I wonder if the aforementioned person realized that most of the people who watch one channel watch the majority of the sector, and the bad publicity is an issue for him? I know I unsubscribed following that stuff. Side note I wonder how long till a pre-workout with a gorilla on it includes this in it.
2,4-dinitrophenol was also used as a contact herbicide. maybe you could try spotting a small amount of bam15 in solvent onto plant foliage and seeing if it causes bleaching and necrosis to show that it is uncoupling oxidative phosphorylation
11:14 Just a note here. You drew the 2-Fluoroanaline performing SN2 on an SP2 carbon, which just isn't a thing because the antibonding orbital isn't available for bonding. It's more likely that the fluoroanaline attacks, pushing the double-bond up onto N. The double bond can then reform and pop off Cl. I realize that it's a bit semantic, and you were probably just trying to save yourself some chemdraw, so everyone can feel free to ignore me. I just have strong feelings about mechanistic chemistry.
@@dca24100 for real though, not that this is anything anyone should ever do, but if one had a cheap additional calorie source based on calorie dense food such as plant oils, maltodextrin, starch or sugar, I wonder whether it'd be possible to heat yourself through the winter cheaper than with regular heating. Not that its valid besides the safety issues even because your flat or house would probably get issues from the constant cold too, but like, as a thought experiment, that's interesting.
It would be even funnier if he was just talking about an unrelated chemist friend of his who's in on the joke. "What? No, I meant my buddy Greg Chemistryman."
The recommended quench for POCl3 is to slowly pour it into hot water so it reacts immediately and u don't have the delayed thermal runaway due to the immiscibility with cold water
I disagree. The point was clear and made in another video. Isn't that enough? I don't think it's good to be an asshole to a clearly mentally ill person, even if they're also an asshole. Definitely not if the comment is just joking about their weight. It's a boring joke about an already iffy subject.
@ to be fair do we know they are mentally ill? Also, the issue isnt over or anything, as long as this isnt cleared up from his side I think its fair game to make jokes like that. Although I do agree that a simple weight joke is kind of a dick move, but from his standpoint I can more than understand why he does it, I mean, he contacted his father to induce family drama...
@@derenjoy3r I would call drug induced big shift in personality "mental health". I also don't think it's bad to err on the side of caution when discussing people like this. Even so, calling someone fat as an insult is a very cheap shot that impacts more people than just the target of the joke. I think I just really dislike it when drama gets petty like this.
I had been "lucky" to work with POCl3 in my first projects as student at research institution. Really glad for procedures refined by older colleagues. The best way to deal with POCl3 or PCl5 is to pour it into a huge excess of just ice, let it melt and extract/filter after.
@@dfvxxgewyjgb Yes. The difference between "controlled reaction" and "runaway reaction" is only a few degrees, so you need a large thermal absorption buffer.
That pocl3 quench was so sus, lol. I've never seen those cursed furanozoles before, I can't believe it's as simple as dehydrating the dioxime. This synthesis is also surprisingly simple, only three steps to string it all together.
6:45 "the product is purified by hand" that is something i wanna see in a paper, seriously. Has anyone seen something like that? Do they write it in fancier terms?
Now that I've started to study chemistry myself, it's interesting to watch your videos again after a long pause and now recognizing many of the things you use. Felt a little like that Leonardo DiCaprio meme every few clips.
I loved the video, but a quick side note about the mechanism: Intermolecular proton abstraction is HIGHLY unfavored in 1,3 systems, and in most cases, intermolecular reactions won't occur in standard conditions unless there is a highly favorable orbital overlap. To solve this, chemists usually only show intramolecular mechanisms where there is a 1,5-atom count difference (5-atom away rule). This is taught in some graduate-level mechanism courses. The concerted step with the di-hydroxyl wouldn't occur until one of the oxygens was protonated and then eliminated as water. Hope this helps! Not trying to be nit-picky, but I think being aware of this always helps chemists to understand how molecules work. Secondly, in the SN2 reaction, where the aniline N attacks the carbon, the electrons would more likely break the pi of the imine and be donated to the N, and then in a second step, the nitrogen would re-donate into the sigma* of the C-Cl forming the imine again. This is because pi systems are FAR easier to donate into and require significantly less energy to donate into than sigma* systems. This is why you see electrons flow into the oxygen when a nucleophile attacks an acyl halide, rather than just kicking off the leaving group, it's two steps rather than one. Have a great one!
