I'm surprised you experienced such a mild taste from the DMSO. I got a tiny drop of it (lab grade) on my skin and a minute later there was a disgusting onion/garlic taste in my mouth. I also visited a veterinary barn where one of the equine patients with septicemia/toxic shock had been given 20cc IV DMSO and the whole place stank to high heaven for the rest of the day.
DMSO itself shouldn't have much of a direct taste when pure, it just contains sulfide impurities that make it taste a bit like dirty vegetables. I didn't have an aftereffect of garlic taste, I think that could be genetic
@@Chemiolis This was DMSO from Sigma-Aldrich which they claim is ≥99.9%. Yeah, it could be genetic as you say. I remember someone telling me that sensitivity to HCN is genetic. I can always tell immediately if someone in the lab has been using it, even when they can't smell it themselves. Mind you, the smell receptors also quickly desensitize to (or are killed off by?!) cyanide.
Apparently "Part of the DMSO is transformed to the volatile metabolite dimethyl sulfide, which gives a characteristic garlic- or oyster-like smell when excreted through the lungs", according to Adverse reactions of dimethyl sulfoxide in humans: a systematic review (10.12688/f1000research.16642.2).
I wonder if the high cost of certain chemicals (like Icilin) is due to lack of economy of scale. That is, you're essentially paying some other chemist to make your specific order just for you, rather than paying some amount from a much larger batch (possibly made by the same chemist).
To some degree, yes. But also, it's a useless chemical to a chemist, who could easily make it themselves anyway. So the only ones who would be interested in the molecule are molecular biologists, and those people generally don't need more than a few mg to do an experiment, so suppliers are more than happy to charge the same price for 10 mg that one would for 10 g if they were selling to a chemist.
@@adrianpip2000 I suppose, given its properties and uses, one might also be paying for USP-quality chemicals as well (as opposed to non-USP-quality ones, which I assume are cheaper to make).
I've got an exercise in awful for you to try. Isolate whatever is in a green persimmon, the small variety, that instantly dries the mouth and even the teeth, and taste that. I've never experienced something else that could make my teeth dry.
First time I tried a persimmon I thought I was having an allergic reaction from how bitter it was and how it made my mouth dry. I only found out after googling that the it was because I ate a unripe one. I still haven't tried to eat a ripe one out of fear of getting that bitter taste again.
Very cool heterocyclic chemistry! More of that please! For the dihydropyrimidinone reaction, maybe you could have avoided the initial precipitation and vigorous HOCN gas evolution (apparently poisonous) by adding KOCN into the AcOH solution of your starting material which would allow for a controlled formation of HOCN. Then add HCl to drive the elimination of water. But again, love the target molecules you're making. Keep it up!
The initial precipitation was not part of the plan! I would have just added it in portions into stirring liquid, but no. Either way it was fine, this reaction is very fast.
@@notsmoothie It should dissolve in something with fats in it. Idk, like ice cream that makes your mouth cold for an hour after you ate it or something...
Random but I really hope someday a talented chemist will be able to discover a pain killer that DOESN'T cause negative physical reactions once someone stops using it. If someone can discover that it could genuinely change the world and improve so many peoples lifes. People that have never experienced physical withdrawals don't fully understand. Someone can fully be mentally ready but no matter what you do, physical withdrawals are completely unavoidable and it makes you feel like an utter failure and our society has a very misunderstood negative perspective on physical withdrawals and physical dependency. I truly believe if some scientist could discover something that doesn't cause physical dependency but helps with pain relief, then I really think it could positively impact the world.
If you actually have debilitating chronic pain then why are you trying to get off? You should be on long-term maintenance therapy, and therefore withdrawals shouldn't be an issue unless you are taking your medication improperly and are running out. All your language of "someone being mentally ready" makes it pretty clear that you are an opioid addict who can't stay clean and want a wonder drug that lets you get lit without the consequences, which hell, that sounds pretty sick, if that existed I'd want some too. 🤷 Also, physical withdrawals are definitely NOT "unavoidable" if your are actually trying to get clean. Buprenorphine is an EXTREMELY effective medication and a slow buprenorphine taper will give you essentially zero withdrawal systems.
Please synthesise conolidine! No lab will make it, it's too complicated they say. It's not illegal, it's a calcium channel modulator and ack3 blocker, it's a fascinating molecule. Con-ol-idine. It comes from Tabernaemontana Divaricata plants. There is a published write up for its synthesis. It uses unusual metal salts in the synthesis.
