Definitely, but also, if we know what poor organ function looks like in terms of biomarker data, then we can optimize it in youth. I expect that will minimize disease risk, and potentially, extend longevity.
Regarding LDL, I read an article saying that a combination of high LDL and low triglycerides might be caused a diet with lots of mono and polyunsaturated fats, because that causes LDL-A ( LDL larger with less density ) to be high and LDL-B ( LDL-B, small with higher density ) to be low. So generaly speaking, the absolute number of LDL might not be the only thing to take into account. My 2 cents..
Definitely. I think the emerging story is that low LDL is usually within the context of low albumin and HDL, and high glucose. In contrast, what if LDL is low, but albumin and HDL are relatively high and glucose is low, as that combination is found in youth? That will be the focus of the video.
Thanks again Michael for your indepth report. I wonder why prescription medication the gentleman was taking? Since medications cause the body to do a different function to get a result. I wonder what significance this had on his lifespan? Thanks again for all your hard work!❤️
Thanks KET TOO. From the paper, " Jiroemon had not been received any regular medical treatment including prescription medication until the age of 115."
Great video as always! Regarding ALT - the data you showed that suggested 18 is optimal is from a south korean study, but note that the meta analysis in your blog that suggests 10-13 is optimal, presented 2 seperated graphs, one for ALT in asain population and the second for the rest, so they may be a genetic difference. So for a white American, the data in the meta analsys may be more relvant for you.
So most of his blood work came back as poor but he lived to 116yrs which is a 1 in 500mm achievement. It’s even less likely for a man to live this long. Longevity is mainly genetic. Very interesting videos for sure. I’ve read multiple books on the subject of aging and it’s a fascinating topic.
Hi Dr, If you wanted to maximize healthspan and not lifespan, how would you approach that? Should we look at things like minimum CVD risk, and minimum cancer risk instead of minimum all-cause mortality risk in this case?
Hi Obi z, the approach would be the same-if we optimize biomarkers of organ and systemic function, while young and then for as long as possible, I expect that both healthspan and lifespan would be maximized.
Thanks Michael. Would be very informative if we had is data at 70 and 90 or there abouts and compare to typical and healthy current populations as it might help us better focus in differences that matter the most. I would expect more of his markers to deviate from optimum in his last years.
Thanks Peter, and definitely I agree. Unfortunately, none of the existing large epi LDL studies adjusted for malnutrition, so we'll have to wait to see that data.
This data could mean a lot of things, but it's impossible to know which is the correct interpretation without having more data points from a younger age.
Thank you Dr Mike for this video. But I feel it's unfair to judge 110+ years old biomarkers with population level biomarkers which are for population 70-80 years old. Someone who lived till 116 is a 1 in 1 million case.
Hi Rohit, yes, Jiroemon is an outlier for longevity, but I disagree about judging his biomarkers. By performing the analysis in these 2 videos, we can postulate which areas of his physiology were functioning well (insulin sensitivity, for example), but also not well, including his kidneys and liver. And then, could the weaknesses be improved to further improve his health and longevity? That's the goal.
@@NickWestgate Ha, Nick, now we're venturing into the philosophy of aging, which I usually try to stay away from. Evolution only cares about survival, and less about cruelty...
Hi bridgey, what's your GOT level? Yes, yGTP is great. Also, how does the rest of your biomarkers look-CRP, glucose, creatinine, etc? More context is always better in terms of biomarkers.
@@conqueragingordietrying123 my GOT was 16, blood sugar 88, creatinine and CRP wasn't included on the test. LDL 87, HDL 60, Triglycerides 65. Everything was within reference range
I have 2 data points in 2021 for that, another is currently being analyzed-I hope to have enough data by the end of the year to compare it against my own blood test results.
Perhaps there are situations where biomarkers going in the "wrong" direction are actually protective against certain aspects of aging. I don't really have data to support this theory. However, we know that HGH falls with age, and perhaps that is protective against cancer growth?
@@conqueragingordietrying123 I did not mean to imply that anything you said is or might be incorrect. I was just wondering whether there sometimes might be a protective effect of certain bio markers going in the direction opposite of youthful biomarkers.
No worries, @@jackbuaer3828 I know what you meant. But note that I'm not married to any ideology, I'm always open to the possibility of an alternative explanation.
He made it to a grand old age - I often wonder what value there is in looking at markers in isolation like this. It's not like we can (in many cases) selectively alter a single parameter without influencing another parameter (including those not tested for). Eat well. Sleep well. Exercise and don't worry.
If you're unfamiliar with this channel, I prefer greater specificity than that, which is why there's an emphasis on many biomarkers (21 in the 2 parts of this video series).
Great presentation, I appreciate all the details. Some people are good, some are just lucky. Seems like his longevity was due to a little bit of both.
Interesting potential insight revealed; all biomarkers are important, but perhaps some are more important than others? Nice work.
Definitely, but also, if we know what poor organ function looks like in terms of biomarker data, then we can optimize it in youth. I expect that will minimize disease risk, and potentially, extend longevity.
Thank you for this.
Well done!
Thanks susy may!
Regarding LDL, I read an article saying that a combination of high LDL and low triglycerides might be caused a diet with lots of mono and polyunsaturated fats, because that causes LDL-A ( LDL larger with less density ) to be high and LDL-B ( LDL-B, small with higher density ) to be low. So generaly speaking, the absolute number of LDL might not be the only thing to take into account. My 2 cents..
