Yeah, agree. He has been getting pretty irrelevant lately. Its not like he has 3 million subs or anything😂 Come on man... how can you talk down upon someone who is literally curing millions of people around the world?? @@Jimmy-Legs
@@BarabasCsaba7I think we can see who is trying to be relevant in this chat 😂. I immediately thought the same thing as you. 3 million people think he’s worth listening to.
Im a 66 year old woman with 30 yr history of type 2 Diabetes. I've been shuttled from actos to Metformin to Victoza back and forth until I was put onto Lantus and Novolog. I continually gained weight with worsening symptoms. Im a cardiac patient due to the stresses in 2020, causing takotsubo cardiomyopathy. I started the keto diet recently and have seen a reduction in the needed insulin. However, I'm thinking carnivore is the only thing that is going to save my life. I have no one on my medical teams that agrees with Keto, let alone all animal products. I'm honestly going to have to nod my head at appointments and go home to do MY OWN THING. Thank God I know how to track my blood pressure, take my medications, and I wear a continuous glucose monitor. Please wish me luck, I'm going to seriously need it. My husband will do this diet, too.
Please meat eat with confidence and you have a hubby too. Help each other. You will find a goldmine of guidance from good docs you will soon learn to be out there. Also kind people telling their victories. Welcome.
Been there for almost 7 years. Mostly carnivore with at least 70% of my calories from animal fats. Drs don't have to know about everything, but my lab numbers tell me everything I need to know. Type 2 diabetic and a heart bypass almost 8 years ago. 77 years old, still work 4 hours per day 5 days per week and walk 2-4 miles per day
DO IT! You will see the results on your CGM. if your vaxed that heart condition is a documented side effect. You'll find on pubmed. Ignore your doctor's. Look what they've done to you already! Believe it or not, my cardiologist and electrocardiologist both totally support me being Carnivore! You're going to do great! I think Dr Boz might be good for you too. 🎉
Thank you for your research. 17 yrs ago I had a massive heart attack,(5 bypass surgery), my cardiologist almost in passing said did you know you’re diabetic? I had no idea. And treated my heart problems only 11 different meds. I walked into the hospital 183 lbs in shape. 9 days later walked out 224 lbs. six months later blew up to 265 lbs, walking 10 miles aday everyday. Then diagnosed with COPD and was put on prednisone. I blew up to 315 lbs. all my cardiologist & primary care doctors treated me with metformin, statins, high blood pressure meds, & Ozempic switched to TRULICITY switched to majourno . I started the carnivore diet 10 wks ago. I started at 316.8 lbs; waist was 62.5 inches & my average blood sugar was 134 daily. Today I’m down to 300.2 lbs, waist is 57.5 inches & my blood sugar is 112 average. You have helped me sooo much by teaching me about my insulin resistance. Sorry so long I
@@yvonnekiwior9633 why are more Dr.’s not focusing on the insulin resistance? They constantly check our A1C but never insulin. My A1C has been 6.1 the past 4 or 5 times checked every 3 months
I was so disheartened when a woman in her 70's with T2D was stuffing herself with sugar laden desserts and when she asked why I wouldn't eat this I explained briefly why. She then said, I want to enjoy my life and I'll take my metformin. I had to bite my tongue and walk away because I'm not her healthcare provider. As a board certified Family nurse practitioner with over 50 years of treating T2D I have heard this more times than I can count. Americans want to compensate for all their bad behaviors with a "PILL" because that's how medicine has socialized this culture. Just watch TV. There's a "Pill" or "Drug" advertised for everything, especially T2D!! When is this going to stop? I tell my patients, "You ate your way into this and you can eat your way out of this".
@@benbikman thank you for reading my comment and for your response. I have so much respect for what you are doing and freely providing education for all to access. God bless your mission in this life.
If there was more support for people with diabetes this may not happen, your comment is uncalled for. You don’t have diabetes you have no idea what it’s like to live with this disease.
Hi meatdog- I just noticed your name - and wondered if you were carnivore ? Anyway I liked what you said. Maybe poeple are responding to things being called “bad behavior’! @@meatdog
I bought your book “Why We Get Sick” and read it three times and have lots of yellow highlights.. this book helped me understand what I was already doing but NOW I UNDERSTAND WHY IM DOING IT! I gave it to a few people at work who are into fitness and they were wowed by it… one guy started reading it at 5pm and read it all the way through and went to bed at 3am! Thank you so much for your life long work for everyone to read! Just think about all the people you are helping!!!
My blood glucose isn't terribly high but my doctor thought that I should be on metformin. For the last several weeks I've been working metal to fabricate new production equipment. In the past I always gained muscle when moving all that metal around. This time I'm actually getting weaker and I'm becoming very very sore. I'm starting to suspect that it's not age but the metformin that's causing it.
Fuck yes Metformin !!! I cried to my Endo that it was exhausting for me to walk. I was extremely fit, walking the hills where I Iive prior. Metformin made it impossible to even walk to my letterbox. Endo thought I was being melodramatic informing me that millions of people take Metformin and the next step was insulin. The diabetes educator told me I had to exercise but on Metformin I was too weak to even stand up in the shower. Not only B12 but also B1 which is required to oxidize glucose was decimated. As a 65 yro female, it is going to take hard work to get my strength back. These Drs should be liable for the damage they do.
Yes it's the metformin. It hinders your mitochondria from working. Once I stopped berberine, which works the same way as metformin, I started gaining muscle at the gym.
@@mirellamatotek4294 So sorry to hear your of your fatigue. You can bounce back. I lost a lot of muscle when I was fasting and also broke my wrist. I got dumbells and walked. Today I felt awful, so I only walked for a few minutes. It counts! Just a few minutes- you can do it. Take your time, but do it, a little and build up. Good luck
@@amyb3680 Bless you and thank you. Your words gives me hope knowing it is doable. I need to trust my body and make a conscious effort to increase steps every day. The weather is warmer, making it easier.being outside walking. I started also doing farmer's walk, I can manage 15 kg in each hand going upstairs. So I am hopeful. I feel like a baby learning to walk again. What was effortless, now takes conscious and deliberate effort.
Hey Ben, great talk. My personal experience with metformin is that during training (cycling to be precise) I would get insane hypos when training time exceeded 2 hours. I experimented a lot, but I couldn't keep up with glucose intake. I did a lot of experimentation on myself to figure this out nothing worked. Then I had a talk with my diabetes practitioner and I explained my hypothesis that the hypos were caused by the metformin. She didn't understand a word I was saying and telling me it probably it was something else and we should stick to the protocol. A few months later I was pulled metformin and I never had a hypo since. This happened in April 2020. You exactly explained my hypothesis in this talk. By the way during long endurance training blood glucose tends to go down, but never into the hypo territory.
Of all the numerous UA-cam masterminds on this topic, I find that Dr. Ben Bikman always rises to the top. I personally cannot believe that he doesn't have several million subscribers by now. No click bait, no fancy shmancy props, just the facts laid out in a way that the average layperson should be able to easily grasp. Thank you for everything that you do. Type 2 in remission here, thanks to the likes of you and others that so generously share their time & expertise on a subject that mainstream GP's seemingly do not understand. Hopefully the next generation of family doctors wise up. Thanks again.
I took Metformin for about 8 years before I found out how it affects B12. No one informed me of a B12 deficiency caused by taking Metformin. Not taking Metformin anymore however. Diet controlled now.
Nobody told me either! Here's something else they don't tell you --> Metformin is poison to Mitochondria and impairs their production of energy by decreasing ATP synthesis. Everyone on Metformin basically has Dysfunctional Mitochondria.
They make things worse because no one tells us that the only cure for T2D is a drastic and immediate dietary change so we think we are being fixed by what amounts to a chemical bandaid that masks the issue. Been there. Done that.
@@anitacontarini3394 Well that bus needs to be backed up to the cause of Diabetes. I was under the assumption that it was hereditary and unavoidable and unfixable without drugs. then I found out the drugs are a scam and probably killed my dad from Bile Duct cancer. I changed my diet after my blood work last may made that abundantly clear. I could not trust the finger stick readings to be the real story.