I would be very interested in the development of a “cold sauce”, or the opposite of a hot sauce. I’m thinking that would be a perfect application of icilin because it doesn’t have to taste like mint.
WS-23 is one I hate, its frequently in E-Liquids and the cold sensation is waayyyy to strong in the throat it actually hurts breathing in after if you vape a good amount
@@mduckernz haha how did you come to do that? Was it from coolant for E-Liquids or how did you come across it? The feeling really is horrible though. Especially if its in your throat, every breath hurts
yeah, i accidentally once blasted some straight ws-23 from a mech mod....... once lol i think i'd prefer a dry hit from burning cotton in a mesh vape than that again... or mustard gas
@@BoyKhongklai his vids take a long time to produce because is projects have grown in scope. He’s put some banger long format vids in the past few months.
This is the difference between receptor affinity vs efficacy - think of affinity as how well a key fits in a lock, and efficacy as how far the lock turns
danm i wish i had a lab so i could make it and sell it at half or quarter price. how much would it cost to setup making it on average since its easier than most other things?
my org chem lecturer would scream that you deportonated at the enolisable positions but did not show the mechanism as proceeding through formation of enolate followed by carbonyl reformation to kick off diethylamine, instead going directly to the ejection xD
Okay but how do you predict the way molecules will rearrange themselves within the right conditions with the right reagents? How do you ensure the chemical bonds as intended? Is it simply chance, followed by a gleaning of the intended chemical?
Good old DMSO - always enjoyed how quickly the taste of oysters appears when it touches skin. Usually advised to use 85% aqueous since it's hard on your skin if it's pure....(some people use it as a topical analgesic, but the readily available MSM (methylsulfonylmethane) apparently does the same thing....did you know that MSM was briefly a controlled substance in California?
Have you tried making candies with it? Like heating it up with a little bit of water and a lot of Saccharose (and maybe some glucose) till all the sugar melts Then letting cool down in small pieces (basically making menthol candy on steroids) The this could distribute it rather well in the sugar and make it easier for the rezeptors to detect
I draw them myself and usually let someone else check them. If I don't know it I ask someone. Often it is not readily found online and we draw the most reasonable/likely explanation.
Do you take suggestions? I think it would be cool to have a video detailing the differences between food grade/lab grade/industrial/military etc chemical preparation.
A little suggestion: using your Eppendorf pipette for highly corrosive and volatile liquids like conc. HCl will dramatically decrease its lifetime because it can corrode the mechanical parts inside. At least that's what's been told during my undergrad.
i wonder if 'chewing gum' companies like extra/wrigleys/orbit etc would love this stuff to be encapulated in some kind of nanoparticle to make a chewing gum that would last forever or at least much longer than anything out there right now.the cold peppermind and wintergreen sensation is what everyone loves and associates with the flavor lasting a long time. so interesting!
I was stoked to see this and immediately wondered "what about the WS- compounds?" Interesting historical note, the WS in WS-5, WS-12, and WS-23 alludes to "Wilkinson Sword", a shaving products brand that evolved from a gun manufacturer in Great Britain started around 1775. Apparently they wanted better cooling sensation compounds for things like shaving creams and discovered some that are now in chewing gum and pretty much everything else. Which brings me to the question: Why doesn't Japan approve amides as food additives?
DMSO with WS 12 may have potential as a pain killer. However the enhanced solubility of DMSO may lead to toxicity. I don't know if it been greatly researched? I plan to show how to make DMSO, copper nanoparticles and spearmint essential oil extract.
I mean, it reminded me of the toffees I used to make at home, with Chili and Menthol Flavor... I called them the Hot and Cold. Very strange feeling eating them.
is it safe to randomly taste a chemical without doing some tests before? i dont know anyzhing about chemistry but to me it seems unsafe/dangerous. wasnt one of the chemical something with cyanide?
No, you have to analyze it or know for sure that it is fine. In this case I did a simple but effective test and found it only contains the desired product. It is also important to take into account tasting vs ingesting, I always spit it out afterward. Besides, the amount is extremely small, even if my product was 95% pure, it is unlikely to cause harm. There aren't many compounds that are toxic enough to case harm with several milligram exposure. Experience and understanding the reaction and product is also ideal. With that, you can tell that there is no reason to suspect anything dangerous. There are more factors to take into account, such as literature precedent (the discovers tasted and ingested it too) etc.