In your future video about optimal LDL, it would be great if you can try to explain the descrepency between the south korean study (
Definitely. I think the emerging story is that low LDL is usually within the context of low albumin and HDL, and high glucose. In contrast, what if LDL is low, but albumin and HDL are relatively high and glucose is low, as that combination is found in youth? That will be the focus of the video.
is that video already out?@@conqueragingordietrying123
Thanks again Michael for your indepth report. I wonder why prescription medication the gentleman was taking? Since medications cause the body to do a different function to get a result. I wonder what significance this had on his lifespan? Thanks again for all your hard work!❤️
Thanks KET TOO. From the paper, " Jiroemon had not been received any regular medical treatment including prescription medication until the age of 115."
@@conqueragingordietrying123 Thank you I missed that. Interesting I am not on medication. Only early 70's.
Great video as always! Regarding ALT - the data you showed that suggested 18 is optimal is from a south korean study, but note that the meta analysis in your blog that suggests 10-13 is optimal, presented 2 seperated graphs, one for ALT in asain population and the second for the rest, so they may be a genetic difference. So for a white American, the data in the meta analsys may be more relvant for you.
Yes, that's a fair point, thanks Obi z!
So most of his blood work came back as poor but he lived to 116yrs which is a 1 in 500mm achievement. It’s even less likely for a man to live this long. Longevity is mainly genetic.
Very interesting videos for sure. I’ve read multiple books on the subject of aging and it’s a fascinating topic.
His biomarkers were poor in the last few years of his life, his biomarkers at 80 were better than the average 50 year olds.
Hi Dr, If you wanted to maximize healthspan and not lifespan, how would you approach that? Should we look at things like minimum CVD risk, and minimum cancer risk instead of minimum all-cause mortality risk in this case?
Hi Obi z, the approach would be the same-if we optimize biomarkers of organ and systemic function, while young and then for as long as possible, I expect that both healthspan and lifespan would be maximized.
Keen!
Thanks Michael. Would be very informative if we had is data at 70 and 90 or there abouts and compare to typical and healthy current populations as it might help us better focus in differences that matter the most. I would expect more of his markers to deviate from optimum in his last years.
Thanks Peter, and definitely I agree. Unfortunately, none of the existing large epi LDL studies adjusted for malnutrition, so we'll have to wait to see that data.
This data could mean a lot of things, but it's impossible to know which is the correct interpretation without having more data points from a younger age.
Would like to see what his NAD level was
Would love to see a video on LOW LDL!
It’s in the queue, likely sooner than later!
What did you think of Dr. Fahy's 1/22/2022 TRIMX update? They've started to track PhenoAge.
Hi Paul, I didn't see that update-is there a link? YT may block links, so you may have to enter keywords instead.
@@conqueragingordietrying123 ua-cam.com/video/fWIU1SZuqvY/v-deo.html
What's a good crp? The tests I take just say less than 1 is good
I did a deep dive into the published literature-as low as < 0.3 mg/dL may be optimal:
ua-cam.com/video/W2pGmEDihdo/v-deo.html
Thank you Dr Mike for this video. But I feel it's unfair to judge 110+ years old biomarkers with population level biomarkers which are for population 70-80 years old. Someone who lived till 116 is a 1 in 1 million case.
Hi Rohit, yes, Jiroemon is an outlier for longevity, but I disagree about judging his biomarkers. By performing the analysis in these 2 videos, we can postulate which areas of his physiology were functioning well (insulin sensitivity, for example), but also not well, including his kidneys and liver. And then, could the weaknesses be improved to further improve his health and longevity? That's the goal.
@@conqueragingordietrying123 Aging is death by dyshomeostasis. (Yes, that's a real word.) Cruel and unusual punishment!?
@@NickWestgate Ha, Nick, now we're venturing into the philosophy of aging, which I usually try to stay away from. Evolution only cares about survival, and less about cruelty...
All my liver enzymes are on the low side, my yGTP is 13 which is great, but GPT is 12 which is maybe too low?
Hi bridgey, what's your GOT level? Yes, yGTP is great. Also, how does the rest of your biomarkers look-CRP, glucose, creatinine, etc? More context is always better in terms of biomarkers.
@@conqueragingordietrying123 my GOT was 16, blood sugar 88, creatinine and CRP wasn't included on the test. LDL 87, HDL 60, Triglycerides 65. Everything was within reference range
Do you have data with you own clock horvath?
I have 2 data points in 2021 for that, another is currently being analyzed-I hope to have enough data by the end of the year to compare it against my own blood test results.
This suggests that bio markers may not be as significant as thought.
That's not what it suggests
For platelet : PMCID: PMC2967549 ?
Perhaps there are situations where biomarkers going in the "wrong" direction are actually protective against certain aspects of aging. I don't really have data to support this theory. However, we know that HGH falls with age, and perhaps that is protective against cancer growth?
I'm happy to be proved wrong, if there's published data that disagrees with the assessment in the video...
@@conqueragingordietrying123 I did not mean to imply that anything you said is or might be incorrect. I was just wondering whether there sometimes might be a protective effect of certain bio markers going in the direction opposite of youthful biomarkers.
No worries, @@jackbuaer3828 I know what you meant. But note that I'm not married to any ideology, I'm always open to the possibility of an alternative explanation.
He made it to a grand old age - I often wonder what value there is in looking at markers in isolation like this. It's not like we can (in many cases) selectively alter a single parameter without influencing another parameter (including those not tested for). Eat well. Sleep well. Exercise and don't worry.
If you're unfamiliar with this channel, I prefer greater specificity than that, which is why there's an emphasis on many biomarkers (21 in the 2 parts of this video series).