Dr. Oded Rechavi: Genes & the Inheritance of Memories Across Generations | Huberman Lab Podcast
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- Опубліковано 20 тра 2024
- In this episode, my guest is Oded Rechavi, Ph.D., professor of neurobiology at Tel Aviv University and expert in how genes are inherited, how experiences shape genes and remarkably, how some memories of experiences can be passed via genes to offspring. We discuss his research challenging long-held tenets of genetic inheritance and the relevance of those findings to understanding key biological and psychological processes including metabolism, stress and trauma. He describes the history of the scientific exploration of the “heritability of acquired traits” and how epigenetics and RNA biology can account for some of the passage of certain experience-based memories. He discusses the importance of model organisms in scientific research and describes his work on how stressors and memories can be passed through small RNA molecules to multiple generations of offspring in ways that meaningfully affect their behavior. Nature vs. nurture is a commonly debated theme; Dr. Rechavi’s work represents a fundamental shift in our understanding of that debate, as well as genetic inheritance, brain function and evolution.
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Dr. Rechavi
Academic Profile: en-lifesci.tau.ac.il/profile/...
Lab Website: www.odedrechavilab.com
Twitter: / odedrechavi
TEDx Talk: www.ted.com/talks/oded_rechav...
Articles
Neuronal Small RNAs Control Behavior Transgenerationally: bit.ly/2HZxrzO
Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans: bit.ly/41xRf47
Timestamps
00:00:00 Dr. Oded Rechavi
00:02:08 Sponsors: ROKA, HVMN, Eight Sleep
00:06:04 DNA, RNA, Protein; Somatic vs. Germ Cells
00:14:36 Lamarckian Evolution, Inheritance of Acquired Traits
00:22:54 Paul Kammerer & Toad Morphology
00:28:52 AG1 (Athletic Greens)
00:30:06 James McConnell & Memory Transfer
00:37:31 Weismann Barrier; Epigenetics
00:45:13 Epigenetic Reprogramming; Imprinted Genes
00:50:43 Nature vs. Nurture; Epigenetics & Offspring
00:59:06 Generational Epigenetic Inheritance
01:09:03 Sponsor: InsideTracker
01:10:20 Model Organisms, C. elegans
01:21:50 C. elegans & Inheritance of Acquired Traits, Small RNAs
01:26:02 RNA Interference, C. elegans & Virus Immunity
01:34:13 RNA Amplification, Multi-Generational Effects
01:38:41 Response Duration & Environment
01:47:50 Generational Memory Transmission, RNA
01:59:36 Germ Cells & Behavior; Body Cues
02:04:48 Transmission of Sexual Choice
02:11:22 Fertility & Human Disease; 3-Parent In Vitro Fertilization (IVF); RNA Testing
02:17:56 Deliberate Cold Exposure, Learning & Memory
02:29:26 Zero-Cost Support, Spotify & Apple Reviews, UA-cam Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com
The Huberman Lab podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. - Наука та технологія
I am native American. I got my first sewing machine when i was a teenager. I grabbed an old pillowcase and made a miniskirt with 3 orange ribbons. I didnt use a pattern, i just grabbed scissors and thread and ribbon and let it rip. Loved that thing and wore it often.
It wasnt until years later i learned the significance of the ribbon skirts in our culture. I cried for a long time. It's really powerful how these memories live through us.
Another example is Frances Bean Cobain had scratched a band name into her door jam. Years later she saw her dad Kurt had done the same thing when he was a kid.
Nature is so powerful.
Wow!
Watching this episode of Dr. Rechavi talk about the heritability of acquired traits gave me one of the greatest shocks of my life. When I was probably 6 or 8 years old I began to have a recurring dream about an airplane coming out of the sky toward me and I'm frantically running to get under or behind something to escape it. It was an occasional thing, maybe once a month or less, but not at all forgettable as I was very frightened and it would usually cause me to wake up. Over the years, the dream went away. I think sometime around the age of 18 was the last it happened. When I was about 35 years old my father and mother joined me and my wife and children on a camping trip. My father and I were walking along a road in the campground when a plane flew overhead at a very low altitude and at high speed, the noise of the plane was extreme. My father instantly dove headfirst under the closest camper. I was shocked and wondered what happened. My father then explained that the plane instantly brought back the time when he was hit by bullets coming from a plane as he was taking troops to shore on a landing craft in the invasion of north Africa on November 2 of 1942. He was hit by 3 bullets, one of which went through his lung and blew a huge hole in his back. The fellow who was standing beside him died shortly after this event. Fortunately, another soldier was able to get the boat running and took dad to a hospital ship where they did surgery and saved his life. I was born in December of 1943..... I was watching this video where Dr. Huberman was interviewing Dr. Rechavi and all of a sudden I thought about my dreams and dad's experiences. I had never made the connection prior to this time. I am 79 years old and I am an extreme skeptic. I believe in nothing outside of chemistry and physics. I majored in Physics and came to believe in nothing that can not be shown to be evidence-based. I have been watching videos about Dr. Michael Levin's research on flatworms and how memories seem to be transmittable from one generation to the next in those animals. These are astonishing ideas.
Thank you for sharing this incredible story with us.
but instincts are all in our DNA. You have no problem with that?
Truly incredible story.
We don’t know the first thing about DNA
Maybe your Father or someone else in the family told this story when you were a kid, and as a result of it you started to have this dream.
