to see these studies applied to Long Covid patients. It is one of the most talked about and positively regarded supplementation for Long Covid. I would love to try out to see if my symptoms improve, but I'm too scared due to a history of blood pressure, diabetes and heart disease in the family.
Long hauler here. Started with natto a year ago, slowly built up to 4000 a day and saw an increase in energy 10-20%. not a cure but it definitely helped
I wish they would have tested some parameters for which many long covid patients take for, which is clot dissolution, blood thin 1:04:57 ning etc. D dimer, VEGF, Von Wilebrands Wilabrands etc.
I regularly take 4,000 FUs....but when I upped the dosage to 8,000 (attempting to follow the 10,000 FU study that showed reversal of plaque)...I noticed pronounced dizziness, i.e., blood pressure too low....So, yeh, nattokinase really does appear - from this 'n=1' study - to lower blood pressure, but caution is recommended here.
Two years ago I had a CAC test. My score was 550. I started nattokinase (12,000 FU)/K2/aspirin (81mg) supplementation two months ago. I'm curious to see what my score will be 10 months from now.
4 months ago, CAC 247. 10,000FU, K2m-7, 83mg Asprin. Exercising HIIT rowing. I’ve cut out red meats, and focused on leafy deep greens. It would be great if we could compare results.
Great deep dive. Did they get CAC scores in any of these. It’s nice to know about lipids and BP but what were the vessel clearing effects? Maybe I missed something.
I take high doses of nattokinase, lumbrokinase, and serrapeptase and k-2. I hedge my bets it works. I had varicose veins on my foot that are completely gone after half a year. I do find I bruised easier so I added 3 gram vitamins C twice maybe at most 3 times a week and that solved the issue. I also get dizzy on really high doses but that was a temporary side effect of high dose lumbrokinase doesn’t happen on nattokimase or serrapeptase.
Worth noting some nitric oxide boosters also have effect on blood platelets, so adding nattokinase of you are taking pre-workout could cause internal bleeding.
Very interesting. Thanks. I was wondering if specially in that long term study the diets and general lifestyle the participants had were in any way controlled, as this would probably influences directly the cholesterol levels...
Conclusion: Nattokinase does not clinically show to reduce atherosclerosis. The studies are questionable and the one that many cite that used just over 1000 subjects and was a retrospective study has its authors employed by those who make nattokinase. More studies are needed but odds are we won't see them. Also, take what Chinese scientists do with a grain of salt. Chinese scientists are compromised.
Very helpful. I have high Lp(a). Should have a drug available for that in about 1.5 years. Everyone should be tested! Good topic for a video hint hint. For now my Lipidologist put me on PCSK9 inhibitor along with my current statin. Goal is to reduce LDL to 30 or below. PCSKs will also reduce Lp(a) 20-30% in the mean time while we wait for the new drugs for Lp(a). He has seen in patients that this aggressive treatment literally liquifies plaques in arteries and helps to stop and in some cases reverse heart disease. In addition, I am taking nattokinase 7.5k fu, cataplex c and cyruta. I have a high CAC score, but due to keto ish (focused on high protein and low carb..fats come with my proteins) healthy eating I have fixed my past poor health and metabolism including now having very low to no inflammation (crp and Lp-PLA2). Praying now I am healing my arteries! I am 60 and believe I am lucky that I am addressing all this before I have had any events given my high Lp(a) which we just discovered!
Thank you. Started that way on keto now more focused on building muscle. Very lean and thank keto for getting me here. Kefir, sauerkraut and kimchi for sure agree! Get lots of those. My fasting insulin is 3.5 with high protein so it works well with my healthy metabolism. OMAD too. Will be on at least Lp(a) med for life given that is hereditary. As far as ldl I need to fix the past so I am ok going below 30 for a few years to get things cleaned up! Healthy as a horse but recognize some things still need fixing!
@physionc Very good video. I was most interested in the effects of this on clotting as I have DVT and looking for solutions. However, I was sad to see the cost of your lowest tier for the insiders subscription at 19.99. I trust the content is thorough and worthy of a fee, but as I'm only interested in this particular video atm, and at twice the cost of some streaming services, I find it way too expensive, so will have to try and find these studies and review them myself I suppose (which I'm not sure I'm qualified to do). I was also interested in the timing and frequency of the doses and if they were taken with food or on an empty stomach but this wasn't mentioned. Hopefully that doesn't sound ungrateful but just some feedback from someone with a lower income who feels a little locked behind a pay wall. Keep up the good work!
If it reduced BP, & we know there's a strong link of long term high BP to cardiovascular disease. There is no side effect other than taste😅. So it's a no-brainer. From my personal experience natto (fermented soybeans) has very low glycemic effect on my blood glucose. Again, high BG is implicated in all forms of cardiovascular inflammation, IR issues.
I love your explanations of the studies Nick. Very well done. I like that you check for conflicts also. I have read thousands of studies myself, in the ten plus years after my cancer surgery, and it has served me well. Especially throughout the pandemic. I was already taking everything they found useful for COVID, way before the pandemic began. Except for Nattokinase and Ivermectin. As Narkybark just mentioned a bit earlier, Nattokinase is mostly used for its fibrinolytic activity. Also to help combat atherosclerosis, and possibly degrade spike proteins that may exist. And while lowering lipids is beneficial, it is not nearly the biomarker for heart disease that atherosclerosis is. That is the #1 predictor of heart disease. And in a study (272) you analyzed, you skipped right over the most important findings. >>> No results were found with doses 3,600 FU's or lower. Suggesting many of the studies in your meta might have been under dosing. But they were looking at hyperlipidemia anyway, which isn't Nattokinase's main benefit. >>> Its reduction in arterial plague (36%) was very significant. >>> 1,000 subjects using 10,000 FU's for a year, confirmed its great safety profile. >>> This study was a follow up of a previous smaller study by the authors, testing the same markers with extremely similar results... Clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidemia (July 2017) And anytime you can reproduce similar results, that adds weight to the evidence, that the results are authentic. Retrospective studies might not be RCT's, but when you are able to reproduce results, it adds strength to its findings. Proteolytic enzymes have been used in clinical settings for over ten years in Asia. More info... >>> ohbaby's substack
I took 4,000 IU and my blood pressure went from normal up to 150/95+ for 4 days and nights nonstop… heart rate also increased. Would love to take this supplement in hopes of it reducing my high CAC score and 60% soft plaque blockage (I’m in my 30’s, healthy bmi) but that experience was scary.
I have found this with higher doses of K2 complex several years back - K is blood thickening, which is why it is recommended with warfarin. A friend of mine also found disrupted sleep, which ceased when stopping.
@@AngelofD69 Do you realise what a random and, well frankly stupid question that is? There is a well known book titled "The Clot Thickens: The Enduring Mystery of Heart Disease", the title should give you some idea as to why your question is slightly stupid.
For those who prefer to get nutrients from food rather than supplements, you can make natto yourself. It’s a relatively simple fermentation process. Natto has lovers and haters, but if you love the taste that’s an added benefit.
