Palmitoylation and β cell failure in diabetes / Cell Metab., Jan. 11, 2023 (Vol. 35, Issue 2)

Guifang Dong, Clay Semenkovich, and colleagues have discovered that the depalmitoylation enzyme acyl-protein thioesterase 1 (APT1) is altered in pancreatic islets from people with type 2 diabetes and in nondiabetic islets exposed to hyperglycemia. APT1 deficiency in mice increases insulin secretion that promotes β cell failure in the setting of metabolic stress, suggesting involvement of palmitoylation in diabetes pathogenesis.
Check out the paper at www.cell.com/cell-metabolism/f....
G. Dong, S. Adak, G. Spyropoulos, Q. Zhang, C. Feng, L. Yin, S.L. Speck, Z. Shyr, S. Morikawa, R.A. Kitamura, et al. (2023). Palmitoylation couples insulin hypersecretion with β cell failure in diabetes. Cell Metab. 35.
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