Could it be that the reaction of acetophenol is driven by anchimeric assistance (aka neighbouring group participation) of the carbonyl oxygen? This would form an oxocarbenium intermediate, which is very sensitive towards nucleophilic substitution and would definitely allow this specific substitution to occur at mild conditions.
Heat? Very interesting. I have some menthyl methyl lactate, I wonder how this compares. I'm guessing the heat is because both propylene glycol and DMSO are causing a heating sensation when they pull moisture from your mouth, or are actually heating up from exotherm.
Well that was a good peek into the world of chemistry, My probably (at least to the best of my own perception, grades aside) least understood school subject, that I've never further build upon after end of High School. Considering how most of what is going on inside humans is affected by exactly stuffs like that... Imagine what the people that understand, understand this science do... and can do... Like that was a week long process by a single person to make an bubble gum compound on steroids, now multiply that by 100ths of staff members of well funded government orgs operated for years upon years, having all the previous research and know how available. Well ~or private.
Chemistry is very interesting, but in indian high schools we have to just remember organic name reaction and whole s,p,d,f block elements reaction. We learn 99.5% Chemistry theoretically. Teacher asks Chemistry practical question svia theory 😔. No one gives importance to practical and experiment...
WS-12 is used in vapes. This might be able to be used too, but with a nitro group being present it might not be very heat stable? Just at a glance, WS-12 looks like a more stable molecule that won’t polymerise or decompose readily under heating, unlike this Icilin
Clean with only one spot on TLCs with Cerium phosphomolybdic acid stain. I don’t see a reason to expect impurities here either. Precursors wash out earlier and Icilin is cleaned easily in the end with its poor solubility.
@@Chemiolis idk, just strange that a "add everything and mix step" resulted in a x2 yield compared to literature. Maybe they didn't break the solid precipitated mass of the last passage, so that mixing was suboptimal
I would’ve done a column before tasting it just to be sure 😂 Also, is it legal to sell chemicals for ingestion? Is there a license for that? Do you have to use food grade precursors? Or is it okay to as long as you don’t call it a food/flavouring agent/medicine? I’m genuinely curious, because I have an interest in the niche flavour compound market. Thanks
@@MarcusAu3relioThat heavily depends on country and state/local laws. To sell stuff marked for human consumption you need certified lab, certified precursors and to have the entire process reviewed,and then have analysis done on each product batch - that's in EU, and I assume the US has equally if not more stringent regulations. Which is why nobody bothers, same with cosmetic ingredients.
Paraformaldehyde is less toxic, doesn't stink as much and it's a solid at room temperature while formaldehyde is a gas. So it's easier and safer to handle.
Pretty chill molecule.
Oh how does it feel to be the funniest person on earth
pretty cool too
Man, thats just cold@jakelancaster5889
tasting your own chemicals just like the good ol days
Always remember the quote: "If it don't contain nitrogen, I'm snaccin"
After 9/11
He casually mentions that the researchers did too. It's hard to resist with something like that
@@y33t23 uranium: am i a joke to you?
@@multiarray2320 the context there was organic molecules, I can very well live without heavy metal poisoning
Mix it with Capsaicin, Bromelain & Malic acid and apply to tongue.
Why malic acid? Anyway sound kinda irritating!
Are you trying to make the tongue implode, open a portal, or what
@@user255it’s what candy companies use to make stuff sour
Instant death
@@chemistryofquestionablequa6252 They use many other organic acids as well. I thought you have something more specific in mind.
You have the coolest taste for chemistry subjects for these videos. I enjoy your work.
Keep it up!
Hehe cool
Hehe taste
OUR BOY BEAT THE LIT YIELD % EVERYONE!!! CLEANEST CHEMIST ON UA-cam #1!!!!!
Lmao
I mean if you get everything from Sigma obviously you’re gonna get a purer synthesis
you mean ligma baldrich
11:40 I like the fact that you use gloves to handle the product, but at the same time you spread it on your skin 🤣
Can't wait to try this on my mucous membranes!
All of it
chilly foreskin
I'd rub it on my D before a good F.
I'm surprised you experienced such a mild taste from the DMSO. I got a tiny drop of it (lab grade) on my skin and a minute later there was a disgusting onion/garlic taste in my mouth.