@@wolfrahmphosphoros5808 In broad strokes, it's much like the fermentation process for yogurt. Obtain a package of prepared natto and a quantity of soybeans. Cook the soybeans, cool, drain, and then thoroughly mix in the contents of the package of prepared natto. Cover and keep at a temp of around 100 degrees Fahrenheit for about twelve to 18 hours. Bagging up the mixture and immersing it in in a sous vide might would probably work a treat, but I haven't tried that yet. Let it age under refrigeration for two to three days. Then enjoy all that stringy funky goodness!
@Physionic I've been on a 4 month run. I've not had updated labs and or a measure of my plaque since. I had showed some stenosis in Dec 2023. And I've also added other drugs and supplements since. A low dose statin, exetemibe, an ARB, a baby asprin, and a plethora of well studied supplements for cardio health. But I have noticed a visual effect of my veins being more visible when I lift weights in the morning. In addition, I tend to bleed a bit more when pricked.
Nattokinase is called such because it is obtained from natto, the stringy and funky soybean goo popular in Japan as a breakfast food. There is also the soybean paste known as miso, but I'm not aware of any significant amount of nattokinase present in any of the varieties of miso. Natto is an acquired taste, but it didn't take long for me to acquire it. The first serving I ate I had to wolf down rapidly while holding my nose. By the third serving, I was an enthusiast.
I'm a health oriented statistics nerd and I love your depth, but damn it is hard to obtain statistical significance. But that's science. Meta analysis is hard & sample size rules!
"It looked like a dish of pygmy toes in brown wheat paste, and...OH, GOD!!!...TASTED LIKE IT, TOO!!! 'GOOD GOD, MAN! ARE THESE PYGMY TOES?!' I yelled at the waiter. At first, he looked very puzzled, like he didn't understand a word of English, but then he made a big insufferable smile, and mockingly said in a weaselly tone, 'Not toe, not toe.'" --from _The Travels of Ishmael_ Chapter 17: "The Night I Ended Up in a Japanese Jail!"
Wow. Tom's a REALLY good teacher. He explains difficult statistical issues well, and why they matter. I wish I could afford his in-depth analysis class (Physionic Insiders): I'd love to hear more of this. Unfortunately, I can't - it's pretty expensive. If you have an extra $50/month you'd learn a lot, I think. Tom didn't bring up two apparent glaring problems with the research he's analyzed. I'd like to hear what he thinks about these: 1) Sample size is suspect. Tom didn't criticize the particularly small studies for being particularly SMALL. The Wu study, for instance, has an 'n' of 30: a treatment group of 15 + a placebo group of 15. I'd contend that's pathetic, but very typical of medical studies. He's found some much larger studies too, but including tiny studies like this is likely to skew your perception of outcomes relevance, your understanding of the results. A study size of 15 will generate more statistical noise than potential signal for all but very strong results. I'll bow to Tom as authority on this, but my gut reaction is to chuck tiny studies. That narrows the field of published research to consider dramatically, but why try to glean insight from crap? You're deluding yourself. Could be worse: in psychiatric journals they still accept "case studies" of 3-4 patients as acceptable research studies. 2) Meta analyses are crap Tom offers analysis of a meta-analysis, analysis of synthesized results of a group of studies. In recent years meta analyses have claimed to deliver the highest level of quality in scientific analysis. They claim to be able to synthesize results from many disparate studies of similar but often different experiments (looking for different outcomes, under different trial conditions, performed by different trial teams using (maybe) different approaches, tools & analyses). With respect (& not much) this is errant nonsense. The old maxim (Garbage in, garbage out) comes to mind. You can't analyze results from different experiments conducted by different teams with different approaches & conditions, even different methodologies, and expect to be able to derive much of value. You can compare the studies, certainly. You can analyze each. But what you can't do is combine the results to derive anything much of value, asserting that you can magically message the data to remove statistical anomalies or differences generated by inherent differences in the studies. I know, meta study advocates argue they can: I don't believe it. They're delusional. This is probably an unfair stereotyping, but I'd argue meta studies are a fraud & we're all better off looking for value in individual well-constructed well-run studies. Which are rare: science is hard. Math is hard This kind of thing happens because statistics is also hard. Tom obviously has some facility with the field & demonstrates that with the ability to explain pretty clearly how to approach & understand the data presented. I used to sell the stats analysis software tools for commercial use; can't claim to do stats myself but can recognize someone who can't, & possibly recognize when someone at least appears competent. Most medical researchers suck at it That's not my assessment, it's the assessment of John P.A. Ioannidis, a PhD/MD who researches the quality of published research, currently from Stanford U. His paper "Why Most Published Research Findings Are False" (download it free from PMC or PubMed) is the MOST CITED paper in scientific history: everyone accepts his findings that most published research is bunk; no one believes it applies to THEM. Hilarious!! I commend it to you: not written to be funny - it's a research paper - but he pulls no punches & it's a hoot to read. Bottom line: medical researchers generally can't do stats. Medical clinicians can't even spell it (clinical medicine doesn't filter for anyone with ability, much less interest, in math). One outcome of this ridiculous situation is the rise of meta studies. 3) Experiment duration is short The studies done tended to have a duration of a couple of months. That's pretty good for medical studies; many of those are much shorter. It's rare to find a long study (year-long or multi-year): they're expensive and time-consuming to run. Researchers gotta publish, now! I get it. But humans live long lives, we're not lab rats (30 months). People live long (& hopefully, prosper) Our internal processes operate slower, on a longer time-scale than lab rats'. We don't observe significant differences in metabolic processes in the studies over a period of, say, two months. Should we expect to? Some systems will conceivably respond quickly to experimental nudges, but many may take many months to show change, or to show significant change. To offer a very crude example, perhaps dissolving long-established plaque or even clots may take weeks or months, and changing the biological system that produced them: that could take a year or more. That's conceivable. Should we expect to see significant changes within 2 months? Should we believe we've actually learned anything if we DON'T see significant changes within 2 months? Comparisons: getting into ketosis for the first time after you've lived on a high-carb diet for life, that can take weeks, not just days. Changing your lipids profile to improve cardiovascular health can take many months. People are complicated Our bodies are running complex inter-linked systems with complex feedback systems that tend to self-balance. Nudging one deliberately in search of a simple goal - dropping your LDL levels or something as simple as losing weight - isn't straightforward & simple, even if the goal is. Decrease your calorie intake or increase your activity levels: either way your body will try to compensate by changing your metabolic rate. You may initially lose weight, but after a short while your returns will drop even if your weight doesn't any more. Systems seek stability, they get anchored at a given point, "fight back" and resist attempts to destabilize them. I don't often see published research acknowledge that this can happen, and have yet to see a study try to compensate for this occurring, or extend the study length to allow for such changes to be overcome. Instead, we see endocrinologists claim keto can't treat type 2 diabetes, or its precursor metabolic syndrome, because a quick 4 or 8 week study showed no significant impact on disease symptomology. Or neurologists claim similar short-term studies show no improvement in peripheral neuropathy symptoms. Changing your metabolic system will take months, and significantly changing your disease state perhaps a year or more. Reversing nerve damage will DEFINITELY take years. So claiming to have proved/disproved anything with a study of weeks or months is a joke.
