I like how she simply asked what the guest eats right at the start and he totally switched the topic and rambled about how he doesn't know what the perfect diet is based on rat studies.
To see people like these two brilliant individuals having such an insightful conversation is truly amazing. You could almost listen both brains firing wildly as they shared ideas and argued different theories. There was an information overload almost in every minute of the conversation. I love these interviews Rhonda! Thank you for making this information available to a wide audience.
Thanks much to Dr. Patrick for taking the time to define the physiological terms that appear throughout the interview. Great interview even when Dr. Attia went off course once in a while (he seemed to wanting to talk about a lot of things). The interesting thing about Dr. Attia is his constant reminder that our brains thrive when the appropriate lipids are given. Can't wait for part 2!!
I loved this conversation because it had so much intellectual dialogue!! I really enjoy when people are able to share different views and come away with so much more insight!! it was brilliant!!
I loved every minute of this talk. I literally want to download both your brains. Such a wealth of knowledge and information. I am so happy to know there are people like you out there interested in these issues and I know that so many people will benefit from your experience. Thanks to you both for the interview.
I really enjoy the conversation, both of your brains at work, and the humility. I wish I had doctors like this! I learned so much I feel like I should pay y'all tuition.
Even though I didn't understand most of what you two were talking about. I still really loved watching this video because you two seem like very smart people.
Hey Rhonda, I absolutely love your videos! A tip that makes your longer videos more attractive to watch more than once-- put time stamps with the sub topics.
The bit about diet and sinusitis was very interesting. Although I don't get colds or flues, I used to get sinusitis and sinus headaches often, then I stopped my intake of diet sodas and diet sweeteners for my coffee and within 2 weeks I stopped having those issues. Note according to my DNA test, I respond well to absorption of vitamins and minerals and I believe it is likely antagonistic chemicals also affect me more than most people.
Ronda seems completely unfazed by a guy constantly interrupting her. Not that he's being rude .. But she is picking up his thought and tossing rejoinders back as soon as he cuts her off. Good chemistry. Learned alot
Interrupting people is a sign of ADHD and also narcissism. However, in this case, I would like to think it’s passion to share knowledge that is so needed and you’re right she is the best. She knows she’s here to find out what he knows because her audience- we already know (LOL but) a lot of what she thinks. That makes her awesome! I’m a huge fan.
@@CarolCarolDoddDodd I tend to not make armchair diagnosis around behaviours that are obviated by being disciplined. I have adhd and I am certainly able to refrain from that kind of thing in formal settings - and unable to control it in personal heated interactions. As for narcissism. It's such an unproven and weaponized term I would never want to put that in the mix about people in a critique. It's borderline character assassination. I'm not a therapist and I'm certainly not his therapist. I just don't feel qualified to throw those terms around about strangers. I'll go with passion over riding professionalism and agree with you on dr Patrick - also I've watched attia. He usually isn't this bad
Having worked with medical researchers for years, I can tell you that this is standard, as far as how conversations go. They are heavily engaged, fast moving, and branch horizontally onto all kinds of tangents anyone wants to take them and then they get collectively steered back to center. This is a very typical interaction between passionate researchers with high intelligence and knowledge and pretty standard when they are attempting to come to a mutual or collective truth or scientific foundation between each other. They are also clearly both high in extroversion and very excited to share information with each other, again which is typical when you two people like that interact. I see how you can view it that way, I used to as well when I first became involved in these types of discussions, but what I found is that they are not only acceptable but also often the norm.
@@jeandivine3 . not sure that doesn't describe any human endeavor at a high level. And in every cohort there are those who conflate urgency to speak with having alot to say. It probably annoys me because I'm often that guy
She impressed me and was correct on things that he had to take a Mulligan on, although that was fairly balanced. Attia is awesomely smart but exaggerates. He crosses into the border zone of toxic masculinity. Kidding! Great discussion overall.
Loved this exchange between two passionate and knowledgeable individuals. I really appreciated the pusback on the benefits of gut health. I believe about 90% of serotonin and dopamine is produced in the gut. As the saying goes...it is your second your brain. It is supremely important in overall wellness imo. So sauerkraut, yoghurts & especially kefir are staples of my diet. Key to make sure they include a broad spectrum of probiotics though. As if you consume a probiotic food/supplement that is just a few strains then you will have a gut flora of just oak trees. It's important to make sure you nurture variety to create a rainforest.
He's a gut skeptic because he's never had severe gut problems. If you've been suffering from gut pain all your life, it becomes the issue you're randomly trying to figure out.
Interesting conversation Rhonda, thanks for sharing! Your first question to Peter was: “What are you eating then to try to delay the aging process?” To be honest, I haven’t heard the answer :)
(From Transcript) Peter :- So I will explain conceptually how you do it. How you do it at the individual level is empirical and I think prescriptive, meaning you have to be able to try something, iterate on it, and make a measurement. But here's the conceptual way to do it. The conceptual way to do it, at least the way I do it, is you consume more or less the least amount of protein you can consume to maintain and grow muscle mass. But you don't need any more than that. So it depends on the individual, it depends on the timing of that protein ingestion, the quality of that protein and the type of metabolic and conditioning stimulus you put into it, but there's an amount. But for most of us I think we're probably over consuming protein relative to that actual need, so we raise protein level until we hit that amount. Carbohydrate, we do the opposite. Carbohydrate, we are basically lowering it until we reach the highest point...or pardon me, the lowest point that we can tolerate where we can maintain, and again, this is quick and dirty but it's the lowest possible fasting insulin. And in my mind I typically like to see that at below 3 or 4 as IU of insulin. And you want to limit, sort of, post-meal glycemia. And I actually use a standardized test which is an OGTT which has its limits because it's liquid, you're drinking liquid glucose. I like to limit that postprandial hyperinsulinemia to a number and I use a checkpoint of 30 that I want to be able to see within one hour of a 75-gram glucose challenge if you can keep insulin below 30. So in my mind, because I can't do what's called an AUC, an area under the curve. So the really rigorous way to do this would be I'd put a catheter in your arm and I would sample your blood every 30 or 60 minutes over the course of a day while you ate. And I'd integrate that function and there would be an area under the curve of insulin, and that's actually the number I care about. But since I can't do that outside of a research setting, I rely on these other proxies. So the bottom line is your carbohydrate content is highly variable by the individual, by their insulin sensitivity, by their muscle mass and their capacity to dispose of glucose and a host of other factors. But the bottom line is you don't want to consume any more carbohydrate than you can without blowing through those parameters, and you don't want to consume any more protein than you need to to preserve that. And then basically, fat becomes the fill. And so the point here is that that becomes a highly different diet for different people. For some people that's 40% carbohydrate and 20% protein, and the remainder of fat. For others that's 20% carbohydrate and 15% protein and the remainder of fat.
