Making Chemical Hair Remover
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- Опубліковано 5 лют 2025
- In this video I am making the active ingredient of Nair (chemical hair remover) and testing it on myself, what could go wrong?
Don't conduct any chemical reactions without proper and professional safety analysis and risk management. Measures taken can be invisible, not filmed, not properly visible on camera or misjudged by the viewer due to setup or video construction. Always conduct own appropriate measures regardless of video setup.
For entertainment and education purposes only.
Do not use chemicals on urself.
Mechanism/reaction sci-hub.se/htt...
Patent/procedure worldwide.espa...
General sci-hub.se/htt...
sci-hub.se/htt...
![Making [1.1.1]Propellane](http://i.ytimg.com/vi/iTlRvQuIyqE/mqdefault.jpg)
![Making [1.1.1]Propellane](/img/tr.png)
"add a random amount of HCl..." - spoken like a true chemist. You have no idea how deeply I empathize.
And laboratory technicians too. Chemist lite.
@@tonyflamingo3285 Lab techs are the really scary ones because they combine the chemistry jank with the engineering jank
lower the PH with HCL until it does something.
@@tonyflamingo3285You leave on 2 table lamps with 2 different kind of bulbs. You wait to see which type of bulb burns out first after a while and how long it takes.
Would you consider this example to be a scientific experiment ?
@@stevetheborgYou leave on 2 table lamps with 2 different kind of bulbs. You wait to see which type of bulb burns out first after a while and how long it takes.
Would you consider this example to be a scientific experiment ?
The complexity of this chemistry, when it sounded simple at first, blows me away. Nice work!
I wonder how long it took a research team to come up with something that would break that double sulfur bond, without dissolving much skin?
It's a pretty polar and short molecule, skin is fatty so good solvents for that are usually apolar. I bet the hair removal effect of this stuff was discovered as an oopsie though :P
it was originally used (and still is) to remove hair from animal hides
The discover was probably the analysis of some random natural hair remover who have it
Hair removal recipes have been known for more than 5000 years.
Although you may find today's methods to be smart, I find it humorous.
I have to admit that any time I see a thiol functional group my first thought is "hey I can attach that molecule to a gold surface". And now I'm probably going to spend the rest of the night thinking about what one could use a gold surface decorated with glycolic acid for.
@@qaziquza Prank razor that removes your hair 😧
You could make a thioether (sulfane), oxydize it to sulfone or sulfoxyde and alkylate the alfa position on the acid and then cause elimination of sulfenic acid making an unsaturated acid.
And I bet somebody in the 70s have already done that...
.
gilded testicles
This channel is like Nilered but with intimidating complexity.
I used to work with this stuff in bulk in a previous job (in a 1920s-built factory that made perming lotions, among other things)
they used to make perming lotions in batches of 2 tons at a time, and the smell of thio acid combined with ammonia would stink out the whole building - good times!
No chemical burns? That is not something people usualy brag about.
I count all of those days as a win!
Chemists mostly brag about things other people usually don't brag about. Like how many sanity points organic chemistry has cost them and such.
I'm pretty sure chemists do. I was doing some stuff with HF and didn't realize that it was actually condensing on a watch glass. I ended up just dumping concentrated HF all over my thumb when I picked up the watch glass. Not even a single chemical burn.
"It'll be fine, right?"
beats
hold my beer
@@htomerifYou leave on 2 table lamps with 2 different kind of bulbs. You wait to see which type of bulb burns out first after a while and how long it takes.
Would you consider this example to be a scientific experiment ?
Very nice, gotta love the organosulfur chems!
Love your channel btw :) I was thinking of starting my own channel but idk if explosive chem is ok to do vids on in the US lol
@@IdiotWithEducationthanks! It's possible to get a license and do it legally, but as long as you never reveal your face or name (or do anything particularly questionable), the authorities usually won't bother you. Of course, UA-cam has a history of taking down explosive content, so there's no guarantee you're content will stay up... sticking with obscure or "educational" explosives has proven to be the safest route all round.
I don't know why but the way you say the word "concentrated" massages my ears
More editing than usual. I like it.
5:06 this is the cutest glassware i have ever seen
Tried Nair once. Got chemical burns and had to shave them in the end anyway. Much pain. Good times :/
i've tried nair before. it worked fine for me
Same. "Suitable for sensitive skin" my left asscheek.