I'm so happy my children will inherit the knowledge I just gained from this podcast 😊
😂🙌😁
Oh if only I had children who would be even a little bit curious about this . ❤
was it THAT hard to watch?? hahaha
unless u going skydiving while u watch this i figure u don’t got enough adrenaline to imprint this knowledge so maybe not
lol 1:55:00 "none of our listeners kids will remember this conversation no way this is impossible "
This is wild and great to hear. About 40 years ago I began practicing as a Hypnotherapist and I did "past life regressions" as part of my practice. After doing a number of them, for various reasons I concluded there was no such thing as "past lives" and my clients were having memories of relatives that were stored in their DNA and likely extended back to the inception of their families. Most colleagues told me I was out of my mind and that, of course, there were past lives (apparently none had read the Hebrew scriptures). I have repeated my theory to many people over the years but it never got much traction and I had no "proof" anyway. But in the last several years I've seen the idea expressed several times in different iterations. I now feel VINDICATED. Many mental blocks can be cleared understanding this phenomenon and using hypnotherapy techniques for quick and easy resolution of these problems (like "irrational" fear of water, for example). I don't practice anymore but my theory has now obviously shown to be sound! Thank you Dr Rechavi.
Granted, the memories you unearthed might have been inherited, but technically speaking, they were still "past lives".
It's already incredible and astounding what topics you have covered on your podcast. Then, you go and cover a topic (inheritance of memories across generations) that I am sure most people would never *imagine* could be true. I can't wait to see what other mindblowing science-based topics you cover next. Thank you for everything that you do. You really are a gift to humanity.
To me it seems pretty obvious it would be true. We've observed it countless times in animals, especially dogs who we've trained to do unnatural behaviors for centuries, and now will immediately perform those behaviors given the opportunity without any training or learned parental behavior.
See sheep herding dogs and pointer dogs. They do it without ever learning it from anywhere.
So why would humans be the exception to this? People like to say "we're not animals", but we are.
😂
Why would most people think there’s no way it can be true bro
@rocean, well put. Dr. Huberman continues to impress me more and more. I got hooked on Robert Sapolsky but Huberman is gaining quickly to bump him off my favorite log.
@@Xzsxztreiii have you ever spoken to majority of western scientists? It's an echo chamber of ignorance masked as arrogance. This was a huge topic of contention years ago. They could not fathom such a silly suggestion could possible be expressed in genes. Actually many still do, and this topic is pretty controversial.
Blessed are those who inherit the memory where the treasure is hidden.
Aye
It was overwritten
🤣😂
Fuck I love tressure
Nice pointless comment
2:03:55 This study was done in 2013 on Emory University School of Medicine on stressed male mice descendants. It was thought to a first mice generation to be afraid of acetophenone (similar to cherry blossoms). This was done by a first generation of male mice receiving an electrical discharge at the same time they smelled it. Two generations later, when mice descendants were submitted to the floral smell they shocked and avoided the smell. Mice inherited smell sensibility and fear response associated to it
This is a cool topic. I have a good story to tell you about inheritance. I grew up doing flooring, I was first taught by my brother from the time i turned 15 to now, and eventually I quit working for him and now I do my own thing and I specialize in hardwood and tile floors. I recently found out my mothers Grandma did floors as well, and i had no idea. My Grandpa's work is still around today, one example is the floor in the back of Oaks Park roller rink in Portland, OR. My grandfather built the wavy floor in the back of the rink, he specialized in steaming and bending hardwood floors and counters. Without realizing it my brother, his son, and myself carried on his skills and still do floors today 70 years later.
10,000 years ago when we lived in caves, your ancestors were making the rush-mat flooring for them. 😉
That’s an amazing story.
Just discovered your site! I am 82 with no science background (I quit school at age 14). However, being self centered, genetics fascinates me. I had to stop midway your presentation, my brain getting on overload. Several factors were in play. English being my second language, the speaker's accent, plus my basic ignorance of the subject, all made it difficult to follow. I finished listening this morning. Having had my misconceptions challenged, and having the astonishing complexity of life exposed, made for an exciting experience. I was born too early and without the right environment. Instead of expressing myself with paint and brushes, I believe that I would have gone the science road. Thank you. i am looking forward to more enlightening.
😂born too early , as a 25 year old , I'd rather go back , you can have the 21st century
If I had to pick just ONE topic from Neurobiology it would probably be MEMORY.
Thank you again for all your work, Andrew
That’s because memory results in personality.
@@noone8418 true. Do u think there are other factors as well?
@@noone8418 if you allow it, yes. Dr. Joe Dispenza is leading epigenetics and states how memories don't necessarily need to govern your life. So to Dr. Bruce Lipton, who leads epigenetics as well. :3
Speaking of inherited traits; I have a first cousin, 2 years younger, who lives in England. I moved to Australia when I was 6 years old and don't remember my cousin except through family stories. My brother and family visited England a few years ago, reuniting with all our English relatives. They were astounded, on spending time with this cousin, by her having many of my mannerisms. She used her hands to articulate conversations in the same manner as me, spoke with the same cadence (although with an English accent), had similiar facial expressions, walked and sat in a similiar manner. They were quite taken aback, wondering if she had been cloned 😂. Fascinating and very interesting. Thank you so much for this episode.
I love that Dr. Rechavi didn't dumb down the information he had to share. One of the best, in my opinion, episodes.
I have been a genealogist for almost 50 years and became very interested in genetic genealogy as soon as it became a "thing." Due to life events I found myself turning toward gardening as a partial livelihood. I found it seemed I had a knack for it and know my grandfather loved gardening and I spent little time with him when he was gardening, but when I did he mentioned I would make my great-great grandfather proud. I didn't have any idea what he was talking about until thirty years after my grandfather passed. I learned through some genealogy research, my third and fourth great grandfathers worked on developing hybrids adapting plants and trees to grow in different zones within the U.S. They were the "go to" farmers for seeds and and trees in the 1830 when Missouri and Kansas were being settled. I later discovered I inherited more of their shared longer unbroken autosomal segments than four of my siblings. None of whom really showed an interest in gardening at all. I Love this episode.Two of my siblings became outstanding educators. I later discovered they share more DNA with some ancestors who were never know, but I discovered and found they were loved educators. I wonder if this DNA study could explain social attitudes in specific generational increments.