Peter has brilliant and so funny capability to confuse Rhonda, who is not easy to be confused brilliant doctor. Both are among really the best promoters of healthy medicinal knowledge to the masses. Excellent interview, thank you Peter and Rhonda.
Always a pleasure to overhear two knowledgeable people passionately discuss their interests (even if only following half of it). Rhonda is sonething else once wound up.
two beautiful minds for a healthier society. Really amazed by these scientists' works, providing us the knowledge that will bring us away from the road of the human species involution built on wrong habits/ideas that were like "driven", never profoundly investigated and given low importance. Concept hard to explain, but these scientists are what the society really needs
+Pete Farrow I'm a Dr. Patrick follower. That was a terrible podcast and if you put her on a lie detector machine she would tell you at least 3 times she wanted to smack some sense into that pompous ass. If you know anything about body language you would have seen Dr. Attia not showing any respect towards Dr Patrick. He interrupted her over a dozen times and when he wasn't interrupting his body language was tense. Most likely because the only voice he wanted to hear was his own. Rhonda was uncomfortable because she is respectful and kind. She should have realized because you have the letters MD after your name does not make you smarter than a researcher. I was done as soon as Attia started talking about the professional athlete's he treats and less concussions. I guarantee he doesn't know your brain s concussed simply by jumping rope. He is decades behind the newer research.
+John Pandolfo No, they were having very healthy intellectual discussions. I didn't think Dr. Attia was rude or disrespectful, and it was great to see neither were passive in portraying their thoughts while being receptive to ideas at the same time.
2bluema I respectfully disagree. In fact just today when I was speaking to a patient I found myself stressing, moving my hands the stressful way doc was in this video. Also and I'm assuming you have at least basic knowledge of reading body language. Just watch the video again. Dr Attia was stiffening up his legs,arm's neck and his hands were screaming I need to talk over you and when you're speaking I'm just trying to figure out how to start talking again. Maybe you can't read body language. If you could we wouldn't need to message. Watch the video again. He could care less about anything else but himself. It was uncomfortable to watch and I know if you asked Dr Patrick if she thought that went well under a lie detector she would say she thought that was a terrible interview and Attia is an egotistic ass.
I respectfully disagree with YOU. Attia strikes me as a very humble man. Both in this video and in others I've seen of him, he talks about not knowing all the answers, something few doctors are capable of doing these days.
Bonnie Half-Elven You know since I posted my comment I have seen other interviews with Attia and while I still think he was clearly a egomaniac that had no clue that Dr. Patrick is probably going to be the US top researcher on nutrition and the physiology behind why she states.In other inerviews he didn't behave like he did here. During this interview it's clear Dr. Patrick was the more intelligent of the two and maybe that's why he behaved so poorly. Watch him. He's not even listening to Rhonda when she talks. He's just waiting for her to stop so he can be seen as the expert. Even the most basic reading of body language will show you Attia tenses up and uses most of his energy trying not to interrupt her. With that said , Dr Attia has other info out there for us to see and it's solid info. Though today, June 4th 2016, he doesn't have a 10th of the knowledge ha Dr. Patrick has. Not putting him down. Just saying he clearly didn't realize he wasn't the smartest person in the room that day. Rhonda's work has changed health care. Very few physicians know who Dr Attia is. Since Rhonda started going public with her work my entire way of practicing has changed. I never checked off the Magnesium box on a blood work script. The new work Rhonda has been doing on Cytokinesis will when she finishes literally change the way we exercise. Unfortunately many physicians saw this interview and Dr Attia comes off as a complete egomaniac while Rhonda is biting her tongue. I'm glad I looked at other interviews with Attia because he's not the guy he is during his interview. With professionals he lost any credibility he might have had..which is unfortunate. He simply didn't realize Rhonda is changing health care in a profound way.
I agree with Dr. Attia in regards to AD and diabetes mellitus and hyperinsulinemia. They have termed AD as Type III diabetes. He's so spot on. That and regarding ApoB and LDL particle number in determining susceptibility for CHD.
Very informative. You are a great interviewer Rhonda, he seemed hard work and slightly intimidating, but you handle him with grace. I wouldn't like to play poker with him.
I think you got it the other way around...this guy IS the real thing regarding longevity and health science- that’s just he’s over achieving tendency to get the perfectly correct answer according to the most current data...a machine ,,
You are right, it is 100% opposite. Longevity doesn't require muscle growth based on typical protein metabolism pattern. Wrong fitness practices shorten a lifespan.
This discussion was amazing! Thank you for filming it, and sharing it with us. The discussion was so rich in information, and to be quite frank, as a layman, a lot of it went over my head. I am going to have to listen to it several times to digest it all. Dr. Peter Attia is such a pleasure to listen to, because he has such a wealth of knowledge.
I'm healing now from a serious brain injury which occurred in 1976, at age 14 (motorcycle accident, no helmet, landed in the grass and rolled.) The injury somehow went undiagnosed until 2011. I am now 53. I found a doctor who is helpingme, and the supplement Protandim (turmeric, green tea, bacopa, ashwaganda, milk thistle) has been hugeley helpful to me. I noticed a dramatic response to it after being on it for 3 weeks. I am also using frequency specific microcurrent and a home hyperbaric chamber. All three of these tools are helping my brain to finally heal. I was a mess, headed for a nursing home.
