Synthetic Peptide Libraries Part 3: Mischa Schüttel

Solid-phase peptide synthesis in 4×384-well plates, Mischa Schüttel
Purification-free synthesis and screening of thousands of cyclic peptides
The lab of Prof. Christian Heinis at EPFL (Lausanne, Switzerland) is on the cutting-edge of technology by applying robotic automation, acoustic dispensing and tip-less liquid handlers for performing chemical synthesis in microtiter format. In this webinar, experienced members of his lab will describe their latest work in high-throughput chemistry of peptidic macrocycle libraries for screening against challenging targets.
Three-part lecture:
Talk 1: Dr. Alexander L. Nielsen (2nd year postdoctoral researcher)
Introduction to peptidic macrocycles and synthetic approaches for their preparation in high-throughput
Talk 2: Mischa Schüttel (4th year PhD student)
Solid-phase peptide synthesis in 4×384-well plates
Talk 3: Edward J. Will (3rd year PhD student)
Case studies: Picomole-scale synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification
www.epfl.ch/labs/lppt/
Selected publications:
•     Nat.Commun. 13, 3823 (2022).
www.nature.com/articles/s4146...
•     Org. Biomol. Chem. 20, 5699-5703 (2022).
doi.org/10.1039/D2OB00910B
•     ACS Chem. Biol. 17, 181-186 (2022).
pubs.acs.org/doi/full/10.1021...
•     Angew. Chem. Int. Ed. 60, 21702-21707 (2021).
onlinelibrary.wiley.com/doi/1...
•     Chem. Sci. 11, 7858-7863 (2020).
doi.org/10.1039/D0SC01944E
•     Sci. Adv. 5, eaaw2851 (2019).
www.science.org/doi/full/10.1...