Supercentenarian (112 - 116y) Blood Test Analysis (Part I)
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- Опубліковано 21 лип 2024
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Papers referenced in the video:
Clinical course of the longest-lived man in the world: A case report
pubmed.ncbi.nlm.nih.gov/34973...
Age and cystatin C in healthy adults: a collaborative study
pubmed.ncbi.nlm.nih.gov/19749...
Cystatin C and long-term mortality among subjects with normal creatinine-based estimated glomerular filtration rates: NHANES III (Third National Health and Nutrition Examination Survey)
pubmed.ncbi.nlm.nih.gov/21109...
High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults
pubmed.ncbi.nlm.nih.gov/33313...
High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study
pubmed.ncbi.nlm.nih.gov/18403...
The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population
pubmed.ncbi.nlm.nih.gov/30202...
Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study
pubmed.ncbi.nlm.nih.gov/28811...
HbA1c levels in non-diabetic older adults - No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confounders in a meta-analysis of individual participant data from six cohort studies
pubmed.ncbi.nlm.nih.gov/26867...
White blood cell count and mortality in the Baltimore Longitudinal Study of Aging
pubmed.ncbi.nlm.nih.gov/17481...
High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults
pubmed.ncbi.nlm.nih.gov/33313...
Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies
pubmed.ncbi.nlm.nih.gov/24164...
Variation in serum creatinine level is correlated to risk of type 2 diabetes
pubmed.ncbi.nlm.nih.gov/24396...
Risks of mortality associated with common laboratory tests: a novel, simple and meaningful way to set decision limits from data available in the Electronic Medical Record
pubmed.ncbi.nlm.nih.gov/23729...
Commonly used clinical chemistry tests as mortality predictors: Results from two large cohort studies
pubmed.ncbi.nlm.nih.gov/33152...
The effect of age on serum creatinine levels in an aging population: relevance to vascular surgery
pubmed.ncbi.nlm.nih.gov/12379...
Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages
pubmed.ncbi.nlm.nih.gov/32732...
Age and sex variation in serum albumin concentration: an observational study
pubmed.ncbi.nlm.nih.gov/26071...
Centenarian TG data: michaellustgarten.com/2020/02... - Наука та технологія
That .03 hs-CRP level for anyone 111.5 year old is insane. If we're looking for an anomaly biomarker in a person who lived to anomaly lifespan, that seems to stand out.
Glucose, HbA1c, TG data, too
I liked the interview when Jiroemon was 115:
"I stood in awe of Kimura's energy, how it seemed to burst from some infinite inner geyser, too powerful to be held back by the realities of an aging body. As the nurse led him out, I told him that although he had lived a long life, he still seemed very young.
He turned around and quipped like a confident athlete headed to a race, "This is just the beginning!"
I think his mindset also played a big reason for his longevity. Very positive, always laughing, even on his death bed.
Kimura was health-conscious and active. He woke up early in the morning and read newspapers with a magnifying glass. He enjoyed reading newspapers and watching sumo wrestling and parliamentary debates on television. Also, he enjoyed talking to guests. He credited eating small portions of food (hara hachi bun me) as the key to a long and healthy life. He said his secret to his longevity was eating light to live long . He had never suffered from any serious diseases until 2013. He was positive and optimistic, and would be cheerful when visited by guests. His grand-daughter-in-law, Aiko, said his positivity helped him to live so long.
Nice video!
Centenarian data is really important for us the understand longevity. I am also really intrigued by the genetic and microbiome data from centenarians. While we cannot change our genes, we can still figure out what gene variants are important and influence gene expression (epigenome) with diet and lifestyle.
The microbiome is somewhat easier to change but, unfortunately, we know far less about it.
Thx prof.Lusgarten for this another fascinating video.
The only trait common to all centenarians and especially the super ones is an extremely low hsCRP, close to 0.03
It would be interesting to have some details about the lifestyle of this man, peace and respect for him.
The analysis of Creatinine, BUN and Cystatin C was very useful for understanding kidney function. Thank you!
The 2nd set of labs with the glucose in the pre diabetic range makes me question if he was really fasting at that time.
I had the same thought, especially since his HBA1c were all within the same relative range.