Real good video & sooooo much information. Just one of the many things Dr Attia discusses is how we all have cancer cells in & how we should avoid amplifiers etc... Never ever do I hear other doctors discuss this simple fact. These two are brainiacs! First time I have seen this channel & am subscribing. Looking forward to more of Dr. Rhonda's videos!
Two titans in the aggregation and dissemination of metabolic studies and aging research for potential clinical application. They should do this recorded presentation once every 12 months as an update. Excellent. Don't you wish your doctor followed the Nerd Safari and the Found My Fitness podcasts?
Thanks for this. Fascinating, informative video. So many of the videos on longevity focus on that we believe that we can reverse aging through science but very few say what to do about it. I think that has a lot to do with because so many people still need to be convinced that we can do anything but we need more of this type of video
Another excellent video. Seeing this rigorous scientific approach is refreshing. I don't understand the details of the biochemistry - my last course was 40 years ago and you have shown a far greater grasp of body process - with an open mind to advances that may contradict currently held notions.
I always love your videos and wish you would put out more! I really appreciate the definitions on the screen, it helps a lot. I wish I had more smart friends like you two!! Keep up the great work
Love the podcast! Super informative, and always interesting. My only comment from viewer standpoint would be to perhaps create your own podcast space. You are clearly a talented podcaster and your guests are always interesting, so why not go all out and create a legitimate space where you and your guest can sit more comfortably and less awkwardly? In my own experience podcasting (which of course is nothing compared to yours) I find that simply changing your surroundings can actually make conversations like this flow better. Either way, I'll continue to watch and learn!
Rhonda, your podcasts and insights are great, as always. I would like to provide 2 pieces of feedback however. 1) the position you interview your guests in doesn't appear to make them comfortable and thus doesn't always seem to create as free-flowing a conversation as possible. What Joe Rogan does (sitting across the table from each other), for example, is much better and allows for a more relaxed guest and therefore better overall discussion. 2) whilst it is clear that you have an amazing knowledge on a variety of relevant topics, I do feel that you need to make the interview more about the guest and distilling their advice/knowledge/wisdom and experienes. Afterall, you are having THEM on your podcast. Other than that, keep up the great work - you're a star!!
#2 is exactly what she did at the open of the podcast and for the first 25 minutes but I see where she started getting into her own take on the gut after that half way point. But it was also cool where he agreed and had a different take on it which he never would have stated if she had not gone that way . . .
Firmly disagree with point 2. Dr. Rhonda did a great job of of asking probing questions of Peter and discussing how this may fit with other knowledge in the field. It’s that back and forth that is really illuminating, showing the different perspectives on what’s happening.
This is a great discussion. Several things mentioned made a lot of sense to me (after researching the terms they used) Particulary: "Alzheimers is diabetes of the brain." and starting at Min 31:15. This made me feel slightly better about having APOE 3:4. Phenotype not genotype could be more predictive of Alzheimers. I.E. The higher the expression of APOE the higher the risk.
+Michael Brashier APOE4 is actually associated with a reduced expression of APOE, and this is problematic because reduced APOE in the brain has been shown to reduce glucose uptake. www.ncbi.nlm.nih.gov/pubmed/25469919 (Doing these podcasts where the conversation is on the fly and can last up to and over an hour makes it super easy to get tripped up on details sometimes. )
+FoundMyFitness thanks for that link. I'll have to think about this to sort out what it means. "INTERPRETATION: Low plasma levels of apoE are associated with increased risk of future Alzheimer disease and all dementia in the general population, independent of ε2/ε3/ε4 APOE genotype. This is clinically relevant, because no plasma biomarkers are currently implemented. Hence, plasma levels of apoE may be a new, easily accessible preclinical biomarker."
Does anyone else feel how much opportunity they passed, looking back? Knowing you could have acquired this knowledge, and instead of being a consumer, you could have added value. To me, it’s painful. But were supposed to be positive, always.
French pharmacist here although now in California; I won’t do research as a type this at 245am on a Saturday morning :) I’m a firm believer in glycolysis NOT being the faulty pathway as described by many nowadays, yes inefficient but I don’t think that’s bad. You seem to imply there’s a positive role to ROS and I’m sure oxidation is crucial for health! We shouldn’t swing from a very pro oxidative lifestyle to a fully anti oxidant lifestyle. The healthy carbs and a normal glucose metabolism provide both the antioxidants and trigger a degree of ROS. So the last part of the interview highly spiked my interest. I wish you all the success in that direction in cancer research! I believe that the solution is to stray away from all things Standard Western Diet (and smoking, and blue light, and sedentary lives) however high fat diets should be compared to very low fat diets clinically. Too many publications don’t even go below 25% lipids which leaves me frustrated.
Thanks for the time to make this. Regarding the theoretical nutritional approaches to moderating mTOR and IGF-1, since there is a level of variability in the prescriptions, what tests, factors, observable measurements can individuals take to know what levels/qualities of protein are sufficient to maintain and/or efficiently build muscle? And like-wise for carbohydrates ... levels/qualities necessary for their benefits but still maintain safe disposal? Again, def subscribed to your channel and thanks for your time.