@@catboy_officialis that where you used it?
Nice, a UA-cam Chemist who actually puts out videos
is the video you were referring to the one that... nvm
The peaches in the first shot should be an obvious enough hint that yes, he is referring to that one.
He's slowly getting more chaotic...
I'm loving where it's going.
hey chemiolis i have enjoyed watching you work a lot, i think your a really good chemist, In-fact ive never seen nileR doing column chromatography before. Good man.....
Thank you for your creativity, sir! you are cool)
Don't put Nair on your nuts!
What about one's ass?
You shouldn't put anything other than your partner(s) on your nuts.
Think of the squirrels
Calcium salts will sterilize you, yeah?
I have tried it and i must say either you have really sensitive skin or i have some weird skin, because i have never gotten burns nor irritation from it. I find it useful as it keeps must of my slow growing hair back a good 2 weeks. So i dont have to shave every morning. But thats just me.
you have to use it absolutely correctly or it will most likely cause irritation. note that he rubbed it in (bad) and rubbed it off (bad), and then kept touching the area (also bad). also, jfc the fumes that come off these creams is NUTS if you're a hairy fuck like me and don't at least trim it shorter first. almost as pungent as brake cleaner lmao.
From my experience, the best Nair to use is actually the men's formula (the one shown at the beginning of the video). It contains aloe and lanolin, which seems to do a better job at preventing skin irritation than the coconut oil and vitamin E found in the sensitive formula.
I love that you can make your own grocery store/pharmacy products.
I love your explanation and videos!
Friend, you are a shining example of how young scientists constantly push the limits; and cook themselves and their friends! Hahaha keep going knowledge is a painful mistress!
Ammonium thyoglycolate is the active ingredient in perm solution, the fixing solution is mostly H2O2
That was surprisingly easier than I expected the procedure to be, nice
You leave on 2 table lamps with 2 different kind of bulbs. You wait to see which type of bulb burns out first after a while and how long it takes.
Would you consider this example to be a scientific experiment ?
can you synthesize super glue or epoxy resin? ive wanted to see that for so long
The first 3 seconds of the nair video and you'll never be the same 🤣🤣
trichloroisocyanuric acid is my new favourite molecule
Now THIS is an educational video.
Honestly, ive tried making chloracaetic acid before with the sulfur method, with very limited sucess. Ive tried a diffrent method that seems to promise higher yeilds, which also produces purer product, with lesser di/tri chlorinated compounds present.
Same setup, however alongside the glacial acetic acid, 5%(wt.) of H2SO4 and 25%(wt.)Acetic anhydride is used. The yeild of the reaction is considerably higher, ive let the reaction run for around 5 hours. when using 70g of GAA, around 50-60g of chloroacetic acid was produced, Leting the reaction run for like a day should increase yeild to near theoretical, with literature claiming to have produced a yeild of 95-98%.
The amount of GAA you seem to have used, with the microscopic amount of yeilds obtained, is such a waste in my opinion, so if you ever plan to re-synthesis chloroacetic acid, give this route a try.
We use mercaptopropionic acid in my lab to add carbonyl groups onto gold surfaces
Can we say sulfur is a catalyst in the first reaction if it's used up ?
do you use some sort of a program to simulate those multi-stage reactions, do you get it from some paper or are there just rules that you learn about how these reactions take place? [obviously i'm a complete noob in chemistry]
It's a combination depending on the availability. Most of the time I draw/come up with them myself, with the known rules and help from standard ones online. Often I ask another chemist to check them, and sometimes they draw them for me. Rarely do papers draw mechanisms (that include all the intermediates), but if it is multi-stage and they mention the reaction order or reaction type, a general one can be found online that u can use to apply to yours (or u can easily come up with a mechanism because the products are known).
@@Chemiolis i'm particularly curious to know exactly how much you need to find, how much you need to understand and how much you need to remember in the chemistry you're doing.
i’m using that chemical for a synthesis in lab right now…so odd that this video pops up for me haha
Thioglycolic acid hair burner. Smells foul if acidified (thiol). Reminds me of trichloroacetic acid as a skin peel agent.
Organic chemistry: 10/10….on the formulation side, still some work to do :)
You seem to love short path destillations
You got to take a shot every time he says that.