My Doctor sent me to a dietician for diet advice to help. It was a high carb diet and the advice was you could still have dessert treats. I just ended up on more and more medicine. It was all a lie! 🇬🇧
@@lindasmeeth9053perhaps you can check out Dr David Unwin here on UA-cam, he is a family doctor in Southport UK and reverses T2D in his patients via low carb diets and lifestyle interventions.
Brilliant lecture. What a gentle and kind professor, full of wisdom. Thank you for your vids and all the diligent work you do to bring health knowledge to all. Extreme appreciation.
Good for you Dr. Ben for emphasizing the opposite nature of HYPOinsulinemia (I) vs HYPERisulinemia (II). This is something that the general public *really* needs to understand.
the most impressive part of this video is when someone asked him the effect of metformin on vit B12 around 43:12, he said he's never heard of it with total honesty. And I trust him.
Before I started my carnivore journey 3 years ago, I was T2D taking Metformin and I was not happy with what it was doing to me. My doc was blaming me for my worsening health as in his opinion I was not doing enough exercise, but I was doing regular resistance exercise as I hated aerobic. Over time I found that I wasn't getting the results that I was expecting in the gym, and I was hurting myself more often. I also felt that whilst my weight wasn't reducing, I just felt that I was getting fatter, and this was borne out when I realised that Metformin was causing my fat cells to be less resistant to the effect of insulin, thereby allowing more fat to be stored. Once I stopped taking Metformin and by changing my diet to low carb, I started losing weight and all other issues disappeared along with the meds I was taking ie high blood pressure and the statin. 3.5 years later, no meds and on a carnivore diet - I haven't felt better although my doc doesn't approve. He keeps on harping on about my high LDL, but I ask him about my HDL / Triglyceride ratio which is a truer indicator of heart disease than high LDL.
~8:00 Please also mention at some point another important set of effects of hyperglycemia: First, in addition to raising HbA1c, it also significantly raises the glycation of ApoB-100, the signaling protein attached to LDLs, and this renders those proteins unrecognizable by their receptors. This can eventually lead to an increase in pattern B LDL, which is an increase in SDLDL, which is a big chronic problem. The American Diabetes Association knows about this; they have published papers about the glycation of ApoB-100. Second, please go into details about the effects of hyperglycemia on the kidneys. There are at least 4 areas on the nephrons with glucose receptors. One of those areas is on the acending loop and distal tubules, and is responsible for sodium concentration. High insulin causes sodium retention by increasing reuptake, and low insulin results in loss of sodium to the urine. Please also look into the details of the other three insulin receptor areas in the kidneys and describe their functions. Thanks!
Type 2 and have been confounded why my muscles can't build and haven't been what I consider "normal" for years. I've been on metformin for years... I've been afraid to stop it in large part because of having PCOS. I think I need to take another look at how I'm handling everything.
I used to have type 2 diabetes. It went away after 60 days on carnivore. My A1c didn't budge while I was (previously) doing plant based, whole food keto and intermittent fasting. Bonus positive was that my triglycerides also dropped 90 points in the same (1st) 60 days on carnivore. They only went down 10 points during the previous year on plant based, whole foods keto. Additionally, on plant based, whole foods keto, my gut issues were AWFUL. The gut issues have steadily improved on carnivore.
Your talks have made an impact on my life and my husband life. He has been a Type II DM since 2012, and with only a few weeks of diet change to ketogenic diet, he has made a serious impact on his blood glucose levels to the point he off his DM medications and maintaining normal levels on diet and daily exercise alone. Thank you for contributing to our success!
Thank you very much, am physician and diabetic, iall you interviews and lectures are helping me, eitger in my practice as primary care phtsician and myself being diabetic
41:30 - It seems to me that metformin prevents the uptake of fluids from the intestines, so fluids, glucose and B12 will be lost that way. A high dosage can give you diarrhea. KenDBerryMD said in a quick video that a lack of B12 could lead to "irreperable damage," but as far as I can recall he didn't get more specific. Anyway, if you take metformin, you have better monitor the level in your blood and make sure you can supplement with exogenous B12. According to some you can have too much B12, but others say any surplus will go out with the urine.
What is suggestive when insulin doesn’t lower blood glucose? Diagnosed T2 two weeks ago and started metformin and 10 units of Basaglar. With low carb diet, first morning after 10 units, BG was 274. Dr. Has since increased to 36 units at night and morning BG is 270. Not eating after 6 PM. Low carb, exercise, etc. Can’t figure it out. A1C was 14.3. 35 year old male, athletic build, not overweight.
Thanks for your comment. You may want to consider joining our community to get a little more support and some ideas from our coaching team and from other like-minded people working on their metabolic health. You can do a 10-day trial at no cost: www.insuliniq.com/insulin-iq-community-membership-signup
I'm not sure about the "glucose isn't sweet" statement. I know that fructose is something like 7 times sweeter, but I had a Kraft test and drank 75g of glucose. It was sweet. Did they add something to make it sickly sweet?
Hi, at about 25:10 in the video you say it's virtually unheard of to have type two diabetes and not be overweight. I am now at two plus years of being diagnosed with type 2 diabetes. I am 5 foot 6 inches and weigh 140 pounds. So I am not over weight. My father was type two diabetes and his side of the family are Mexican and most are type 2. My mother was Chinese, 5 foot two inches, and thin, but she had type 2 diabetes. Probably from eating the American diet.
How Type 2 Diabetes was diagnosed? Did your physician ask to check C -PEPTIDE/Insulin level? Increased level of Insulin tends to store fat in the body.
@@mithidas4295 I will get T2 levels chronically if I increase my daily protein above 120g but closer to 90g as a male. My insulin levels are in a good position, c-peptide is showing insulin is working well, trigs below 70, HDL above 50, height to waist ratio is below .50, same as it was in high school. very fit, in my late 40s, and the one lever that will push me to Type 2 levels is protein as strict Carnivore for over a year and a half. Weight on its own will not determine diabetes and neither will carb content alone, protein seems to be an issue for many more than low-carb docs want to acknowledge or don't quite know yet.
I have the same issue, I am very fit and all my markers show I am not insulin-resistant. After well over a year of testing, I have found that protein will push me up to type 2 levels, chronically. It won't have the large swings carbs do, yet it is still keeping my BG at elevated levels. I have to keep my protein to below 120g daily but it's better at around 90g daily which takes me out of Type 2 / Pre-Diabetic levels but BG is still not at the optimal levels. That makes it difficult to not under-eat, unfortunately. I do eat close to 75% - 85% plus from fat so it seems to be working to a degree. It is still a factor for me that too much protein will make me a Type 2 diabetic despite what all these internet Dr in the Carnivore space say. I do not put Ben Bikman in that category, I respect what he is doing as he is basing it off of studies, not biased opinions around the general subject. It may not align exactly to what my results are but that is very likely because he hasn't had the opportunity to study the groups that have these issues. From what I can tell, there are a lot of people that are largely ignored in this space. Here is the thing I wonder about. If this is happening to some of us, it's likely happening to everyone to a degree. Same as people are unaware of the damage of BG with carbs until they are diabetic, is that resulting from excessive protein until the point they are damaged as well. Too much we just don't know about yet and the self-proclaimed experts don't know either.
I am really enjoying all of the information that I am gathering from listening to you Dr. Bikman. Thanks for posting your videos. I was curious as to if you are going to ever have a UA-cam lecture on Anti-Diabetic supplements and how they work, etc.? I am a type2 with an a1c in remission standards and take Berberine, as well as I have taken other supplements that affect blood glucose levels. I have also read that Berberine can improve lipid metabolism and lower cholesterol. It would be really great to hear some of the science explained by you behind how Berberine and others work concerning blood glucose management. Thanks again for your lectures Dr. Bikman and I look forward to listening to more as you post them, as well as seeing more of the interview type UA-cam videos with you in them.
~8:00 Fatty liver disease appears to be a consequence specifically of high dietary consumption of *fructose* which is almost completely intercepted by the liver and converted into glyceraldehyde (toxic) and dihydroxyacetone-phosphate, and not directly related to hyperinsulinemia.