I also visited a veterinary barn where one of the equine patients with septicemia/toxic shock had been given 20cc IV DMSO and the whole place stank to high heaven for the rest of the day.
DMSO itself shouldn't have much of a direct taste when pure, it just contains sulfide impurities that make it taste a bit like dirty vegetables. I didn't have an aftereffect of garlic taste, I think that could be genetic
@@Chemiolis This was DMSO from Sigma-Aldrich which they claim is ≥99.9%. Yeah, it could be genetic as you say. I remember someone telling me that sensitivity to HCN is genetic. I can always tell immediately if someone in the lab has been using it, even when they can't smell it themselves. Mind you, the smell receptors also quickly desensitize to (or are killed off by?!) cyanide.
we should do a genetic test based only on the compounds you can smell and taste, then we could elect the genetically-best chemist in the world xD
Apparently "Part of the DMSO is transformed to the volatile metabolite dimethyl sulfide, which gives a characteristic garlic- or oyster-like smell when excreted through the lungs", according to Adverse reactions of dimethyl sulfoxide in humans: a systematic review (10.12688/f1000research.16642.2).
@@Kenionatus Interesting, thanks!
Your explanations of chemical transformations sound like some strategy war game steps.
I wonder if the high cost of certain chemicals (like Icilin) is due to lack of economy of scale. That is, you're essentially paying some other chemist to make your specific order just for you, rather than paying some amount from a much larger batch (possibly made by the same chemist).
Very likely. There is not really a market for it so vendors can also get away with charging ridiculous prices.
To some degree, yes. But also, it's a useless chemical to a chemist, who could easily make it themselves anyway. So the only ones who would be interested in the molecule are molecular biologists, and those people generally don't need more than a few mg to do an experiment, so suppliers are more than happy to charge the same price for 10 mg that one would for 10 g if they were selling to a chemist.
@@adrianpip2000 I suppose, given its properties and uses, one might also be paying for USP-quality chemicals as well (as opposed to non-USP-quality ones, which I assume are cheaper to make).
Would think that makers of things like icy hot or bengay and other topical analgesics would be interested in that chemical
I've got an exercise in awful for you to try. Isolate whatever is in a green persimmon, the small variety, that instantly dries the mouth and even the teeth, and taste that. I've never experienced something else that could make my teeth dry.
Probably immature tannins
First time I tried a persimmon I thought I was having an allergic reaction from how bitter it was and how it made my mouth dry. I only found out after googling that the it was because I ate a unripe one. I still haven't tried to eat a ripe one out of fear of getting that bitter taste again.
Khat (Catha edulis) does this too.
@@KyleJones734 Persimmons are bitter to you guys? I’ve always found them super sweet
@@eliasdraper1143 if they are not ripe, they are super bitter
I was eyeballing this chemical for a while now, cool to see a video about it
0:50 example of Sigma Aldritch being Ligma-Baldritch
Sigma-Eldritch, of ELDRITCH HORROR PRICES 😂
Very cool heterocyclic chemistry! More of that please! For the dihydropyrimidinone reaction, maybe you could have avoided the initial precipitation and vigorous HOCN gas evolution (apparently poisonous) by adding KOCN into the AcOH solution of your starting material which would allow for a controlled formation of HOCN. Then add HCl to drive the elimination of water. But again, love the target molecules you're making. Keep it up!
The initial precipitation was not part of the plan! I would have just added it in portions into stirring liquid, but no. Either way it was fine, this reaction is very fast.
I kinda want to try using it in cooking.. Putting a tiny bit into some refreshing fruit deserts during the summer sounds banger...
Seems like it would be difficult to dissolve in stuff 🤔
@@notsmoothie It should dissolve in something with fats in it. Idk, like ice cream that makes your mouth cold for an hour after you ate it or something...
Random but I really hope someday a talented chemist will be able to discover a pain killer that DOESN'T cause negative physical reactions once someone stops using it. If someone can discover that it could genuinely change the world and improve so many peoples lifes. People that have never experienced physical withdrawals don't fully understand. Someone can fully be mentally ready but no matter what you do, physical withdrawals are completely unavoidable and it makes you feel like an utter failure and our society has a very misunderstood negative perspective on physical withdrawals and physical dependency. I truly believe if some scientist could discover something that doesn't cause physical dependency but helps with pain relief, then I really think it could positively impact the world.