The thing with POCl3 is that it has a period of latency when mixed with water. So it can seem tame at first, you keep quenching and then it just hydrolyzes explosively at once.
proudly announcing that for the 4 years i have been watching this channel this is the first time to me to understand mechanisms before he explain it . there is no enough words able to let me share my feelings with ya all I'm still a 3rd year undergrad but hell yeah that mech feels good 🔥🔥🔥🔥❤🔥❤🔥❤🔥❤🔥
Classic POCl3 runaway exotherm. Your idea of quenching at ice temperature actually exacerbates the problem by slowing the initial hydrolysis rate and reducing POCl3 solubility in water. Since the quench is exothermic, every hydrolysis event increases the temperature and ACCELERATES the hydrolysis of unreacted reagent, resulting in the exponential behaviour you encountered. Instead, you should add the reaction mixture dropwise to *warm* (30-40 °C) water with vigorous stirring so the reagent is destroyed rapidly before you add the next drop. If you add too fast or the temperature is too low, you'll get accumulation of reagent that can cause a runaway exotherm.
Oh, the furazans. I’ve worked with dichlorofurazanopyrazine for my unfinished PhD thesis. Having a lot of PTSD here with this compound and a constant need to synthesize it. You can recrystallize it from 5:1 chloroform:EtOAc mix, and the dichloro compound is VERY reactive, the chlorines just want to be substituted due to strong electron acceptor in the ring, which furazan definitely is.
We also made this compound about 7 years ago and one of the frog looking intermediates literally did BAM lmao. I don't remember which one it was, I think it was that diol but I am not sure. Nobody got injured luckily but it was quite the bang.
3:50 just a note that there are commercially available oral semaglutide options (Rybelsus I think) as well. the injections/tabs are pretty cheap (relative to brand name) if you get it from the right source allegedly
Also the danger of acute toxicity of mitochondrial upregulation-mechanism drugs like DNP and BAM-15 is well known in the body building community (I.e mpmd) and has a reputation for hospitalizing people who accidentally take an extra dose
Ooh, another molecule I ought to run a "human study with population=1 " on... With hopefully less need for ice baths and cooled IV fluid (as compared to DNP I used for contest prep - which was scary, unpleasant and made me feel like shit and loose 20% of strength more than usual during cut).
5:00 When describing reaction mechanisms, it could be educational for some viewers if you also provided a name for the reaction taking place. I.e. in this case a condensation reaction.
2-4-dinitrophenol has been around since forever, costs pennies a gram and is highly effective. It's a proton pump decoupler. Also extremely dangerous if you take too much.
I don't think your mechanism for the last step is correct. I think a nucleophilic aromatic substitution is more likely. The SN2 esque mechanism won't happen on an sp2 hybridized carbon
Though the way it's presented it does look a little to concerted for my taste, you are right. The way I imagine it would lead to some intermediate that then eliminates HCl reforming the C=N double bond
It's an Imidoyl chloride which reacts analogous to an acyl chloride. It's therefore similar to SNAc reactions. The arrows for the N=C bond flipping to the N and back are missing
@@hantrio4327 Agreed, that's what I was aiming at. Whether it's a nucleophlic acyl substitition or an aromatic nucleophilic one could be argued either way, but this is what is comes down to.
NGL, I'd try blood-letting for weight loss before I'd try mitochondrial leak-inducers, because they're kinda the same principle. It just seems like such a bad idea. Cool synthesis, just keep it away from my mitochondria.
ya this part confused me as well, because if it's not going through the electron transport chain it should not require use of oxygen, but it's been 20yrs since I took biochem so maybe I'm misunderstanding something.
