T cell development in the Thymus

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  • Опубліковано 21 жов 2024
  • This video gives a quick overview about the development process of T cell inside the thumus

КОМЕНТАРІ • 198

  • @tarunkant95
    @tarunkant95 4 роки тому +20

    I listen to your video more than I watch it. Great content but just a friendly suggestion, some words because of the accent are very hard to grasp in one go, try to minimize it and keep up the good work.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому +6

      Tarun Parihar thanks for the feedback ....it would help me to improve in future

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому +7

      Please share among your friends and help me to reach big audience

    • @tiffanyhoward9935
      @tiffanyhoward9935 4 роки тому +8

      Animated biology With arpan I appreciate your willingness to teach. Oddly, I appreciate the accent because it encourages me to truly pay attention rather than multitasking as I do with other videos.

    • @tarunkant95
      @tarunkant95 3 роки тому

      @@animatedbiologywitharpan you're most welcome. I wish you success.

  • @usmanamini1871
    @usmanamini1871 3 роки тому +8

    Medical student at germany. This video made it so easy for me to learn this topic. thank you.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому

      Please my friend share my channel link with your classmates. I am unable to reach big audience

  • @phoenixkepo2743
    @phoenixkepo2743 2 роки тому +5

    Lucid, clear and to the point. Love your presentation

  • @missesCarmenB
    @missesCarmenB 3 роки тому +9

    This makes learning biochemistry so much easier, I wish this was available when I was a student, many years ago. Thank you

  • @ChrisObrienE
    @ChrisObrienE 2 місяці тому +1

    Love the comparison with a soldier!! You're a great teacher

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 місяці тому

      Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

  • @olinko2849
    @olinko2849 2 роки тому +5

    Thank you so much!! I was stuck so long on this because I couldn't visualize it right. Keep up the good work :)

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому +1

      In order to make high quality content consistently, we need support from you. Please support us by using super thanks option. Super thanks icon is present below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Small contribution like $5 means a lot for us.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому +1

      Don't forget to check out my entire immunology playlist. Please share my youtube channel link with your friends

  • @nidhishukla8095
    @nidhishukla8095 2 роки тому +3

    your videos are genuinely very helpful for me tomorrow I have a test and I am crying for not covered anything and don't have a time for reference reading but your video is going to helping me out of this situation thank you , thank you for this favorable explanation ...........👌👌👌👌👌👏👏👏👏👏

  • @gladysudoka193
    @gladysudoka193 2 роки тому +1

    This is good , very simplied and enhances the understanding of difficult subjects as this. well done

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому

      In order to make high quality content consistently, we need support from you. Please support us by using super thanks option. Super thanks icon is present below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for us.

  • @sanroopramesh7620
    @sanroopramesh7620 Рік тому +1

    Very useful. I like the comparison at the beginning

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  Рік тому

      Please support my channel via super thanks. Your small contribution like 1$ means a lot for us. The super thanks option is present at the lower right corner of any video, a heart sign with $ in it.

  • @priyadarshinighosh6461
    @priyadarshinighosh6461 4 роки тому +4

    Your channel deserves a lot more subscribers !

  • @hariigaire
    @hariigaire 4 роки тому +2

    Your explanation is very beautiful.
    Keep on posting more videos.
    Love from Kathmandu

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому +1

      Thanks and keep on supporting.......please share among friends and help me to reach big audience

  • @jeffreykennedy3707
    @jeffreykennedy3707 2 роки тому +1

    Your video is well structured and very easy to understand. GREAT JOB!!! You should create more content.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому

      Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance
      I'm on Instagram as @animatedbiologywitharpan. Install the app to follow my photos and videos. instagram.com/invites/contact/?i=1p41h314q3fv8&

  • @RayyannAlqadry
    @RayyannAlqadry 4 роки тому +1

    According to a research paper in the Journal of Experimental Medicine, T Cell training takes only 4 days. Just a sharing. Everything else is amazing, exactly what I was looking for

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому +1

      Rayyann Alqadry thanks for your detailed feed back it would help me to improve my content..... also I am a learner and the audiance like you would help me to learn

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому

      Rayyann Alqadry please share my channel link with your friends and help me to reach big audience

    • @RayyannAlqadry
      @RayyannAlqadry 4 роки тому

      @@animatedbiologywitharpan Oh, I wanted to know, where did you find the information that only 10% of the T Cells pass through Positive Selection? Thank you in advance

  • @gurunathvenugopal4642
    @gurunathvenugopal4642 3 роки тому +2

    Very well explained. Thank you for teaching

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому

      Please share my channel link with your friends and help me to reach big audience .

    • @lurker7522
      @lurker7522 2 роки тому

      @@animatedbiologywitharpan Hi, I have a question. Do regulatory T cells go through the same training process as other T cells?

