Hemoglobin Structure; What's In Your Red Blood Cell?

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Can you please do a video explaining how the genetic defect porphyria effects the Heme mechanism? I liked this video.

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Kindly answer my question, its very important for me: In cooperativity binding, whats the sequence of oxygen binding to the hemoglobin subunits, I mean which chain binds to O2 first, and whats the sequence, is it alpha1, then beta1, then alpha2, beta 2?? .Pls ans me soon, will be thankful

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[@bruryrosally]

01:37
You said that everything end with "in" is protein. Then why protorpophyrin is among nonprotein?
Thanks ustadz

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There are exceptions to every rule.

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I think the iron is non protein it’s a mineral. Protoporphyrin is a protein coded by certain gene.

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which protein consist of haemoglobin with iron containing parphyrin is it meltaprotein

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[@jeremiahbaker6396]

Chemistry connection . The reason why Fe 2+ is more stable with Oxygen vs Fe 3+ is because of how the electrons fill the orbitals (A levels chem)
Fe : 26th element
Therefore :
Fe = [Ar] 4s2 3d6
Ar represent 18 electrons (18th element)
Fe 3+ = loss 3 electrons, but because s orbitals lower energy than d orbitals, you remove from the 4s first
[Ar] 3d4
Vs
Fe 2+ = 2 electrons lossed = [Ar] 3d5 (loss 2 from 4s)
This half filled 3d subshell is more stable than 3d 4
D subshells can hold 10 electrons, p 6, s 2
So Ferrous is more stable because it has half filled 3d subshell. Vs ferric
Ferric cause fenton rxn :
Fe3+ and O2 ==> trouble aka Reactive oxidative species e.g. OH, O2 2-, H2O2 (which play a active role in many pathologies e.g. G6PD deficiency in hienz body formation)
Result from Methaemaglobineamia which is a ADR to drugs like Sulfanomide (blue baby syndrome) and Benzocaine because they have nitrite deivities. This also promote allergic rxns usually skin related e.g. Steven Johnson Syndrome

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try it in 1.25 guys its perfect

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Did you talk about sickle cell?

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Hello, how does haptoglobin relate to hemoglobin formation? My haptoglobin is high, ferritin is high, but my hemoglobin is low.

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That's good explain . Thanks

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I had to play it at 1.25 speed, but thought the video was overall very helpful

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Forward 2x and save your time. Thanks for the video though

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so cute hemoglobin lol

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Watch the video on 1.25 speed

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how does the protein (hemoglobin here) decides the shape of the red blood cell?

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I don’t know the mechanism.

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[@AliYassinToma]

idk if still look at comments 3 years later but why does my university not mention protoporphyrin they say heme= porphyrin and iron not protoporphyrin

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I think it’s protoporphyrin, but that’s not a big deal.

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How haemoglobin binds to oxygen in reversible manner?? I doesn't get how in reversible mannner....

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Because hemoglobin can bind oxygen, and can let it go.

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@@MedicosisPerfectionalis soo what reversible here??

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That it can leave it after binding it...Irreversible binding means forever...This is not irreversible.

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He's high on hemoglobin xD

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Could you speak a little faster? Otherwise a nice video.

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