No, that's correct. What's being bypassed is the last part before ATP synthase. That's why it's useful, the mitochondria act like a pump trying to work harder to keep a constant pressure despite the leak caused by an uncoupler. That also is where the name comes from, ATP synthase is becoming partially uncoupled from the rest of the respiration pathway.
@@MandrakeFernflower would be an extremely bad idea. it's a relatively weak uncoupler so you need a lot of it to get any effect, and it also causes a nasty prolonged phase of respiratory alkalosis and electrolyte losses in overdose before the uncoupling really kicks in and you switch to metabolic acidosis. if you somehow magically got around all of that you then have to deal with gaping stomach ulcers and your blood being thinner than water in the long term with such large salicylate dosages. DNP might honestly be more manageable for the purpose, as crazy as that is to say lmfao. probably safest just to stay away from uncouplers altogether, unless someone finds a miracle drug with good activity but high therapeutic index
This is not medical advice - I believe doctors do recommend lowering overall body weight and a healthy diet of losing fat to improve type 2 diabetes outlooks
Hey man im supposed to be a second year next year and uhm i want to change courses to chemistry next year, i do wonder though what chemistry major where u?
I'm not sure, but from what I've read about cancers cells, they tend to do fermentation rather than respiration (done in mitochondria). It seems that reactivating the mitochondria, somehow, is needed to induce apoptosis of cancer cells, and this could be one way to go about it.
Watching before it gets copyright struck by our favorite chemtuber.
I'll download it just in case
What is the state of affairs with the chemtube drama?
@@the-one-and-only-mkultra Like April 30, 1945 (colorized).
@@hasselnttper3730 one day there will be hour long documentaries made about this turning point.
I wonder if the aforementioned person realized that most of the people who watch one channel watch the majority of the sector, and the bad publicity is an issue for him? I know I unsubscribed following that stuff. Side note I wonder how long till a pre-workout with a gorilla on it includes this in it.
chad chemist chemiolis: synthesizes a new drug
virgin chemist (copywritten): taste tests spicy chicken
lmfaooo
2,4-dinitrophenol was also used as a contact herbicide. maybe you could try spotting a small amount of bam15 in solvent onto plant foliage and seeing if it causes bleaching and necrosis to show that it is uncoupling oxidative phosphorylation
dinoseb my beloved
Sounds like a cool idea😅. Is BAM 15 accumulative?
I don't think it's a good idea to use fluorinated compounds in agriculture
@@lostolli7766yeah I am not working with those haha
It was also used in explosive
11:14 Just a note here. You drew the 2-Fluoroanaline performing SN2 on an SP2 carbon, which just isn't a thing because the antibonding orbital isn't available for bonding. It's more likely that the fluoroanaline attacks, pushing the double-bond up onto N. The double bond can then reform and pop off Cl.
I realize that it's a bit semantic, and you were probably just trying to save yourself some chemdraw, so everyone can feel free to ignore me. I just have strong feelings about mechanistic chemistry.
Finally, a way to stay warm during the winter months!
finaly
@@dca24100 for real though, not that this is anything anyone should ever do, but if one had a cheap additional calorie source based on calorie dense food such as plant oils, maltodextrin, starch or sugar, I wonder whether it'd be possible to heat yourself through the winter cheaper than with regular heating. Not that its valid besides the safety issues even because your flat or house would probably get issues from the constant cold too, but like, as a thought experiment, that's interesting.
legit my first thought when i heard it described was "so youre saying i can just eat a lot of food and then take it and keep warm"
@@Jengordyn that is literally what Peating is
"I dont need to lose weight however I do know a chemist who does" LOL
4:02
I GASPED
It would be even funnier if he was just talking about an unrelated chemist friend of his who's in on the joke. "What? No, I meant my buddy Greg Chemistryman."
*BAM* ‼️ 👊💥 15, right in the mitochondria… 😵💫🥵 sick burn. and by burn i mean leaking protons. but seriously folks WE DO NOT MASS SHAME.
Shots fired.
