Hypoxia & cellular injury - causes, symptoms, diagnosis, treatment & pathology
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- Опубліковано 7 вер 2024
- What is hypoxia? When cells are deprived of oxygen, a series of events take place that leads to cellular injury and-if deprived long enough-eventually apoptosis, or programmed cell death. Find our full video library only on Osmosis: osms.it/more.
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Is it just me, or is cytoskeleton hugely underrated in early high school books?
I agree
very much agree
😅😅😅
It is. Mine doesn't even mentioned it.
Oh don't remind me of those elementary books..they ruined me. All my life became a lie as soon as I entered the med school! Fuck.. where was this mf cartwheel shit in elementary education? ??
I never comment on videos but wanted to let you know that this was well explained and well illustrated. It helped solidify concepts that I need to know for school. I will probably check out your other videos in the future. Keep up the good work!
Thanks, James! We’re glad you like the videos. If you want to further supercharge your medical studies, check us out on our website! In addition to having exclusive access unreleased videos (which include an 8-part series on ECG, a series on embryology, and unreleased videos on physiology and pathophysiology) Osmosis Prime members have access to thousands of board-style quiz questions and flashcards, study scheduling tools, and much, much more! Check us out here: bit.ly/2ut5ZEJ
We've updated this video. In Anaerobic Glycolysis --2 ATP are produced per GLUCOSE (not per Oxygen as mentioned in the original video )
Osmosis team ,
Alhamdulillah
thanks for efforts, update
Osmosis Please make a video on Heart Murmurs
Osmosis, If a person has chronic hypoxia, if the Carbohydrate intake is high, doesn’t the Glucose intake convert to Lactic acid exaberating the acidic pH?
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Brilliant! I'm a neonatal nurse trying to produce some teaching material on neonatal hypoxic ischaemic encephalopathy and how therapeutic hypothermia and xenon gas work. There's plenty of literature on this, but it's written for doctors, who have a better understanding of the background physiology than I have. I think I'm now getting the picture! Believe me, I'm deeply grateful.
Thank you! This is why we're doing this. It would be awesome if you and your friends could review us on Facebook! facebook.com/pg/OsmoseIt
I hope osmosis will continue to produce free videos like these on UA-cam. As a flight paramedic student, these are very informative and easier explained than most textbooks
Thank you, Nicholas and it's our pleasure to help 🙏🏼
Hey, Osmosis! Please do Sepsis. We nurses are loving the vids.
Me: decides to use something other than Khan Academy to study for once
Also me: Finds myself on a UA-cam video narrated by the same guy 😂😂😂
Our video team started out with three former Khan Academy employees. We've expanded quite a bit since then.
@@osmosis and we respect the effort both of you
I am tired of hitting likes for each video .. Awesome job
There are two options when you die, either heaven or hell. If you want to go to heaven you need to repent and believe in Jesus Christ
Hypoxia is a process which slowly becomes irreversible if not tacked in early stages ( like in the case of an MI ) and the end result is cell death . A good clinical pathological correlation would be with the 4 types of Hypoxia fundamentally explained. Thank you for posting . Great Job .
well that was just about the most helpful video I've watched on hypoxia.
I'm a fan of your videos in general but I have to the animation and narration for this video was spot on! Very effective.
extremely helpful video thankyou. It will always blows my mind how on earth these processes can be understood in such detail given how absurdly small a cell is. 🤯
Glad it was helpful! 😊
So amazing! I'm in my 4th year of the career in Venezuela and there are things that you remark on some videos that my teachers say and are not actually in the books. Great job guys!
Thanks so much! It would be awesome if you could review us on our Facebook page. facebook.com/OsmoseIt/
Osmosis made me understand Cell injury and it's causes in 7 minutes and saved from diving into Robbins pathology for 7 days
Wow! Our pleasure to help, Muhammad! 🙌🏼 💕 ✨
Such an amazing video!!!!
So simple, but powerful. I don't know how to thank you, I was wandering around browsing internet throughout the day to make clear about this subject. And now iam cleared all my doubts regarding hypoxia .
Such an useful video, always keep supporting..
This was amazing! So informative, I understood this better than books. Well done, thank you!
Precise and direct... amazing video. Thank you, please keep posting!
Thanks! 🙏🏼
The diagrams and graphics are amazing in detail and enjoyable to watch.. what neat handwriting!!
Great man, really very big shortcut to study medicine without mugging up the books pages.
Wow
Great video really helps in my pathophysiology class!
