"Great video! You did an excellent job explaining the roles of topoisomerase I and II in DNA replication. I now fully understand how topoisomerase I removes positive supercoils ahead of the replication fork, while topoisomerase II (gyrase) introduces negative supercoils behind the fork to relieve tension. The distinction between their actions and how they complement each other is much clearer to me now. Well done!"
"Great video! You did an excellent job explaining the roles of topoisomerase I and II in DNA replication. I now fully understand how topoisomerase I removes positive supercoils ahead of the replication fork, while topoisomerase II (gyrase) introduces negative supercoils behind the fork to relieve tension. The distinction between their actions and how they complement each other is much clearer to me now. Well done!"