  • @iot3136
    @iot3136 Місяць тому +1

    ❤❤❤🙏 Excellent work. Could you please playlist for immunology. You are very talented in teaching immunology mate.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  Місяць тому

      immunology complete playlist ua-cam.com/play/PLKtiwIJ8Q7rq77W7r4cXPrbhi_VpLWw8c.html&si=Bh-eDMPn7QHw8Z-i

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  Місяць тому

      Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

  • @iambliscanna1592
    @iambliscanna1592 Рік тому +1

    Brilliantly explained! Thank You!
    SUBSCRIBED! 😀

  • @hxdcm
    @hxdcm 3 роки тому +2

    Such an interesting video, thanks for making it

  • @abhibittu16
    @abhibittu16 4 роки тому +2

    Very simple and easy explanation. Thanks👍

  • @nil7425
    @nil7425 3 роки тому +1

    Arpan da! Just another masterpiece. ❤️

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому

      Please share my channel link with your friends and help me to reach big audience

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому

      ua-cam.com/channels/4IpyopsGWSjaPACNTZLuqg.html please subscribe to my other channel

  • @zainabjummah7383
    @zainabjummah7383 3 роки тому +1

    Thanks you help me to understand this complicated process... go on

  • @shakir1325
    @shakir1325 Рік тому +1

    This is osm ❤❤
    I understood very well
    Thank you

  • @nedunchezhian9914
    @nedunchezhian9914 2 роки тому +1

    Nicely demonstrated

  • @012-p6t
    @012-p6t 4 роки тому +2

    Beautiful and easy explanation! thank you

  • @tusharsarve6586
    @tusharsarve6586 4 роки тому +2

    Recent one!.. liked it bro. Animation is good and description as well. Really nice and helpful

  • @phoenixkepo2743
    @phoenixkepo2743 2 роки тому +2

    Special forces selection training @ the cellular level. Amazing!

  • @tanmayatripathy3944
    @tanmayatripathy3944 4 роки тому

    superb sir....your context and describing style is mindblowing

  • @HarryPotter-vl3pc
    @HarryPotter-vl3pc 3 роки тому +2

    Woww... this really is awesome

  • @hope.pk1028
    @hope.pk1028 Місяць тому +1

    Infornative ! good job

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  Місяць тому

      Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

  • @hibakaleed387
    @hibakaleed387 3 роки тому +1

    Amazing video thank you so much

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому

      please share my channel link with your friends and help me to reach out big audiance

  • @partibhapanchal7030
    @partibhapanchal7030 2 роки тому +1

    Insightful video.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому +1

      Please share my channel link with your friends and help me to reach big audience

    • @partibhapanchal7030
      @partibhapanchal7030 2 роки тому +1

      @@animatedbiologywitharpan I'm on to it. Content might be available on sites but the way u delivered it making ur videos superb 👌.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому +1

      Thanks for the kind words

  • @Mchc167
    @Mchc167 3 роки тому +1

    This was very helpful thank you

  • @awestphal9602
    @awestphal9602 11 місяців тому +1

    The regeneration of the Thymus is a current topic. Particularly, the use of Russian bioregulators such as Vladonix (A-6) and Thymic Protein A. Teach us how we can regenerate the Thymus and overcome future illnesses. Apparently, there are scientific studies and experts supporting the regeneration of the Thymus.

  • @GauravKumar-fc7sr
    @GauravKumar-fc7sr 5 років тому +2

    Awesome sir,,,, all basic concepts clear 😘😘😘

  • @customking8467
    @customking8467 4 місяці тому +1

    Some much better than my lecturer

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 місяці тому

      here is immunology playlist for complete revision ua-cam.com/play/PLKtiwIJ8Q7rq77W7r4cXPrbhi_VpLWw8c.html&si=eafq-0lBBzfGLrAt

  • @youhani9459
    @youhani9459 Рік тому +1

    amazing video! Very well explained :D

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  Рік тому

      In order to make high quality content consistently, we need support from you. Please support us by using super thanks option. Super thanks icon is present below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for us.

  • @pranav6143
    @pranav6143 2 роки тому +2

    @Animated biology With arpan sir as it says the thymus will be inactive on adulthood,then how is the t lymphocytes matures in the adulthood time?
    Bcz the TCR(t cell receptors)forming on the T cell membrane are said to be specific to the pathogenic antigen(by the response of related specific genes like TAG 1 or TAG 2 genes).Isnt this process of new pathogen encounter to be happened in furthur phase of ones life,so then isnt the thymus need to be active for those specific kind of functioning related to T Lymphocyte development?
    So again,my qstn is is thymus active in adulthood,if not ,how the t cells are developed in adults?

    • @pranav6143
      @pranav6143 2 роки тому

      I got the answer sir,
      Bcz on t cell production itself diff types of TCR having diff t cells are produced.So during an infection ,the t cells having the tcr, ie compactable to those pathogen will get activated and do their function
      Isn't it sir?