Thanks, Ashley! We're glad you like the videos! If you haven't yet checked out our educational platform we’re working hard to be a one-stop shop for educating future clinicians. We have unreleased videos, tens of thousands of flashcards and multiple-choice practice questions, study workspaces, and daily exam schedule organizers to help you learn medicine. Check us out here! bit.ly/2ut5ZEJ.
That was very helpful. I've watched a couple of your videos as I take Pathophysiology and it is helping me understand. Thanks for your help!
You studying for a Pharmacy paper too? Just curious.
Precise and direct to the point ❤
I think this video explains the two main characteristics of the morfology wich the cells go through: cell swelling and lipid vacuoles. And it´s interesting how just one simple cause, like hypoxia, change everything on the cell until it´s death.
Haha the red button part just so cute XD
Your videos clarify everything, from the basics to the most complicated concepts.
Keep it up!
Hats off! :)
Thank you, sqtheeta! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on UA-cam? Check it out here: bit.ly/2u35D6J
So it is basicly a conbination of Carbondioxide poisoning and celluar depravity of fresh oxygen? Good to know. Still is there also a video how Hypoxia involved with diving in the deep areas and also force surfacing?
This vid is great. I’ve been searching for info on why I need to live on a breathing machine. This vid helped immensely, thank you.
Glad we could help, Wihiria! 🙏🏼
I dont think i would have done pathology properly if you guys weren't here to help us😊
Thanks
Thank you, Ibro! We're glad you like the videos! If you haven't yet checked out our educational platform we’re working hard to be a one-stop shop for educating future clinicians. We have unreleased videos, tens of thousands of flashcards and multiple-choice practice questions, study workspaces, and daily exam schedule organizers to help you learn medicine. Check us out here! bit.ly/2ut5ZEJ.
I just believe osmosis is the future of all education system..best thing in corona days...pretty good explanation, whoever making these are doing great, nice narration, nice illustration, if investment will good osmosis can replace all education system, and can gather lots of customer, hope for a bigger brighter future.
This was so helpful, thank you!!!!
To me, hypoxia mechanism looks similar to digoxin mechanism so if we give digoxin to the patient, isn't it increase hypoxia. Can you explain to me. I'm really confused.
One of the most informative medical channels on UA-cam
Great job really , thank You for every Video you have made .
Superb
I lost my mum to this tonight. She wasn’t breathing for over 10 minutes and suffered massive brain damage. Started by a cardiac arrest. It’s been the worst 48 hrs of my life.
I can’t believe what’s just happened.
Stewart King why are you leaving a comment then go help her
Shush I know it was 3 weeks ago
Hi Stewart.. Now my mom is suffering with such kind of things... Now I'm. In ur shoes...
Amazing actually.. but where do I fine the apoptosis and necrosis videos?
Hi! You may hop on to osmosis.org to access these videos (and more) when you sign-up for 7-day free trial. No worries, your account won't be charged once the trial expires. 😊
We, nurses, find your videos helpful!
Watching in 2020 with the face mask controversy. Great info! Thanks 👍
Sir i did overbreathing for 5 minutes twice a day for 1 month, i noticed brain fog like symptoms and double vision in center, i stopped and getting better gradually, was it hypoxia ?, Does it damage nerves ?
Hello there. Id like to add that small charged molecules dont just diffuse into the cell.They need passive diffusion channels. This is needed because the cell needs such ions but at regulated levels. During hypoxia ATPases like the pumps fail more so then the ion channels do. So to stop all this from occuring you need to stop the ion channels from being expressed. Disrupt enough and the ion exhangers wont have the gradients needed either to work and the cell is free from bleeding out until apoptosis. In addition mitochondria could initiate apoptosis is their memebrane potential drops too, or mistakenly undergo mitophagy which is not what you want either. Lactate can be epelled from cells too by tranporter channels which is what cancer cells use to grow rapidly as they inside tumors dont have acess to sufficient oxygen.
is intermittent hypoxia good for health ?,, how some athlets do work out in mountains and high area ?
you are a gifted gift
Edema is a characteristic for Necrosis. When Apoptosis happens to a cell, it shrinks instead of swelling :)
Check it out in Robbins in it's 9th edition.
stfu
Hey, are there any blood tests I can do to tell if I'm at a stage where damage is happening? ❤️
CBC test
@@jadep4802
@@yemen9219 thanks but what part of the blood count? I already have raised mcv and mch.