You may want to create a free Basic Membership on our website which gives you access to our introductory course, “Raising Your Insulin IQ for Improved Metabolic Health”. This may really help you with your questions: www.insuliniq.com
I have diabetes but struggling to control it because I have hemochromatosis my ferritin is very high my iron overload is still high I just don't know what to do I'm doing the carnivore diet but my blood glucose is very high I'm not loosing weight nor feeling better ..have you any videos on diabetes and hemochromatosis?
Type 2 person here. I have noticed that if I don't take Metformin WHILE I'm eating, then my blood sugar testing will remain high, especially the next morning. If i take the metformin at the SAME TIME I am eating carbs, especially carbs that I know will make me higher, things like desserts and soda, then my blood sugar test will remain low 3 hours after a meal and especially the next morning after I wake up (overnight fast). This had led me to believe that the Metformin is reacting with the food more then with tissues or blood. Is my assumption incorrect ?
I am same as Jackie with ketone, ketovore, and SGL2. Xigduo. I quit taking, w/o doctors help, but I am so sick of this, BG coming down avg 14 days 157, quit measuring ketone bc I moved and never found my tester. PS was on Metformin 14 years, slowly creeping up, Xigduo for 4 years.
Appreciate your talks so much, Dr. Bikman, and your analysis -- especially the discussion of how Type 1 autoimmune diabetes compares and contrasts with Type 2 insulin resistance. You clearly think about this topic a lot, and are looking for optimal solutions. I do have a bit of a disagreement with what you said about "LADA" as being "rare" and "late onset." No, sorry, that's not correct. New cases of autoimmune diabetes are mostly diagnosed in adults, but we are stuck with this lingering belief that "Type 1 diabetes happens mostly in children." Nope, it happens in every decade of life, and if adults were tested more, we would all see that autoimmunity is actually more prevalent than "the medical establishment" has led us to believe. What would "late" be anyway? Teens, 20s, 30s, 40s, 50s, 60s, 70s, 80s. I've talked to many individuals and seen reports of all these ages. So, there's no dividing line between "Type 1" and "Late onset Type 1." As you say: LADA is just Type 1 diabetes. But you mentioned it in context of Type 2, and saying people are also developing autoimmunity. No, I don't see this at all. Mostly adults are simply being misdiagnosed as Type 2 from the start. And generally that is because of this old belief about Types are determined by age. Or that "gestational diabetes predicts Type 2 diabetes in 50% of cases" -- um, except sometimes it isn't Type 2, and is again autoimmune diabetes that was going to show up eventually, if the pregnancy hadn't revealed it. One can can have "double diabetes" -- with both autoimmunity and resistance. But that isn't LADA (nor is that the so-called "Type 1.5"). Type 1 are not immune from developing insulin resistance and developing fatty deposits, for all the same reasons as you discuss. So, would appreciate a clarification that "LADA" is not related to Type 2 in any material way; autoimmunity is the problem. And also that saying "late" is misleading and potentially harmful to patients, because they end up delaying essential insulin therapy, either because they don't want to believe they have Type 1 autoimmunity; or because their doctor doesn't want to believe it. (They might also get this nonsense diagnosis of "Type 1.5.") So, another reason medications don't work for some diabetics is because they are being treated for the wrong disease. When in fact, they cannot make enough insulin, and do absolutely need insulin injections. But these people are getting exposed to all of the wrong messages: "Insulin for Type 2 is life threatening." Okay, for too many genuine T2D patients -- but people with the incorrect T2D diagnosis walk away with an aversion to taking insulin, and may end up hospitalized with DKA; or otherwise thinking they "failed" to take care of themselves properly, and remorsefully need insulin. All of the other medications would be masking the reason for the high glucose. So, what you say here is well-reasoned for Type 2; but please also emphasize that patients first need the correct diagnosis -- autoantibodies and C-peptide. If the insulin levels are not ever measurably high, then increasing possibility that the patient does not have Type 2 insulin resistance, and may be misdiagnosed. Autoantibodies are found in "Type 1" diagnosis in 90% of people with that diagnosis. Insulin therapy shouldn't be made into the boogeyman; people need proper testing to be given the proper drugs. But too many times, they don't get it. Thanks for your work. I have so many questions on other diabetes issues.
There is a study, I believe by the NIH, that metformin affects nerves. I had severe peripheral neuropathy then, taking 50mg of Lyrica. I stopped taking metformin and supplemented with 1000 mgs of B12 in 2019. Have not had nerve pain since...no lyrica. BTW, I self medicated myself because my MD is not into research, except for the latest in anti-diabetic drugs.
My question is related to insulin resistance in general and not directly related to this particular lecture (which was excellent). My understanding is that there seems to be pathology directly from hyperinsulinemia and other pathology due to cells not responding to insulin, as though there isn't enough (insensitive). I'm wondering if Dr. Bikman could summarize in a chart the issues related directly to hyperinsulinemia vs. those that are related to the cell's non-responsiveness to insulin?
They are opposite sides of the teeter toter. One goes up and one goes down. Before you wake up cortisol goes up and your liver puts sugar in your blood. Cortisol drops and insulin rises. So you get fed your blood sugar in your cells.
I think cortisol tends to raise blood glucose (it’s a “counter regulatory” hormone) while insulin lowers blood glucose. But I also think I’ve heard that cortisol high for long periods of time might make someone more insulin resistant (lack of sleep and stress maybe doing that? ) @@NansGlobalKitchen
Cortisol Is Negatively Associated with Insulin Sensitivity in Overweight Latino Youth www.ncbi.nlm.nih.gov/pmc/articles/PMC3050109/#:~:text=Specifically%2C%20cortisol%20is%20negatively%20associated,insulin%20resistance%20in%20this%20population. One paper that I found that supports what you thought
Excellent question. My HbAlc is 6.2 but I've eliminated all carbs and sugar for the last 18 months. So I figured I have to get my HbAlc down by taking berberine which I started this week. Berberine, like Metformin, addresses the insulin problem too. I'm getting a bit confused at this stage.
Dr. Ben, Is there any glucagon inhibitor without causing side effects? Is it possible that stevia or similar products here glucagon reducing effect? It will be a great help for diabetics if such thing exists. I’m not talking about GLP1 agonists which have their own problems. Nagi Reddy, India. Ps. I read your book. Most comprehensive and informative for the people who can understand some biology.
I understand the mechanism of insulin resistance leading to hyperglycemia / diabetes type 2. Therefore I have been thinking why surgery / transplant patients are injected with insulin because of corticoids induced hyperglycemia / diabetes. Is it not that in this case , insulin is still ample but not effective rather than a lack of it? While it sounds insensible, the insulin injection has been done everywhere worldwide and has proved to be helpful. I have been scratching my head on this, and would appreciate your explanation.
If, after years of eating the SAD diet, one eats low carb but still cannot lower glucose to normal levels, what drug, if any, would you recommend. I am aware you are a researcher, but curious…
Thank you Dr. Bikman for clarifying the mechanism employed by GLP1-RAs like Semaglutide. I've been on Ozempic off and on (due to shortages) and found that after some time it becomes ineffective. What could be the reason in your expert opinion?
Excellent info! Thank you for taking the time to share. I particularly wanted to ask about exercise and protein consumption relative to insulin secretion. I have read your informative book, but noted that you seem to be saying that protein -in the absence of sugar- does not have a significant effect on insulin production. I understand the importance of protein in conjunction with exercise, but am concerned about rhino testing my pancreas every time I consume protein.
I’m a 70 years old male, 20 as t2d, 10 on insulin therapy. As a result of your talks I have been able to cut out injecting insulin and have lost 12% (10kg) body weight. Also wear a CGM now, it has helped a lot. Blood pressure stabilised nicely. I am still on three medication and want to cut them over the next 6 months. Metformin, Forxiga and Janumet. I am trying to work out which category of drug the Janumet falls under. Any advice? 🙂
You should have given the common names associated with the tech names. For example, ozempic is what ? Gardiane is what acronym ? See why I am at a loss right now?
They induced my wife's pancreatic cancer. It was prescribed, apparently four months later pulled from approval, I determined that a year later and four months after she died..
