Heme Synthesis Pathway (and Associated Diseases)

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  • Опубліковано 5 лип 2024
  • ​​SUPPORT/JOIN THE CHANNEL: / @dirtymedicine
    My goal is to reduce educational disparities by making education FREE.
    These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
    For educational purposes only; NOT medical or other advice.
    Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
    Opinions are entirely my own.

КОМЕНТАРІ • 126

  • @DirtyMedicine
    @DirtyMedicine  3 роки тому +97

    Correction: Sulfonamides are P450 INHIBITORS however Sulfonamide antibiotics are still contraindicated

  • @partofaheart
    @partofaheart 3 роки тому +251

    I use AminoLEAVEulinic acid (leaves the mitochondria).

  • @faisalal-tamimi4683
    @faisalal-tamimi4683 2 роки тому +37

    Dude, you saved me from failing the part of heme synthesis, gigantic thanks to you.

  • @BooksOverKindle
    @BooksOverKindle 6 місяців тому +7

    You're a terrific teacher, hands down the best one to convert the burden of memorizing biochemistry cycles into a cakewalk.

    • @BooksOverKindle
      @BooksOverKindle 6 місяців тому

      Thankyou so much for all your efforts Sir🙌

  • @haganlawson8332
    @haganlawson8332 2 роки тому +9

    I have so many resource available to me -- this is by far the best video I have seen covering this topic! Really great job here!

  • @ave8197
    @ave8197 3 роки тому +12

    I wish I'd seen this this morning right before my practice test with like 5 questions on this topic *cries* seriously it's like you know exactly what I struggle with and make videos on it thank you soooo much

  • @user-zz4qs7uz3q
    @user-zz4qs7uz3q Рік тому +1

    Your video is AWESOME! Thank you so much. You have no idea how excellent this was!

  • @fabehaali9013
    @fabehaali9013 2 роки тому +5

    Tysm! U r an amazing teacher. Your mnemonics actually make sense and the way u teach is just amazing!! Please keep making more videos!!

  • @zak99msu
    @zak99msu 9 місяців тому +1

    Thanks you for providing such an amazing resource and making it available for medical students without cost!!!

  • @mesiloa
    @mesiloa 2 роки тому +4

    I am going to support your channel, it has been helpful to summarize a lot of Biochemistry which is very confusing.

  • @oconnor5628
    @oconnor5628 2 роки тому +15

    For lead signs, I think "A Basic Stapler vs a Lead Pipe"... Lead pipes are linear so you get the burton lines and lead lines on bones. Additionaly, Basic Stapler for the basic stippling. Stapler holes in papers once they are removed look kind of granular . Just my memory hook.

  • @user-fc9tn1sk4j
    @user-fc9tn1sk4j Рік тому

    Dirty! I love you! Porphyrias always were my problem until this video! Thank you so much!

  • @disneygirl19714
    @disneygirl19714 3 роки тому +5

    iconic, yet again. my mans don't miss.

  • @robertocordero9742
    @robertocordero9742 3 роки тому +12

    KING!! its the ✨mnemonics✨ for me 💕

  • @komaldiptianandmaisuriya4301
    @komaldiptianandmaisuriya4301 7 місяців тому +1

    Your biochem , pharma ,patho video really really helped me pass step 1 .so grateful.god bless.really beyond. great work doc.

    • @muzamara
      @muzamara 5 місяців тому

      Congrats!! Is the real deal similar to UWORLD or the NBMEs?

  • @ewertonuchoaMD
    @ewertonuchoaMD 3 роки тому +5

    I think the Heme Synthesis Mnemo was the best until now :D. Awesome Video as always.

    • @mbbslife3780
      @mbbslife3780 3 роки тому +2

      Loved this video on heme synthesis ❤️❤️😘

  • @Krishna-ub6ij
    @Krishna-ub6ij 3 роки тому +5

    Thank you so much . This topic is extremely volatile for me and you made it easy.