Hello, thank you so much for the content it's really really really well made. I am an IB student and I am rather interested in writing my EE on Natto, but I can't do animal and human testing. Are there any recommended research questions that I can do on this topic? I am right now thinking about doing the effects of the temperature of the natto bacteria on the rate which amino acids in the beans are broken down but it seems a bit "lame" so I really appreciate if anyone could give me some suggestions thank you :)
i’ve been taking 12000FU’s of NK for 15 months and it has not had any effect on inflammation markers. LP-PLA2 was 66 12 months ago now is 65 … oxLdl 31 now 35, MPO 244 now 241, apoB 40 still 40. my 2c if you’re looking to reduce inflammation and soft plaque eat more plants, less saturated fats and use statins/ezetimibe .. they give you huge effects .. NK just maybe a rounding error. (and i was very biased to NK having an effect). Both the Chinese studies (12000FU) which showed a 30% decrease in intema media thickness their average CIMT was 1300um I think mean age 70 (quite diseased for their age group) i experienced a 27% reduction in CIMT over 3 years by keeping apob in low 40’s and also experienced an lp-pla2 reduction from 269 to 66.
Interesting. Your markers were low to begin with, so naturally you wouldn't see much improvement with Nattokinase. An apoB of 40 is quite good. Can't get much lower than that. And that is probably the best marker of all the markers you mentioned concerning heart disease and plague build up. And as shown in those two studies by the same authors, (36% decrease in plague buildup), Nattokinase is most beneficial in those who need it. MK-7 (K2) is in short supply in the majority of population. Inactive MGP levels (dp-ucMGP) are elevated in various diseases that are associated with elastic fiber calcification and degradation such as hypertension, CVD and obesity. But is also a risk marker and strong predictor of cardiovascular disease and mortality. Importantly, studies have shown that inactive MGP levels can be decreased markedly by daily vitamin K2 supplementation. “There is an alarmingly high prevalence of vitamin K deficiency and suboptimal recommended intake among the general population in the USA.” Vitamin K2 - a neglected player in cardiovascular health - PMC (Cleveland, Ohio 2021) More info >>> ohbaby's substack
@@jp7357 Why bother? Nattokinase is safe, affordable, and beneficial. Especially with this virus circulating. You have already seen great results (27%). Just keep doing what you are doing. How could further testing help? Eat your fatty fish and build muscle. Protein is very important for us older gents. Also with gut health intricately tied to our immunity,... probiotics, digestive enzymes and prebiotics (fiber) can be of help. There are other nutrients lacking for those getting on in age. i.e.... CoQ10, glutathione (NAC), Mg, Zinc, etc...
I wonder if you could figure out if NAO helps dissolve blood clots and helps stop blood clots from forming? that's really what NATO is meant for. However, you didn't mention that in this video. I'm curious about that. Is there another video on it?
I always thought the point of natto/lumbo was it's action as a clot/plaque buster, not anything for cholesterol or glucose. The lowering of blood pressure makes sense to me if it does indeed clean out the pipes. When I first started the combo my blood pressure greatly dropped from being borderline high to 60/110. I have NEVER had readings that low, and my primary retested me just to make sure. Placebo, fluke or something else? Entirely possible, but for now that's what I'm guessing happened.
A plc vs Nattokinase study on only subjects with high blood pressure AND covid vax stratified by vax type (mrna or not) would be interesting provided that it would be sufficiently powered.
I like the way you designed that. I don’t think you’ll get a study that nuanced, though - however, you could get some info on that using correlative modeling. :)
Interesting. I recently had a blood draw for routine tests and the puncture site has a vivid, painless bruise around it. The bruising is unusual for me. I started supplementation with 12,000 FU of nattokinase two months ago. I will note I've experienced several superficial cuts over the course of the past month (I'm a bit of a klutz), but have observed no increase in bleeding or delay in clotting.
I think your work is great.... but I hope there is a condensed version of the is video... this is very long. maybe I'll just read the comments to glean the gist of your video. thanks
These are almost all the studies on nattokinase, and the ones I couldnt access didn't mention anything (from what I could tell) about TMG or methylfolates
It would be better to do more research on the DNA molecules that have a major role in preventing calcification of arteries and the regulation of blood viscosity as they know how to interact with other molecules by design... Matrix Gla Protein (MGP): This is a vitamin K-dependent protein that is believed to play a crucial role in preventing the calcification of arteries. MGP is produced by the cells in the arterial wall and helps inhibit the formation of calcium deposits, which can lead to the hardening of the arteries (atherosclerosis). Plasmin: This is an enzyme that plays a key role in regulating the viscosity of blood by breaking down fibrin, a protein that forms blood clots. Plasmin is involved in the process of fibrinolysis, which helps dissolve blood clots and maintain normal blood flow.
Matrix Gla Protein (MGP) and Plasmin. Two reasons why Mk-7 (K2) and proteolytic enzymes are very beneficial. dp-ucMGP levels are elevated in various diseases that are associated with elastic fiber calcification and degradation such as hypertension, CVD and obesity. But also a risk marker and strong predictor of cardiovascular disease and mortality. Importantly, studies have shown that inactive MGP levels (dp-ucMGP) can be decreased markedly by daily vitamin K2 supplementation. "Lumbrokinase,..... has a dual mechanism in clot degradation: acts on fibrin directly and activates plasminogen and converts it into plasmin, which subsequently induce plasmin-based clot dissolution." Role of Fibrinolytic Enzymes in Anti-Thrombosis Therapy - Frontiers (May 2021) More info >>> ohbaby's substack
@@Markhypnosis1 "If that really was a concern, then he would have mentioned it." - this is called an assumption. Just as he didn't wear a hat in the video, I cannot say he doesn't like hats.
Consider pulse pressure. You act like lowering diastolic blood pressure is a good thing. If diastolic pressue decreases more than systolic, that means "pulse pressure" increases. High pulse pressure is associated with an increased risk of cardiovascular diseases. It reflects increased stiffness and decreased elasticity of the arterial walls, conditions commonly seen in atherosclerosis and aging. This arterial stiffness can lead to increased workload on the heart and higher risks of heart damage and events such as heart attacks and strokes.
I understand that you are constrained to the studies at hand....but consider incorporating natto into a diet (it's not that hard to make) and removing the high saturated fat based proteins in equivalents per gram....I believe it would outperform the studies you're working with in this video
The name nattokinase is named after nattokin, the Japanese name for the bacteria responsible for fermenting soybeans into natto. So it would be pronounced more like, natTOKinase.
No it's not. Nattokinase is two words..... Natto, and Kinase. Natto is the Japanese name for the fermented food, and Kinase is the scientific name for a specific enzyme.
I do know nattokinase has become considerably more expensive in last few years. Popularity is ever increasing. If soybeans for consumption had any real fit use this would be about the only real one as far as for human consumption. Thanks!
That is not true, soybeans are generally very healthy for humans in just about any form. Edamame, tempeh, tofu, natto, fermented tofu, all very healthy with varying benefits.