@@daniellem1838 She was prescribed the original combination of Onglyza with metformin called Kombiglyze ( ua-cam.com/video/t8oAWSVRZQg/v-deo.html ). What is now sold as Kombiglyze is a combination of Saxagliptin/metformin which may be better, I don't know.. She took it from April through July when they took her off it. The following New Years eve, after seeing her internist twice and a gastric guy she was diagnosed with stage 4 pancreatic cancer by the emergency room doctor who saw it immediately in the scan she took to rule out the "big things." She lived another 15 months. Until the final diagnosis, no doctor had even broached the idea of cancer even though if you Googled the word Konbiglyze, lawyers were the first two pages of listings.
Professor Bart Kay states there is never a case of insulin resistance but only a situation in which the mitochondria is full of glucose and has just “closed the door” on any more insulin but has not built up any so called “resistance” to insulin. I realize this is somewhat of a semantics debate but would like to get Dr. Bikman’s opinion.
Have been a diagnosed DIABETIC for 6 years, oh after today I have to go on this diet for six months. I cannot take metformin very bad side effects .. so I was put on 50 units of humulin 3 (isophane) KwikPen BD..9am & 4pm daily before I eat two meals a day.. IF after 7pm-9am. Can I come off insulin immediatly, continue on Low carb keto diet, eating below 50 grams of carb..I have gained weight (10 kgs in two years..
Super Video, as a lay person trying to understand it is very easy to get caught up in social media arguments that one cannot really unpick because of a lack of education or IQ probably. Once such area is the idea of insulin resistance being poo pooed in favour of 'the Randle cycle'. Is it possible to unpick this? My super simplistic understanding is that insulin resistance is about the signal from insulin being less effective because hyperinsulinaemia causes tolerance, so more is required i.e shouting louder. The Randle cycle saying that it is not 'resistance'. It is the fact that the cells are already full of energy and have chosen to close the doors. They won't accept any more 'energy'? Is this just nitpicking does it matter anyway consequentially? (to a lay person of course, to somebody interested in the actual biochemistry there will be an answer, I assume?) But for myself, I would like to understand in broad terms which is the right way of thinking about it.
I'm stuck on ozempic. I eat almost zero carbs yet my glucose level won't come down unless I stop taking the ozempic, even with that the average still doesn't come down more than 25 points. How can this drug keep my glucose raised?
@@smooth_pursuit Ozempic increases insulin production and inhibits glucagon production so blood sugar levels should come down a little with ozempic alone, with no carb intake it should drop fast.
Bodybuilders who've tried metformin typically report that it doesn't noticeably harm their muscle growth or lifting performance. Maybe it's more harmful in older adults, but it can't be all that detrimental in young to middle-aged adults or someone would've noticed.
Since I went on Statin drugs since my bypass operation a few years back my glucos levels have been increasing to the point that they're putting me on you guessed it. Also, the statin drugs cause severe constipation. I was taking psyillium fiber with minimal success. I recently added oat fiber and it made a big difference.
Very helpful session. Thank you. My only concern is when you answer a question with information you aren’t totally familiar with or haven’t researched (example vit B12 and metformin). Why not just say you aren’t sure, instead of answering in a way that adds a negative connotation to the drug? As scientists and experts, we should state the limitations to our opinions and not be afraid to acknowledge what we don’t know or aren’t sure of. Thanks for considering this.
You commented that protein is unlikely to convert to glucose. I don't understand. I am a one-year, completely strict Carnivore, and if I eat more than 90g - 120g of protein per day, regardless of whether it is split up, my glucose levels will go to type 2 diabetic levels and stay there until I reduce my protein intake to that 90g to 120g. Been Carnivore for a year and a half, and this hasn't changed, so I don't understand how the low-carb world can say protein won't cause blood sugar levels to rise abnormally. Its definitely slower and doesn't have the drastic swings carbs do, yet it still can put me in a type 2 diabetic levels. All other metabolic markers are solid besides blood glucose levels. Completely at a loss.
@@mohhrageh3792 It ranges from a minimum of 70% from fat, yet it more often is closer to 80% sometimes more to get enough food so I am not undereating. From looking for solutions to this, it seems like it is way more common than the low-carb community will openly discuss, not sure why.
Dr Bickman, my T 2 husbands glucos goes up with meat. If Metformin and Insulin are so bad what is the way to get his blood sugar to lower so he isn’t having damage to his organs etc.??
You have to play with fat-protein ratios. I have to keep my protein around 90 to 120 grams per day or my BG will raise to type 2 diabetes. Protein is the only lever I can pull, all other testing over a year and half of this, that is the only thing that afffects my glucose on a strict Carnivore diet. You will rarely hear low-carb people even mention this. They either don't know do to their own dogma or are afraid of losing viewers and reducing their audience by saying anything negative about protein.
Excellent lecture here that everyone with Type 2 Diabetes (currently) needs to watch!
Thanks, Ken.
Berry trying to stay relevant.
Yeah, agree. He has been getting pretty irrelevant lately. Its not like he has 3 million subs or anything😂
Come on man... how can you talk down upon someone who is literally curing millions of people around the world?? @@Jimmy-Legs
@@BarabasCsaba7I think we can see who is trying to be relevant in this chat 😂. I immediately thought the same thing as you. 3 million people think he’s worth listening to.
@@coffeemachtspass exactly😁
Im a 66 year old woman with 30 yr history of type 2 Diabetes. I've been shuttled from actos to Metformin to Victoza back and forth until I was put onto Lantus and Novolog. I continually gained weight with worsening symptoms. Im a cardiac patient due to the stresses in 2020, causing takotsubo cardiomyopathy. I started the keto diet recently and have seen a reduction in the needed insulin. However, I'm thinking carnivore is the only thing that is going to save my life. I have no one on my medical teams that agrees with Keto, let alone all animal products. I'm honestly going to have to nod my head at appointments and go home to do MY OWN THING. Thank God I know how to track my blood pressure, take my medications, and I wear a continuous glucose monitor. Please wish me luck, I'm going to seriously need it. My husband will do this diet, too.
Please meat eat with confidence and you have a hubby too. Help each other. You will find a goldmine of guidance from good docs you will soon learn to be out there. Also kind people telling their victories. Welcome.
Been there for almost 7 years. Mostly carnivore with at least 70% of my calories from animal fats. Drs don't have to know about everything, but my lab numbers tell me everything I need to know. Type 2 diabetic and a heart bypass almost 8 years ago. 77 years old, still work 4 hours per day 5 days per week and walk 2-4 miles per day
Good luck and prayers for your success.
Good!!!!
DO IT! You will see the results on your CGM. if your vaxed that heart condition is a documented side effect. You'll find on pubmed. Ignore your doctor's. Look what they've done to you already! Believe it or not, my cardiologist and electrocardiologist both totally support me being Carnivore! You're going to do great! I think Dr Boz might be good for you too. 🎉
Thank you for your research. 17 yrs ago I had a massive heart attack,(5 bypass surgery), my cardiologist almost in passing said did you know you’re diabetic? I had no idea. And treated my heart problems only 11 different meds. I walked into the hospital 183 lbs in shape. 9 days later walked out 224 lbs. six months later blew up to 265 lbs, walking 10 miles aday everyday. Then diagnosed with COPD and was put on prednisone. I blew up to 315 lbs. all my cardiologist & primary care doctors treated me with metformin, statins, high blood pressure meds, & Ozempic switched to TRULICITY switched to majourno .
I started the carnivore diet 10 wks ago. I started at 316.8 lbs; waist was 62.5 inches & my average blood sugar was 134 daily. Today I’m down to 300.2 lbs, waist is 57.5 inches & my blood sugar is 112 average.
You have helped me sooo much by teaching me about my insulin resistance. Sorry so long
I
Thanks for sharing your story!
Glad we have been able to help you. Thanks for commenting.
@@benbikman you, Dr Ken Berry, & Anthony Chaffee the woman from 5 minute body from down under dark hair big smile 😉
Thrilled to hear you are have great results🎉🙏
@@yvonnekiwior9633 why are more Dr.’s not focusing on the insulin resistance? They constantly check our A1C but never insulin. My A1C has been 6.1 the past 4 or 5 times checked every 3 months
I was so disheartened when a woman in her 70's with T2D was stuffing herself with sugar laden desserts and when she asked why I wouldn't eat this I explained briefly why. She then said, I want to enjoy my life and I'll take my metformin. I had to bite my tongue and walk away because I'm not her healthcare provider. As a board certified Family nurse practitioner with over 50 years of treating T2D I have heard this more times than I can count. Americans want to compensate for all their bad behaviors with a "PILL" because that's how medicine has socialized this culture. Just watch TV. There's a "Pill" or "Drug" advertised for everything, especially T2D!! When is this going to stop? I tell my patients, "You ate your way into this and you can eat your way out of this".