Hello! Can someone please respond.. I have severe B12 deficiency with macrocytic anemia and I believe I'm dealing with hypoxia. Are there any tests I can have done to see if it's causing irreversible damage? I'm struggling 😭
ribosome detachment should be independent from the detachment but acidosis
What a great video to help me understand Hypoxia. Thank you.
Thanks for the nice feedback! Always glad to be of help!
Great! Terrific video.
The only down-side was that I spent the entire time waiting for the video to abruptly end midcourse, with its remainder pre-empted by a sales pitch to buy a membership.
A lot of people are economically suffering right now. This would be a wonderful time for Osmosis to offer their videos free of charge, like Ninja Nerd, Khan Academy and Crash Course. (In my mind, Osmosis and Ninja Nerd are the best medical videos out there, by a wide margin.)
(Also, in the past, comprehensiveness of your collection was a problem if you paid the monthly fee. The videos you had were great-- but there were too many gaps. That was a few years ago, so that might not still be an issue.)
But the real issue is-- Great Job! A genuine public service. I hope you keep it up.
Great videos you make! But haven't you forgot the role of mitochondria?
Why is hypoxia very dangerous?
So is there a connection between Hypoxia and production of free radicals as well?
Thank you 😊 the video was really helpful
Awesome, thanks! 😊
I suffer from hypoxia and am presently on an oxygen concentrator, my concern is what is this doing to the rest of my organs such as liver, heart, etc. I've had sarcoidosis of the lungs (now in remission for many years) what can I look forward to for the foreseeable future. Thanks
I really enjoyed this lecture and you explained it very well. =)
That was very helpful, thank you
You're welcome, Bassant! 😊
This is perfect.. ty
Thnks for making it simplest
I wonder what hypoxia would do to nerves (thinking of the sodium-potassium reaction).
I been getting worse daily starting with sepsis myocardial infarction to a comma 4 days
Released from hospital with anemia left untreated 3 years leading to chronic hypoxia I cannot walk to bathroom or get dressed I fear death daily my doctors are shit!
I have good reinsurance and yet why am I denyed proper medical care
As you can see my nerves are shot out I am in bad shape my lungs heart eyes and part of my brain has been affected I will use what I have left till I can't no more I have no other choice millions$$$$$$ charged and payed but my condition deteriorates every hour
That was FABULOUS!! Thank you!!
,,, god bless you, live more and more.. you are.. very much helpful
The mitochondria is the powerhouse of the cell
Awesome animation!
THE BEST UA-cam CHANNEL i love all you're videos, keep up the great work
imene imaya agreed.
Saudi future doctors sending u love you r Amazing keep it up
Thanks for the support! 🙏🏼
Thank you for useful material, good explanation.
Is there any pain during Hypoxia. If the process is painless I would suggest the law to make it legal for this one to be imposed on habitual criminals or mentally disturbed humans or old aged people with no support. It's one way of helping those who are addicted to disorder life and set them free from miseries. Human population will increase, anyway no matter how many people die ( That's because media only talks about deaths and ignores how many being born during any incident of loss of life, (one sided view) )Priceless information.I subscribed. Thank you.
wow I still can't get over how well this was explained :D
Thanks for the feedback, Jasmine! 😊
Sir I like your animation style
Like program death
Or apoptosis
You are incredible! Thank you for this video!
You're welcome and thanks! 🥰
Incredible teaching.
Thanks.🙏🙏
mind blowing concept. thanks for that
i think you guys forgot to mention the treatment in the video 😅
Samah A finally it’s the phagocytosis of apoptotic bodies by adjacent healthy cells or macrophages .
Treatment of Hypoxia is Oxygen.
Excellent explanation!!!!!!!
what is the difference between Hypoxia and Cyanosis?
I am eagerly waiting for yr video to release. thanks sir. please upload daily new video
can ayone suggest me some medical related educational channels? Thanks in advance. From Bangladesh 🇧🇩
Mitochondria also swells?
Amazing video.Thank you!
Thank u ❤
You're welcome, Anwar! 😊
excellent and fantastic description
Thanks, Najdat! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on UA-cam? Check it out here: bit.ly/2u35D6J
In Very smart way u hv teach me
Love the visual; great job
Your videos are great, thank you so much
Like your video and explanations. Your drawings like an art and I can watch it for hours.hahaha. You make it so interesting. Thank you.
Thank you! It's a delight to know that you enjoy our work! 😊
Anyone else here wondering about wearing masks during the covid crisis reducing oxygen intake?