Not sure if you mentioned it but may be inappropriate if using warfarin to prevent blood clotting (K2, K blood thickeners). This was mentioned in the K2 book, The Calcium Paradox.
@@Lovehandle1339 Thank you, check back with me in a week, I'll let you know what my next blood test reveal and can confirm if being on Ctirus Bergamot has lowered my LDL or Total Cholesterol or Triglycerides, (sadly taking Niacin and Red Yeast Rice for over 6 months didn't lower them that much in my case)
I take 10,000FU of Nattokinase daily in addition to Crestor, Ezetimibe abd other supplements My CAC score went from 102.9 to 32.01 in 18 months Same hospital Same machine
yeah been taking it as a powder with K2 supplement and recently noticed a cut took longer than usual but not too long to stop (clot) maybe meaning less sticky blood?
The beginning part of this video correctly describes the mechanisms by which atherosclerosis advances. The key point being that Oxidized LDL plays an important role in the disease. He then waste much of the rest of the time talking about cholesterol and never mentions oxidized cholesterol again. Oxidized cholesterol is oxidized Omega-6 PUFA.
@matthewhunter6421 As resident of Japan, I can assure you people care. And you yourself cared enough to comment on a 4 month old comment. Thank you for caring to comment.
Nattokinase does *not* have oral bioavailability and thus I don't understand why so many studies looking in oral dosing. It just can't work. UA-cam keep on deleting my replies, so I post my source here: "Research progress on the utilisation of embedding technology and suitable delivery systems for improving the bioavailability of nattokinase: A review"
@@IlIKRATOSIlI Well, that is very basics of human physiology (you need to look it up from a textbook dealing with digestion), but most of these studies admit the problem in the introduction section. Nattokinase is very sensitive to acidity and digestive proteases (see DOI: 10.1016/j.foostr.2021.100219 ). Also large proteins do not go to blood stream, that would cause immune reaction etc problems. Again that can be found from any textbook.
Actually, a lot of enzymes exhibit oral bioavailabilty, indeed is low below 10% even when enteroprotected, thus effects are clinically noticeable in many of these. One of the proven mechanism of absorption is the para-cellular diffusion. Moreover in the nattokinase case the phamacokinetics has been proven in animal models and the plasma levels were measured. There are some medicines too based on oral enzymes with systemic effects. Another proteolytic enzyme (subtilisine, let's say an analogue of nattokinase ) adsorbed on radiated support is also a medicine (Trombovazin) in some CIS countries.
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Nah-Tow if you wanted to know how to pronounce it :) 😮
What is the effect of thrombolytics like nattokinase on kidneys, notably the nephrons? Do all these dissolved clots end up passing through the kidneys and if so, why would that not show up in degraded kidney performance?
Thank you for uploading! After being a functional food(Natto) for over a thousand years it amazes me why more studies aren't done on Nattokinase? I shared here before how it helped me. The recommended 2000fu is way too low in my opinion. Store bought Natto comes in portion size of approx 2000fu. I didn't start seeing results until i increased the dosage to 5000-6000fu twice per day. Severe claudication and shortness of breath are a thing of the past. BP is near normal now. I also take Glynac at 7grams per day, 3.5g twice per day. I think this protocol should be mandatory for over 50's.
because western medicine intends to keep ppl sick, then treat them, not cure them. why would they do studies on a substance they cant patent that can cure and prevent their money making sicknesses? thats pretty simple to answer
What brand do you use?
@@branjay3588Double Wood
_"After being a functional food(Natto) for over a thousand years it amazes me why more studies aren't done on Nattokinase?"_
Probably because nattokinase does not have oral bioavailability and thus there is no plausible mechanism for working.
@@user255 stomach acid destroys the enzymes but the supplements you take on empty stomach can be studied. anecdotal says it reverses plaque
Nicolas, I cannot thank you enough. I just got done listening to the full version over on, insiders. I had asked only a short time ago you review one study that was being promoted, I am sure many others appreciate your analysis and asked as well. Thank you for putting out all the free information that you do!
Thanks! I do what I can. Thankful it’s helpful :)
I would have loved to see these studies applied to Long Covid patients. It is one of the most talked about and positively regarded supplementation for Long Covid. I would love to try out to see if my symptoms improve, but I'm too scared due to a history of blood pressure, diabetes and heart disease in the family.
Natto is fermented soja beans. The Nattokinase is produced by the fermenting bacteria. Why are you afraid of food?🤔
Long hauler here. Started with natto a year ago, slowly built up to 4000 a day and saw an increase in energy 10-20%. not a cure but it definitely helped
I wish they would have tested some parameters for which many long covid patients take for, which is clot dissolution, blood thin 1:04:57 ning etc. D dimer, VEGF, Von Wilebrands Wilabrands etc.
>long covid
Ngmi
I regularly take 4,000 FUs....but when I upped the dosage to 8,000 (attempting to follow the 10,000 FU study that showed reversal of plaque)...I noticed pronounced dizziness, i.e., blood pressure too low....So, yeh, nattokinase really does appear - from this 'n=1' study - to lower blood pressure, but caution is recommended here.
Thank you for sharing the information. The presentation was made easy to understand 🎉
Two years ago I had a CAC test. My score was 550. I started nattokinase (12,000 FU)/K2/aspirin (81mg) supplementation two months ago. I'm curious to see what my score will be 10 months from now.
so youre taking 600 mg of nattokinase supplements? per day?
@@1111111111202 I don't know the mass of the supplement, only the FU rating provided by the manufacturer.
4 months ago, CAC 247. 10,000FU, K2m-7, 83mg Asprin. Exercising HIIT rowing. I’ve cut out red meats, and focused on leafy deep greens. It would be great if we could compare results.
@@alpenglow1235would love to hear about any follow up calcium scores
please share -- I'm about to start on the same stack and would really like to hear how it works for you
Wow, your efforts and knowledge, just astound me. Thank you.
Hi thoughti was going to be bored but u made it so interesting in laymans language. So thank you.
Great deep dive. Did they get CAC scores in any of these. It’s nice to know about lipids and BP but what were the vessel clearing effects? Maybe I missed something.
Have been taking 6000fu of nattokinase for about a month and had to come of my BP meds as my BP was dropping to low
Please discuss prolonged fasting and reversal of atherosclerosis
I take high doses of nattokinase, lumbrokinase, and serrapeptase and k-2. I hedge my bets it works. I had varicose veins on my foot that are completely gone after half a year. I do find I bruised easier so I added 3 gram vitamins C twice maybe at most 3 times a week and that solved the issue. I also get dizzy on really high doses but that was a temporary side effect of high dose lumbrokinase doesn’t happen on nattokimase or serrapeptase.
I wish he would have given the date of each study and the dosage used. Can reversing arterial plaque be from a placebo effect? Hmm...
Worth noting some nitric oxide boosters also have effect on blood platelets, so adding nattokinase of you are taking pre-workout could cause internal bleeding.