So well said. Thank you for your comment.
@@benbikman thank you for reading my comment and for your response. I have so much respect for what you are doing and freely providing education for all to access. God bless your mission in this life.
If there was more support for people with diabetes this may not happen, your comment is uncalled for. You don’t have diabetes you have no idea what it’s like to live with this disease.
Hi meatdog- I just noticed your name - and wondered if you were carnivore ? Anyway I liked what you said. Maybe poeple are responding to things being called “bad behavior’! @@meatdog
Can you elaborate more? @@craftygirl17
I bought your book “Why We Get Sick” and read it three times and have lots of yellow highlights.. this book helped me understand what I was already doing but NOW I UNDERSTAND WHY IM DOING IT! I gave it to a few people at work who are into fitness and they were wowed by it… one guy started reading it at 5pm and read it all the way through and went to bed at 3am! Thank you so much for your life long work for everyone to read! Just think about all the people you are helping!!!
Thanks for your comment. You’re kind. Glad it has helped.
21:08
My blood glucose isn't terribly high but my doctor thought that I should be on metformin. For the last several weeks I've been working metal to fabricate new production equipment. In the past I always gained muscle when moving all that metal around. This time I'm actually getting weaker and I'm becoming very very sore. I'm starting to suspect that it's not age but the metformin that's causing it.
Fuck yes Metformin !!! I cried to my Endo that it was exhausting for me to walk. I was extremely fit, walking the hills where I Iive prior. Metformin made it impossible to even walk to my letterbox. Endo thought I was being melodramatic informing me that millions of people take Metformin and the next step was insulin. The diabetes educator told me I had to exercise but on Metformin I was too weak to even stand up in the shower. Not only B12 but also B1 which is required to oxidize glucose was decimated. As a 65 yro female, it is going to take hard work to get my strength back. These Drs should be liable for the damage they do.
Yes it's the metformin. It hinders your mitochondria from working. Once I stopped berberine, which works the same way as metformin, I started gaining muscle at the gym.
Research how it effects Mitochondria and how it impairs their production of energy. Everyone on Metformin basically has dysfunctional Mitochondria.
@@mirellamatotek4294 So sorry to hear your of your fatigue. You can bounce back. I lost a lot of muscle when I was fasting and also broke my wrist. I got dumbells and walked. Today I felt awful, so I only walked for a few minutes. It counts! Just a few minutes- you can do it. Take your time, but do it, a little and build up. Good luck
@@amyb3680 Bless you and thank you. Your words gives me hope knowing it is doable. I need to trust my body and make a conscious effort to increase steps every day. The weather is warmer, making it easier.being outside walking. I started also doing farmer's walk, I can manage 15 kg in each hand going upstairs. So I am hopeful. I feel like a baby learning to walk again. What was effortless, now takes conscious and deliberate effort.
Dr. Bikman one of the Top Doctors in Diabetics!
Thank You so much!
Hey Ben,
great talk. My personal experience with metformin is that during training (cycling to be precise) I would get insane hypos when training time exceeded 2 hours. I experimented a lot, but I couldn't keep up with glucose intake. I did a lot of experimentation on myself to figure this out nothing worked.
Then I had a talk with my diabetes practitioner and I explained my hypothesis that the hypos were caused by the metformin. She didn't understand a word I was saying and telling me it probably it was something else and we should stick to the protocol. A few months later I was pulled metformin and I never had a hypo since. This happened in April 2020.
You exactly explained my hypothesis in this talk.
By the way during long endurance training blood glucose tends to go down, but never into the hypo territory.
Interesting!
Research how it effects Mitochondria and how it impairs their production of energy. Everyone on Metformin basically has dysfunctional Mitochondria.
Of all the numerous UA-cam masterminds on this topic, I find that Dr. Ben Bikman always rises to the top. I personally cannot believe that he doesn't have several million subscribers by now. No click bait, no fancy shmancy props, just the facts laid out in a way that the average layperson should be able to easily grasp. Thank you for everything that you do. Type 2 in remission here, thanks to the likes of you and others that so generously share their time & expertise on a subject that mainstream GP's seemingly do not understand. Hopefully the next generation of family doctors wise up. Thanks again.
Thank you.
Most people are averse to truth.
I took Metformin for about 8 years before I found out how it affects B12. No one informed me of a B12 deficiency caused by taking Metformin. Not taking Metformin anymore however. Diet controlled now.
it blocks uptake of b1 also
@@気にしない-o8qreally?
Nobody told me either! Here's something else they don't tell you --> Metformin is poison to Mitochondria and impairs their production of energy by decreasing ATP synthesis. Everyone on Metformin basically has Dysfunctional Mitochondria.
They make things worse because no one tells us that the only cure for T2D is a drastic and immediate dietary change so we think we are being fixed by what amounts to a chemical bandaid that masks the issue. Been there. Done that.
But ehen i advise prleople onthe low carb theu do not want to listen anyway, they have never cooked vegetable soup in their miserable lives
@@anitacontarini3394 Well that bus needs to be backed up to the cause of Diabetes. I was under the assumption that it was hereditary and unavoidable and unfixable without drugs. then I found out the drugs are a scam and probably killed my dad from Bile Duct cancer. I changed my diet after my blood work last may made that abundantly clear. I could not trust the finger stick readings to be the real story.
My Doctor sent me to a dietician for diet advice to help. It was a high carb diet and the advice was you could still have dessert treats. I just ended up on more and more medicine. It was all a lie! 🇬🇧
@@lindasmeeth9053perhaps you can check out Dr David Unwin here on UA-cam, he is a family doctor in Southport UK and reverses T2D in his patients via low carb diets and lifestyle interventions.
@@lindasmeeth9053every diabetic nutritionist I’ve seen pushed so many carbs.
Brilliant lecture. What a gentle and kind professor, full of wisdom. Thank you for your vids and all the diligent work you do to bring health knowledge to all. Extreme appreciation.
Good for you Dr. Ben for emphasizing the opposite nature of HYPOinsulinemia (I) vs HYPERisulinemia (II). This is something that the general public *really* needs to understand.
the most impressive part of this video is when someone asked him the effect of metformin on vit B12 around 43:12, he said he's never heard of it with total honesty. And I trust him.
Before I started my carnivore journey 3 years ago, I was T2D taking Metformin and I was not happy with what it was doing to me. My doc was blaming me for my worsening health as in his opinion I was not doing enough exercise, but I was doing regular resistance exercise as I hated aerobic. Over time I found that I wasn't getting the results that I was expecting in the gym, and I was hurting myself more often. I also felt that whilst my weight wasn't reducing, I just felt that I was getting fatter, and this was borne out when I realised that Metformin was causing my fat cells to be less resistant to the effect of insulin, thereby allowing more fat to be stored. Once I stopped taking Metformin and by changing my diet to low carb, I started losing weight and all other issues disappeared along with the meds I was taking ie high blood pressure and the statin. 3.5 years later, no meds and on a carnivore diet - I haven't felt better although my doc doesn't approve. He keeps on harping on about my high LDL, but I ask him about my HDL / Triglyceride ratio which is a truer indicator of heart disease than high LDL.
Check out Mindy Pelz and fasting.
Why do they say you may lose weight on Metformin?
doctors never admit to the bad things many meds cause people dont beleive doctors think for yourself
~8:00 Please also mention at some point another important set of effects of hyperglycemia: First, in addition to raising HbA1c, it also significantly raises the glycation of ApoB-100, the signaling protein attached to LDLs, and this renders those proteins unrecognizable by their receptors. This can eventually lead to an increase in pattern B LDL, which is an increase in SDLDL, which is a big chronic problem. The American Diabetes Association knows about this; they have published papers about the glycation of ApoB-100.