The recommended quench for POCl3 is to slowly pour it into hot water so it reacts immediately and u don't have the delayed thermal runaway due to the immiscibility with cold water
So, eat BAM15 and go naked into a snowstorm? IVE GOT HEATED WINDSHIELDS NOW
sick new arctic explorer meta
Would love to see the experimental procedure: “product was purified by removing impurities by hand” 😂
Hahaha the that chemist side-stab was just great. Any updates on the topic? Great video as always my dude
I disagree. The point was clear and made in another video. Isn't that enough?
I don't think it's good to be an asshole to a clearly mentally ill person, even if they're also an asshole. Definitely not if the comment is just joking about their weight. It's a boring joke about an already iffy subject.
@ to be fair do we know they are mentally ill? Also, the issue isnt over or anything, as long as this isnt cleared up from his side I think its fair game to make jokes like that. Although I do agree that a simple weight joke is kind of a dick move, but from his standpoint I can more than understand why he does it, I mean, he contacted his father to induce family drama...
@@derenjoy3r I would call drug induced big shift in personality "mental health". I also don't think it's bad to err on the side of caution when discussing people like this.
Even so, calling someone fat as an insult is a very cheap shot that impacts more people than just the target of the joke. I think I just really dislike it when drama gets petty like this.
I had been "lucky" to work with POCl3 in my first projects as student at research institution. Really glad for procedures refined by older colleagues. The best way to deal with POCl3 or PCl5 is to pour it into a huge excess of just ice, let it melt and extract/filter after.
Это настолько прям жопа?
@@dfvxxgewyjgb Yes. The difference between "controlled reaction" and "runaway reaction" is only a few degrees, so you need a large thermal absorption buffer.
I saw fluorine in this molecule. Better watch it now before it’s illegally copyright struck again.
Love that subtle burn towards whoever that chemist he was talking about...
That pocl3 quench was so sus, lol. I've never seen those cursed furanozoles before, I can't believe it's as simple as dehydrating the dioxime. This synthesis is also surprisingly simple, only three steps to string it all together.
Cool
4:00 Spit out my drink, omfg. I know who it is, it's... what's *that chemist* called again... darn, guess I forgot. Nice burn 🤫
Quenching POCl3 is always pain, i feel you bro :) And adding ice just makes you wait even longer until it boils randomly anyway
I love watching real chemistry happen. Not just a bunch of lame tier list videos.
My man now adds the solid reagent before the liquid reagent/solvent. ❤
6:45 "the product is purified by hand" that is something i wanna see in a paper, seriously. Has anyone seen something like that? Do they write it in fancier terms?
Now that I've started to study chemistry myself, it's interesting to watch your videos again after a long pause and now recognizing many of the things you use. Felt a little like that Leonardo DiCaprio meme every few clips.
same HAHAHAHAHAHHA
If you want to see the effects of a mitochondrial decoupler, you can watch one of Chubbyemu video about a man who took a DNP for weight loss
that sounds like a great way to get an extreme fever
Now, tell me a difference between hyperthermia and fever 😊
If you don't want to go to school🤕🤕
If this ever became a prescription drug then people taking it need to (as Chemiolis stated) take the drug as prescribed and drink lots of water.
Extremely informative, keep the good work up!
Until I used logic I thought this was a weight gaining drug and not a potential competitor oops
Lol me too
Dude as a grad student I looooove to see the mechanisms, that's so awesome of you
the mitochondria is the *_POWERHOUSE_* of the cell!
An this makes it go buck-wild!
Presenting to the emergency room
you meant the coal burning plant of the cell right??
I loved the video, but a quick side note about the mechanism: Intermolecular proton abstraction is HIGHLY unfavored in 1,3 systems, and in most cases, intermolecular reactions won't occur in standard conditions unless there is a highly favorable orbital overlap. To solve this, chemists usually only show intramolecular mechanisms where there is a 1,5-atom count difference (5-atom away rule). This is taught in some graduate-level mechanism courses. The concerted step with the di-hydroxyl wouldn't occur until one of the oxygens was protonated and then eliminated as water. Hope this helps! Not trying to be nit-picky, but I think being aware of this always helps chemists to understand how molecules work.