Interesting discussion. Dr Attia's reasoning behind his preferred macronutrient balance seemed mainly based upon the ability of protein and sugar/carbs to negatively effect cellular longevity pathways (insulin, IGF-1 and mTOR). So limit them and fill the calorie void with fats? Shame there wasn't more discussion on protein/carb types, or any discussion on fats. Thought there was an odd atmosphere toward the end. Dr Attia seemed very uncomfortable and restless, kept interrupting Dr Patrick with more questions/challenges and not giving her time to respond. Felt like he was almost on the defensive? I think the discussion went out his comfort zone; he clearly had lack of general understanding regarding the gut and brain; perhaps areas which might challenge his fat bias? Like Rhonda, I think the gut microbiota is really important. We have evolved as superorganisms. Rhonda rightly mentions fiber (indigestible carbs) as one clear way to positively affect gut microbiota and health; there could have been lots of discussion here particularly on immunity and insulin sensitivity. The lack of fiber in modern diets relative to other primates and hunter-gatherers (paleo and modern) is pretty remarkable. On the other hand, it would be interesting to see what Dr Attia thinks about all the current research showing how (saturated) fat induces gut dysbiosis, intestinal permeability to endotoxin and inflammation in mice and humans. cellfatigue.blogspot.co.uk/2016/03/how-saturated-fats-induce-inflammation.html I also think more discussion on evolution and epidemiology would have added balance to things. Cellular and mammalian evolution will be pretty important for understanding longevity signaling pathways. Epidemiology is important for understanding environmental associations with chronic diseases. For instance look at the blue zones, where people live the longest and healthiest lives. en.wikipedia.org/wiki/Blue_Zone Thanks,
I read the link about cell fatigue. It was interesting but not about a specific scientific research. I only follow studies where all possible factors are controlled. What I saw were mostly references to medical papers that were written by medical professionals and the article was a study not scientific research. There is a difference. I'm not saying it is an absolutely wrong conclusion, I'm just saying that it isn't proof. Petri dishes, rats, pigs, rabbits, gorrills, humans..... All different metabolic and nutritional needs and can't be automatically interchanged as evidence. As far as humans, how much processed food, coffee. Cigarettes, alcohol, fiber, fruit, medications, etc did they have while eating or not eating saturated fat? Did they eat the saturated fat in small or large quanties for a day, a week, a year, a decade? One experiment I know about was done on raunits where they fed them a high saturated fat diet.... Well you can just imagine how it turned out.... Obviously rabbits wouldn't eat those fats naturally because they couldn't even find it if they wanted. Just don't believe every conclusion/impression/theory in an article written with a dozen footnotes referencing other old and dodgy studies on a variety of animal life without strict control groups. Just my opinion.
Dr . Rhonda , Thank you for interview, according to to Dr. Russell Blaylock who wrote natural strategies for the cancer patient , Free radicals cause cancer, chemotherapy is carcinogenic and produces large amounts of free radicals. Taking antioxidants is crucial to prevent more cancer from the toxic chemo therapy. Taking antioxidants is complimentary and has protective effects.
His theory on Alzheimer's would be easy to test just asking all hospitals to find out if the patients are diabetic or near diabetic and check for the APOE and find out the percentage. I'd bet he is right and its high 90% or better. The determination to have that done will win someone a Nobel prize.
I would love it if you would do a talk with Dr Attia or Gary Taubes about the saturated fat/cholesterol myth and saturated fat's effect on the body/brain and it's epigenetic effect.
Get the show notes and transcript!
www.foundmyfitness.com/episodes/peter-attia
FoundMyFitness just
Lll
00000⁰000000⁰000p⁰⁰
eZ😊😊😊@@sharonschroeder8393
I like how Rhonda actually visit the people to interview them in person. It makes the podcast a much higher quality.
I like how she simply asked what the guest eats right at the start and he totally switched the topic and rambled about how he doesn't know what the perfect diet is based on rat studies.
I like how she actually wears clothes. It's nice
That’s because you don’t understand who this guest really is...go and read bro
True
To see people like these two brilliant individuals having such an insightful conversation is truly amazing. You could almost listen both brains firing wildly as they shared ideas and argued different theories. There was an information overload almost in every minute of the conversation. I love these interviews Rhonda! Thank you for making this information available to a wide audience.
I had to replay it a few times brain explosion 💥
Thanks much to Dr. Patrick for taking the time to define the physiological terms that appear throughout the interview. Great interview even when Dr. Attia went off course once in a while (he seemed to wanting to talk about a lot of things). The interesting thing about Dr. Attia is his constant reminder that our brains thrive when the appropriate lipids are given. Can't wait for part 2!!
It's like a heavyweight think tank of my two favorite experts on longevity. Great show!
Great job Dr Rhonda Patrick!!!
Great video from Dr. Rhonda Patrick! It was annoying though how he kept cutting her off sometimes. She's so sweet.
I love watching these two together.... two very sharp, informed minds exploring a range of ideas.
I loved this conversation because it had so much intellectual dialogue!! I really enjoy when people are able to share different views and come away with so much more insight!! it was brilliant!!
Dr Attia and Dr Patrick are my two favorite people to listen to for the amount of great hands on implemented research.
Lol at 36:40, Dr. Attia, "No one's even watching at this point." Oh yes, yes we are! Keep going, so interesting!
Attia is a male chauvinist pig!
@@kittyvine823 Is he? How so? I'd never heard anything bad said about him in that way
I'm watching her.
I loved every minute of this talk. I literally want to download both your brains. Such a wealth of knowledge and information. I am so happy to know there are people like you out there interested in these issues and I know that so many people will benefit from your experience. Thanks to you both for the interview.
a science geek-out! fantastic! paused the video and read each definition, which transformed the conversation for me, thank you! great info!!
I wish life came with these definition cards
wonderful guest and excellent interview, thanks for all the goodness you are bringing into the world, its a better place because of you. thank you.
I really enjoy the conversation, both of your brains at work, and the humility. I wish I had doctors like this! I learned so much I feel like I should pay y'all tuition.
Even though I didn't understand most of what you two were talking about. I still really loved watching this video because you two seem like very smart people.
Great to see these two talk. Way Dr.Ronda acts is so positive and the smarts of Dr.Attia... amazing guys! Thanks a lot
I never miss a chance to hear Dr. Attia. Wow. These two are great.
Rhonda, your videos are officially my favorite content on youtube. Thanks for your work.
Thanks for the notes at the bottom giving lay explanations for some of his terminology. Very helpful!
Hey Rhonda, I absolutely love your videos! A tip that makes your longer videos more attractive to watch more than once-- put time stamps with the sub topics.
The bit about diet and sinusitis was very interesting. Although I don't get colds or flues, I used to get sinusitis and sinus headaches often, then I stopped my intake of diet sodas and diet sweeteners for my coffee and within 2 weeks I stopped having those issues. Note according to my DNA test, I respond well to absorption of vitamins and minerals and I believe it is likely antagonistic chemicals also affect me more than most people.