Fascinating. Thank you for sharing that story. My son is more like his grandfather than his own father. Something interesting about this idea about handing down skills and traits without being taught.
Thank you for sharing. That was interesting to read
Wow! As a psych grad and a biology high school student many years ago, this podcast was riveting. I am aged 80. Vinaka from Fiji.
This took me a few seconds to figure out. An 80 year old high school student who found this podcast riveting many years ago. I even checked if it was a re-upload 🤦♀️
@MissMentats thank you ...I will try to get my grammatical ducks in a more understandable row from now on...
@@lorraineevans681 I undrestood it fine. Not everybodies first language is Eng. Fiji must be wonderful btw!
Wow, what an incredible episode! I was absolutely blown away by Oded Rechavi's insights into genetic inheritance and how experiences shape our genes. His research on the heritability of acquired traits challenges long-held beliefs about nature vs. nurture and sheds new light on the complex interplay between genetics and environment. The idea that memories can be passed down through generations via small RNA molecules is mind-boggling, and it opens up a whole new world of possibilities for understanding key biological processes such as metabolism, stress, and trauma. This episode has truly expanded my horizons and left me with a newfound appreciation for the wonders of science.
traits like temperament or mental disorders like ADHD that could impair the ability to learn perhaps but not knowledge. even though my dad was a doctor i would still have to go to med school.
Are you familiar with the book, The Heart's Code? It was written by a transplant surgeon, regarding memories transferred from transplant donors to recipients, and the memories that are transferred. It is truly fascinating!
Thanks for that reference! I've heard some mysterious anecdotes and would love to learn more.
There is a book I read recently called “The Many Daughters of Afong Moy” by Jamie Ford , and although it’s fiction , the whole book is about the memories that were passed from 3 generations of women and inherited trauma and the use of epigenetics. It’s a book I’ll never forget, and it broadened my sense of the more I learn the less I know .
About 35 years ago a friend of mine was telling me she thought she had memories of her “past lives”. I threw out a hypothesis to her as follows-You know Joni, I’ve heard it said that every memory we have causes a “wrinkle” in the brain. Yet we have “wrinkles” in the brain when we are born. Since eye color, disease, etc. can be inherited, couldn’t those “wrinkles” we’re born with possibly be memories we’ve inherited from our ancestors? It left thoughts to ponder. I’ve pondered it for more than 30 years. I can’t wait to watch this podcast to see if it wanders down that path I just mentioned. I wanted to comment before viewing.
I have one more semester left for my Bsc in biology in Tel Aviv university and I had the pleasure of having dr rechavi as my professor for biology 101 course. I have to say that he is even more impressive in class and when speaking in Hebrew. These podcasts are a treasure trove for all people including future scientists. So THANK you so much 🙏🏼
What an amazing privilege to have had Dr. Rechavi as your professor! Lucky you that you speak, Hebrew❤
Nice. Fellow Jewish people. A lot of vegan stuff there too. I've not been there yet. Hehe.
Hebrew is a language of something more than ideas
Yes! Huge treasure trove!
As if
Finally someone is taking this topic seriously! I personally believe that memories and/or mental issues related to past trauma could be passed down but didn't know exactly how. All I knew was that me and my siblings all have clinical levels of neurodivergence and/or mental health impairments, and "coincidentally", my extended family on both sides have major issues commonly linked to stress and/or trauma (alcoholism, cancer, and generational poverty on my mom's side, and Autism/adhd, heart problems, and obesity on my dad's side, and coincidentally his family was generationally involved in the oil industry working with toxic petrochemicals). It'd be fascinating to also hear from someone like Dr. Huberman about Autism, since he's already discussed conditions like ADD/HD and PTSD and how those affect neurological function.
I've had the same sentiment passed down traumas without the original story. Come from a family of neurodivergent folks and dad and sister with schizophrenia
Ancestral shadows.
Generational poverty, can cause gene defects. The stressed body from nutrient deficiencies are a cause of these disorders not a deficiency in meds. That's why meds don't really work.
Have you learned about the MTHFR gene mutations yet? There’s an autism link. I myself have it and I have Lupus. Not being able to detox is very frustrating, but vital to our health.
We are over 35 million women in North America between the age of 45-65. We need a full podcast on pre/peri/full on/post menopause with the right tools. So much informations out there and I feel most of it is just there to get our money and does not truly help us. You did talked about it in a previous podcast but only briefly. Thank you
I loved science growing up. As a career I chose computer science, and enjoyed it, but after started listening to your podcasts, my love for biology and chemistry are resurfacing to the point I get goosebumps thinking about the fact that I will now learn/relearn about genes when I heard the introduction to this episode. This is the kind of joy I didn't think I'd experience, especially now being in my thirties, but most importantly when I don't have to learn science to pass an exam, it's just there for pleasure and self improvement. Words cannot describe this feeling, I guess it's dopamine but I never expected so much release of it while thinking about academics! Lesson here- raise children to love learning and generate pleasure from learning, not just grades. Thank you for these incredible podcasts, Dr. Huberman.
Good for you. Follow that light.
A documentary about CROWS was genuinely fascinating to me. It featured a study that found that crows can not only distinguish faces and alert others in their group, but also their offspring INHERITED the ability to recognize the “bad people” from the “good people”! Truly amazing 🤩
Do you remember the title / author of that documentary, please?
@@innuendo4469 I’ll try to find it. It was on UA-cam.
A decade or more ago, there was a god awful racket from half a dozen crows greatly disturbed over sometime going on in a pine tree behind the house. I walked out there and discovered a dead or dying baby crow on the ground, and what might be a nest up in the tree. I climbed the tree and peeked into the nest to find one more small crow staring me in the face. I retreated and the crows eventually settled down.