Second, please go into details about the effects of hyperglycemia on the kidneys. There are at least 4 areas on the nephrons with glucose receptors. One of those areas is on the acending loop and distal tubules, and is responsible for sodium concentration. High insulin causes sodium retention by increasing reuptake, and low insulin results in loss of sodium to the urine. Please also look into the details of the other three insulin receptor areas in the kidneys and describe their functions. Thanks!
Type 2 and have been confounded why my muscles can't build and haven't been what I consider "normal" for years. I've been on metformin for years... I've been afraid to stop it in large part because of having PCOS. I think I need to take another look at how I'm handling everything.
I used to have type 2 diabetes. It went away after 60 days on carnivore. My A1c didn't budge while I was (previously) doing plant based, whole food keto and intermittent fasting. Bonus positive was that my triglycerides also dropped 90 points in the same (1st) 60 days on carnivore. They only went down 10 points during the previous year on plant based, whole foods keto. Additionally, on plant based, whole foods keto, my gut issues were AWFUL. The gut issues have steadily improved on carnivore.
Glad you are doing well. Thanks for your comment.
I am physician and teacher myself,love your class ❤
Your talks have made an impact on my life and my husband life. He has been a Type II DM since 2012, and with only a few weeks of diet change to ketogenic diet, he has made a serious impact on his blood glucose levels to the point he off his DM medications and maintaining normal levels on diet and daily exercise alone. Thank you for contributing to our success!
Thank you very much, am physician and diabetic, iall you interviews and lectures are helping me, eitger in my practice as primary care phtsician and myself being diabetic
Pls reverse your diabetes via Dr Jason Fung and Dr Unwin methods: low carb and time restricted eating
41:30 - It seems to me that metformin prevents the uptake of fluids from the intestines, so fluids, glucose and B12 will be lost that way. A high dosage can give you diarrhea.
KenDBerryMD said in a quick video that a lack of B12 could lead to "irreperable damage," but as far as I can recall he didn't get more specific. Anyway, if you take metformin, you have better monitor the level in your blood and make sure you can supplement with exogenous B12.
According to some you can have too much B12, but others say any surplus will go out with the urine.
I just can't get enough of these lectures, and always look forward to a new Dr Ben video!
What is suggestive when insulin doesn’t lower blood glucose? Diagnosed T2 two weeks ago and started metformin and 10 units of Basaglar. With low carb diet, first morning after 10 units, BG was 274. Dr. Has since increased to 36 units at night and morning BG is 270. Not eating after 6 PM. Low carb, exercise, etc. Can’t figure it out. A1C was 14.3. 35 year old male, athletic build, not overweight.
Thanks for your comment. You may want to consider joining our community to get a little more support and some ideas from our coaching team and from other like-minded people working on their metabolic health. You can do a 10-day trial at no cost: www.insuliniq.com/insulin-iq-community-membership-signup
I created a Dr. Bikman folder in my saved UA-cam videos and this one is especially key.
Going to class is fun and exciting. I finally )ketovore 3.5 years) have the mental clarity to take the info in and process it.
I am so excited for the uptick in videos as of late!! I could watch and learn every day! I cannot thank you enough.
Me too! I am so thankful to be able to learn!
You’re kind. Thanks.
Thanks for commenting.
I'm not sure about the "glucose isn't sweet" statement. I know that fructose is something like 7 times sweeter, but I had a Kraft test and drank 75g of glucose. It was sweet. Did they add something to make it sickly sweet?
Hi, at about 25:10 in the video you say it's virtually unheard of to have type two diabetes and not be overweight. I am now at two plus years of being diagnosed with type 2 diabetes. I am 5 foot 6 inches and weigh 140 pounds. So I am not over weight. My father was type two diabetes and his side of the family are Mexican and most are type 2. My mother was Chinese, 5 foot two inches, and thin, but she had type 2 diabetes. Probably from eating the American diet.
Exactly what Dr. Robert Lustig says. Diabetes rates go up in "normal weight" people, too. It's the diet, Not the weight.
How Type 2 Diabetes was diagnosed? Did your physician ask to check C -PEPTIDE/Insulin level? Increased level of Insulin tends to store fat in the body.
@@mithidas4295 I will get T2 levels chronically if I increase my daily protein above 120g but closer to 90g as a male. My insulin levels are in a good position, c-peptide is showing insulin is working well, trigs below 70, HDL above 50, height to waist ratio is below .50, same as it was in high school. very fit, in my late 40s, and the one lever that will push me to Type 2 levels is protein as strict Carnivore for over a year and a half. Weight on its own will not determine diabetes and neither will carb content alone, protein seems to be an issue for many more than low-carb docs want to acknowledge or don't quite know yet.
I have the same issue, I am very fit and all my markers show I am not insulin-resistant. After well over a year of testing, I have found that protein will push me up to type 2 levels, chronically. It won't have the large swings carbs do, yet it is still keeping my BG at elevated levels. I have to keep my protein to below 120g daily but it's better at around 90g daily which takes me out of Type 2 / Pre-Diabetic levels but BG is still not at the optimal levels. That makes it difficult to not under-eat, unfortunately. I do eat close to 75% - 85% plus from fat so it seems to be working to a degree.
It is still a factor for me that too much protein will make me a Type 2 diabetic despite what all these internet Dr in the Carnivore space say. I do not put Ben Bikman in that category, I respect what he is doing as he is basing it off of studies, not biased opinions around the general subject. It may not align exactly to what my results are but that is very likely because he hasn't had the opportunity to study the groups that have these issues. From what I can tell, there are a lot of people that are largely ignored in this space.
Here is the thing I wonder about. If this is happening to some of us, it's likely happening to everyone to a degree. Same as people are unaware of the damage of BG with carbs until they are diabetic, is that resulting from excessive protein until the point they are damaged as well.
Too much we just don't know about yet and the self-proclaimed experts don't know either.
You’re correct according to Dr Robert Lustig. You can be fat and NOT have diabetes, or thin and have it.
1. Metformin
2. Insulin
3. Meglitinide
4. Sulfonylureas
5. GLP 1 Agonist
6. Thiazolidinediones
7. SGLT 2 Inhibitors
8. Amylin Analog
I am really enjoying all of the information that I am gathering from listening to you Dr. Bikman. Thanks for posting your videos. I was curious as to if you are going to ever have a UA-cam lecture on Anti-Diabetic supplements and how they work, etc.? I am a type2 with an a1c in remission standards and take Berberine, as well as I have taken other supplements that affect blood glucose levels. I have also read that Berberine can improve lipid metabolism and lower cholesterol. It would be really great to hear some of the science explained by you behind how Berberine and others work concerning blood glucose management.
Thanks again for your lectures Dr. Bikman and I look forward to listening to more as you post them, as well as seeing more of the interview type UA-cam videos with you in them.
Thanks for taking the time to comment. I appreciate it.
~8:00 Fatty liver disease appears to be a consequence specifically of high dietary consumption of *fructose* which is almost completely intercepted by the liver and converted into glyceraldehyde (toxic) and dihydroxyacetone-phosphate, and not directly related to hyperinsulinemia.
Do Berberine cause the same "mitochondrial problem" of metformin?
Thank you from Ethiopia, I am a diabetic and need such explanations badly.
You may want to create a free Basic Membership on our website which gives you access to our introductory course, “Raising Your Insulin IQ for Improved Metabolic Health”. This may really help you with your questions: www.insuliniq.com
I have diabetes but struggling to control it because I have hemochromatosis my ferritin is very high my iron overload is still high I just don't know what to do I'm doing the carnivore diet but my blood glucose is very high I'm not loosing weight nor feeling better ..have you any videos on diabetes and hemochromatosis?
My father had hemochromatosis and often physicians suggest donating flood frequently.
Type 2 person here. I have noticed that if I don't take Metformin WHILE I'm eating, then my blood sugar testing will remain high, especially the next morning. If i take the metformin at the SAME TIME I am eating carbs, especially carbs that I know will make me higher, things like desserts and soda, then my blood sugar test will remain low 3 hours after a meal and especially the next morning after I wake up (overnight fast). This had led me to believe that the Metformin is reacting with the food more then with tissues or blood. Is my assumption incorrect ?