Ronda seems completely unfazed by a guy constantly interrupting her. Not that he's being rude .. But she is picking up his thought and tossing rejoinders back as soon as he cuts her off. Good chemistry. Learned alot
Interrupting people is a sign of ADHD and also narcissism.
However, in this case, I would like to think it’s passion to share knowledge that is so needed and you’re right she is the best. She knows she’s here to find out what he knows because her audience- we already know (LOL but) a lot of what she thinks. That makes her awesome! I’m a huge fan.
@@CarolCarolDoddDodd I tend to not make armchair diagnosis around behaviours that are obviated by being disciplined. I have adhd and I am certainly able to refrain from that kind of thing in formal settings - and unable to control it in personal heated interactions. As for narcissism. It's such an unproven and weaponized term I would never want to put that in the mix about people in a critique. It's borderline character assassination. I'm not a therapist and I'm certainly not his therapist. I just don't feel qualified to throw those terms around about strangers. I'll go with passion over riding professionalism and agree with you on dr Patrick - also I've watched attia. He usually isn't this bad
Having worked with medical researchers for years, I can tell you that this is standard, as far as how conversations go. They are heavily engaged, fast moving, and branch horizontally onto all kinds of tangents anyone wants to take them and then they get collectively steered back to center. This is a very typical interaction between passionate researchers with high intelligence and knowledge and pretty standard when they are attempting to come to a mutual or collective truth or scientific foundation between each other. They are also clearly both high in extroversion and very excited to share information with each other, again which is typical when you two people like that interact. I see how you can view it that way, I used to as well when I first became involved in these types of discussions, but what I found is that they are not only acceptable but also often the norm.
@@jeandivine3 . not sure that doesn't describe any human endeavor at a high level. And in every cohort there are those who conflate urgency to speak with having alot to say. It probably annoys me because I'm often that guy
She impressed me and was correct on things that he had to take a Mulligan on, although that was fairly balanced. Attia is awesomely smart but exaggerates. He crosses into the border zone of toxic masculinity. Kidding! Great discussion overall.
Loved this exchange between two passionate and knowledgeable individuals.
I really appreciated the pusback on the benefits of gut health.
I believe about 90% of serotonin and dopamine is produced in the gut. As the saying goes...it is your second your brain. It is supremely important in overall wellness imo.
So sauerkraut, yoghurts & especially kefir are staples of my diet. Key to make sure they include a broad spectrum of probiotics though.
As if you consume a probiotic food/supplement that is just a few strains then you will have a gut flora of just oak trees.
It's important to make sure you nurture variety to create a rainforest.
He's a gut skeptic because he's never had severe gut problems. If you've been suffering from gut pain all your life, it becomes the issue you're randomly trying to figure out.
Great interview. Two brilliant minds in the field of nutrition, health, and longevity. Keep up the good work.
Interesting conversation Rhonda, thanks for sharing! Your first question to Peter was: “What are you eating then to try to delay the aging process?” To be honest, I haven’t heard the answer :)
(From Transcript) Peter :- So I will explain conceptually how you do it. How you do it at the individual level is empirical and I think prescriptive, meaning you have to be able to try something, iterate on it, and make a measurement. But here's the conceptual way to do it. The conceptual way to do it, at least the way I do it, is you consume more or less the least amount of protein you can consume to maintain and grow muscle mass. But you don't need any more than that. So it depends on the individual, it depends on the timing of that protein ingestion, the quality of that protein and the type of metabolic and conditioning stimulus you put into it, but there's an amount. But for most of us I think we're probably over consuming protein relative to that actual need, so we raise protein level until we hit that amount.
Carbohydrate, we do the opposite. Carbohydrate, we are basically lowering it until we reach the highest point...or pardon me, the lowest point that we can tolerate where we can maintain, and again, this is quick and dirty but it's the lowest possible fasting insulin. And in my mind I typically like to see that at below 3 or 4 as IU of insulin. And you want to limit, sort of, post-meal glycemia. And I actually use a standardized test which is an OGTT which has its limits because it's liquid, you're drinking liquid glucose. I like to limit that postprandial hyperinsulinemia to a number and I use a checkpoint of 30 that I want to be able to see within one hour of a 75-gram glucose challenge if you can keep insulin below 30.
So in my mind, because I can't do what's called an AUC, an area under the curve. So the really rigorous way to do this would be I'd put a catheter in your arm and I would sample your blood every 30 or 60 minutes over the course of a day while you ate. And I'd integrate that function and there would be an area under the curve of insulin, and that's actually the number I care about. But since I can't do that outside of a research setting, I rely on these other proxies. So the bottom line is your carbohydrate content is highly variable by the individual, by their insulin sensitivity, by their muscle mass and their capacity to dispose of glucose and a host of other factors. But the bottom line is you don't want to consume any more carbohydrate than you can without blowing through those parameters, and you don't want to consume any more protein than you need to to preserve that. And then basically, fat becomes the fill.
And so the point here is that that becomes a highly different diet for different people. For some people that's 40% carbohydrate and 20% protein, and the remainder of fat. For others that's 20% carbohydrate and 15% protein and the remainder of fat.
@@kiranshri which text book you use bro?
@@tntramzy12 written transcript from this interview
Dr. Attia for Surgeon General!
Peter has brilliant and so funny capability to confuse Rhonda, who is not easy to be confused brilliant doctor. Both are among really the best promoters of healthy medicinal knowledge to the masses. Excellent interview, thank you Peter and Rhonda.
Always a pleasure to overhear two knowledgeable people passionately discuss their interests (even if only following half of it). Rhonda is sonething else once wound up.
you rock Rhonda. It's great to see you interviewing such thought-leaders in the diet/health world.
She is interviewing herself ! So annoying .....