I walk every day now and most often see a few crows nearby. For years I’ve been calling out “prettybird” when I see them and quite often a single crow will fly close and turn a couple somersaults directly overhead. I always wonder if it could be the baby I had a close encounter with. I don’t know the lifespan of a crow, but now I have to wonder if it’s THAT crow, or maybe the next generation?
@@Bitterrootbackroads I love this story! Crows are so intelligent. My high school mascot was a Blue Jay, so I grew up admiring them. When I learned about crows, my fascination with them grew. Now I love crows… I hear them in the backyard and try to make friends 😍 I don’t need crow scorn lol
Totally felt Dr. Rechavi's spirit. This episode of the Lab seemed even more important than most--and that's saying a lot!
It's amazing to see not only someone explain something advanced and hard to comprehend truly but do so in a 2nd language. How impressive. Seriously.
I was just having a conversation about this concept yesterday with a friend of mine. Such a wonderfully timed and bizarre coincidence. Looking forward to listening. Thanks for all your efforts.
Wild! I’v always thought we could inherit memories from our ancestors and I used to call it “Genetic memory” but never did any science research etc etc. My friends make fun of me for it. Fascinating talks! Thank you! 🙏
*One main reason I started to think about these things is through my children. Seeing them take on traits of family members that they’ve never meet; laugh, words they say & how they say it…mannerism and it goes deeper than that. Wild stuff. Always learning. Always learning ❤
I see it from my great grandfather , down through siblings and alcohol dependency. .it's a strong gene , . 4 generations , drawn to addiction on some level ,
I get cranial sacral therapy done and man it gets all the things out. I highly recommend. Would love to see studies/interviews with these type of therapists.
This is an amazing episode! Thank you! My story is pretty amazing, I was born out of wedlock. My mother was 16. I never met my biological father. We migrated to another country from my birth country, I was 3 years old. When I was around 18 I was told my biological father was a Dr and his father was also a Dr. Since I was young science interested me and I was learning about anatomy. I am 50 now , when I was 35 I became a naturopathic Dr. I love medicine. I can listen to talks like this forever and understand medical studies and can read as a hobby. 🎉. I was never around Drs or medical Enviroment when I was growing up. We do inherit a map. Or cells that can predetermine our destiny ❤
My family shares your belief. We are all teachers or librarians.
Genetic memory is one of my Nerdoms.The effects of my Grandma living through the depression and my Grandpa living through the German occupation in Norway have effected myself and my children.
It would be good to hear what the effects were. Can you be sure that there was/is a physical component rather than cultural only? I hope that all in the family are okay today, anyway.
Turns out there’s actually science behind memory inheritance & it’s not just woo?!Finding out about this is cool and wild.Thank you for constantly giving us your audience cool,new stuff to learn to the forefront Dr. Huberman😄
also TCM, ayurveda and other eastern teachings, with their four or five elements, are useful metaphors for their very useful eastern system of medicine. They are, in fact, related to movement, chaos or entropy, driving force, and acid/base, resonance etc. so it's not woo either. just sayin. love these podcasts!
Don’t discount the woo just because science has not or cannot figure it out.
there's a myriad of mysteries regarding memory. i like Rupert Sheldrake's theory of Morphic Resonance -- similar to Jung's Collective Unconscious.
@@blissbrain the takeaway from these podcasts is that there must be "rigorous experiments/study and peer reviewed research". That is the "work" of what seperates fact from fiction. Just because a practice or belief exists for a long time or by many people, does not make it "true" or efficacious beyond a placebo. Take the example of the virgin birth belief of a western religious icon...making that figure more sacred and holy. You must show extraordinarily good research to make extraordinarily big claims.
Yet again Alex Jones is proven to be a better source of information than public school.
I watched this podcast with a question I have long wondered. I am an old woman who all my life has loved horses. Many horse people have wondered I have talked to all wonder where we got this intense love of an animal no one else in our family had. I didn’t grow up with them or had access to them but from the moment I saw them as a tiny child I was mesmerized. I drove my city born parents crazy. I have had horses since I was a teenager to old age. It is a feeling that is intrinsic, a memory of this love of horses deep down that I have wondered about. My story is not unique. Horse people have called it the horse gene! Over the years I felt that somewhere in my ancestry there had to have been this memory of the love of horses from somewhere passed down in some way. I loved hearing about the exciting science that has opened up and is being studied! It would not surprise me or thousands of “aging horse women” online who have the same vague feeling that this is indeed a memory carried in dna.
This completely confirmed my beliefs! I've never heard anyone discuss this before - THANK YOU Dr. Huberman!
Mind-blowing! Incredible! I once met a spiritual healer/ practitioner healing from DNA trauma inheritance. It is like you carry the trauma of your mother, and that is what stresses you. Back then, my reaction was Nonsense. Now, I know that it could be possible 😮
I've had the unique experience of being an adopted child that was able to meet my birth family as an adult. Upon meeting them, it became immediately clear that I had some shared traits and characteristics in common with them. I can definitely see aspects of both families in me (slightly more similarities with my birth family) but for the most part I've carved my own path and live a very different life than that of either my birth or adoptive family.
I met my “twin cousin” when we were in our early 30s. She was given up at birth, but I always knew she was out there! Our mothers are identical twins. She was born two months before me. We are truly sisters (but not the same fathers). It’s like we were raised together. We are so much alike. I always called it genetic memory because I KNEW she existed. (She was a closely guarded family secret.) When I first met her, I said I’ve been waiting for you!
@@Somewhere-In-AZ My family was always close too. Didn't know that my bio parents frequently shopped at the store I worked at at the time nor did they know who I was and that I was their son they gave up many years ago. Thanks for sharing your story!
I have an adopted child , IT was only after meeting and understanding the family to which my child belongs by birth, that I understood what lies within my child as angst and Trans issues , The connection is deep and strong in the family line and is manifesting from possibly 4 generations down to today, These days I understand the heartache more and more , and some just have to live in their differences , But true love is unconditional , God is LOVE , ❤
I so appreciate the deep education, openness , and humble spirit between the two of you was unlike so many podcasts I ‘ve also enjoyed. Bravo!
