Lipid and protein transport in the lymphatic system | NCLEX-RN | Khan Academy
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- Опубліковано 27 лип 2024
- Learn about a third function of the lymphatic system. See how it finds a sneaky way to get fats and proteins into your bloodstream. By Patrick van Nieuwenhuizen. . Created by Patrick van Nieuwenhuizen.
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This video is awesome. I have Lipoedema and Lymphedema and your video is very helpful in understanding the lymphatic system. I've shared this video with our lipoedema support group! THANK YOU!
Thanks for this wonderful video it’s very educational but it also would be interesting to know that the lymphatic system is 100,000 miles long that is just unbelievable
Thank you, sir!!! This is an amazing video!
You really broke that down. Thanks for this
Thanks so much for these videos, Helpful, awesome ,, thanks again so much
Excellent video indeed! Thank you very much! 👍👏👏👏
Thank you!!!
thanku!
Why don't you write all the key words you use in your videos. They might be not important in you point of view, but I think as a students they are very important for me.
Thanks.
*correction of some video mistakes and a bit more indept*
Firstly remember that fatty acids travel in micelles before enterocyte absorption and in albumin later. If fatty acids were liberated from TAGs and phospholipids in the absence of albumin they would act as a detergent and dissolve cell membranes. Also fatty acids dont simply diffuse from the intestinal lumen into the enterocytes in the wall. They are absorped by *facilitated diffusion* , they are assisted by FABPs (fatty acid binding proteins) located at the enterocyte membrane. Another factor aiding the diffusion gradient/ translocation of fatty acids and monoacylglycerols from the *micells* and into the enterocyte is the rapid re-esterification of long-chain-fatty-acids into 2-MAG into triacylglycerols already happening inside the enterocyte (completed by the enzyme acyl-CoA-cholesterol acyltransferase, ACAT) - just so you wont think chylomicrons are carrying fatty acids, theyre not! They carrying TAGs along with cholesterol and fat soluble vitamins A, D, E and K.
Speaking of cholesterol, cholesterol also associates within micelles similar to fatty acids and MAGs, and are similarily absorbed by a different *sterol* -carrying protein in the enterocyte membrane. However much less cholesterol is absorbed this way (about 40% compared to 90% in fatty acids and MAGs), this is because cholesterol is reabsorped in the ileum together with bileacids in a salvaging hepatic circulatory system designed for the liver to re-use cholesterol in the making of bileacid.
We are more interested what time it is we’re really not interested how the clock was made
@@MrSchnickel I was simply adding a layer of knowledge for anyone (scholars or otherwise) who would need this for exams, presentations, or anything that requires a more in-dept understanding. If you dont need it or if its too complex for your level of understanding then simply skip it.
Hi there, thank you for the video. There's just one thing I don't understand. If chylomicrons and some proteins/hormones/ waste products are too large to enter the BV then how are they now small enough to enter the BVs after travelling through the lymphatic system? thanks
Listen.....for any molecule or a substance to enter blood vessels,it must pass through the pores of the endothelium (walls of capillaries).But the pores in these blood capillaries are quite small,hence these digested fats(or chylomicrons),larger protein molecules cannot enter these directly.On the contrary,lymph capillaries have comparatively larger pores, so all the tissue fluid, proteins,chylomicron seep into these capillaries...now these capillaries join the subclavian vein near collar bone and since these all these substances are now present in the lymph they are drained into subclavian vein directly (it doesn't need to pores so it can easily go into these veins)
Mohit Verma awesome
thanks for the video very helpful. i was just wondering why do we have to turn the monoglycerides and the fatty acids which are produced by the small intestine into chylomicrons? and therefore pass straight through into the capillary. why do we make chylomicrons and therefore fats have to be transported into the lymphatic system into the blood? surely it would be quuicker to just pass fats through the capillary near the small intestine
+Frances Holder I think the answer to your questions has 2 parts. 1) Fats are too big to pass straight into capillaries, and 2) As fats are considered to be "non-polar", they need a protein structure to be carried in circulation (i.e -chylomicrons), as the circulation is a polar environment. If you just stuck a bunch of fats into circulation without a carrier protein, they would all stick together due to the hydrophobic effect, and clog up circulation. I hope that answered your question.
yes that did thank you ever so much!!
actually i just have one more question, does glucose transport into the cells of the small intestine (microvilli) by the use of a sodium potassium pump (to get sodium out into the capillary and potassium into the cell thereofre creating a concentration gradient of sodium) or is sodium transported out just by active transport to create the concentration gradient, and there is no sodium/ potassium pump. some textbooks say no sodium potassium pump is used to create the concentration gradient its just sodium is being actively transported out of the cells, however some say a sodium potassium pump is used to create the concentration gradient? im not sure what to believe, sorry that was really long winded hope you can understand what im trying to say
The transport of glucose from the intestines, and across microvilli cells, is achieved via a secondary active transport system. This secondary active transport system utilizes the Na+ gradient that is first set up by the Na+/K+ active transport system. As you remember, the Na+/K+ Active Transport systems, creates a system where there is low Na+ (Sodium) inside the cell, and increased concentration of potassium inside the cell, compared to the outside. Glucose, uses the Na+ gradient to travel into the cell via a transporter protein. Once glucose is inside the cells of the micro villi, Glucose uses facilitated diffusion to travel to the blood. As glucose is a polar substance, it can freely travel in blood. So, without the concentration gradient created by the active transport system in the first place, Glucose would not be able to travel into the microvilli cells from the intestinal lumen. The Na+/K+ gradient created by the active transport systems is essential for regular glucose transport. This is at least what I have been taught in school. I hope that helps!
+Mohammed Sayeem thank you that has helped me so much!
You forgot villi.
Don’t the lymphatic vessels drain into the VEINS, then how will the cells be able to absorb and make use of the digested fats?
Because veins carry the blood containing the waste material which has to be ejected out of the body right
Blood is recirculated from venous system to arterial...
RAH Bruhn-Howard yes but isn’t the waste and the carbon dioxide given out of the body first? So won’t the digested fats go out somehow too?
@@bhaktiagarwal8331 no your lungs can't put out fats through alvioli
You repost the video of true owner
1:32 sperm?