    • @lunam7249
      @lunam7249 2 роки тому

      HIV attacts the thymus....the thymus is "said" to contract and shrink normally with age, however this is not as significant as the common medical knowedge believes

  • @triggerednj2709
    @triggerednj2709 2 роки тому +1

    Superb presentation

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому

      Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance
      I'm on facebook & Instagram as @animatedbiologywitharpan. Install the app to download notes and flash cards. instagram.com/invites/contact/?i=1p41h314q3fv8&
      You can support the channel by clicking on the super like icon below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for me

  • @sherbetstraw8605
    @sherbetstraw8605 3 роки тому +2

    sensational thank you

  • @mindspaceinvaderskibinhhon4465
    @mindspaceinvaderskibinhhon4465 2 роки тому +2

    Sorry but can someone please explain me more about the positve and negative selection when
    T cells are trained by the thymic epithelial cells? what is "MHC restriction" like? I need it for the coming test at school. If you know, guide me as soon as possible. Thank you so much

  • @gaurishah9086
    @gaurishah9086 4 роки тому +1

    Easy explanation, thank you

  • @vascofachada9774
    @vascofachada9774 7 місяців тому +1

    good job, thanks!

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  7 місяців тому

      Please share my channel link with your friends and help me to reach big audiance

  • @getitdone0010
    @getitdone0010 Рік тому

    Hi Sir,
    I think at 6:00 you indicated the alpha vs. Beta chain captions wrong to their respective pictures... wont B-chain will have VDJ-C and alpha chain will have VJ-C recombination pattern for genes. Please correct me if I am wrong.

  • @azkaarshad4773
    @azkaarshad4773 4 роки тому +1

    Thank u and may god bless u

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому +1

      Azka Arshad please share among your friends

    • @azkaarshad4773
      @azkaarshad4773 4 роки тому +1

      @@animatedbiologywitharpan OKAY and stay safe ,lots of respect from pakistan

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому

      @@azkaarshad4773 You also stay safe my brother . Love from India

    • @azkaarshad4773
      @azkaarshad4773 4 роки тому +1

      @@animatedbiologywitharpan Thank you so much umm i am a medical student and i am a girl.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому +1

      Ups sorry ....I called you brother....my bad... please share my channel link among your friends and help me to reach big audience

  • @africkinamerican
    @africkinamerican 3 роки тому +1

    Fascinating. How do the T cells know when /how to enter the bloodstream to travel to "school"?

    • @aaquib608
      @aaquib608 3 роки тому

      Thymic epithelial releases certain chemokines which attracts immature T cells towards Thymus.

  • @avantikachauhan1837
    @avantikachauhan1837 3 роки тому +1

    Thanku for explaining this well

  • @sobis6670
    @sobis6670 4 роки тому +1

    Thank you very helpful 👍

  • @roselinkitherik6972
    @roselinkitherik6972 2 роки тому +1

    Superb bro

  • @biancaelena6675
    @biancaelena6675 3 роки тому +1

    Nice explanation

  • @zzzsss00
    @zzzsss00 3 роки тому +2

    Can u please make a video what happens if u remove thymus gland and how would effect people after?

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому +1

      Adaptive 8mmune response would be compromised in short...i will make a video on that

    • @zzzsss00
      @zzzsss00 3 роки тому

      @@animatedbiologywitharpan thank you very much! Waiting for your video👍

    • @amandaczymbor281
      @amandaczymbor281 Рік тому

      Was a video made on this?

  • @biotechstudent8658
    @biotechstudent8658 2 роки тому +1

    First of all thank you for this video, but I should ask for one concept, the hematopoietic stem cells are multipotent stem cells as I read from the other articles and from my stem cell lessons, Can I ask that where is it available the information of the HSC cells are pluripotent stem cells ?

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому

      Kuby immunology 7th ed (not 6th ) chapter 2 or you can refer to revire article. Pdf of the book is there in pdfdrive

  • @muntakaalhassan959
    @muntakaalhassan959 4 роки тому +1

    Thank you very much

  • @biologylover1565
    @biologylover1565 4 роки тому +1

    Hematopoietic multipotent stem cell found in bone marrow.
    So it is multipotent stem cell able to give all cell of same linage of blood cell.

    • @millbankowusuemmanuel4572
      @millbankowusuemmanuel4572 4 роки тому

      Yes, it's the basic pluripotent cell that differentiates depending on the chemical signal received from the body for specific demands

  • @s.papadatos6711
    @s.papadatos6711 2 роки тому +1

    Well explained, however the β chain is the one that has D genes, not the α.