🤔 good interview.. haven’t seen any interviewer on the same level with attia until now. Brilliant people and a very heavy discussion.. 👍
two beautiful minds for a healthier society. Really amazed by these scientists' works, providing us the knowledge that will bring us away from the road of the human species involution built on wrong habits/ideas that were like "driven", never profoundly investigated and given low importance. Concept hard to explain, but these scientists are what the society really needs
You guys definitely needed another hour!
Another great podcast!
+Pete Farrow I'm a Dr. Patrick follower. That was a terrible podcast and if you put her on a lie detector machine she would tell you at least 3 times she wanted to smack some sense into that pompous ass. If you know anything about body language you would have seen Dr. Attia not showing any respect towards Dr Patrick. He interrupted her over a dozen times and when he wasn't interrupting his body language was tense. Most likely because the only voice he wanted to hear was his own. Rhonda was uncomfortable because she is respectful and kind. She should have realized because you have the letters MD after your name does not make you smarter than a researcher. I was done as soon as Attia started talking about the professional athlete's he treats and less concussions. I guarantee he doesn't know your brain s concussed simply by jumping rope. He is decades behind the newer research.
+John Pandolfo No, they were having very healthy intellectual discussions. I didn't think Dr. Attia was rude or disrespectful, and it was great to see neither were passive in portraying their thoughts while being receptive to ideas at the same time.
2bluema I respectfully disagree. In fact just today when I was speaking to a patient I found myself stressing, moving my hands the stressful way doc was in this video. Also and I'm assuming you have at least basic knowledge of reading body language. Just watch the video again. Dr Attia was stiffening up his legs,arm's neck and his hands were screaming I need to talk over you and when you're speaking I'm just trying to figure out how to start talking again. Maybe you can't read body language. If you could we wouldn't need to message. Watch the video again. He could care less about anything else but himself. It was uncomfortable to watch and I know if you asked Dr Patrick if she thought that went well under a lie detector she would say she thought that was a terrible interview and Attia is an egotistic ass.
I respectfully disagree with YOU. Attia strikes me as a very humble man. Both in this video and in others I've seen of him, he talks about not knowing all the answers, something few doctors are capable of doing these days.
Bonnie Half-Elven You know since I posted my comment I have seen other interviews with Attia and while I still think he was clearly a egomaniac that had no clue that Dr. Patrick is probably going to be the US top researcher on nutrition and the physiology behind why she states.In other inerviews he didn't behave like he did here. During this interview it's clear Dr. Patrick was the more intelligent of the two and maybe that's why he behaved so poorly. Watch him. He's not even listening to Rhonda when she talks. He's just waiting for her to stop so he can be seen as the expert. Even the most basic reading of body language will show you Attia tenses up and uses most of his energy trying not to interrupt her. With that said , Dr Attia has other info out there for us to see and it's solid info. Though today, June 4th 2016, he doesn't have a 10th of the knowledge ha Dr. Patrick has. Not putting him down. Just saying he clearly didn't realize he wasn't the smartest person in the room that day. Rhonda's work has changed health care. Very few physicians know who Dr Attia is. Since Rhonda started going public with her work my entire way of practicing has changed. I never checked off the Magnesium box on a blood work script. The new work Rhonda has been doing on Cytokinesis will when she finishes literally change the way we exercise. Unfortunately many physicians saw this interview and Dr Attia comes off as a complete egomaniac while Rhonda is biting her tongue. I'm glad I looked at other interviews with Attia because he's not the guy he is during his interview. With professionals he lost any credibility he might have had..which is unfortunate. He simply didn't realize Rhonda is changing health care in a profound way.
I agree with Dr. Attia in regards to AD and diabetes mellitus and hyperinsulinemia. They have termed AD as Type III diabetes. He's so spot on. That and regarding ApoB and LDL particle number in determining susceptibility for CHD.
Loved hearing both experts talking. It was too short. Very interesting and informative
One of your most profound interviews. Thanks for sharing 👌🏽
Very informative. You are a great interviewer Rhonda, he seemed hard work and slightly intimidating, but you handle him with grace. I wouldn't like to play poker with him.
Dr. Attia is also a mathematician...potentially dangerous at the poker table if only for his ability to calculate the odds on the fly.
Yeah She is no dummy either
I think it was he was the one that was intimidated.
I think you got it the other way around...this guy IS the real thing regarding longevity and health science- that’s just he’s over achieving tendency to get the perfectly correct answer according to the most current data...a machine ,,
Anyone else do as much pausing and reading as watching? Great discussion.
this is so cool. thank you for this.
The more I listen to Rhonda the more I realize the diet to maximize muscle growth is not the diet to optimize longevity
You are right, it is 100% opposite. Longevity doesn't require muscle growth based on typical protein metabolism pattern. Wrong fitness practices shorten a lifespan.
Yeah, I also don't think that athletic performance is equal to optimal health. At least not in some cases.
Yeah, choose your poison
It sounds like Rhonda and Peter's opinion on IGF-1 has been evolving - case may not be so clear cut: ua-cam.com/video/oXQ9yvGVJDE/v-deo.html
Agreed, I am however curious about the selective and timely use of leucine pushing IGF into the muscle when it is needed - no more, no less
This discussion was amazing! Thank you for filming it, and sharing it with us. The discussion was so rich in information, and to be quite frank, as a layman, a lot of it went over my head. I am going to have to listen to it several times to digest it all. Dr. Peter Attia is such a pleasure to listen to, because he has such a wealth of knowledge.
Wow these two are going to cure cancer! It’s amazing to see them figuring it out in real time. Truly amazing
I'm healing now from a serious brain injury which occurred in 1976, at age 14 (motorcycle accident, no helmet, landed in the grass and rolled.) The injury somehow went undiagnosed until 2011. I am now 53. I found a doctor who is helpingme, and the supplement Protandim (turmeric, green tea, bacopa, ashwaganda, milk thistle) has been hugeley helpful to me. I noticed a dramatic response to it after being on it for 3 weeks. I am also using frequency specific microcurrent and a home hyperbaric chamber. All three of these tools are helping my brain to finally heal. I was a mess, headed for a nursing home.
@36.49 , oh yes Peter, we are still watching and it's really interesting!