If you actually have debilitating chronic pain then why are you trying to get off? You should be on long-term maintenance therapy, and therefore withdrawals shouldn't be an issue unless you are taking your medication improperly and are running out. All your language of "someone being mentally ready" makes it pretty clear that you are an opioid addict who can't stay clean and want a wonder drug that lets you get lit without the consequences, which hell, that sounds pretty sick, if that existed I'd want some too. 🤷
Also, physical withdrawals are definitely NOT "unavoidable" if your are actually trying to get clean. Buprenorphine is an EXTREMELY effective medication and a slow buprenorphine taper will give you essentially zero withdrawal systems.
You are the best practical organic chemist on you tube. I need about 2 or 3 lifespans to get really good at chemistry.
Surely ill buy chemicals from a stranger online to taste! ;)
Your tasting is well documented, great stuff
Erythritol is similar, I think. That slight “coolness” is gives to chocolate makes me think it activates the same receptors.
Please synthesise conolidine!
No lab will make it, it's too complicated they say. It's not illegal, it's a calcium channel modulator and ack3 blocker, it's a fascinating molecule. Con-ol-idine.
It comes from Tabernaemontana Divaricata plants. There is a published write up for its synthesis. It uses unusual metal salts in the synthesis.
That stock footage of the lab guys is hilarious
damn i didn't know u were chill like that 😳🥶
Screw spice tolerance, don’t talk to me until you got your cold tolerance up
I would be very interested in the development of a “cold sauce”, or the opposite of a hot sauce. I’m thinking that would be a perfect application of icilin because it doesn’t have to taste like mint.
Is it really chemistry if u don’t taste the products?? 🤷♂️😉🍻
i'm surprised this isn't used more, given how easy and cheap it is to make
Sounds like a good ingredient to use in my limonada.
WS-23 is one I hate, its frequently in E-Liquids and the cold sensation is waayyyy to strong in the throat it actually hurts breathing in after if you vape a good amount
I have accidentally ingested some of the pure material and it was BAD, like it went way beyond cold, into just pure pain
0/10, would not do again
@@mduckernz haha how did you come to do that? Was it from coolant for E-Liquids or how did you come across it?
The feeling really is horrible though. Especially if its in your throat, every breath hurts
yeah, i accidentally once blasted some straight ws-23 from a mech mod....... once lol
i think i'd prefer a dry hit from burning cotton in a mesh vape than that again... or mustard gas
@@StephenMcGregor1986 nightmare fuel honestly speaking
It's interesting that making double bond at @10:00 does not go towards the creation of the long conjugated system of double bonds.
Fantastic. Always enjoyable and well explained
I'm glad I found this channel because nilered was getting boring with barely any uploads except shorts. Bye nilered, hello Chemiolis 😊
Don't forget Extractions&Ire.... if you don't mind chaos energy.
Nile blue too
@@andersjjensengarage chemistry will always have a special place in my heart
@@b3dubbs72 Everything Nile, I'm done with. Nowadays he's living off old vids I guess. As soon as he moved out of his parents garage, he went south.
@@BoyKhongklai his vids take a long time to produce because is projects have grown in scope. He’s put some banger long format vids in the past few months.
How is „potent“ vs „strong“ defined? How can something be stronger but less potent?
This is the difference between receptor affinity vs efficacy - think of affinity as how well a key fits in a lock, and efficacy as how far the lock turns
It's 6am, I should be sleeping.
Yeah, that happens.
Man I really love this Kind of videos
Ive always wanted to try icilin
You make awesome videos!!! ❄❄
Nice concise video, thanks!
That would be awesome to add to drinks just so they taste cold even if they arent
Icillin probably is so inaccessible because menthol is dirt cheap and easily available.
danm i wish i had a lab so i could make it and sell it at half or quarter price. how much would it cost to setup making it on average since its easier than most other things?
This is like the fentanyl of spearmint
my org chem lecturer would scream that you deportonated at the enolisable positions but did not show the mechanism as proceeding through formation of enolate followed by carbonyl reformation to kick off diethylamine, instead going directly to the ejection xD
That’s a lot to scream in one breath.
Doesn't the data saftey sheet say this compound is very toxic?
