How Muscle protects against Heart Disease, without Exercise [Study 277]
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- Опубліковано 2 кві 2024
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References (Copy & Paste DOI into Search Engine)
[1] [Study 277] doi:10.1113/EP087396
[2] doi:10.1159/000453544
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#heartdiseaseawereness #heartdiseaseprevention
My Mother had one of those "natural arterial re-routes" of angiogenisis. At 55, she had been experiencing chest pains for awhile and it turned out she had two partially blocked and one completely blocked areas 70, 30, and the 100% blockages. She managed to reverse to partially ones and the 100% blockage had already managed to reroute itself, and she lived another 33+ years and never passed from her heart conditions. Angiogenisis is definitely pretty cool!
So cool - thanks for sharing!
Cool, What did she do to reverse the partial ones?
The body genetically of itself wants to live. Life wants to keep living.
@@ceili She essentially retired from her job that she had worked at since age 16 and took up dancing. A lot of daily dancing namely feet movement..She had had a broken shoulder in an accident in the 1950's, that had never been reset properly so her factory job had been murder on her lifting ability. A lot of dancing is what she credited her health changes to. I was away in the military, but my siblings say dancing had become a big part of her life. She had become "fat phobic" in the early 1980's as so many people did. That didn't stop her getting heart disease. She did go on statins, and an even more rigid on fat, and this time, sugar reduction, but the active dancing and less stress on her body from lifting at her job probably were the two main factors that helped. Her parents lived to their nineties and never officially got heart disease even. All of them passed from complications of dementia. She just passed away less than two weeks ago at 88 and a half.
@@tracymullane8818 That had to be true on some most primal levels! I have heard that having extra estrogen made angiogenisis more common in Women, but IDK if that still stands.
I always enjoy your content. Biology and chemistry where my favorite subjects in high school and in college. Unfortunately due to an eye disease and losing my vision I was not able to pursue a career in either. And since I am visually impaired I use talk to text so please excuse the typos.
Which muscles help the most?
Also, angiogenesis is for growing small capillaries while vasculogenesis is for growing new veins. I think to bypass a blockage of blood flow to your heart, you actually need vasculogenesis. My question is whether there is a difference between the two when it comes to the biological process?
I have not exercised for exercise sake for over 40 years :-0)
I doubt most farmers have either yet they probably have more muscle than most people.
Yes, very true. But their muscles are optimized for durability and endurance. They won't get that explosive athletic power by grinding like that. Nonetheless, it is effective for what they do.
Unfortunately there is a high rate of obesity were I live so any extra muscle they might have from farming probably isn't going to help much.
Well the word "exercise" is probably a relatively modern invention since we made modern conditions that put you in anomalously low level of activity. While the further you go back in time the more normal part of daily life it was to move. But now it's done in a way that's disconnected from life, so to speak. So understand "exercise'' as just any activity that is straining enough to support some level of muscle mass.
A bit of a rant : Which on a side note is kind of fucking stupid how compartmentalized some tasks are done in 'modern' society. They should be more integrated like in naturalistic conditions. For example instead of just lifting weights in the gym for an hour or two, or walking on a threadmill ect. for no other 'purpose' than to stimulate muscle growth/to upkeep muscle, at LEAST attach the damn machines to the electric grid, so all those gym rats make some electricity. Just do something with that movement, anything! Not just moving for muscle upkeep disconnected from anything else.
@@mitkoogrozev
" Just do something with that movement, anything! "
Thers a lot of litter along the highways that takes a lot of work to pick up. Walk, bend over, walk, squat down, walk, . . . :-0
@@2Truth4Liberty Excellent! Ultimately we should stop the source of the litter, but then picking up whatever is already out there...yeah, good idea :D There you go :D !
Fascinating stuff. Human biology is so complex. Some of the specifics honestly go over my head, but still interesting to listen to!
Wow - this is so cool!. Thanks for a great video.
Glad you liked it!
Extraordinary. Great video, very informative. Thank you.
Perfect timing as I put this on when I was beginning my resistance bands exercise 😊 have a beautiful day !!
Another great video, keep it up !
Greatings from Poland
Thank you
This video was wild. Thank you for sharing this interesting study. As a neurotic individual, understanding how the things I do (weight training) may translate to unique health benefits gives me hope for a long life!
Thank you.
I had a complete blocked of my LAD at the top, I went on a holiday with my family to europe from australia and back until they discovered it and placed a stent. I even did treadmill stress tests. They also found a few days after the stent that I had sleep apnea with a drop on O2 to 52%
How did they know you had sleep apnea? Did you get a sleep study?
Wow thanks for sharing your story.