Secondly, in the SN2 reaction, where the aniline N attacks the carbon, the electrons would more likely break the pi of the imine and be donated to the N, and then in a second step, the nitrogen would re-donate into the sigma* of the C-Cl forming the imine again. This is because pi systems are FAR easier to donate into and require significantly less energy to donate into than sigma* systems. This is why you see electrons flow into the oxygen when a nucleophile attacks an acyl halide, rather than just kicking off the leaving group, it's two steps rather than one.
Have a great one!
I really appreciate your explanations and exploration of different molecules, thank you for sharing your knowledge.
4:04 WAS THIS THAT CHEMIST SHADE!???!?! LMAOO
The thing with POCl3 is that it has a period of latency when mixed with water. So it can seem tame at first, you keep quenching and then it just hydrolyzes explosively at once.
BAM15? more like BAM!! NO MORE FAT
proudly announcing that for the 4 years i have been watching this channel this is the first time to me to understand mechanisms before he explain it . there is no enough words able to let me share my feelings with ya all I'm still a 3rd year undergrad but hell yeah that mech feels good 🔥🔥🔥🔥❤🔥❤🔥❤🔥❤🔥
Classic POCl3 runaway exotherm. Your idea of quenching at ice temperature actually exacerbates the problem by slowing the initial hydrolysis rate and reducing POCl3 solubility in water. Since the quench is exothermic, every hydrolysis event increases the temperature and ACCELERATES the hydrolysis of unreacted reagent, resulting in the exponential behaviour you encountered.
Instead, you should add the reaction mixture dropwise to *warm* (30-40 °C) water with vigorous stirring so the reagent is destroyed rapidly before you add the next drop. If you add too fast or the temperature is too low, you'll get accumulation of reagent that can cause a runaway exotherm.
Oh, the furazans. I’ve worked with dichlorofurazanopyrazine for my unfinished PhD thesis. Having a lot of PTSD here with this compound and a constant need to synthesize it.
You can recrystallize it from 5:1 chloroform:EtOAc mix, and the dichloro compound is VERY reactive, the chlorines just want to be substituted due to strong electron acceptor in the ring, which furazan definitely is.
Sheeeesh that burn is hotter than if that someone took this.
We also made this compound about 7 years ago and one of the frog looking intermediates literally did BAM lmao. I don't remember which one it was, I think it was that diol but I am not sure. Nobody got injured luckily but it was quite the bang.
Would be nice to see this hit the market, Ozempic made me violently ill otherwise I'd be taking it.
This one would make you sweat all the time unless in a cold room
Try taking a lower dose, and also Mounjaro /Zepbound is worth a shot.
3:50 just a note that there are commercially available oral semaglutide options (Rybelsus I think) as well. the injections/tabs are pretty cheap (relative to brand name) if you get it from the right source allegedly
Also the danger of acute toxicity of mitochondrial upregulation-mechanism drugs like DNP and BAM-15 is well known in the body building community (I.e mpmd) and has a reputation for hospitalizing people who accidentally take an extra dose
such a great video, amazing as ever!!
Ooh, another molecule I ought to run a "human study with population=1 " on... With hopefully less need for ice baths and cooled IV fluid (as compared to DNP I used for contest prep - which was scary, unpleasant and made me feel like shit and loose 20% of strength more than usual during cut).
Pretty wild to see a compound from my research group as I’m casually scrolling through UA-cam.
A like for this geniusly wrapped "look at this fat idiot who miss used the dmca for like no fing reason whatsoever" joke. 😂
4:04 SHOTS FIRED
Thank you This Chemist.
5:00 When describing reaction mechanisms, it could be educational for some viewers if you also provided a name for the reaction taking place. I.e. in this case a condensation reaction.
I'm a fat ass, and my best friend who is a chemist studying total synthesis sent me this 😂😂😂 I suppose I need to lose weight.