This mean a lot to people who are concieved through egg donation (and receivers mothers as well) knowledge that pre and post natal epigenetics have such a big influence.
This has been one of my longest standing questions.
Thank you Dr. Huberman and Dr. Rechavi.
Genetic inheritance is one of my most favorite academic subjects of all time; the reason being, its direct connection to who we really are as human beings. This topic is also directly related to the nature v nurture controversy and up to the explanation for how and why savants are as miraculous as they are in their extraordinary knowledge and abilities in specific know-how disciplines. I am thrilled that you are discussing this incredibly interesting and important topic today - thank you, and thank you again!
On the subject of nature v nurture, if pressed, because of my knowledge of the extraordinary contribution genetics plays in our everyday lives, right up to the formation of our physical likenesses to our personalities, I’d have to give the preponderance of influence to nature at around 70%, and 30% percent nurture. In other words, the ingredients of who and what we are and become are already baked in our proverbial human ingredient cake. That is, all things being relatively equal, and that someone was not, for instance, raised by wolves.
Lastly, in my extensive research over the years on this subject, there is only one single group of people that can definitively point science and geneticists in the right direction to ever truly understanding human genetics, and that one amazing, astonishing, miraculous, and most important, but underrated and under-researched is the savants among us. These people are nothing short of extraordinary and superhuman… they are the true supermen and superwomen among us!
מדהים!!
I grew up in a beautiful, suburban home that dripped with trauma; silenced by the screams of the neighbors. During times of abuse, I recall a ‘cognition beyond my years’ my brain’s equivalent to the cold water dunk, saying, “Remember this, this human is not making a choice right now, it is habit. They don’t know better but you do.” I knew, I was born to be a stop gap to the generational abuse of children by parents who didn’t have the capacity to see beyond their own conditioning. It didn’t always happen but when it did, it was a tangible shifting of awareness. A change in my genetic potential.
That might sound crazy but I see the evolution in my children. They are better humans than I am; kinder, more compassionate.
Andrew, Thank you for your ceaseless sense of inquiry.
Ho’oponopono
Why everyone here is obliterating what Stanford has coined as the "social contagion" ?
Must be horribly difficult to design a study able to put out this mighty factor...
More over there is this concept explained by Thich Nhat Hanh: "inter-be". In a nutshell it means that one cannot BE, without the environment. We always Inter-Be.
Having been deeply and steadily abused by my overwhelmed ignorant mother, i have read your comment with great interest.
Finally it comes to the concept of freedom. Freedom for me is escaping from that unconscious transmission of behavioral pattern and along our lives filtering out further bad social contagion.
For my part i chose not to have children as it took me too much effort and time to heal from these (auto)destructive patterns.
I have witnessed nature versus nurture , over years , bringing up an adopted child,I was always aware that this child marched to a different drum, YEARS have passed and the inherited genetic memory of the birth family is winning out in my dear child , IT seems an inevitability, that the strong Trans genetic memory , is becoming overpowering and dominant , especially in a world that has become more conducive for those traits , Lemmings look for cliffs theory ?
You give me chills. “Remember this.” I told myself this ever and over as a child. My plan was to be able to tell someone, someday, when I was no longer in danger from the adults. It worked too well. Although I was able to have a very successful career and raise my kids with love and understanding, I still have these images in my head that emerge as intrusive thoughts and night terrors. I do believe that despite my best efforts my past infected my kids while they were in utero. Or maybe I subconsciously trained my trauma in to them. They are admirable adults, but each has an underlying sorrow they try to hide. I regret that I may have unknowingly passed my own trauma on to them. I wish I had never told myself to “remember this.”
From the inner experience of my CPTSD and being 62 years I start to see some reactions of mine are deeply sourced in my nervous system.
70 years old and same.
Thank you! I've studied this for years. I live with CPTSD from multi generational trauma.
Mental health care has never had parity with physical health, and the US medical system is based on profit. Medical science always advanced through war by necessity, but mental health has only advanced since the 19th century.
The greatest problem with mental health is that it is not measurable by any physically measurable metric like physical health.
I remember this episode, as if I‘ve seen it already … wait a minute!
Ha! Good one.
Haaaa!! 👏🏻👏🏻👏🏻👏🏻
My mind is blown. Thank you for bringing important topics to help us have science-based information to help understand ourselves, make the appropriate changes in our lives. You are an American treasure. A true gift to all of us! Thank you and much respect. I never miss your podcasts.
As the granddaughter of a Holocaust survivor, many of us have known about this for a long time. (Haven't watched it yet, just the intro)
Happy to see him on here, I'm already a fan of his memes on twitter.
On a serious note, I have always believed that we carry intergenerational trauma within our bodies. I'm so glad there is serious work being done to understand it (and hopefully help a huge number of people).
1:01:06 Mr. Huberman here some hint to your question: Rachel Yehuda believes that the epigenetic modifications induced by inherited stress from the father is produced before conception and is transmitted by father’s sperm - from the book “It didn’t start with you, Mark Wolynn, 2016” 😊
Always great when someone knows the historical context of the branch of science during a discussion. This was a really good one!
What a time to be alive in. I am truly grateful for you, your team, and all of the guests you bring to this podcast. Thank you for your hard work and for sharing your knowledge with us.
This is why we need free speech in a healthy and productive society. Knowledge is a stock but also a flow.
I was enthralled by Dr Rechavi's enthusiasm and insights. Another wonderful guest and podcast. Thank you.
Jesús Christ this is by far the best conversation I’ve heard on genetics thank you!!!