I think he was fasting but raided the freezer at night for mochi
A microbiome study would have given us even more helpful information
I don't think that data exists for Jiroemon, but one of the research groups that I'm a part of is currently analyzing that data in centenarians. Stay tuned, hopefully it will be published sometime this year!
Thanks for the review. Inflammation seems to be key. I still have to maintain those beautiful stats for the next 50 yrs to live longer.
Wow, this is very cool, thanks for this video! It adds a real-world check on a bunch of assumptions and makes the science look like it has real practical applications. You give us hope!
Excellent analysis! Thank you!
Interesting analysis!
What an interesting analysis! So informative, thank-you once again!
Amazing information Michael, I am much absorbed in your studies. Thank you again for all of your work!!
Thank you.
Given the delicate nature of the glomeruli and the data you presented, looks like some serious work is needed into cross linking and kidney function.
Great information, thanks for sharing! Many of his markers are better than average middle age Americans. Question: I’m sure you’ve seen the data from the Conboy lab diluting old mice plasma with albumin and saline. I wonder if the positive effects are from increasing albumin in the blood (Mr. Kimura has very low albumin) rather than elimination of something accelerating aging as they conclude.
Depends on what cause of death was determined as?
Cause of death was heart failure and pneumonia
Did you really leave LDL out of this video?
Funny “we can see he’s off to a bad start with his BUN” … after all … he’s was on 111 !! … excellent yt …
The goal is to have youthful levels of BUN (and all other biomarkers!) at 111...
nice video and awesome. but looks a bit rushed and fast.
Yep, sorry about that, I hope that my speed in presenting has slowed down since this video was posted!
Thanks for sharing!! Was ldl-c or apo-b given? Thanks!
Thanks Christopher L. LDL was (71, 85, 74), but ApoB data wasn't in the paper.
@@conqueragingordietrying1797 thanks again! Those are optimal lipid values across the board.
Good morning what is his blood group?
That info wasn't in the paper
Excellent and very enjoyable video. Understandably chronic diseases i.e cancer, heart disease are number one killer of Americans maybe those who escape chronic disease should be emphasizing kidney health and other biomarkers which contributed to the negative all cause mortality column of this supercentarian . With such low CRP inflammation and possible low atherosclerotic plaques I question how he died of heart disease and pneumonia? Maybe he lost the will to live. Also thanks for posting the study. Looking forward to reading it now. Review of abstract: is AV a development? It does not happen overnight. And when it was detected maybe the family decided the risks out weigh the benefits? Conclusion: do nothing? Fascinating.
Thanks Deb Stay Blessed. He died of heart failure-his heart was too weak to continue pumping blood, which is different from heart disease. In terms of pneumonia, although his total WBCs were good, the distribution of neutrophils, monocytes and lymphocytes were probably not. It's possible that he had ~1000 (or less for lymphocytes), but ~4000 for neutrophils and monocytes.
@@conqueragingordietrying1797 Reason has a good post on the the Fight Aging blog from 2010 - 'Why Supercentenarians Die'. Discusses Senile Systemic Amyloidosis and how it results in congestive heart failure.
@@rhyothemisprinceps1617 When considering that Jiroemon died of pneumonia and heart failure, and that there is a link between amyloidosis with infection, it's likely that SS amyloidosis may have contributed to his death.
@@conqueragingordietrying1797 Pneumonia is an infection, so he died from infection? Perhaps his ldl was too low to help him fight it. You've talked about that issue in a video.
@@conqueragingordietrying1797 Wow! Thanks, Dr. Lustgarten I will definitely check out that article on why centerarians die. Regarding his heart just couldn't pump any more I was considering the work of Dr. David Sinclair, that ageing itself is a disease and so what variables impacted the heart to wear out like that? Again appreciate your work 😁
"nicotinamide riboside"
have u ever considered adding 30ml (1 shot glas) of red wine to ur diet (3-4g alcohol per day for men, 2-3 for women)? the meta-study science on it seems pretty solid that it improves like 15 things and messes with like 4 (net positive), also nice hormetic stressor which cant be wrong evolutionary speaking
(and yes the weird addicted people will say the healthy amount is like 150-250 ml, but they r just delusional xD)
id be curious how it would impact ur numbers 😁
I have, but for a different reason: DHEA-S levels can potentially be increased as a result of alcohol intake.