Yes, it is the reason I watched this video.
Me too
THANK YOU 🙌🏻
Am I the only non-future doctor that likes watching these?
Marcus Tullius Cicero Nope I'm major in engineering but so do I !
Education is my hobby. I'm a loser irl.
LOL I can't believe you guys watch this for fun. I suggest you go have real fun instead
Im an engineer i but keep on watching these. Haha
Hahahaha i'm a studying nurse, but I found this very interesting. It's crazy what lack of oxygen does on a cellular level.
Thanks sir 😌
Thank uuu sir 🙏🙏🙏 .
Very helpful, thank you
Always glad to help, Amitis! 🙌🏼 💕 ✨
Hello
Thank you very much for your important video about hypoxia
Unfortunately, the dangers of chronic hypoxia and the main reasons causing hypoxia due to lack of oxygen in the inhaled air are given a little information and most importantly in connection with the adaptive capabilities of the body during chronic hypoxia and in general with a lack of oxygen in the air - in fact people they may not notice the absence of oxygen, since carbon dioxide is not recognized by them, and people in a closed room (for example, closed windows and vents in winter) people can breathe the same air for a long time and not notice it !
The lack of oxygen there.
And then what can happen?
The human body begins to adapt to a lack of oxygen by changing the metabolism of the main functions of the body, and in particular cellular and tissue respiration, to oxygen-free mechanisms of energy production.
In the end, nothing good.
Further, with time of prolonged oxygen starvation, dysfunctions of various organs or systems are possible, and diseases may occur, the true causes of which may not be unraveled either by the patient himself or by doctors. Thus, people who actually suffer from chronic hypoxia may be treated symptomatically, without knowing the true causes of the disease.
In general, the other day I googled in search of the causes of chronic hypoxia and found almost no information.
The importance of clean air for life expectancy cannot be denied and should be put in the first place in importance this is my very opinion, but not for or to diet for example.
Without air, a person cannot live for even a few minutes, and without food, for example, a week can be.
Also , Dear Friends, I would like to share important information with my colleagues and with everyone interested in Health - Why people used to live much longer in ancient times
I have an article in my profile - called Way to Longevity - Please find time for attention.
I don’t give a link here because it’s seems to inconvenient to do that here, but from other side I feel that I have to disclose such an information
Please forgive my long comment.
Wishing you good health and all the Very Best
Dr
THANK YOU you just saved my life 😂
if atp is produced with oxygen but then without oxygen it can still produce atp but for a limited time then when do all these events occur such as the bulging and the sodium pump fail. does the anaerobic glycolysis immediately kick in with the absence of oxygen or does the oxygen stop coming, these problems start to develop and then the backup anaerobic process kicks in. not sure if ive worded this well but i dont get when these problems can occur if you have a backup process that can still work without oxygen.
Its very helpful।।।just love it।।
well explained....nice
thanks
How long it takes to cure hypoxia??
Great video, thank you :-).
Is there any video on types of necrosis ?
Amazing thank youu
Question: You're saying that the sodium molecules "physically block" the water. I struggle to understand this analogy, since sodium itself is dissolved in the water. Also, as far as I know, water is kept in the extracellular solely because of osmosis? What you've described sounds more like some kind of substrate inhibition.
Recall that mass cannot be created nor destroyed. Hence, when salt (let's take the traditional table salt NaCl) is dissolved into water, the crystal lattice of the salt is broken. However, the breaking of this lattice is only possible because of solvation.
Water is a polar molecule. That is, the oxygen side is a little more negatively charged than the hydrogen sides, since there are more protons in oxygen. Therefore, water molecules have a slight dipole (a positive and negative charge on the same molecule). This dipole allows water to form solvation interactions with the sodium and chloride ions. The negative side of many water molecules surround sodium ions, and the positive side of many water molecules surround many chloride ions, so as to maintain a relatively neutral charge.
Because of this interaction between the salt ions and water, it is more energetically favourable for water to be relatively close to the salt ions. That is, the easiest state for water and salt to settle is by mixing together into a homogeneous solution. In fact, it would require energy - lots of it - to pull water and salt apart. In this way, sodium (and chloride!) hinder the movement of water molecules.
Perhaps it would have been best not to call it "physical blocking". I hope this thermodynamic explanation helps clear some confusion.
Luke. ery lpw iron for years i mean St nearly zero.and in conjuvtion with neuroleptics.