Okay but how do you predict the way molecules will rearrange themselves within the right conditions with the right reagents? How do you ensure the chemical bonds as intended? Is it simply chance, followed by a gleaning of the intended chemical?
how like how for the first time he has made more than the literature says
Byproducts? Greasefat? 😂
Good old DMSO - always enjoyed how quickly the taste of oysters appears when it touches skin.
Usually advised to use 85% aqueous since it's hard on your skin if it's pure....(some people use it as a topical analgesic, but the readily available MSM (methylsulfonylmethane) apparently does the same thing....did you know that MSM was briefly a controlled substance in California?
Have you tried making candies with it?
Like heating it up with a little bit of water and a lot of Saccharose (and maybe some glucose) till all the sugar melts
Then letting cool down in small pieces (basically making menthol candy on steroids)
The this could distribute it rather well in the sugar and make it easier for the rezeptors to detect
@NileRed should do this too
Hi Chemiolis, great vid. I was wondering, where do you get your reaction mechanisms from? Do you draw them yourself?
Thanks!
I draw them myself and usually let someone else check them. If I don't know it I ask someone. Often it is not readily found online and we draw the most reasonable/likely explanation.
I usually draw reaction mechanisms with ChemDraw, which I licensed with my uni account.
@@Chemiolis What software do you use to draw structures?
@@adamorylski8195 Can almost guarantee he's using ChemDraw with the ACS 1996 template
@@adamorylski8195 Chemdraw 21
Do you take suggestions? I think it would be cool to have a video detailing the differences between food grade/lab grade/industrial/military etc chemical preparation.
Cool chemistry you got here 😂 🥶
Is it not lipophilic? I was a bit surprised when you said “this leaves me with one option” and it wasn’t an oil.
A little suggestion: using your Eppendorf pipette for highly corrosive and volatile liquids like conc. HCl will dramatically decrease its lifetime because it can corrode the mechanical parts inside. At least that's what's been told during my undergrad.
i wonder if 'chewing gum' companies like extra/wrigleys/orbit etc would love this stuff to be encapulated in some kind of nanoparticle to make a chewing gum that would last forever or at least much longer than anything out there right now.the cold peppermind and wintergreen sensation is what everyone loves and associates with the flavor lasting a long time. so interesting!
Best vid ever
Taking "got ice in my veins" to a whole other level
I was stoked to see this and immediately wondered "what about the WS- compounds?"
Interesting historical note, the WS in WS-5, WS-12, and WS-23 alludes to "Wilkinson Sword", a shaving products brand that evolved from a gun manufacturer in Great Britain started around 1775. Apparently they wanted better cooling sensation compounds for things like shaving creams and discovered some that are now in chewing gum and pretty much everything else. Which brings me to the question: Why doesn't Japan approve amides as food additives?
I think the problem with a lot of amides is that they can enzymatically hydrolyse in the body to give back the amine that is usually toxic.
DMSO with WS 12 may have potential as a pain killer. However the enhanced solubility of DMSO may lead to toxicity. I don't know if it been greatly researched?
I plan to show how to make DMSO, copper nanoparticles and spearmint essential oil extract.
if menthol is used on drinks to make them fresh, would it be viable to make an icilin soft drink?
Would you be willing to cover RB-64 at some point (salvinorin derivative compound)?
I mean, it reminded me of the toffees I used to make at home, with Chili and Menthol Flavor... I called them the Hot and Cold. Very strange feeling eating them.
This is straight up alchemy
I think a really cool project for you to consider is making ferrari pigment red
I have actually vaped ws24, but am very interested to try icillin!
Need to put this in my pre workout…
bro skill issued literature OMEGALUL
is it safe to randomly taste a chemical without doing some tests before? i dont know anyzhing about chemistry but to me it seems unsafe/dangerous. wasnt one of the chemical something with cyanide?
No, you have to analyze it or know for sure that it is fine. In this case I did a simple but effective test and found it only contains the desired product. It is also important to take into account tasting vs ingesting, I always spit it out afterward. Besides, the amount is extremely small, even if my product was 95% pure, it is unlikely to cause harm. There aren't many compounds that are toxic enough to case harm with several milligram exposure. Experience and understanding the reaction and product is also ideal. With that, you can tell that there is no reason to suspect anything dangerous. There are more factors to take into account, such as literature precedent (the discovers tasted and ingested it too) etc.