I first learned about the inheritance of acquired traits in Carl Zimmer's fabulous book She Has Her Mother's Laugh. This is a great refresher and thank you for inviting another wizard in the field to let us have a peek into the lab. Wish it was longer though. Would absolutely love to learn more about the myriad unconventional aspects of genetics, e.g chimeras, mosaicism, etc. A series on this topic would be a nice break from all the hours on nutrition, exercise and productiviy🙏
On a tangential note, can we have someone, or a few, on the show to give a run down on quantum biology?
At first I had so many doubts, but I trust Andrew so much that I gave this episode a shot. Now I am convinced animals can inherit acquired traits and I'm completely amazed!
I studied genetics in the 70s when non of this was discussed. It was suggested that histones must do something etc. If only they new then? This talk highlights how knowledge grows exponential.
I loved every minute of this lecture.
Thank you.
What a wonderful guest! I love how enthusiastic he is about his work and what he is learning through it. He is also very good at explaining things for the lay person. Excellent episode.
I had a hypothesis about this a long time ago. It's great to see it being taken up by greater minds and studied more intensively.
I've experienced emotions and memories of my mother and grandmother...also I sense that my hands carry generations of craftwork...knitting, sewing...relationships with trees, timber, woodwork.
I feel at a loss with some of these things in Australia, because most of my (most recent) ancestral wisdom is not of this land but is on the nothern parts of Europe.
This video...germ cells and soma cells...all incredible!
.. is utterly in tandem with body memories and brain ..
Inheritance of experience is beyond mind body..and interacts with contexts in which the experiences take place.
I sensed on two separate occasions while I was pruning trees with a saw, that I had held a sword in both my left and right hand. Then while watching Game of Thrones I had a flashback of having been a blacksmith and working with swords in the fire. A couple of years later I asked my mother what her father and grandfather had done for work. Turns out my great grandfather was a blacksmith in the army. I think we all carry in our cells a super power of knowledge and skills from past generations - we just have to learn to be open to it and let it come to the surface.
If you were adopted and never met these people, I doubt you would think that way.
It's so amazing to listen to your podcast,my mother had a stroke when she was 7 months pregnant with me she lost her speech and took 2 yrs to speak again.For years, I had a problem talking in front of people and essential tremor which becomes worse when I'm stressed. Thank you
HuberMonday ... Class is in session🙌🙌
I wonder if part of the reason younger generations are struggling these days is because the challenges we face are so much different than those of our parents and grandparents. So maybe the epigenetic effects that may provide similar protections from adults to children aren't working due to the differing challenges? This is all fascinating though.
There’s a joke in my family that every generation believes that.
No wonder I threw away my iPhone when I couldn’t find the dial . ☎︎
But seriously for it’s true that challenges appear very different but in some ways we just have different variables for the same equations.
I can’t wait for them to learn more about this in humans. I’ve experienced numerous examples of traits and memories from ancestors in my life. The firsts-born son in our family (such as I) have three specific nervous ticks that occur at specific ages and disappear before adulthood. It seems to have happened for several generations. What seems to be particular to me is memories of Scotland from ancestors several generations back. My most recent ancestors to have lived in Scotland are at least 6 generations back. But long before I even knew that had ancestors from the Western Highlands, I was deeply moved by the smell of peat moss and especially peat smoke. I was in my 30s when I smelled peat smoke for the first time. I instantly had a sort of out-of-body experience in which I was standing on a moor looking out over a mostly barren plain. It wasn’t until a few years later that I saw, to my shock, a photo of that very place, which was near Ben Nevis. Later, I learned that some of my ancestors had lived in that region for ages.
Interesting.. I can relate because i visited the land of my ancestors for the first time last year, Switzerland, and it all felt so familiar like I had been there before.. it felt like I was home! And now I’m feeling the pull to go back and stay there. My grandparents still spoke the Swiss German language but they are gone now, but I felt a strong connection to them when I was in Switzerland.
Imagine how you would feel in Africa since your ancestors were there millennia longer than Ben Nevis
Blocked out 2 1/2 Hrs of my workday to listen to this important conversation. Thank you Dr. Rechavi and Dr. Huberman for your invaluable contribution to our species.
Such an incredible communicator of science was locked into the screen watching this conversation!! 🎉
I love the Andrews disclaimer on IKEA not being a sponsor! Laughed out loud ! I really enjoyed the topic and the guest dr. Rechavi. For me the biggest lightbulb was close to the end - how to utilize the cold water and the spike of adrenaline !
Every time I have a AHA moment during my personal growth moment or after the intentional subconscious work on myself, I need to use the cold water to write newly obtained knowledge/ideas from RAM to hard drive (or ROM).
And a suggestion on topic for future podcast - on fascia. I am not sure if it was already adressed on podacast.
My husband's maternal grandmother and her siblings all inherited the "nice gene" from their parents...Norwegian immigrants. I had the privilege to know the aunts and uncles, and they all shared a family trait of human generosity.
Dr. Huberman has the neural energy of ten men who else churns out this amount of quality content
Odd I stumbled on this video and will ask everyone what they think. I’m 64 and took up machine sewing last year. My mom sewed a lot, from what I’m told, but I have no real memory of her actually sewing. She taught me hand sewing crafts early like embroidery, crewel, basic stitches, but nothing more. I do recall the annual trip to the “good tailor shops” to pick out a new winter wool coat. The tailor would mark it up with chalk and it would be ready the next month. Here’s the thing - I also “remember” a lot of technical sewing terms. As I’m learning to sew garments now, I watch a lot of UA-cam videos. Almost always, i “know” what the terms mean and when I see it demonstrated, I’m thinking, oh, right. Now I remember how that’s done! I’m pretty sure mom never explained what stitching in the ditch meant let alone how a double welt pocket is put together. Yet I somehow just know it. Can I sew it? No. My hands apparently didn’t keep whatever knowledge is needed. But I will say the first garment I sewed, I was able to do alterations to the pattern for an exact fit. That’s not reflective of my beginner’s skill - and I consider myself a beginner sewist and hardly a tailor. But where did all this easy understanding come from? It’s like I did this all before. Am I nuts? 😅
I've been preaching this "idea" for over a year that history and consistent patterns through history have always been a thin parallel line between biology, and humans, even down to the cell, are adaptive through memory and experience. 1+1=2. I'm glad there's people like you finally talking about this stuff
Seriously! It took genetic inheritance 2000 years to br developed, it was not Darwin's theory alone. Darwin himself never u understood the mechanism of adaption. His theory in it's day was so controversial that his own grandfather had worked on it but never published " because he had 10 children to feed."