Very interesting. Thanks. I was wondering if specially in that long term study the diets and general lifestyle the participants had were in any way controlled, as this would probably influences directly the cholesterol levels...
bummer that the important conclusions are behind a paywall
Really sucks for those of us who can't afford another subscription thanks to high food prices on a fixed income!!!!
Conclusion: Nattokinase does not clinically show to reduce atherosclerosis. The studies are questionable and the one that many cite that used just over 1000 subjects and was a retrospective study has its authors employed by those who make nattokinase. More studies are needed but odds are we won't see them. Also, take what Chinese scientists do with a grain of salt. Chinese scientists are compromised.
@@rickboyd3857in which case the conclusions are irrelevant as you can’t afford the supplement anyway.
Very helpful. I have high Lp(a). Should have a drug available for that in about 1.5 years. Everyone should be tested! Good topic for a video hint hint. For now my Lipidologist put me on PCSK9 inhibitor along with my current statin. Goal is to reduce LDL to 30 or below. PCSKs will also reduce Lp(a) 20-30% in the mean time while we wait for the new drugs for Lp(a). He has seen in patients that this aggressive treatment literally liquifies plaques in arteries and helps to stop and in some cases reverse heart disease. In addition, I am taking nattokinase 7.5k fu, cataplex c and cyruta. I have a high CAC score, but due to keto ish (focused on high protein and low carb..fats come with my proteins) healthy eating I have fixed my past poor health and metabolism including now having very low to no inflammation (crp and Lp-PLA2). Praying now I am healing my arteries! I am 60 and believe I am lucky that I am addressing all this before I have had any events given my high Lp(a) which we just discovered!
Thank you. Started that way on keto now more focused on building muscle. Very lean and thank keto for getting me here. Kefir, sauerkraut and kimchi for sure agree! Get lots of those. My fasting insulin is 3.5 with high protein so it works well with my healthy metabolism. OMAD too. Will be on at least Lp(a) med for life given that is hereditary. As far as ldl I need to fix the past so I am ok going below 30 for a few years to get things cleaned up! Healthy as a horse but recognize some things still need fixing!
@physionc Very good video. I was most interested in the effects of this on clotting as I have DVT and looking for solutions. However, I was sad to see the cost of your lowest tier for the insiders subscription at 19.99. I trust the content is thorough and worthy of a fee, but as I'm only interested in this particular video atm, and at twice the cost of some streaming services, I find it way too expensive, so will have to try and find these studies and review them myself I suppose (which I'm not sure I'm qualified to do). I was also interested in the timing and frequency of the doses and if they were taken with food or on an empty stomach but this wasn't mentioned. Hopefully that doesn't sound ungrateful but just some feedback from someone with a lower income who feels a little locked behind a pay wall. Keep up the good work!
If it reduced BP, & we know there's a strong link of long term high BP to cardiovascular disease. There is no side effect other than taste😅. So it's a no-brainer. From my personal experience natto (fermented soybeans) has very low glycemic effect on my blood glucose. Again, high BG is implicated in all forms of cardiovascular inflammation, IR issues.
what was this guy's stance on the covid vaccines?
Do you have any research on papain? Thank you.
I love your explanations of the studies Nick. Very well done. I like that you check for conflicts also. I have read thousands of studies myself, in the ten plus years after my cancer surgery, and it has served me well. Especially throughout the pandemic. I was already taking everything they found useful for COVID, way before the pandemic began. Except for Nattokinase and Ivermectin.
As Narkybark just mentioned a bit earlier, Nattokinase is mostly used for its fibrinolytic activity. Also to help combat atherosclerosis, and possibly degrade spike proteins that may exist. And while lowering lipids is beneficial, it is not nearly the biomarker for heart disease that atherosclerosis is. That is the #1 predictor of heart disease. And in a study (272) you analyzed, you skipped right over the most important findings.
>>> No results were found with doses 3,600 FU's or lower. Suggesting many of the studies in your meta might have been under dosing. But they were looking at hyperlipidemia anyway, which isn't Nattokinase's main benefit.
>>> Its reduction in arterial plague (36%) was very significant.
>>> 1,000 subjects using 10,000 FU's for a year, confirmed its great safety profile.
>>> This study was a follow up of a previous smaller study by the authors, testing the same markers with extremely similar results...
Clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidemia (July 2017)
And anytime you can reproduce similar results, that adds weight to the evidence, that the results are authentic. Retrospective studies might not be RCT's, but when you are able to reproduce results, it adds strength to its findings.
Proteolytic enzymes have been used in clinical settings for over ten years in Asia.
More info...
>>> ohbaby's substack
En route to a microscopy career, after taking micrographs of viral action I switched to electrical engineering out of pure terror
Hello Nick! Would love to hear your analysis on the supplement agmatine and it's effects on the the brain and for exercise.
I took 4,000 IU and my blood pressure went from normal up to 150/95+ for 4 days and nights nonstop… heart rate also increased. Would love to take this supplement in hopes of it reducing my high CAC score and 60% soft plaque blockage (I’m in my 30’s, healthy bmi) but that experience was scary.
I’ll add I was eating low carb / keto at the time. Maybe my electrolytes were off?
Why do you have a high cac score in your 30s?
I have found this with higher doses of K2 complex several years back - K is blood thickening, which is why it is recommended with warfarin.
A friend of mine also found disrupted sleep, which ceased when stopping.
Have you tried exercise in combination with NK? I did. I know I moved some clots or plaques. My digestion has improved, too.
@@AngelofD69
Do you realise what a random and, well frankly stupid question that is?
There is a well known book titled "The Clot Thickens: The Enduring Mystery of Heart Disease", the title should give you some idea as to why your question is slightly stupid.
For those who prefer to get nutrients from food rather than supplements, you can make natto yourself. It’s a relatively simple fermentation process. Natto has lovers and haters, but if you love the taste that’s an added benefit.
cool, please share how to make it. regards.
@@wolfrahmphosphoros5808 In broad strokes, it's much like the fermentation process for yogurt. Obtain a package of prepared natto and a quantity of soybeans. Cook the soybeans, cool, drain, and then thoroughly mix in the contents of the package of prepared natto. Cover and keep at a temp of around 100 degrees Fahrenheit for about twelve to 18 hours. Bagging up the mixture and immersing it in in a sous vide might would probably work a treat, but I haven't tried that yet. Let it age under refrigeration for two to three days.
Then enjoy all that stringy funky goodness!
I have heard natto can clear a room. As in...smells like dead cats.
@@Merzui-kg8ds lets of fermented foods smells bad.
I take freeze dried natto powder. While I cannot speak on any other changes, my IBS has completely disappeared on a quarter teaspoon a day.
Just started listening and eager to hear your analysis. I currently take 12K FU Nattokinase and 120K SPU serrapeptase.
What's your experience been?
What has your experience been?
@Physionic I've been on a 4 month run. I've not had updated labs and or a measure of my plaque since. I had showed some stenosis in Dec 2023. And I've also added other drugs and supplements since. A low dose statin, exetemibe, an ARB, a baby asprin, and a plethora of well studied supplements for cardio health. But I have noticed a visual effect of my veins being more visible when I lift weights in the morning. In addition, I tend to bleed a bit more when pricked.