@@Chemiolis thanks for the reply. what test have you done to make sure its just the desired product? (or have i missed it in the video)
I did TLC but I will probably also do NMR later
they sell propylene glycol at pharmacies as a pure powder to treat constipation
Could it be that the reaction of acetophenol is driven by anchimeric assistance (aka neighbouring group participation) of the carbonyl oxygen? This would form an oxocarbenium intermediate, which is very sensitive towards nucleophilic substitution and would definitely allow this specific substitution to occur at mild conditions.
now make toothpaste :)
ICEEE 🥶
Solomon's Preparation
Heat? Very interesting. I have some menthyl methyl lactate, I wonder how this compares. I'm guessing the heat is because both propylene glycol and DMSO are causing a heating sensation when they pull moisture from your mouth, or are actually heating up from exotherm.
Well that was a good peek into the world of chemistry, My probably (at least to the best of my own perception, grades aside) least understood school subject, that I've never further build upon after end of High School. Considering how most of what is going on inside humans is affected by exactly stuffs like that... Imagine what the people that understand, understand this science do... and can do... Like that was a week long process by a single person to make an bubble gum compound on steroids, now multiply that by 100ths of staff members of well funded government orgs operated for years upon years, having all the previous research and know how available. Well ~or private.
I want an Icilin vape!
I don't understand what you mean by 2.5 times stronger when it at the same time needs 200 times less of icilin than menthol? Please explain?
200 times less required to activate the receptor, and the cold feeling is 2.5x stronger
Quick question, how do I learn analytical techniques and literature like this?
What happens when you mix capsaicin with icilin?
I want to taste this molecule!
Get John Cena to promote it when your store goes online. I-Cilin is the new Bing Chilling. 🍦❄☃️
Good job and interesting molecule!
Can you involve the papers that you used?
Where can I buy Icilin? Thank you
Chemistry is very interesting, but in indian high schools we have to just remember organic name reaction and whole s,p,d,f block elements reaction. We learn 99.5% Chemistry theoretically. Teacher asks Chemistry practical question svia theory 😔. No one gives importance to practical and experiment...
That’s too bad, the practical side is the fun part!
I want some icilin chewing gum
Propylene glycol. Interesting. Could it be used in vapes?
WS-12 is used in vapes. This might be able to be used too, but with a nitro group being present it might not be very heat stable? Just at a glance, WS-12 looks like a more stable molecule that won’t polymerise or decompose readily under heating, unlike this Icilin
this guy spills less without a funnel than chemdelic with one
Can anybody give me the source of the recipe he used?
How many weeks until somebody tries to vape this stuff
What if we put it in a cig
How this substance creates cold feeling?
DMSO is tastable???
Did you characterize it? Maybe the yield is so high because of some unsoluble impurities
Clean with only one spot on TLCs with Cerium phosphomolybdic acid stain. I don’t see a reason to expect impurities here either. Precursors wash out earlier and Icilin is cleaned easily in the end with its poor solubility.
@@Chemiolis idk, just strange that a "add everything and mix step" resulted in a x2 yield compared to literature. Maybe they didn't break the solid precipitated mass of the last passage, so that mixing was suboptimal
I would’ve done a column before tasting it just to be sure 😂 Also, is it legal to sell chemicals for ingestion? Is there a license for that? Do you have to use food grade precursors? Or is it okay to as long as you don’t call it a food/flavouring agent/medicine? I’m genuinely curious, because I have an interest in the niche flavour compound market. Thanks
@@MarcusAu3relioThat heavily depends on country and state/local laws. To sell stuff marked for human consumption you need certified lab, certified precursors and to have the entire process reviewed,and then have analysis done on each product batch - that's in EU, and I assume the US has equally if not more stringent regulations. Which is why nobody bothers, same with cosmetic ingredients.
Canada is watching....
WHAT IF YOU TASTE THIS MIXED WITH RESINIFERATOXIN?
Or capsaicin. (because it's safer)
isn't dmso a possibly problematic chemical? are you sure it's safe to ingest?
Yellow chemistry
imagine an Icilin vape juice lmao
Why you don't just use formaldehyde instead of peraformaldehyde?
Paraformaldehyde is less toxic, doesn't stink as much and it's a solid at room temperature while formaldehyde is a gas.
So it's easier and safer to handle.
@@Hammerbruder99 got it🙃
you should try drinking cold water after tasting it to get the full experience
Да, хорошие синтезы автор проводит.!