  • @annad6619
    @annad6619 2 роки тому +10

    great as always 😍👏🏻
    Also for Lead, I use:
    ALA (girl) & Ferro (boy) played with lead 😄

  • @betinahnamaganda1805
    @betinahnamaganda1805 2 роки тому +1

    U are extremely good. Thank you so much Sir! U have simplified my life

  • @udennaebii1585
    @udennaebii1585 2 роки тому

    I'm so grateful. Thank you

  • @rueloka
    @rueloka 3 роки тому +32

    YESSSS!!!! 🙏🏾🙏🏾🙏🏾 test in 5 days

    • @priyam1550
      @priyam1550 3 роки тому +4

      Good luck! Mine is in 10!

    • @rueloka
      @rueloka 3 роки тому +4

      Good luck guys 🥺🥺🥺🥺 y’all got it!

    • @siphiwechanza1420
      @siphiwechanza1420 2 роки тому +4

      Test in the next 8 hours 😭🕯️

    • @Be1smaht
      @Be1smaht 2 роки тому +1

      3 day!

    • @siphiwechanza1420
      @siphiwechanza1420 2 роки тому

      @@Be1smaht All the best
      God bless

  • @KASH.ISH16
    @KASH.ISH16 Рік тому

    I just want to say thank you and u r a great teacher toooo 🎉 congratulations

  • @priyam1550
    @priyam1550 3 роки тому +2

    Thank you! Just in time for my exam!

  • @drcaocuong
    @drcaocuong 5 місяців тому

    you saved me from biochemistry. Thanks to you !

  • @padmajahawaldar4319
    @padmajahawaldar4319 4 місяці тому +1

    God of teaching medicine ❤

  • @mennaayman2972
    @mennaayman2972 2 роки тому

    thank you so much for your dedication

  • @levi--ackerman
    @levi--ackerman Рік тому

    WHY ON EARTH IS HE SO UNDERRATED?!

  • @acepokemontrainer1
    @acepokemontrainer1 2 роки тому +1

    Thanks for another great video!

  • @ja4615
    @ja4615 9 місяців тому

    This video is very helpful! Thank you!

  • @KinzaHussain
    @KinzaHussain 3 роки тому +2

    Thank you xx

  • @aradhanakkannan5450
    @aradhanakkannan5450 Рік тому

    Easily registered... thank u doc!

  • @cristinalee5174
    @cristinalee5174 2 роки тому +1

    For the pathway mnewmonic "for" can be where Fe+2 enters the pathway

  • @khulooda4921
    @khulooda4921 Рік тому

    Bro I’m thankful for you forever

  • @CP-ov8sd
    @CP-ov8sd Рік тому +4

    another way to remember which steps occur in the mitochondria: just remember the FIRST and LAST step are the ONLY ones to occur in the mitochondria (if you dont wanna remember his mnemonic and this conceptually makes sense to you)

  • @agarwalshivam844
    @agarwalshivam844 3 роки тому +32

    Amazing video!
    Is there an easy way to learn the anatomy of the respiratory tree (like where we find goblet cells, cartilage, club cells, pseudo-stratified epithelium, smooth muscles, cilia etc)?

    • @mahekrai8915
      @mahekrai8915 2 роки тому +2

      If you find this, please tell 🥺

    • @DrRomaMD
      @DrRomaMD Рік тому +4

      Cartilage till bronchi
      start of club cells in bronchioles
      Cilia last to disappear till respiratory bronchioles start from the travhra

  • @AbubakarUmarMusa
    @AbubakarUmarMusa 2 роки тому +2

    Great Lectures

  • @somalarif6474
    @somalarif6474 3 роки тому +1

    thanks for the vedio
    Your lecture helped me to make my assignment

  • @anjumiqbal1676
    @anjumiqbal1676 2 роки тому

    Very informative and easy to understand video

  • @dr-bg8tn
    @dr-bg8tn 2 роки тому +1

    amazing thanks dr , is there a vid for lymphoma ?

  • @HazratAli-oz9ty
    @HazratAli-oz9ty 2 місяці тому

    love the way you teach sir🥰

  • @ThienTruong-iy5ix
    @ThienTruong-iy5ix 3 місяці тому +2

    a mnemonic for the Heme synthesis pathway if you prefer an alternative
    Great Scholars Always Prioritize Higher Understanding, Creating Profound HEMEpothesis(hypothesis)
    Cheers,

  • @tawfeekb24
    @tawfeekb24 Рік тому +1

    Dirty, you and all who make similar videos deserve a special spot in heaven.