@@josephkoerner4856what supplements for cardio health ? Thanks!
Nattokinase, Lumbrikinase, Serrapeptase, Bromalase....Been taking them for heart disease and fibrin from long covid. No results yet...🙏🔥❤️
some claim Lumbrikinase is the most powerful one
I don't want to open a can of worms here, but....both Serrapeptase and Lumbrikinase involve the little wiggly friends of the fisherman. 🤣🤣🤣
@@thomascantasano7816 Does it matter ?so long it works for you. Think about fecal transplant.
Unfortunately it's the most expensive one.
Is Nattokinase related to fermented Japanese soybean paste?
Yes it is
Yes
Nattokinase is called such because it is obtained from natto, the stringy and funky soybean goo popular in Japan as a breakfast food. There is also the soybean paste known as miso, but I'm not aware of any significant amount of nattokinase present in any of the varieties of miso.
Natto is an acquired taste, but it didn't take long for me to acquire it. The first serving I ate I had to wolf down rapidly while holding my nose. By the third serving, I was an enthusiast.
@satoyamazaki3659My cardiologist is ignorant of Nattokinase. I eat Natto regularly. 🙏🏻👹🏋🏻🏊♀️
I'm a health oriented statistics nerd and I love your depth, but damn it is hard to obtain statistical significance. But that's science. Meta analysis is hard & sample size rules!
"It looked like a dish of pygmy toes in brown wheat paste, and...OH, GOD!!!...TASTED LIKE IT, TOO!!! 'GOOD GOD, MAN! ARE THESE PYGMY TOES?!' I yelled at the waiter. At first, he looked very puzzled, like he didn't understand a word of English, but then he made a big insufferable smile, and mockingly said in a weaselly tone, 'Not toe, not toe.'"
--from _The Travels of Ishmael_ Chapter 17: "The Night I Ended Up in a Japanese Jail!"
I went to an Asian market, and they thought inwanted nacho
😂
Wow. Tom's a REALLY good teacher. He explains difficult statistical issues well, and why they matter. I wish I could afford his in-depth analysis class (Physionic Insiders): I'd love to hear more of this. Unfortunately, I can't - it's pretty expensive. If you have an extra $50/month you'd learn a lot, I think.
Tom didn't bring up two apparent glaring problems with the research he's analyzed. I'd like to hear what he thinks about these:
1) Sample size is suspect.
Tom didn't criticize the particularly small studies for being particularly SMALL. The Wu study, for instance, has an 'n' of 30: a treatment group of 15 + a placebo group of 15. I'd contend that's pathetic, but very typical of medical studies. He's found some much larger studies too, but including tiny studies like this is likely to skew your perception of outcomes relevance, your understanding of the results. A study size of 15 will generate more statistical noise than potential signal for all but very strong results. I'll bow to Tom as authority on this, but my gut reaction is to chuck tiny studies. That narrows the field of published research to consider dramatically, but why try to glean insight from crap? You're deluding yourself.
Could be worse: in psychiatric journals they still accept "case studies" of 3-4 patients as acceptable research studies.
2) Meta analyses are crap
Tom offers analysis of a meta-analysis, analysis of synthesized results of a group of studies. In recent years meta analyses have claimed to deliver the highest level of quality in scientific analysis. They claim to be able to synthesize results from many disparate studies of similar but often different experiments (looking for different outcomes, under different trial conditions, performed by different trial teams using (maybe) different approaches, tools & analyses).
With respect (& not much) this is errant nonsense. The old maxim (Garbage in, garbage out) comes to mind. You can't analyze results from different experiments conducted by different teams with different approaches & conditions, even different methodologies, and expect to be able to derive much of value. You can compare the studies, certainly. You can analyze each. But what you can't do is combine the results to derive anything much of value, asserting that you can magically message the data to remove statistical anomalies or differences generated by inherent differences in the studies. I know, meta study advocates argue they can: I don't believe it. They're delusional. This is probably an unfair stereotyping, but I'd argue meta studies are a fraud & we're all better off looking for value in individual well-constructed well-run studies. Which are rare: science is hard.
Math is hard
This kind of thing happens because statistics is also hard. Tom obviously has some facility with the field & demonstrates that with the ability to explain pretty clearly how to approach & understand the data presented. I used to sell the stats analysis software tools for commercial use; can't claim to do stats myself but can recognize someone who can't, & possibly recognize when someone at least appears competent.
Most medical researchers suck at it
That's not my assessment, it's the assessment of John P.A. Ioannidis, a PhD/MD who researches the quality of published research, currently from Stanford U. His paper "Why Most Published Research Findings Are False" (download it free from PMC or PubMed) is the MOST CITED paper in scientific history: everyone accepts his findings that most published research is bunk; no one believes it applies to THEM. Hilarious!! I commend it to you: not written to be funny - it's a research paper - but he pulls no punches & it's a hoot to read. Bottom line: medical researchers generally can't do stats. Medical clinicians can't even spell it (clinical medicine doesn't filter for anyone with ability, much less interest, in math). One outcome of this ridiculous situation is the rise of meta studies.
3) Experiment duration is short
The studies done tended to have a duration of a couple of months. That's pretty good for medical studies; many of those are much shorter. It's rare to find a long study (year-long or multi-year): they're expensive and time-consuming to run. Researchers gotta publish, now! I get it. But humans live long lives, we're not lab rats (30 months).
People live long (& hopefully, prosper)
Our internal processes operate slower, on a longer time-scale than lab rats'. We don't observe significant differences in metabolic processes in the studies over a period of, say, two months. Should we expect to? Some systems will conceivably respond quickly to experimental nudges, but many may take many months to show change, or to show significant change. To offer a very crude example, perhaps dissolving long-established plaque or even clots may take weeks or months, and changing the biological system that produced them: that could take a year or more. That's conceivable. Should we expect to see significant changes within 2 months? Should we believe we've actually learned anything if we DON'T see significant changes within 2 months?
Comparisons: getting into ketosis for the first time after you've lived on a high-carb diet for life, that can take weeks, not just days. Changing your lipids profile to improve cardiovascular health can take many months.
People are complicated
Our bodies are running complex inter-linked systems with complex feedback systems that tend to self-balance. Nudging one deliberately in search of a simple goal - dropping your LDL levels or something as simple as losing weight - isn't straightforward & simple, even if the goal is.
Decrease your calorie intake or increase your activity levels: either way your body will try to compensate by changing your metabolic rate. You may initially lose weight, but after a short while your returns will drop even if your weight doesn't any more.
Systems seek stability, they get anchored at a given point, "fight back" and resist attempts to destabilize them. I don't often see published research acknowledge that this can happen, and have yet to see a study try to compensate for this occurring, or extend the study length to allow for such changes to be overcome. Instead, we see endocrinologists claim keto can't treat type 2 diabetes, or its precursor metabolic syndrome, because a quick 4 or 8 week study showed no significant impact on disease symptomology. Or neurologists claim similar short-term studies show no improvement in peripheral neuropathy symptoms. Changing your metabolic system will take months, and significantly changing your disease state perhaps a year or more. Reversing nerve damage will DEFINITELY take years. So claiming to have proved/disproved anything with a study of weeks or months is a joke.