I love Dr Ben! Thank you for the great info you provide, Doc
🙏🌷🪻🕊
I am same as Jackie with ketone, ketovore, and SGL2. Xigduo. I quit taking, w/o doctors help, but I am so sick of this, BG coming down avg 14 days 157, quit measuring ketone bc I moved and never found my tester.
PS was on Metformin 14 years, slowly creeping up, Xigduo for 4 years.
Appreciate your talks so much, Dr. Bikman, and your analysis -- especially the discussion of how Type 1 autoimmune diabetes compares and contrasts with Type 2 insulin resistance. You clearly think about this topic a lot, and are looking for optimal solutions. I do have a bit of a disagreement with what you said about "LADA" as being "rare" and "late onset." No, sorry, that's not correct. New cases of autoimmune diabetes are mostly diagnosed in adults, but we are stuck with this lingering belief that "Type 1 diabetes happens mostly in children." Nope, it happens in every decade of life, and if adults were tested more, we would all see that autoimmunity is actually more prevalent than "the medical establishment" has led us to believe. What would "late" be anyway? Teens, 20s, 30s, 40s, 50s, 60s, 70s, 80s. I've talked to many individuals and seen reports of all these ages. So, there's no dividing line between "Type 1" and "Late onset Type 1."
As you say: LADA is just Type 1 diabetes. But you mentioned it in context of Type 2, and saying people are also developing autoimmunity. No, I don't see this at all. Mostly adults are simply being misdiagnosed as Type 2 from the start. And generally that is because of this old belief about Types are determined by age. Or that "gestational diabetes predicts Type 2 diabetes in 50% of cases" -- um, except sometimes it isn't Type 2, and is again autoimmune diabetes that was going to show up eventually, if the pregnancy hadn't revealed it. One can can have "double diabetes" -- with both autoimmunity and resistance. But that isn't LADA (nor is that the so-called "Type 1.5"). Type 1 are not immune from developing insulin resistance and developing fatty deposits, for all the same reasons as you discuss.
So, would appreciate a clarification that "LADA" is not related to Type 2 in any material way; autoimmunity is the problem. And also that saying "late" is misleading and potentially harmful to patients, because they end up delaying essential insulin therapy, either because they don't want to believe they have Type 1 autoimmunity; or because their doctor doesn't want to believe it. (They might also get this nonsense diagnosis of "Type 1.5.") So, another reason medications don't work for some diabetics is because they are being treated for the wrong disease. When in fact, they cannot make enough insulin, and do absolutely need insulin injections. But these people are getting exposed to all of the wrong messages: "Insulin for Type 2 is life threatening." Okay, for too many genuine T2D patients -- but people with the incorrect T2D diagnosis walk away with an aversion to taking insulin, and may end up hospitalized with DKA; or otherwise thinking they "failed" to take care of themselves properly, and remorsefully need insulin. All of the other medications would be masking the reason for the high glucose.
So, what you say here is well-reasoned for Type 2; but please also emphasize that patients first need the correct diagnosis -- autoantibodies and C-peptide. If the insulin levels are not ever measurably high, then increasing possibility that the patient does not have Type 2 insulin resistance, and may be misdiagnosed. Autoantibodies are found in "Type 1" diagnosis in 90% of people with that diagnosis. Insulin therapy shouldn't be made into the boogeyman; people need proper testing to be given the proper drugs. But too many times, they don't get it.
Thanks for your work. I have so many questions on other diabetes issues.
Symblime,amolodes?
Any thoughts on dihydro berberine?
Dr Bikman your efforts to teach in the face of opposition from existing institutions is truly appreciated. GOD BLESS YOU and your FAMILY
Thank you for this excellent presentation! I am going to forward this to several people who are looking after Type 2 diabetes patients.
There is a study, I believe by the NIH, that metformin affects nerves. I had severe peripheral neuropathy then, taking 50mg of Lyrica. I stopped taking metformin and supplemented with 1000 mgs of B12 in 2019. Have not had nerve pain since...no lyrica. BTW, I self medicated myself because my MD is not into research, except for the latest in anti-diabetic drugs.
What you you know about Janumet, please?
I took metformin once a day and had diarrhea and upset stomach.I had urinary tract infections and Fournier Gangrene.
Great lecture. Everybody with DM should listen to this
My question is related to insulin resistance in general and not directly related to this particular lecture (which was excellent). My understanding is that there seems to be pathology directly from hyperinsulinemia and other pathology due to cells not responding to insulin, as though there isn't enough (insensitive). I'm wondering if Dr. Bikman could summarize in a chart the issues related directly to hyperinsulinemia vs. those that are related to the cell's non-responsiveness to insulin?
Wonderful, informative video!
Dr. can you cover the Randle Cycle? We can not get a good straight answer.
I'm trying to understand the role of cortisol and its impact on insulin and metabolic flexibility. Will you be discussing this in a future session?
They are opposite sides of the teeter toter. One goes up and one goes down. Before you wake up cortisol goes up and your liver puts sugar in your blood. Cortisol drops and insulin rises. So you get fed your blood sugar in your cells.
Yes I’d love to know the interaction with hypothyroidism too!
Want to know more on this as well, because I heard from another content creator that cortisol and stress makes insulin go higher.
I think cortisol tends to raise blood glucose (it’s a “counter regulatory” hormone) while insulin lowers blood glucose. But I also think I’ve heard that cortisol high for long periods of time might make someone more insulin resistant (lack of sleep and stress maybe doing that? ) @@NansGlobalKitchen
Cortisol Is Negatively Associated with Insulin Sensitivity in Overweight Latino Youth
www.ncbi.nlm.nih.gov/pmc/articles/PMC3050109/#:~:text=Specifically%2C%20cortisol%20is%20negatively%20associated,insulin%20resistance%20in%20this%20population.
One paper that I found that supports what you thought
Genuine question, but doesn't metformin increase insulin sensitivity of the liver - i.e improving impaired fasting glucose. Exercise improves postprandial blood glucose, i.e peripheral insulin sensitivity muscles and fat. so exercising with metformin is actually good?
Excellent question. My HbAlc is 6.2 but I've eliminated all carbs and sugar for the last 18 months. So I figured I have to get my HbAlc down by taking berberine which I started this week. Berberine, like Metformin, addresses the insulin problem too. I'm getting a bit confused at this stage.
What about Berberine?
Thanks!
Thank you. What a thoughtful thing to do. I appreciate it very much.
Thanks for your series on diabetes excellent
Thank you for commenting.
Dr. Ben,
Is there any glucagon inhibitor without causing side effects?
Is it possible that stevia or similar products here glucagon reducing effect? It will be a great help for diabetics if such thing exists.
I’m not talking about GLP1 agonists which have their own problems.
Nagi Reddy, India.
Ps. I read your book. Most comprehensive and informative for the people who can understand some biology.
Thanks to you Dr. Bikman I know more than my Dr.
I understand the mechanism of insulin resistance leading to hyperglycemia / diabetes type 2. Therefore I have been thinking why surgery / transplant patients are injected with insulin because of corticoids induced hyperglycemia / diabetes. Is it not that in this case , insulin is still ample but not effective rather than a lack of it? While it sounds insensible, the insulin injection has been done everywhere worldwide and has proved to be helpful. I have been scratching my head on this, and would appreciate your explanation.
Great information, thank you
Thanks for commenting.
I listen t o every word and every video. Thank you very much!
Thank you. And thanks for commenting.
Glucose does not taste *as sweet* as honey, sucrose or fructose but it does taste sweet. I have consumed many pure glucose tabs. Tastes sweet to me.
I saw an interview where Peter Attia has changed his stance on metformin if you are not using it for insulin resistance.
This is amazing classroom!Thank you so so much dr Bikman for sharing the knowledge🎉
Great lecture. I tapped into your lecture today and was very glad I did. Thanks for sharing this phenomenal information.
Glad it was helpful!
Thanks for an excellent presentation!
If, after years of eating the SAD diet, one eats low carb but still cannot lower glucose to normal levels, what drug, if any, would you recommend. I am aware you are a researcher, but curious…
Thank you Dr. Bikman for clarifying the mechanism employed by GLP1-RAs like Semaglutide. I've been on Ozempic off and on (due to shortages) and found that after some time it becomes ineffective. What could be the reason in your expert opinion?