Gregor Mendrl never understood what he had discovered, DNA, in his lifetime, he just knew he had something, he did not know what.
Mendel and Darwin both looked at each others work and neither understood that Mendel had discovered the mechanism of Darwin's adaption. It took many other scientists in the 1920's to figure out the scope of Mendel's discovery, and still there are people today that still dismiss Darwin's theory., that do not believe it is proven science.
This was an absolutely FASCINATING episode, thank you 🙏 both. And I will definitely be re-listening to this 🙌💜🤗
I continue to enjoy your podcast and the guests you chose to share with us. Thank you for having Dr. Rechavi on. Fascinating!
Some days I need a glossery for Huberman Lab podcasts!
Excited for this collaboration. Thank you for making it happen!
I started delving into this topic when I got pregnant a few years back now, and of course raised more questions than answers! Amazing to hear from an expert on this fascinating topic, thank you
I have to say that Mr. Rechavi has done a wonderful job of explaining the basics, history and state of the art of the field.
im blessed to know about these topic at nineteen , alot dont around my age , alot of adults dont eve n care or know bout this, i will be seein this later on today , protect this man .
Can’t wait to hear your great information . El Paso Texas
I'm very excited about this episode. It very well may be the closest thing to a neuroscience in relation to parenting episode we get so far. To anyone interested in this episode, I highly recommend the book "It Didn't Start with You" by Mark Wolynn. It can have a bit of a "Woo Science" tone at times, but it touches on the subject interestingly. It also offers options to work through your trauma, as with anything you do not have to follow them.
I'm starting to get the feeling that a lot of "Woo Science" is going to feel more and more like reality, like hey we probably actually live in a "Woo" universe lol. Old ideas and atrophied funding/academic models will die out as people begin to realize what actually makes their lives make more sense in a meaningful way.
another good one is " The Unspeakable Mind" by Shaili Jain, MD, she talks about incest and how it changes the child's DNA that experiences it and much, much more.
Another brilliant episode with another fascinating guest. What I found most touching of all is when Dr Huberman compliments Dr Rechavi on the spirit of his research. It was a genuine hearfelt compliment which moistened the eyes of Dr Rechavi. Such a pure moment of shared admiration by two great individuals. That moment encapsulated why we all admire Dr Huberman so much.
Dr Huberman you are a truly an amazing human being !! You inspire me to learn more
Excellent topic
My father was a master mechanic and my son has a natural ability to diagnose and fix vehicles even though he has never once spent time helping my father fix anything, nor has he taken any classes to learn this information. We do get memories from our parents, it just needs a catalist to help bring the memories to the forefront of our minds.
Love today’s topic. Thank you, Andrew 🙏🏼
I started loving science when I first discovered your channel. I love all your content. Respect!
Can't wait to listen to this one! I asked an AMA question on this topic after a brief mention in another episode about memories being inherited. I swear I had several Vietnam War flashback dreams when I was younger that came from my father. Without revealing I had a dream, I got my dad to verify one of the events in one of my dreams was very similar to something he experienced in Vietnam.
Ever since I've been waiting for the clinical proof that memories can make genetic imprints that are inherited. Validation you're not crazy is always nice!
From the earlier episode it sounds like the genetic memory factor is most notable in what's passed on to grandchildren (kind of skips a generation). If so, we may need to explore the mental health impact on the children and grandchildren of people who were in the Vietnam War, and any wars for that matter, or that have experienced unresolved PTSD. There's been a lot of discussion about how younger generations have higher levels of mental health disorders, however, controlling for all of the obvious variables (social media, constant news cycle, etc.) doesn't fully explain the increase. Researchers should maybe find a way to factor this into the equation to see if it's the missing link.
Hey may I ask: where you born after or before your dad went to Vietnam.
Cause I wonder whether pregnancy has smth to do with inheriting memories/experiences.
@@yudoball I was conceived about 13 years after
I was born after my FA returned from Vietnam and have EXTREME sorrow about The Wall. I walk right up to it and trace the names like they were my own brothers. When I go to any re enactments, I feel like I was in a real live situation. I could spend hours in those surplus stores...when I read Civil War books, I fell like a am in character the whole time. After reading it, it takes me weeks to get back into my normal happy go lucky thinking. I don't feel that way when I ready modern war memoirs. I am reading one right now, but if it's history I feel like I am reliving something. My brother was born before my Dad went to Vietnam and he doesn't get all emotional like I do.
@@yudoball I have a brother who was born before, and I was born after...see my reply to the main page for my comments. It's pretty interesting.
@@spunkycat6144 That's very interesting with the one child before and one after. That's not the case in our family so I have no reference in that regard.
The crazy thing is I didn't have much of a reference to the Vietnam War visually to draw from. My dad is a huge movie buff and we would have "mandatory viewings" a.k.a. family movie nights all the time. But he didn't want us watching anything about the Vietnam War growing up. He was actually pretty well adjusted all things considered. He signed up to go to Vietnam, then stayed in the military and had two more combat tours in two more wars (Gulf War and War of Iraq).
He didn't want us watching Vietnam War movies/shows growing up because he wanted us to form an opinion of him separate from any stigma.