  • @robindcole
    @robindcole 2 роки тому

    You are a good person.

  • @prashanth-py9jc
    @prashanth-py9jc 3 роки тому +3

    Superb I learn more from you thank you

  • @noellestarr5158
    @noellestarr5158 Місяць тому

    Absolute banger mnemonic

  • @hakaromer
    @hakaromer 2 роки тому +1

    الله على أخلاقك يا فخر اليوتوب

  • @tasneem5412
    @tasneem5412 3 роки тому +1

    Chef’s kiss 🤌🏻😘

  • @asisababun7543
    @asisababun7543 9 місяців тому +1

    Thanks!

  • @ZhivagoDoctor
    @ZhivagoDoctor 2 роки тому

    Amazing video !!!

  • @jacybaxter5457
    @jacybaxter5457 2 роки тому

    thank you! super helpful video

  • @RyanBintangSatria
    @RyanBintangSatria Рік тому

    Definitely worth to subscribe

  • @meenabarot2037
    @meenabarot2037 Рік тому

    Wow!! Fantastic

  • @AngelaHairston1
    @AngelaHairston1 Рік тому

    Love you too! Thanks.

  • @aremuoreoluwa3649
    @aremuoreoluwa3649 Рік тому +1

    Thank you🥺🥺

  • @KSJ1290
    @KSJ1290 Рік тому

    Clear cut lecture, ty!

  • @maymayansay
    @maymayansay 3 роки тому

    Hahaha when he said BOOM! right after the mnemonic, went ROFL coz the mnemonic's REALLYYYY amazing!!!!!!!

  • @xaaboopinkly
    @xaaboopinkly 3 роки тому +1

    Thanks sir!

  • @mishuhashem8642
    @mishuhashem8642 Рік тому

    Amazing video

  • @johnshrestha5767
    @johnshrestha5767 2 роки тому

    You are the best

  • @zainabhatem85
    @zainabhatem85 2 роки тому +1

    Perfect !

  • @emilioaguinaldo7101
    @emilioaguinaldo7101 3 роки тому +1

    nice summary

  • @eugeniaagnesrombelayuk1789
    @eugeniaagnesrombelayuk1789 Рік тому

    you are a life-saver :')

  • @otmanezogdani
    @otmanezogdani 11 місяців тому

    Hey, thank you for these valuable videos, can you please provide us with the PDF

  • @kisemilekatepa3842
    @kisemilekatepa3842 2 роки тому

    Thanks Much broo!

  • @alijafari25
    @alijafari25 6 місяців тому +1

    And that's why he's GOAT, the GOAT 🐐🐐🐐

  • @elizabethphiri6740
    @elizabethphiri6740 10 місяців тому

    Really useful

  • @redpilledbachelor7776
    @redpilledbachelor7776 3 роки тому +1

    I should study for my nursing final, but nah, I'm watching this first. The test contains anemia and hematology too.

  • @lanaakhras4909
    @lanaakhras4909 3 роки тому +3

    Omggggggg ur the best !!!!!

  • @ajabisong
    @ajabisong 4 місяці тому +3

    Aminolev LEAVES, COP enters.

  • @benwolde3881
    @benwolde3881 Рік тому

    wow, i can not thank you enough.

  • @cjfree8813
    @cjfree8813 2 роки тому

    bro...

  • @davidrios1492
    @davidrios1492 4 місяці тому

    i love you man

  • @ToothTalksHub
    @ToothTalksHub 3 роки тому +1

    Why are you so awesome?🔥🔥

  • @rameezakhan985
    @rameezakhan985 Рік тому

    Thankk uuuu❤❤❤❤❤

  • @sassydancers3601
    @sassydancers3601 Рік тому

    Can you please make a video on gene mutations!!