@@larryc1616 they were probably measuring his blood O2 24/7 just to make sure his blood is working, then saw it crashed sometimes during sleep
52% is really bad, i didnt know it could get that low from apnea. my body gives me a panic attack below like 80% and wakes me up :|
Awesome video as always. One thought: I know we can say "angiogenesis is cool" and "angiogenesis is often good (even essential, to sustain life sometimes)", but there are definitely circumstances in which angiogenesis is detrimental to human health, (like cancer). To your health
Great stuff! Would love to hear your analysis on L-Carnitine 🙏
Your infos are so important to me. My english is not the best but i understand the most and the rest i Research thx 4 all that. That means having and geting muscles the natural way is best man can do... Ok not a suprise but why...this is one of a answer.
Maybe this could explain that i have Heartissuis in my 20s and they all gone till my 30s and at the time no one could explain me why a 20 year old have problems
Thank you 👍🏽💯🔥 Excellent information. My question would be how does that affect tumors, cancer, etc? Is that similar to what some cancerous tumors do?
These compounds might provide excellent targets for angiogenesis inhibition cancer treatments
I felt so much better when I was a bit leaner with a lot more muscle in my body. Then I started shift work, which is also high stress and rosters all over the place. I feel like crap and don't do any exercise or weight training. I see and feel the difference. I'm getting out of this job soon and back on track. I'll be 48 this year. I have been told I have the heart of a twenty year old getting a check up before surgery last year. I didn't know about now though
Did you do a video on what “actually” lowers Lpa. From a diet standpoint
I saw you talk about the si RNA meds coming eventually
Cool, I was just looking up similar stuff yesterday. I have a concerningly wide pulse pressure (50-60) with isolated diastolic hypotension (~60). I'm pretty sedentary with not a large amount of muscle mass and was looking up how more or less muscle mass would affect blood pressure generally. A general sentiment I found was indeed that more muscle mass stabilizes blood pressures or something like that.
In my uneducated experience. Normal pulse pressure is 40 to 60. Above 60 is wide, and below 40 is narrow. If you are experiencing symptoms, these numbers can be concerning. If you are not experiencing symptoms, it might be a good idea to have a discussion with your doctor, but it could be normal. A few things in my experience that can cause your PP to go out of the normal range are medications, like Alpha blockers, electrolyte imbalance, adrenal dysfunction, overstimulated vagus nerve and POTS to name a few. I have been diagnosed with POTS, and my BP and PP go crazy up and down and wide and narrow as well. I am really affected by cold and sometimes heat as well. Just food for thought and a bit off subject. I wish you well.
I will 2nd what the other commenter said, a pulse pressure of 60 is not concerning, and really diastolic of 60 isn't either.
So your BP tends to be 120/70 to 120/60? Unless you're having symptoms that's totally fine. Better than if your diastolic were even higher, I think most would agree.
Hi Physionic!
How are you?
Currently dealing with my once every 5 years cold, so my nose is as red as Rudolph the Red Nose Reindeer.
@@Physionic Light the way Rudolph! :P Be sure to get some rest and drink your liquids. Not being able to breathe through your nose is horrible
@@epichysterics258thanks!
@@PhysionicI hope you are taking zink. Get well soon.
I love your videos about health ❤️ care and also I your character in videos I give A plus this is Mansoor Rashidnia from Palm Harbor Fl I wanted to give you ❤️ hug good luck dear.
One more reason to maintain muscle as we age.
very cool stuff. by the way: isn't there a second thing that muscles do for the body:myokine/cytokines? I read here and there that there are hundreds of them, muscles being the ancient drugstore of the body, repairing many things by sending certain myokine after certain types of training. Would be great to see more research about that. muscles are cool.
A boffin who makes the science both interesting and funny at the same time- class. Good video.
MRNA is not short for Micro RNA as you say, it refers to Messenger RNA.
What about IV infusion of exosomes? Will any exosome do this?
I think Dr. William Lee speaks negatively on angiogenesis, because that's how cancer develops? But we do need it obviously.
Angiogenesis is broad, it's beneficial in some areas, and in other cases it contributes to tumor growth because it provides blood supply It just means capillary origination and growth. Vegf travels around to facilitate other non-endothelial growth and there are studies around how to suppress it when it comes to its role in promoting cancer growth.
As Nic points out the similarity between mammals ie mice and humans is uncanny. The cells are very similar to each other. That's why we can drink cow's milk and benefit from eating animal protein.
For example, insulin was first derived from bovine pancreas, about 100 years ago. Amazing.