Hello, thank you so much for the content it's really really really well made.
I am an IB student and I am rather interested in writing my EE on Natto, but I can't do animal and human testing. Are there any recommended research questions that I can do on this topic? I am right now thinking about doing the effects of the temperature of the natto bacteria on the rate which amino acids in the beans are broken down but it seems a bit "lame" so I really appreciate if anyone could give me some suggestions thank you :)
Edta helped me and tests confirmed. I did also use the enzymes too.
Do you have any information on EDTA treatment?
Do you take oral EDTA or chelation EDTA intravenously?
@@nilskp how could I take it without information on it?
i’ve been taking 12000FU’s of NK for 15 months and it has not had any effect on inflammation markers. LP-PLA2 was 66 12 months ago now is 65 … oxLdl 31 now 35, MPO 244 now 241, apoB 40 still 40.
my 2c if you’re looking to reduce inflammation and soft plaque eat more plants, less saturated fats and use statins/ezetimibe .. they give you huge effects .. NK just maybe a rounding error.
(and i was very biased to NK having an effect).
Both the Chinese studies (12000FU) which showed a 30% decrease in intema media thickness their average CIMT was 1300um I think mean age 70 (quite diseased for their age group)
i experienced a 27% reduction in CIMT over 3 years by keeping apob in low 40’s and also experienced an lp-pla2 reduction from 269 to 66.
Interesting. Your markers were low to begin with, so naturally you wouldn't see much improvement with Nattokinase. An apoB of 40 is quite good. Can't get much lower than that. And that is probably the best marker of all the markers you mentioned concerning heart disease and plague build up.
And as shown in those two studies by the same authors, (36% decrease in plague buildup), Nattokinase is most beneficial in those who need it.
MK-7 (K2) is in short supply in the majority of population. Inactive MGP levels (dp-ucMGP) are elevated in various diseases that are associated with elastic fiber calcification and degradation such as hypertension, CVD and obesity. But is also a risk marker and strong predictor of cardiovascular disease and mortality. Importantly, studies have shown that inactive MGP levels can be decreased markedly by daily vitamin K2 supplementation.
“There is an alarmingly high prevalence of vitamin K deficiency and suboptimal recommended intake among the general population in the USA.” Vitamin K2 - a neglected player in cardiovascular health - PMC (Cleveland, Ohio 2021)
More info >>> ohbaby's substack
@@jp7357 Why bother? Nattokinase is safe, affordable, and beneficial. Especially with this virus circulating. You have already seen great results (27%). Just keep doing what you are doing. How could further testing help? Eat your fatty fish and build muscle. Protein is very important for us older gents. Also with gut health intricately tied to our immunity,... probiotics, digestive enzymes and prebiotics (fiber) can be of help. There are other nutrients lacking for those getting on in age. i.e.... CoQ10, glutathione (NAC), Mg, Zinc, etc...
Does nattokinase, serapeptase or lumbrokinase affect platelet size?
Yes
Sorry today im skipping to conclusions, i cannot focus. Thank you for the tome stamps
I wonder if you could figure out if NAO helps dissolve blood clots and helps stop blood clots from forming? that's really what NATO is meant for. However, you didn't mention that in this video. I'm curious about that. Is there another video on it?
I always thought the point of natto/lumbo was it's action as a clot/plaque buster, not anything for cholesterol or glucose. The lowering of blood pressure makes sense to me if it does indeed clean out the pipes. When I first started the combo my blood pressure greatly dropped from being borderline high to 60/110. I have NEVER had readings that low, and my primary retested me just to make sure. Placebo, fluke or something else? Entirely possible, but for now that's what I'm guessing happened.
A plc vs Nattokinase study on only subjects with high blood pressure AND covid vax stratified by vax type (mrna or not) would be interesting provided that it would be sufficiently powered.
I like the way you designed that. I don’t think you’ll get a study that nuanced, though - however, you could get some info on that using correlative modeling. :)
@@Physionic thanks!
Too high of a dose causes bruising. That would be due to breaking down fibrin, yes?
Interesting. I recently had a blood draw for routine tests and the puncture site has a vivid, painless bruise around it. The bruising is unusual for me. I started supplementation with 12,000 FU of nattokinase two months ago.
I will note I've experienced several superficial cuts over the course of the past month (I'm a bit of a klutz), but have observed no increase in bleeding or delay in clotting.
@@NoToobForYou nattokinase thins the blood.
Yes, it's well known that's what it does. It dissolves fibrin.
Says who? 🙏🏻🙏🏻🏋🏻🏊♀️
Damn, I can’t wait until I can afford the insiders because the info I really wanted was in there haha
I think your work is great.... but I hope there is a condensed version of the is video...
this is very long. maybe I'll just read the comments to glean the gist of your video.
thanks
Yep - coming
@@Physionic Oh great!! THANK YOU! I am curious about natto-kinase and what the scoop is.
“Nah-t toh kainase.” The vowel in gnat does not exist in Japanese.
If anyone anyone cared
@@matthewhunter6421 Anyone anyone should never pretend to speak for everyone.
Any studies on the effects on blood pressure when using TMG or Methylfolates? Thank you 😊
These are almost all the studies on nattokinase, and the ones I couldnt access didn't mention anything (from what I could tell) about TMG or methylfolates
It would be better to do more research on the DNA molecules that have a major role in preventing calcification of arteries and the regulation of blood viscosity as they know how to interact with other molecules by design...
Matrix Gla Protein (MGP): This is a vitamin K-dependent protein that is believed to play a crucial role in preventing the calcification of arteries. MGP is produced by the cells in the arterial wall and helps inhibit the formation of calcium deposits, which can lead to the hardening of the arteries (atherosclerosis).
Plasmin: This is an enzyme that plays a key role in regulating the viscosity of blood by breaking down fibrin, a protein that forms blood clots. Plasmin is involved in the process of fibrinolysis, which helps dissolve blood clots and maintain normal blood flow.
Matrix Gla Protein (MGP) and Plasmin. Two reasons why Mk-7 (K2) and proteolytic enzymes are very beneficial.
dp-ucMGP levels are elevated in various diseases that are associated with elastic fiber calcification and degradation such as hypertension, CVD and obesity. But also a risk marker and strong predictor of cardiovascular disease and mortality. Importantly, studies have shown that inactive MGP levels (dp-ucMGP) can be decreased markedly by daily vitamin K2 supplementation.
"Lumbrokinase,..... has a dual mechanism in clot degradation: acts on fibrin directly and activates plasminogen and converts it into plasmin, which subsequently induce plasmin-based clot dissolution." Role of Fibrinolytic Enzymes in Anti-Thrombosis Therapy - Frontiers (May 2021)
More info >>> ohbaby's substack
Some say taking nattokinaise supplements can cause internal bleeding which is not being mentioned. Can you research this please ?
If you take blood thinnners, you need to be careful with it. Even in Japan
If that really was a concern, then he would have mentioned it.