Therefore, when I had my dreams it wasn't going off of things I had seen in movies, TV, news stories. I was a lover of history but I respected my dad's wishes and didn't delve into the Vietnam War until my college years, well after the dreams occurred.
Like you the thoughts, feelings and visuals seemed to develop from somewhere internal
My family has experienced the trauma of memories through four generations.
What kind of traumatic memories?
Please explain if you have the time and energy one day. People are interested to think about intergenerational memory and if it derives from physical or cultural continuities, and if physical, how? what?
These podcasts are pure nerd royalty. I am listening by splitting each into 5-8 sections. In some difficult subjects, repetition helps! Many thanks Huberman. You make online world very useful and meaningful..
I have felt this from when I was young. I was sexually abused as a child and then developed an eating disorder. Life was shit as a girl, I didn't want to become a woman.
It was then my mum broke down because she had been raped by her father from the age of 8....she admitted she had real problems cleaning me as a baby just in case she did anything wrong...
Then when I was 17 I was rushed to hospital with over a litre of septic blood. Turns out I have/am OHVIRA...a rare genetic situation. Most have 2 fully functional uteruses, one kidney and a blocked vagina. I am convinced my mother's experience, my grandmother's experience of constant sexual abuse, created this genetic situation in me. I am being over simplistic, but intuition is instant intelligence... I know it's related and it saved me, provided a shield.
I watched a special on crows a while back and they were studying how they could recognize particular humans by their facial features, and they would avoid the cruel ones and flock to the nice ones that would feed them.
The crows would then pass the memories on to friends and family.
There’s been a few studies about this. I wonder if any showed that the information was passed down genetically?
Think of it in immune system terms. You and wife had illness a, your child will get antibodies to it. Now in-between that kid and your next you and your wife get sick with illness B and C you will pass down antibodies to the next children(s) that the first child didn't receive from you.
@@brianfitch5469 It makes sense. Often stuff goes on in families every second generation! i.e. a daughter may be more like her grandmother, than mother - character wise, potential health issues in later age, etc.
@@innuendo4469 ya one of my daughters looks more like her grandmother then her mother.
But i believe skills can be passed down through DNA as well. How some people can pick up skills quickly. 80+% of intelligence is genetic. No one will talk about it. You cant fix that with money in schools. Certain demographics can be thrown into poor inner city schools and excell. And others removed into rich schools and still fail. People dont know what to do about that. Because we are all "equal" we are told. Mother nature doesnt distribute her gifts equally. In todays world its career suicide for scientist to work on this. As your labeled racist. But its the same worldwide. Iq stays the same worldwide by race regardless of continent. Funny enough crime does as well. But we cant talk about that.
@@brianfitch5469 Very difficult subject, I agree. The tendencies are obvious, as you mention, yet a simple IQ test can only be harming to those with a lower results. Deeper understanding of one matter or other does not equal being able to communicate about it in IQ135 level, nor the IQ135 makes one better in everything in comparison to the lower result. I strongly believe that most can be good at something, the system, though, is so screwed up, that the chances for the "different one" are super unequal. The game is rigged, for many from generations, and that equals.. well, we know better what after this episode.
@@innuendo4469 The ironic thing is when they blamed the poor iq results because whites designed it. They had the other demographic design one and they did worse on it. There are a couple good books on the subject.
But ya iq isnt everything. Doesnt measure EQ. However it does give a good baseline of where someone is capable mentally. Which is why the military and intelligence agencies use it to join either one you take one. Military calls its the asvab.
Wow..this is fascinating. Thank you and Dr. Rechavi for imparting such a wealth of knowledge with enthusiasm and continued curiosity. This is truly an amazing subject matter.
The information provided today was incredible. Listening to cutting edge peer reviewed science and hearing that it is still in the process of experimentation is so refreshing . So grateful.
Hey Andrew, thanks for the high quality content as always.
I look forward for the episode on borderline as I almost lost a person very close to me because of it.
And man, words can not express how important and life changing your work has been here on youtube.
I wish you the best!
Would love a a talk on brain degeneration and age along with medications with side effects that affect memory and cognition. Medications seem to sometimes cause more problems than they help. With this enormous aging population I think that information on how the aging can care for themselves is extremely useful. Thank you for your informative videos. Between you and Lex I e learnt so much.
Wow this is amazing. I'm so grateful for you Dr H. Also may I thank you for solving a lifetime of panic attacks in my sleep since I've taken your sleep stack. Unreal. You're a gift for us
This was one of my favorite episodes so far. I listened to this episode on Spotify and have been binging all sorts of interviews and talks by Dr. Oded Rechavi since Monday every free minute I get. Truly fascinating. I would have loved to have you both as professors when I took the mandatory neurobiology classes in university.
Goosebumps! For me, this is Andrew’s best podcast yet! Bravo to both men
Oded’s memes have gotten me through academic training. Love his sense of humor
Another wonderful episode. I had an experience years ago when I was nannying a baby (under a year old). His paternal grandparents were in the camps in Nazi Germany. This child would awaken from sleep in what can only be described as terror and no amount of comfort would calm him down. His eyes would dart around the room as if watching something terrible going on. I have always wondered if this could have been an nherited trauma memory. Would love your comment on this.
So tragic; thank you for sharing about that.
Some babies need to hear mums heart beat even after they are born to sleep otherwise they feel fear. They will look around as if they are experiencing fear.
There have been studies on holocaust survivors, genetic inheritance of trauma has been noted in them, same with children of Cambodias Khmer Rouge.
Thank you for this and all of your episodes. This channel has quickly become my favorite and go-to source for reliable science and actionable lifestyle information. I took notes and watched this one twice; the subject matter was so enthralling. I’m ready for my pop quiz.
I really appreciate guests such as Dr. Rechavi who are professors, because their ability to educate and translate this very dense material into a brief lesson is so evident and helpful. He is well spoken, obviously in multiple languages, which is even more admirable. Thanks for having him on Huberman!