You should do a video that summarises just all the health related interventions we should do without going into the studies. (We trust you with that stuff any way). Your viewers just need basic health summary of what to do and don't want to waste time on who says it or why it works etc
No way. Every other guy on here is just "trust me" with suspect science. You should want to read the study and see if it is sound. Otherwise he becomes that "wheat brain" doc.
Quick - what supplement should we take to improve angiogenesis. Yes, I don't exercise..
how do people with the most muscles aka bodybuilders, also have the most heart failures/attacks
PEDs
Because of steroid abuse
^^ :)
Ever wonder how they got those muscles?
Lots of rice, broccoli and chicken breast I assume. Obviously, the bigger the bodybuilder, the more natural he is.
Could you do a video on the evidence for using CoQ10 w/ statins?
Waitaminute... Means that that a leak of oxy. in any muscle in the Body during exercise produce this and release to the body cause the need of mor oxy and need more vesels to do that? That would just a logic consequens right?
Ok u said undependet of exercise but exercise has do rise it cause of need of oxy.?
Would improved angiogenesis not correlate with more aggressive tumour growth (malignancies) , resulting in a higher risk of metastatic disease?
I think if you actually have cancer you are correct but when someone doesn’t have cancer it’s actually beneficial and can be linked to longer lifespan
Are we sure that collagen peptides don't contribute to fibrosis (I know it's a different video). Collagen peptides promote extra synthesis, right? When this exceeds degradation we get fibrosis. What if long term intake of peptides causes blood vessels to become stiff?
Question: what’s the definite or latest on saturated fat from meat and insulin resistance???? It’s so confusing …Dr K, Chaffee, Ken all say it does not …. Went and saw all your videos on saturated fats n you or your research says yes ☹️☹️☹️
Pls help
Is the takeaway to just build some muscle? I'll go do some pushups.
I just read some research that suggests routinely doing pushups reduces chances for heart attack by 20 something percent
I saw that. Does that mean women too?
@@betsyb2256sorry I'm not sure
People are forgetting one key component.
.. You need to give your body a thorough detox multiple times a year
Nah
He said vesicles hehehe.
That is some amazing findings. So many bi-pedals walking around not appreciating the biology that keeps them alive.
Link the papers please. Unfiltered information is way more useful.
They’ve been linked since release
@@Physionic I'm clearly crap at finding them in your text. I'll look again. Thanks.
Angiogenesis via VEGF and exosome-extract ... shouldn't people with a history of cardiovascular problems, be prescribed a batch of those?
Probably not targeted enough, but I wonder if it might be a viable strategy
@@Physionic Only problem is perhaps delivery into the endothelial cells ... and off course, wild vascular growth might not be desirable :)
@@ZappyOhYes because it has a role in cancer growth as well.
I thought too much Angiogenesis was bad for cancer proliferation?
😏👌 Good ol' collateral circulation .
How do you build muscle without exercise. Lol!
1:55 angiogenesis.
I’ve heard from somewhere, probably some UA-camr that angiogenesis is a BAD thing because it can lead to tumours gaining their own blood supplies.
Interesting that the body can bypass blocked vessels around the heart to keep it functioning (helpful case). But what about tumour blood supply? Wouldn’t it encourage the growth of blood vessels to said tumours?
It's true that some cancers undergo significant angiogenesis to keep growing, but that is also a specific scenario and probably not something people should worry about unless they have cancer, but angiogenesis shouldn't be seen as 'good' or 'bad', but context dependent.
Yes, you can look up vegf inhibitors on the internet...
It depends on the mechanism that is sending the VEGF there in the first place. Angiogenesis does not cause cancer. It's a mechanism for various things including healing heart damage, and also feed tumors and give them a blood supply. But generally cancers are tied in with growth, so you have to separate growth of for example muscle, with avoiding growing the cancers. And how do we do that? That's a whole separate question with answers that comprise stacked fields of study.
Some cancers grow hair and teeth too.
Ah nice, a whole video without bursts of comedy attempts. Congratulations, keep it up.
I miss the dad jokes! Bring them back!
I use the joke time, some longer than others, to pause the video, look up terms like VEGF- and all its uses including non-endothelial and activity in tumors, and then come back to the video for context. Learn a lot more that way and Physionics inspires it. And that's probably why you're here too.
No fun allowed!
Muscle is overrated
Oh jeez, I'm too dumb to understand this...
Lovely name, and no you’re not :)
You'll get there! Keep at it@
@@PhysionicMost videos I can, at least, keep up, but this one went way over my head. I just don't know enough about the all the minutia of body processes to follow your string of reasoning. Or perhaps I just didn't pay close enough attention. Either way, thank you for doing the leg work to present these concepts to us normies.