Two very smart persons. No ideology or dirty interest, just pure facts i knowledge
Thk you Dr Rhonda... Great episode
I have recently become addicted to this kind of content. I'm an economist btw
You two are awesome! Keep up the great work!
Real good video & sooooo much information. Just one of the many things Dr Attia discusses is how we all have cancer cells in & how we should avoid amplifiers etc... Never ever do I hear other doctors discuss this simple fact. These two are brainiacs! First time I have seen this channel & am subscribing. Looking forward to more of Dr. Rhonda's videos!
36 minutes in is why I love these podcasts!
Peter Attia seems very knowledgeable.
So interesting to listen to you two geeking out! I love the different perspectives of a doctor vs. a scientist! Great insights!
Excellent interview well educated people! Thank you for your passion and researched knowledge.
Two titans in the aggregation and dissemination of metabolic studies and aging research for potential clinical application. They should do this recorded presentation once every 12 months as an update. Excellent. Don't you wish your doctor followed the Nerd Safari and the Found My Fitness podcasts?
Thanks for this. Fascinating, informative video. So many of the videos on longevity focus on that we believe that we can reverse aging through science but very few say what to do about it. I think that has a lot to do with because so many people still need to be convinced that we can do anything but we need more of this type of video
I love the notes at the bottom of the video!!! Great job on that!
"Whats your diet for anti aging" Egyptian Pharaoh God bloodline.
ok, so there are still people with creative humor...good to know
I don’t think he wants that dna. Lol. Inbreeding in royalty caused a lot of deformities.
@@melikey3758 correct but they had a point, they want to purify there god DNA
The 'Mummy' returns.
@@melikey3758 way to ruin the joke...
Joe "Look at this coyote eating cheetos" Rogan
wait, wrong podcast
Cool Vibrations Your far from home friend
😁
Hahaha yes lad........ELK DMT MICHAEL YOOOOOOOOO
Another excellent video.
Seeing this rigorous scientific approach is refreshing.
I don't understand the details of the biochemistry - my last course was 40 years ago and you have shown a far greater grasp of body process - with an open mind to advances that may contradict currently held notions.
I am going to have to watch this again. There was to much to keep track of while on the treadmill.
Great interview. I feel educated rather than just entertained
Great podcast 2 very bright & brilliant minds come together
Great interview and also educational at the same time. Thanks!
Man these two in the same video, how have I not seen this before now!?
I always love your videos and wish you would put out more! I really appreciate the definitions on the screen, it helps a lot. I wish I had more smart friends like you two!! Keep up the great work
Thank you for this excellent discussion. The on-screen notes were great!
Love the podcast, wish I was smart enough to keep up with their conversation.
Great infos for which we thank you so much!
Love the podcast! Super informative, and always interesting. My only comment from viewer standpoint would be to perhaps create your own podcast space. You are clearly a talented podcaster and your guests are always interesting, so why not go all out and create a legitimate space where you and your guest can sit more comfortably and less awkwardly? In my own experience podcasting (which of course is nothing compared to yours) I find that simply changing your surroundings can actually make conversations like this flow better. Either way, I'll continue to watch and learn!
I am going to have to watch this a few more times.
Dr. Rhonda Patrick interviews. Thank you!
Rhonda, your podcasts and insights are great, as always. I would like to provide 2 pieces of feedback however.
1) the position you interview your guests in doesn't appear to make them comfortable and thus doesn't always seem to create as free-flowing a conversation as possible. What Joe Rogan does (sitting across the table from each other), for example, is much better and allows for a more relaxed guest and therefore better overall discussion.
2) whilst it is clear that you have an amazing knowledge on a variety of relevant topics, I do feel that you need to make the interview more about the guest and distilling their advice/knowledge/wisdom and experienes. Afterall, you are having THEM on your podcast.
Other than that, keep up the great work - you're a star!!
I disagree with no.2, science is the most important aspect and one should be pleased to not have their ego foremost branded against it
#2 is exactly what she did at the open of the podcast and for the first 25 minutes but I see where she started getting into her own take on the gut after that half way point. But it was also cool where he agreed and had a different take on it which he never would have stated if she had not gone that way . . .
2 extremely healthy looking people.
Firmly disagree with point 2. Dr. Rhonda did a great job of of asking probing questions of Peter and discussing how this may fit with other knowledge in the field. It’s that back and forth that is really illuminating, showing the different perspectives on what’s happening.
Thank God for the subtitles. Can't wait this interview comes in English lol!
Right 😅
Good job interviewing and interviewee.
Thank you for the caption. I can't keep up with this conversion when it gets really technical. Good talk.
Thanks Rhonda and Peter!
This is a great discussion. Several things mentioned made a lot of sense to me (after researching the terms they used) Particulary: "Alzheimers is diabetes of the brain." and starting at Min 31:15. This made me feel slightly better about having APOE 3:4. Phenotype not genotype could be more predictive of Alzheimers. I.E. The higher the expression of APOE the higher the risk.
+Michael Brashier APOE4 is actually associated with a reduced expression of APOE, and this is problematic because reduced APOE in the brain has been shown to reduce glucose uptake.
www.ncbi.nlm.nih.gov/pubmed/25469919
(Doing these podcasts where the conversation is on the fly and can last up to and over an hour makes it super easy to get tripped up on details sometimes. )
+FoundMyFitness thanks for that link. I'll have to think about this to sort out what it means. "INTERPRETATION: Low plasma levels of apoE are associated with increased risk of future Alzheimer disease and all dementia in the general population, independent of ε2/ε3/ε4 APOE genotype. This is clinically relevant, because no plasma biomarkers are currently implemented. Hence, plasma levels of apoE may be a new, easily accessible preclinical biomarker."
Some serious brain power sitting there - love these discussions. Go Rhonda!
Love these guys. Learnt so much from them.
Amazing conversation. More, more like this.
Rhonda is just gorgeous. Thank you
+John JKD As is Peter.
+Eddie Strike I prefer Rhonda. LOL
+John JKD Get a life!