@@Markhypnosis1 assumptive reasoning is a sign of early brain rot.
@@doctormarazanvose4373 Sorry, who are you referring to as making assumptions there?
@@Markhypnosis1 "If that really was a concern, then he would have mentioned it." - this is called an assumption.
Just as he didn't wear a hat in the video, I cannot say he doesn't like hats.
I haven't seen a recent video from you lately - your background and áffect are so much more subdued here 🤔
Consider pulse pressure. You act like lowering diastolic blood pressure is a good thing. If diastolic pressue decreases more than systolic, that means "pulse pressure" increases. High pulse pressure is associated with an increased risk of cardiovascular diseases. It reflects increased stiffness and decreased elasticity of the arterial walls, conditions commonly seen in atherosclerosis and aging. This arterial stiffness can lead to increased workload on the heart and higher risks of heart damage and events such as heart attacks and strokes.
I understand that you are constrained to the studies at hand....but consider incorporating natto into a diet (it's not that hard to make) and removing the high saturated fat based proteins in equivalents per gram....I believe it would outperform the studies you're working with in this video
Apart from the solid science, I prioritize your videos for those occasional sarcasm that gets me off guard.
Not as much of that in these lengthier videos. :)
The name nattokinase is named after nattokin, the Japanese name for the bacteria responsible for fermenting soybeans into natto. So it would be pronounced more like, natTOKinase.
No it's not. Nattokinase is two words..... Natto, and Kinase. Natto is the Japanese name for the fermented food, and Kinase is the scientific name for a specific enzyme.
Who cares
I do know nattokinase has become considerably more expensive in last few years. Popularity is ever increasing. If soybeans for consumption had any real fit use this would be about the only real one as far as for human consumption. Thanks!
What??
That is not true, soybeans are generally very healthy for humans in just about any form.
Edamame, tempeh, tofu, natto, fermented tofu, all very healthy with varying benefits.
@@aurorasurrealis1032 Enjoy!
What I said? My opinion.
@@aurorasurrealis1032 Fermented is about the only safe way to eat them.
You sisn’t tell if nattokinaese works or not??
I may be just missing it each time, as im starting and stopping. But were the dosages used?
It varied, but the most common was 2000 FU
@@Physionic I believe the 1 study often cited as successful utilized 10,800 FU. That's what I base my dosing on.
@@Physionic I recall one study which indicated a dose of 10,800 FU was necessary to see any benefits, but I don't remember any other details.
@@Physionic 2000FU is very low. everyone that i know who had results took 6000FU plus
Not sure if you mentioned it but may be inappropriate if using warfarin to prevent blood clotting (K2, K blood thickeners).
This was mentioned in the K2 book, The Calcium Paradox.
I'm addicted to Natto ❤❤❤
AI video summary: it’s a good video you should watch it.
Haha, thanks
I take 60,000 FUs Nattokinase and my plaque has reduced greatly
Sweet Jesus 🤯
Any measurement of the reduction. Before and after info and duration of dose? Thanks
What about fermented cabbage(Germans call it sauerkraut)
It does have some K2 due to the (good) bacteria in fermentation process. However, natto(kinase) has exceptionally high levels
Good on hot dogs 😂
@@claygerard-ys1hi I know 😅👍
@@zperdek just kidding brotha
@@claygerard-ys1hi I'm not.
Can Natto have any positive effects on lowering Triglycerides or APO A ?
He said no difference was seen.
@@Lovehandle1339 Thank you, check back with me in a week, I'll let you know what my next blood test reveal and can confirm if being on Ctirus Bergamot has lowered my LDL or Total Cholesterol or Triglycerides, (sadly taking Niacin and Red Yeast Rice for over 6 months didn't lower them that much in my case)
I take 10,000FU of Nattokinase daily in addition to Crestor, Ezetimibe abd other supplements
My CAC score went from 102.9 to 32.01 in 18 months
Same hospital
Same machine
I'mma have this video for dinner. regards and thank You.
yeah been taking it as a powder with K2 supplement and recently noticed a cut took longer than usual but not too long to stop (clot) maybe meaning less sticky blood?
it thins your blood like aspirin does. i m surprised you guys dont know this
Sounds like im wasting my time taking natokinase . Stuck with plaque.
Check out Japanese studies on Natto. Natto King is informative, on UA-cam. 🙏🏻👹🙏🏻🏊♀️
How dosage are you taking?
@@Markhypnosis1 32.000 fu
Morning & night .
Episode 4 of Shōgun, they eat and pronounce nattō.
The way you should pronounce your last name is ‘fur - who - fun’ with the emphasis on ‘who’ 😉
The beginning part of this video correctly describes the mechanisms by which atherosclerosis advances. The key point being that Oxidized LDL plays an important role in the disease. He then waste much of the rest of the time talking about cholesterol and never mentions oxidized cholesterol again. Oxidized cholesterol is oxidized Omega-6 PUFA.
It wasn't measured. Can't talk about things that aren't measured.
I would think "Nat toe," two Ts. "Na toe," one T.
Its like ASMR bro
ASMR being the acronym for... ?
So nattokinase doesn't do a whole lot. If it does anything at all, 10 minutes of rigor every other day exercise would probably beat it.
I'm now suspicious that you are purposefully mispronouncing it so you get more engagement after the videos from people correcting you 😂
I promise I’m just inept. 🥲
41:00 ... twice as many women has to have some effect
Knot Toe
Natto is pronounced with a short 'a' sound like cat.
What kind of cat? British, American, Australian? German? 😊
No one cares
@matthewhunter6421 As resident of Japan, I can assure you people care. And you yourself cared enough to comment on a 4 month old comment.
Thank you for caring to comment.
Nattokinase does *not* have oral bioavailability and thus I don't understand why so many studies looking in oral dosing. It just can't work.
UA-cam keep on deleting my replies, so I post my source here: "Research progress on the utilisation of embedding technology and suitable delivery systems for improving the bioavailability of nattokinase: A review"
Interesting to see effects from something that doesn't have oral bioavailability, then. :)
@@Physionic Placebo, file drawer effect, industry sponsored studies, etc. Not really that interesting.
@@user255 Got anything to back that theory? Because the studies suggest otherwise.
@@IlIKRATOSIlI Well, that is very basics of human physiology (you need to look it up from a textbook dealing with digestion), but most of these studies admit the problem in the introduction section. Nattokinase is very sensitive to acidity and digestive proteases (see DOI: 10.1016/j.foostr.2021.100219 ). Also large proteins do not go to blood stream, that would cause immune reaction etc problems. Again that can be found from any textbook.
Actually, a lot of enzymes exhibit oral bioavailabilty, indeed is low below 10% even when enteroprotected, thus effects are clinically noticeable in many of these. One of the proven mechanism of absorption is the para-cellular diffusion. Moreover in the nattokinase case the phamacokinetics has been proven in animal models and the plasma levels were measured. There are some medicines too based on oral enzymes with systemic effects. Another proteolytic enzyme (subtilisine, let's say an analogue of nattokinase ) adsorbed on radiated support is also a medicine (Trombovazin) in some CIS countries.