I’ve found that with Rybelsus, 14mg which is currently the maximum dose.
Excellent info! Thank you for taking the time to share. I particularly wanted to ask about exercise and protein consumption relative to insulin secretion. I have read your informative book, but noted that you seem to be saying that protein -in the absence of sugar- does not have a significant effect on insulin production.
I understand the importance of protein in conjunction with exercise, but am concerned about rhino testing my pancreas every time I consume protein.
Any thought on DPP-4 inhibitors such as Januvia?
Yesss, please talk about this class
They are good drugs but are largely being replace by GLP-1 agonists because those are better.
I’m a 70 years old male, 20 as t2d, 10 on insulin therapy.
As a result of your talks I have been able to cut out injecting insulin and have lost 12% (10kg) body weight. Also wear a CGM now, it has helped a lot. Blood pressure stabilised nicely.
I am still on three medication and want to cut them over the next 6 months. Metformin, Forxiga and Janumet. I am trying to work out which category of drug the Janumet falls under. Any advice? 🙂
You should have given the common names associated with the tech names.
For example, ozempic is what ?
Gardiane is what acronym ?
See why I am at a loss right now?
They induced my wife's pancreatic cancer. It was prescribed, apparently four months later pulled from approval, I determined that a year later and four months after she died..
I’m sorry for your loss. May I ask what exactly “they” were that induced the cancer?
@@daniellem1838 She was prescribed the original combination of Onglyza with metformin called Kombiglyze ( ua-cam.com/video/t8oAWSVRZQg/v-deo.html ). What is now sold as Kombiglyze is a combination of Saxagliptin/metformin which may be better, I don't know.. She took it from April through July when they took her off it. The following New Years eve, after seeing her internist twice and a gastric guy she was diagnosed with stage 4 pancreatic cancer by the emergency room doctor who saw it immediately in the scan she took to rule out the "big things." She lived another 15 months. Until the final diagnosis, no doctor had even broached the idea of cancer even though if you Googled the word Konbiglyze, lawyers were the first two pages of listings.
Love your book Dr Ben
Helped me so much
Thankyou
Professor Bart Kay states there is never a case of insulin resistance but only a situation in which the mitochondria is full of glucose and has just “closed the door” on any more insulin but has not built up any so called “resistance” to insulin. I realize this is somewhat of a semantics debate but would like to get Dr. Bikman’s opinion.
Love the awesome information. I need to be able to speed up your videos so I can make time to listen.
thank you Dr!
If metformin affects the muscles then what about the heart muscle. If a laborer uses metformin what could be the consequences?
This is such a valuable lecture! Thank you Dr. Bikaman!
You’re kind. Thanks for watching.
Have been a diagnosed DIABETIC for 6 years, oh after today I have to go on this diet for six months. I cannot take metformin very bad side effects .. so I was put on 50 units of humulin 3 (isophane) KwikPen BD..9am & 4pm daily before I eat two meals a day.. IF after 7pm-9am.
Can I come off insulin immediatly, continue on Low carb keto diet, eating below 50 grams of carb..I have gained weight (10 kgs in two years..
Super Video, as a lay person trying to understand it is very easy to get caught up in social media arguments that one cannot really unpick because of a lack of education or IQ probably.
Once such area is the idea of insulin resistance being poo pooed in favour of 'the Randle cycle'.
Is it possible to unpick this?
My super simplistic understanding is that insulin resistance is about the signal from insulin being less effective because hyperinsulinaemia causes tolerance, so more is required i.e shouting louder.
The Randle cycle saying that it is not 'resistance'. It is the fact that the cells are already full of energy and have chosen to close the doors. They won't accept any more 'energy'?
Is this just nitpicking does it matter anyway consequentially? (to a lay person of course, to somebody interested in the actual biochemistry there will be an answer, I assume?)
But for myself, I would like to understand in broad terms which is the right way of thinking about it.
Another great episode… thank you.
Glad you enjoyed it.
Really appreciate your lectures!!!!
Thanks for commenting, Charles.
I'm stuck on ozempic. I eat almost zero carbs yet my glucose level won't come down unless I stop taking the ozempic, even with that the average still doesn't come down more than 25 points. How can this drug keep my glucose raised?
Can’t you come off the ozempic and lose weight through ketosis, since you already eat zero carbs?
@@smooth_pursuit Ozempic increases insulin production and inhibits glucagon production so blood sugar levels should come down a little with ozempic alone, with no carb intake it should drop fast.
Get off Ozempic. Start eating Keto and start fasting.
What a clear and concise summary. Thank you. A true professor !!!
If Metformin is not the best idea, what about Berberine?
Did nothing for me ,but give me a rash .berberine is barberry .
Or bitter melon 😊
Dihydroberberine helped lower my insulin, and insulin resistance, and moderated my cholesterol levels.
@@cherylradabaugh2720didn’t do a thing for me either and very expensive
Bodybuilders who've tried metformin typically report that it doesn't noticeably harm their muscle growth or lifting performance. Maybe it's more harmful in older adults, but it can't be all that detrimental in young to middle-aged adults or someone would've noticed.
So I know this is anecdotal and I may be wrong. But I feel very strongly that when I first started taking metformin that I put on muscle.
Since I went on Statin drugs since my bypass operation a few years back my glucos levels have been increasing to the point that they're putting me on you guessed it. Also, the statin drugs cause severe constipation. I was taking psyillium fiber with minimal success. I recently added oat fiber and it made a big difference.
Don't take fibers!!!! Follow Dr Paul Mason. Fiber kills You
Hi from paris, you are such a great professeur,
Very helpful session. Thank you. My only concern is when you answer a question with information you aren’t totally familiar with or haven’t researched (example vit B12 and metformin). Why not just say you aren’t sure, instead of answering in a way that adds a negative connotation to the drug? As scientists and experts, we should state the limitations to our opinions and not be afraid to acknowledge what we don’t know or aren’t sure of. Thanks for considering this.
Thank you, Mark, for your comment. I appreciate that you reminded me of this. You’re right. Thanks for watching.
Thank you Ben.
Fantastic Ben thank you. I am watching everything you post now and particularly like your book.
Thank you. And thanks for commenting.
So if I take metformin Exercise is a waste of time?
Do you really need insulin (t1D) if you keep carb really low and exercise frequent.
Thanks for your question. You may want to go to our website and ask my team: www.insuliniq.com
Great informative episode Ben, thanks a lot.
Is there a test for LADA
You commented that protein is unlikely to convert to glucose. I don't understand. I am a one-year, completely strict Carnivore, and if I eat more than 90g - 120g of protein per day, regardless of whether it is split up, my glucose levels will go to type 2 diabetic levels and stay there until I reduce my protein intake to that 90g to 120g. Been Carnivore for a year and a half, and this hasn't changed, so I don't understand how the low-carb world can say protein won't cause blood sugar levels to rise abnormally. Its definitely slower and doesn't have the drastic swings carbs do, yet it still can put me in a type 2 diabetic levels. All other metabolic markers are solid besides blood glucose levels. Completely at a loss.
Interesting. How much is your fat intake along with protein?
@@mohhrageh3792 It ranges from a minimum of 70% from fat, yet it more often is closer to 80% sometimes more to get enough food so I am not undereating. From looking for solutions to this, it seems like it is way more common than the low-carb community will openly discuss, not sure why.
Same here
SGLT-2 blocks the re-uptake of glucose? What happens to the sodium? Are there ramification to that?
Yes, that is what I have been wondering.
Great lecture 😊😊
Dr Bickman, my T 2 husbands glucos goes up with meat. If Metformin and Insulin are so bad what is the way to get his blood sugar to lower so he isn’t having damage to his organs etc.??
You have to play with fat-protein ratios. I have to keep my protein around 90 to 120 grams per day or my BG will raise to type 2 diabetes. Protein is the only lever I can pull, all other testing over a year and half of this, that is the only thing that afffects my glucose on a strict Carnivore diet. You will rarely hear low-carb people even mention this. They either don't know do to their own dogma or are afraid of losing viewers and reducing their audience by saying anything negative about protein.
Very informative lecture. It did not touch upon Teneligliptin ? Our doctors are prescribing. Any thoughts on these please ?