2-4-dinitrophenol has been around since forever, costs pennies a gram and is highly effective. It's a proton pump decoupler. Also extremely dangerous if you take too much.
it's also toxic as hell - the whole idea behind BAM15 is that it has a better ld50 than DNP
I wonder about BAM 15 toxicology vs other Mitochondria decouplers.
Thank you! That's an extremely useful piece of information for me.
We don't need a chemical Brain Burner anymore... that job is done perfectly by two simple letters... AI.
Time to show this to an Ozempic commercial. That commercial jingle will no longer haunt me every moment I tap on a UA-cam video.
Crazy you guys get adverts for drugs lol
@rockyroad356 Yes
As an eu citizen this sounds so dystopian to me
@@derenjoy3r You don’t know the half of it :(
@ wow, thats more cursed that i would have thought
8:42 you need to practice edging your reactions more, it's the second time this happens 😳😳
I don't think your mechanism for the last step is correct. I think a nucleophilic aromatic substitution is more likely. The SN2 esque mechanism won't happen on an sp2 hybridized carbon
SnAr is not ppssible in this molecule , but i agree it is not Sn2 but rather Sn1
I don't think the system is aromatic tho?
To me, this just looks like a nucleophile attacking an imine
Though the way it's presented it does look a little to concerted for my taste, you are right. The way I imagine it would lead to some intermediate that then eliminates HCl reforming the C=N double bond
It's an Imidoyl chloride which reacts analogous to an acyl chloride. It's therefore similar to SNAc reactions. The arrows for the N=C bond flipping to the N and back are missing
@@hantrio4327 Agreed, that's what I was aiming at. Whether it's a nucleophlic acyl substitition or an aromatic nucleophilic one could be argued either way, but this is what is comes down to.
This would be good for hypothermia victims
4:03 I don't like to diss people for things that they might have a real struggle with. But that was some quality burn.
Nice job, but why you still do not characterize the product ? I mean at least TCL, melting point.
Explosive fat-burner? Sounds familiar!
I wonder about the potential for the formation of significant amounts of nitrosamine impurities considering the reactants and conditions
How if there are no nitrites or similar compounds involved?
You gotta work on thumbnails. Too bad this one didn’t do your video any justice. This is a hilarious, well timed idea and beautifully executed.
i dont get all this research into weight loss medcation.
Duct tape already exists. It ain't hard keeping that trap closed
Where are you, That Chemist? I'm ready to report your channel if you take this video down 😈😈😈
BAM! And the dirt is gone.
NGL, I'd try blood-letting for weight loss before I'd try mitochondrial leak-inducers, because they're kinda the same principle. It just seems like such a bad idea. Cool synthesis, just keep it away from my mitochondria.
Quality and informative as always
Let's see if this video get claimed too by a certain someone.
Can you show the cleanup and disposal steps
00:17 - actually, uncouplers do the opposite of “increasing mitochondrial respiration”, correct?
The mitochondria up-regulate to compensate for the energy loss, and meet the unfilled demand.
ya this part confused me as well, because if it's not going through the electron transport chain it should not require use of oxygen, but it's been 20yrs since I took biochem so maybe I'm misunderstanding something.
No, that's correct. What's being bypassed is the last part before ATP synthase. That's why it's useful, the mitochondria act like a pump trying to work harder to keep a constant pressure despite the leak caused by an uncoupler. That also is where the name comes from, ATP synthase is becoming partially uncoupled from the rest of the respiration pathway.
@ hahahaha… worse for me here, took my biochemistry classes in 1994 during med school 👴🏻
@@hammerth1421 pretty sure a “proton leak” is something Scotty would be trying to fix down in Engineering. (cue “Reverse the polarity” in 3… 2…)
Wasn't DNP banned because it killed people due to overheating? And doesn't this do the same thing?
litteraly what i was about to comment
Even worse - it seems to trigger cataract development for unknown reasons. At a time when cataract surgeries were completely ineffective.
Blud, not even 2 mins in he starts explaining how its better than dnp
Was it actually banned? I don’t think 2,4-DNP is controlled, just “not fit for human consumption” if I recall correctly.
@@Sniperboy5551 Correct.