  • @heyitstoast8693
    @heyitstoast8693 7 місяців тому

    I have porphyria, I have a cellular test showing I’m completely deficient in b6, also serine so I’m assuming I could be low in glycine as well. I might have a gene where I can’t covert pyridoxine into Pyridoxal 5 phosphate. I was experiencing severe attacks, hospital couldn’t figure out what was wrong with me. I ordered the active b6 and got immediately better each day. I’m working with a functional dr who found my porphyrians are extremely high. We are still trying to rule out of anything else could be causing this but I’m hoping it’s just b6 deficiency. I can’t drink alcohol either ever. I turn white and need to recover for days after

  • @ashutoshanand8831
    @ashutoshanand8831 3 роки тому

    You are the best .

  • @rafisarhandi5626
    @rafisarhandi5626 Місяць тому

    For Lead , use
    ALEAD instead of ALAD (both pronounced as A lead)

  • @georgeiribar8412
    @georgeiribar8412 Рік тому

    If lead inhibited ALA dehydratase , the pathway should stop here right? So, how come it continues to protoporphyrin 9?

  • @yukizrox
    @yukizrox 3 роки тому +5

    For the slide on sideroblastic anemia, the HY point seems to be incorrectly presented. Should it be isoniazid consumption --> B6 def? Instead of isoniazid deficiency?

    • @DirtyMedicine
      @DirtyMedicine  3 роки тому +2

      I meant to type Isoniazid Induced Deficiency > B6 Deficiency. I left out the word "induced" but if you listen to the words I say you still get to the same end point

  • @sirikadenu5462
    @sirikadenu5462 4 місяці тому

  • @sravyareadyy
    @sravyareadyy 2 роки тому

    how does hydroxychloroquine help in PCT?

  • @augustortiz
    @augustortiz Рік тому

    7:38 That pneumonic should qualify you for a Noble Prize.

  • @tenawobebetwo3917
    @tenawobebetwo3917 5 місяців тому +1

    Please someone explain to me. I am confused with the pathogenesis of lead poisoning. Is it lead poisoning that inhibits those enzymes or does the deficiency of those enzymes lead to lead poisoning? I believe the former is.

  • @rickydhouse18
    @rickydhouse18 Рік тому

    Just in case you need to remember when Iron comes into this process. Same mnemonic, "Get Some Additional..." but change the end "for Heme" to "(Fe)r Heme". Good luck fam.

  • @maabhussein9910
    @maabhussein9910 Рік тому

    ♥️♥️♥️

  • @bookbites101quotes
    @bookbites101quotes 3 роки тому +1

    Congenital erythropoietic porphyria ?

  • @user-mg8tc5ko7q
    @user-mg8tc5ko7q 10 місяців тому

    Where can I download your lectures?

  • @Thegoodchanelsonly
    @Thegoodchanelsonly Місяць тому

    5:10 The first and Last step in Mitochondria

  • @fatemaabdulla2728
    @fatemaabdulla2728 Рік тому

    the mnemonics had me cracking

  • @burteenkhbold6297
    @burteenkhbold6297 Рік тому

    love you Dirty

  • @chiahsuantsauo8375
    @chiahsuantsauo8375 2 роки тому

    Wait so erythropoietic protoporphyria, coproporphyria, and variegate porphyria isn't important?

  • @Thegoodchanelsonly
    @Thegoodchanelsonly Місяць тому

    FEAD LEAD , FE ferrocheltase AD ala dehydretase

  • @jamiek6471
    @jamiek6471 2 роки тому

    i love you

  • @foodiesworldUSA
    @foodiesworldUSA Рік тому

    How does lead poisoning cause sideroblastic anemia

  • @cacayanhilarynicole3620
    @cacayanhilarynicole3620 10 місяців тому

    If only I had watched your video last year, I wouldn't have failed hematology 1

  • @shaynemcgowan4049
    @shaynemcgowan4049 3 роки тому +3

    Amino-leave-ulinic acid 🤔

  • @auzafatima928
    @auzafatima928 3 роки тому +2

    8:30

  • @lyly-wc1rj
    @lyly-wc1rj 2 роки тому +2

    مو دكتور ضيم مع تحياتي لبقية الدكاتره خليعزلون ويفتحون چمبر مخضر 😂

  • @hritvikjain__3594
    @hritvikjain__3594 2 роки тому +1

    good shit dirty!