Pharmacology - ANTICHOLINERGIC & NEUROMUSCULAR BLOCKING AGENTS (MADE EASY)

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Anticholinergic drugs are medications that block the effects of neurotransmitter acetylcholine in the central and peripheral nervous system. Neuromuscular blocking agents are medications that antagonize nicotinic cholinergic receptors on skeletal muscle to facilitate endotracheal intubation and to provide muscle relaxation during surgery. This pharmacology lecture covers topics such as mechanism of action of cholinergic antagonists; antimuscarinic agents, ganglionic blockers, neuromuscular nondepolarizing & depolarizing agents, phase 1 and phase 2 block, anticholinergic side effects. Anticholinergic drugs mentioned include; Atropine, Cyclopentolate, Tropicamide, Scopolamine, Ipratropium, Tiotropium, Tolterodine, Darifenacin, Solifenacin, Oxybutynin, Trospium, Fesoterodine, Benztropine, Trihexyphenidyl, Nicotine, Cisatracurium, Pancuronium, Rocuronium, Vecuronium, Atracurium, Succinylcholine.
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0:00 Intro
0:22 Antimuscarinic agents
4:42 Anticholinergic side effects
5:10 Ganglionic blockers
6:40 Neuromuscular blockers
8:25 Nondepolarizing agents
11:24 Depolarizing agents

[@SpeedPharmacology]

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mechenism of action is not included in thi video..

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Explaining an entire medical school pharmacology lecture in less time and so much more clearly! Can't thank you enough!

[@liltenshi39]

Another way to remember the effects of anticholinergics is "can't see, can't spit, can't pee, can't shit" (if you don't swear, switch it out for poop, which follows the 1st letter pattern "s-s-p-p")

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[@tieb1407]

Awesome mnemonic! Let me add something to that :D :
Can't see, can't spit, can't sweat
Can't pee, can't shit nor do anything in bed.
(lower sweat secretion and erectile dysfunction are also effects of anticholinergics)

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First of allas a Med Student, I'll definitely say that you've summed up 2 hours long work into a video of around 14 minutes. It's really helpful.
But, I would like mention one thing that Cisatracurium has an elimination half life of around 22 minutes (Intermediate Acting), not ~90 minutes as you've mentioned...
And thanks a lot for your great work... 👍🏽

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[@mrkajet]

Nondepolarizing agents doesnt "allow for lower doses of general anesthesia" as you indicate around 9:00!!!!!!! These aren't painkillers or sleep medications!!! They make patients cannot move!!!! That doesnt mean that they are well asleep or don't have pain.

[@SpeedPharmacology]

"paralysis may permit use of lower doses of general anesthetic agents, which may speed recovery and avoid side effects of these agents" Reference: anesthesiology.pubs.asahq.org/article.aspx?articleid=1945289

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