What is the problem with complimenting someone in their looks?
so complimenting a person on good looks means one has no life? you nerd
Does anyone else feel how much opportunity they passed, looking back? Knowing you could have acquired this knowledge, and instead of being a consumer, you could have added value.
To me, it’s painful. But were supposed to be positive, always.
French pharmacist here although now in California; I won’t do research as a type this at 245am on a Saturday morning :) I’m a firm believer in glycolysis NOT being the faulty pathway as described by many nowadays, yes inefficient but I don’t think that’s bad. You seem to imply there’s a positive role to ROS and I’m sure oxidation is crucial for health! We shouldn’t swing from a very pro oxidative lifestyle to a fully anti oxidant lifestyle. The healthy carbs and a normal glucose metabolism provide both the antioxidants and trigger a degree of ROS. So the last part of the interview highly spiked my interest. I wish you all the success in that direction in cancer research!
I believe that the solution is to stray away from all things Standard Western Diet (and smoking, and blue light, and sedentary lives) however high fat diets should be compared to very low fat diets clinically. Too many publications don’t even go below 25% lipids which leaves me frustrated.
My two favorite docs
Thanks for the time to make this. Regarding the theoretical nutritional approaches to moderating mTOR and IGF-1, since there is a level of variability in the prescriptions, what tests, factors, observable measurements can individuals take to know what levels/qualities of protein are sufficient to maintain and/or efficiently build muscle? And like-wise for carbohydrates ... levels/qualities necessary for their benefits but still maintain safe disposal?
Again, def subscribed to your channel and thanks for your time.
Insulin sensitivity seems to be at the root of most illnesses.
Praise the Lard! Attia rocks!
Interesting discussion.
Dr Attia's reasoning behind his preferred macronutrient balance seemed mainly based upon the ability of protein and sugar/carbs to negatively effect cellular longevity pathways (insulin, IGF-1 and mTOR). So limit them and fill the calorie void with fats? Shame there wasn't more discussion on protein/carb types, or any discussion on fats.
Thought there was an odd atmosphere toward the end. Dr Attia seemed very uncomfortable and restless, kept interrupting Dr Patrick with more questions/challenges and not giving her time to respond. Felt like he was almost on the defensive? I think the discussion went out his comfort zone; he clearly had lack of general understanding regarding the gut and brain; perhaps areas which might challenge his fat bias?
Like Rhonda, I think the gut microbiota is really important. We have evolved as superorganisms. Rhonda rightly mentions fiber (indigestible carbs) as one clear way to positively affect gut microbiota and health; there could have been lots of discussion here particularly on immunity and insulin sensitivity. The lack of fiber in modern diets relative to other primates and hunter-gatherers (paleo and modern) is pretty remarkable. On the other hand, it would be interesting to see what Dr Attia thinks about all the current research showing how (saturated) fat induces gut dysbiosis, intestinal permeability to endotoxin and inflammation in mice and humans.
cellfatigue.blogspot.co.uk/2016/03/how-saturated-fats-induce-inflammation.html
I also think more discussion on evolution and epidemiology would have added balance to things. Cellular and mammalian evolution will be pretty important for understanding longevity signaling pathways. Epidemiology is important for understanding environmental associations with chronic diseases. For instance look at the blue zones, where people live the longest and healthiest lives.
en.wikipedia.org/wiki/Blue_Zone
Thanks,
Spot on.
And great blog, btw. Looks like a lot of healthy food for thought. Yummy!
I read the link about cell fatigue. It was interesting but not about a specific scientific research. I only follow studies where all possible factors are controlled. What I saw were mostly references to medical papers that were written by medical professionals and the article was a study not scientific research. There is a difference. I'm not saying it is an absolutely wrong conclusion, I'm just saying that it isn't proof. Petri dishes, rats, pigs, rabbits, gorrills, humans..... All different metabolic and nutritional needs and can't be automatically interchanged as evidence. As far as humans, how much processed food, coffee. Cigarettes, alcohol, fiber, fruit, medications, etc did they have while eating or not eating saturated fat? Did they eat the saturated fat in small or large quanties for a day, a week, a year, a decade? One experiment I know about was done on raunits where they fed them a high saturated fat diet.... Well you can just imagine how it turned out.... Obviously rabbits wouldn't eat those fats naturally because they couldn't even find it if they wanted. Just don't believe every conclusion/impression/theory in an article written with a dozen footnotes referencing other old and dodgy studies on a variety of animal life without strict control groups. Just my opinion.
Dr.Attia seemed a little.. aspergers syndrome-y
Im not in your field, but it is interesting to watch pros going at it in their own field!!
Doctor Rhonda!
Hey!! AWESOME video! Good "heavy" topics, without any fluff!
Thanks!!!!!
“I’ll not tell my favorite story” *tells his favorite story*
Dr . Rhonda , Thank you for interview, according to to Dr. Russell Blaylock who wrote natural strategies for the cancer patient , Free radicals cause cancer, chemotherapy is carcinogenic and produces large amounts of free radicals. Taking antioxidants is crucial to prevent more cancer from the toxic chemo therapy. Taking antioxidants is complimentary and has protective effects.
Quality of life fitness coaching Yes, why on earth would she say taking antioxidants when someone has cancer is dangerous?? Please clarify Dr Rhonda!
Actually, taking anti-oxidants during chemo is bad. It blunts the efficacy of the chemo.
Very high Level discussion. ❤
His theory on Alzheimer's would be easy to test just asking all hospitals to find out if the patients are diabetic or near diabetic and check for the APOE and find out the percentage. I'd bet he is right and its high 90% or better. The determination to have that done will win someone a Nobel prize.
I would love it if you would do a talk with Dr Attia or Gary Taubes about the saturated fat/cholesterol myth and saturated fat's effect on the body/brain and it's epigenetic effect.
I love Gary Taubes
I love this guy!! Lol he's awesome
Peter A: “Don’t ask me about APOE”
Rhonda: *doesn’t ask*
Peter A: *proceeds to give opinion on APOE*
I Love this Episode! My favorite Podcast of yours
What a great discussion. Thanks.