Uncouplers: polyphenols, caffeine, nicotine, THC?, melatonin, exercise, fatty acids especially olive oil, coq10, estradiol (or maybe genistein from soy?)
aspirin is known to uncouple mitochondria but I don't know how one would use for weight loss
@@MandrakeFernflower would be an extremely bad idea. it's a relatively weak uncoupler so you need a lot of it to get any effect, and it also causes a nasty prolonged phase of respiratory alkalosis and electrolyte losses in overdose before the uncoupling really kicks in and you switch to metabolic acidosis. if you somehow magically got around all of that you then have to deal with gaping stomach ulcers and your blood being thinner than water in the long term with such large salicylate dosages. DNP might honestly be more manageable for the purpose, as crazy as that is to say lmfao. probably safest just to stay away from uncouplers altogether, unless someone finds a miracle drug with good activity but high therapeutic index
@@MandrakeFernflowerIt used to be a part of so called ECA stack during "good ole days of bodybuilding" with caffeine... and ephedrine 😂
Loved the jab at That Chemist 😂
How could this compound be considered anti-inflammitory? That doesnt make sense considering what it is doing (raising body temp, etc.)
Fevers are, by themselves, anti-inflamatory.
As a diabetic of the milder type would this make me better or worse in regards to insulin?
This is not medical advice - I believe doctors do recommend lowering overall body weight and a healthy diet of losing fat to improve type 2 diabetes outlooks
better. apparently this resensitises you to insulin
I wonder if you can try and ligate this to a metal
semaglutide has an oral form
I see "DNP" is making a comeback
1:00 I think your structure for the phospholipids is wrong. The glycerin backbone has 3 carbons.
@LeikiBognat I second that!
oopsie!
looks like the product might be fluorescent. Can you check if it glows under UV light?
Naturally, you've gotta make tren next
Hey man im supposed to be a second year next year and uhm i want to change courses to chemistry next year, i do wonder though what chemistry major where u?
Chinese labs I work with already have it , 1 g / 120$
Are you Dutch or Northern European?
“Not worth it to make fluoro compounds yourself” because a certain somebody will copyright strike you 😂
Chemiolis and chemdelic carry yt chemistry 🥵
I could also imagine uncoupler tablets to be useful in cold weather survival kits, to prevent hypothermia. Maybe for lifeboats on ships.
Aren't they permanent so it causes adverse drug effects?
the effect isn't instant, it takes a couple of days to get going. Would not help in an emercgenct sadly.
Assuming you have enough food to produce that energy
Mitochondrial leakage actually decreases during hypothermia. I definitely wouldn’t take this during hypothermia💀
I think niacin would be better, faster, not sure how long you could do it though
how does it help against cancer?
I'm not sure, but from what I've read about cancers cells, they tend to do fermentation rather than respiration (done in mitochondria). It seems that reactivating the mitochondria, somehow, is needed to induce apoptosis of cancer cells, and this could be one way to go about it.
it doesn't.
Help I’ve uncoupled all my mitochondria
Help! I can't hold on to my protons!
Why was I actually just planning on making this yesterday.
lab mice and thermal camera to see if it really is? ;p
Holy hell, that's the chemical structure of Ozempic?
How on earth do you even make that?
not with chemical synth, but with biochemical synth, cell cultures etc.
im gonna be the first trying this compound as weight loss medicine
Bamm bamm bammm bamm bamm bammm
Self-cooking meat!
now make weight gaining medication. I really need those
dianabol
@cvspvr how effective is dianabol?
@@ahmehhhd you will turn into a balloon
So you're making the spontaneous human combustion drug.
FLAME ON....!
Paris Hilton called and said “That’s hot”
Yo, I'm just deep into mitochondrial uncouplers, I'm underweight. Nice!
8:40 tinder date shenanigans.
4:01 I can think of a chemist who likes to try drugs and could lose some weight 👀
ahahah wonder which chemist it was who needs it ;p
yellow chem good?
“further research is needed.”
Synthes rose bengal pls if its possible of syntes easy way
My favourite reagen🙏