@@petevenuti7355 For some videos that would be lethal... If you add "and I ad it to a separatory funnel" to the shot requirement then most videos are, if not lethal, then at least able to give you a 48 hour hangover.
You kinda do the same thing when using a rotavapor
Doing sulfur chloride chemistry without even complaining about the smell or starting a vendetta against things turning yellow? Now you're just rubbing it in. 🤣
Edit - 4:05 whoo, that was spicy
I made it after 10 long years on youtube to see a video when is was
Where is the pressures you used during this synthetic?? Why you do not attach it with the video description?
Why didn't you pass cl2 gas onto sodium acetate? It seems like chlorine could bind to the alpha carbon more easily.
"And a tube 💝💖💗💓💕❤🔥❤💝❤💖💗💕" Lmao
Nice video. And I now know that I'll never use Nair xD That stuff is a toxic mixture of bad stuff xD
Could you make a video on the preparation of acetyl chloride please.
My soul left my body when you added water to concentrated sulfuric acid, that could have ended very badly
I prefer using thioacetic acid and de deprotect it after the adition
Muy buena técnica 👍
That was one chonky stir bar
I wonder, why no cosmetic company produces a depilating cream based on phosphines, like TCEP? It's not toxic like PH3, and would potentially be less irritating.
TCEP is rather expensive compared to thiols. Maybe just a cost thing?
thio acid has a very long history of use, and its toxicity profile is well known; its usage is also regulated in many parts of the world
any new depilatory ingredients would have to undergo a rigorous programme of safety testing, and that represents a very large investment for a cosmetic firm (unless it's a Unilever- or GSK-sized conglomerate) for not much return
@@yorkshirechemist That sounds right, thanks for taking time to answer.
2:35 can someone explain. The hydroxy group is a really bad leaving group and more nucleophilic than the chloride. How can a subsitution happen when those conditions exist?
This is similar to how thionyl chloride converts carboxylic acids into acyl chlorides.
The acid substitutes a chloride on S2Cl2 and then the chloride ion attacks the acyl group substituing the activated OH which is then turned into SO2.
What happens here is activation of the OH towards nucleophilic substitution.
Same thing happens with PBr3, SOCl2, Ph3PBr+, with DCC, many methods of activation of carboxylic acids have been explored.
Well at least you didn't demonstrate it the way the other guy did. But dam for 22 million views, I could see being tempted to do the same! lol!
I wonder if it is possible to do chlorinate ethylacetate with NCS and then do a SN2 reaction with sodium hydrosulphide and then hydrolyse the ester of thioglycolic acid with sodium or lithium hydroxide.
It's like a turtle shell down there bro. 🤙
Dear Sir, no doubt your hard work gives a real hand on experience of experimental procedure. I have a sincere request.... kindly make a series of video 5:02name reaction of organic chemistry.
What sodium base should be used to protect the chloride from water damage?
Why didn't mineral oil dissolve in a so basic pH?🤔
Mineral oil is just medium to long chain alkanes, it won't dissolve in anything polar
Mineral oil is a mixture of long-ish alkanes which don't react with strong bases, whereas vegetable oil is composed of triglycerides which do react with bases to form glycerol and salts of fatty acids (aka soap).
@@grebulocities8225 I thought that mineral oil was some source-different vegetal oil🥲
Thank you
Zia and busted
Thanks, Now I can make my own... nah, I will just go grocery store and buy some Nair instead :))
Oh yea thiosulfate and acids :/
Also happened to me a while ago while quenching some excess bromine in a reaction.
OK, I'll bite ... what's the video going around the internet? I haven't heard of it.
I will use this to make acetanilide
but what did it taste like?
yellow chemistry always looks so tasty i don't get the hate
what could go wrong
Buffalos
fromthe thumbnail i thought you were making chemical bone bender
How about something close, but different: 2-mercapto ethane sulfonic acid. Then you can try to electroplate some shiny copper with it. You already have PEG-4000 as the other interesting additive in the bath. The real tested brightener is the propane homologue, but I'm stuck trying to make the ethane one from taurine `cause I can buy it at the health nut store lol.
Also doesn't thioglycolic acid sound kinda ambiguous? Since thioacetic acid is CH3C(O)SH, one could assume that thioglycolic acid is HOCH2C(O)SH
I can smell this video. 😁
You leave on 2 table lamps with 2 different kind of bulbs. You wait to see which type of bulb burns out first after a while and how long it takes.
Would you consider this example to be a scientific experiment ? ..
Madman.
How a chemist prepares for a date
You leave on 2 table lamps with 2 different kind of bulbs. You wait to see which type of bulb burns out first after a while and how long it takes.
Would you consider this example to be a scientific experiment ?
i panicked a bit when you started rubbing it into your skin…that’s basically just asking for a chemical burn
Never been this early. Was about to comment on the mistake in the title, but apparently nair is a thing
Why you have not tried 2 methyl isoborneol yet?
It is more easier to synthesize it than geosmin and both are same in terms of their smell.
I would love to see the making of tri nitro toluene, which was used as a dye for a while. But youtube and things might be upset with it so im not so sure.
as someone who has used depilatory cream with great success, you're doing it soooooo wrong. you left it on an approprite amount of time, but your skin got more irritated than it otherwise would have because you rubbed it in, which you are specifically instructed (at least for the stuff I've bought) not to do. You're meant to use, effectively, a rubber/silicone scraper or spatula (preferably a softer, more pliable one, but still with a defined and controllable edge) to clear as much off at once as you can so you don't jiggle the skin around and let it into your pores, minimizing contact with the freshly sensitized areas while still clearing as much of it off as you can in one swoop (which also applies more precise force to the weakened/melted hairs removing them more effectively), then you're meant to gently rinse your skin and try to not touch it for a few hours after. I also think (here's where the conjecture begins) that your addition of soap may have made it worse too as your rubbing would have allowed more of the solution in while the detergents also broke down the oils in your pores, making even MORE room for it to get in and cause irritation.
Bro i thought nair was a typo for hair💀💀💀
It pretty much is. 🤷♂️
nair = no hair
they should give the person who came up with the name a damn promotion lol
@@LiaLia0407You leave on 2 table lamps with 2 different kind of bulbs. You wait to see which type of bulb burns out first after a while and how long it takes.
Would you consider this example to be a scientific experiment ?
@@interstellarsurferYou leave on 2 table lamps with 2 different kind of bulbs. You wait to see which type of bulb burns out first after a while and how long it takes.
Would you consider this example to be a scientific experiment ?
@@crabsaresilly8317 not an experiment, but an observation leading to a hypothesis which then will be used during an actual scientific experiment where the number of bulbs is significantly larger to reach a result with a higher probability of being reproducible.
IE if lamp A burns out 20% of the time and lamp B burns out 80% of the time you will have experiments where lamp A burns out first, even though that does not follow the actual larger trend, so an experiment involving just two bulbs would not be enough to establish any theories or results, but it does allow for theories and results as long as the experiment involves multiple bulbs, reaching more certainty the closer to infinite bulbs tested you get.
video idea: is it possible to remove the fingerprint with acid (or something similar)
I read about a criminal doing this long ago, and also one who used rubber bands and razor blades.
If a book mentioned them, it wasn’t as effective as they had hoped.
Repeated exposure to calcium hydroxide works. A lot of bricklayers and concrete workers have unreadable prints because of it.
Cant see the word “nair” without seeing “it”…
Don’t put the nurr in my hurr
I know it's less dramatic, but maybe you could test on a skin analogue like chicken first.
Chemists really don't like to bother with ethical approvals.
You leave on 2 table lamps with 2 different kind of bulbs. You wait to see which type of bulb burns out first after a while and how long it takes.
Would you consider this example to be a scientific experiment ?
Hf?
Piranha?
Thats hilarious
Bruhhhh you should synthesize amoxicillin 😂 ive yet to find a youtuber thatll make antibiotics 😂😂
Mercaptoacetic acid >>>> thioglycolic acid
feel like shitpost
You leave on 2 table lamps with 2 different kind of bulbs. You wait to see which type of bulb burns out first after a while and how long it takes.
Would you consider this example to be a scientific experiment ?
No butt, no watch
Femboy :V
ua-cam.com/video/CQzNB6TDNxk/v-deo.html Everybody take a drink!
I actually didn’t expect anything to come of tbh.
Hope you don’t get any weird bald spots🥲