  • @arindampaul5256
    @arindampaul5256 3 роки тому

    Best understood this topic

  • @backbenchersbio3688
    @backbenchersbio3688 5 років тому

    Thank u sr
    My immuno is not so strong but after watching this vdo t cell maturation is totally cleared
    Sr make vdos on b cell maturation also

  • @gilbertgrejp
    @gilbertgrejp 3 роки тому +1

    Sorry, my Histology book says no HEV in the thymus. Only in lymph nodes and MALT/GALT/BALT

  • @ToniDJohns
    @ToniDJohns 4 роки тому +2

    wow ! Thank you !

  • @bidhisingh9982
    @bidhisingh9982 5 років тому +1

    great exp sir

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  5 років тому +1

      Good.... glad to hear that you guys are liking it... please share among your friends and help me to reach big audience

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  5 років тому +1

      And I am not sir .... I am one of you guys

  • @madhurabanerjee1965
    @madhurabanerjee1965 3 роки тому +1

    Owo u aktually made my doubt clear

  • @knowledgejunction1643
    @knowledgejunction1643 5 років тому +2

    Dear brother arpan yr content r amazing and also teaching but if u want more and more subc , share and populality then pls make video in also hindi language; next as u wish

  • @somid7777
    @somid7777 Рік тому +1

    I loved this video! However i thought VDJ was for B chain and VJ was alpha chain

  • @joesteinwold5782
    @joesteinwold5782 2 роки тому +1

    Can the t-cells from the bone marrow grow the thymus?

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому

      The mature in the thymus but are born in bone marrow. They can't be born in the thymus because thymus don't have the stem cells that produce t cells

  • @chtatarrachid2443
    @chtatarrachid2443 Рік тому +1

    Thanks

  • @mdshahjahan618
    @mdshahjahan618 Рік тому +1

    How to easily improve our body T- cell,plz suggested me.?

  • @RaviKumar-sb4bp
    @RaviKumar-sb4bp 3 роки тому +2

    Helpfull

  • @paulchang8743
    @paulchang8743 4 роки тому +1

    whether negative selection happens in the thymic medullary region?
    by interacting with medullary thymic epithelial cell (mTEC)

    • @johnnielee5618
      @johnnielee5618 4 роки тому

      Please see wiki "thymus". Positive in cortex; negative in medulla. Knowledge should be shared. Good luck.

  • @bio366geethasankar7
    @bio366geethasankar7 6 місяців тому +2

    🙏🏻🙏💖

  • @HatiKeseorangan
    @HatiKeseorangan 2 роки тому +1

    Like ... Wow !!! What happen on this earth... WBC not the one who stop the symbiosis, but thymus....

  • @halima2953
    @halima2953 3 роки тому +1

    For one Tcell and after TCR genes rearrangement will there be MANY types of TCRs or a single type of it which could be ( Alpha, Beta )or (gamma, Delta)

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому +1

      One tcr type should be found in a particular T cell.. because after tcr vdj recombination one particular type is formed. But in a population of T cell we can find diversity of TCR

    • @halima2953
      @halima2953 3 роки тому

      @@animatedbiologywitharpan ok I got it now thanks for replying

  • @DarshiniMB-dc4hi
    @DarshiniMB-dc4hi 9 днів тому +1

    Can it be possibly to get the slides

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  9 днів тому

      @@DarshiniMB-dc4hi you can buy it @250₹ or 3$, if interested email us at arpanparichha1994@gmail.com

  • @snowy2875
    @snowy2875 2 роки тому +1

    I think you should tell us, how to increase the amount of t cell in my body that would be more practical.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 роки тому

      Diet is the most important thing for that. You can watch the following video to get an idea ua-cam.com/video/wf20Gu1y1_o/v-deo.html

    • @snowy2875
      @snowy2875 2 роки тому +1

      @@animatedbiologywitharpan Thanks buddy!!!!!

  • @ritahtezra1386
    @ritahtezra1386 3 роки тому +1

    At what point are the RAG genes involved

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому

      ua-cam.com/video/yc3uW6rr9lM/v-deo.html rag Gene's are essential for tcr receptor vdj recombination. Watch this video to know more

  • @studyonline-kz1gf
    @studyonline-kz1gf 2 місяці тому +1

    Thymic epithelial cells teacher of T Lymphocytes

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 місяці тому

      Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

  • @studyonline-kz1gf
    @studyonline-kz1gf 2 місяці тому +1

    Myeloid progenitor and lymphoid progenitor

  • @xianjia9372
    @xianjia9372 2 роки тому +1

    Pretty slides

  • @missesCarmenB
    @missesCarmenB 3 роки тому +1

    The living cell, the True God's creation in my opinion. So wonderfully intelligent in ALL living beings. The rest is all about Evolution.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 роки тому +1

      I agree with your point

    • @missesCarmenB
      @missesCarmenB 3 роки тому +1

      @@animatedbiologywitharpan I was 19 in my first year studying biochemistry, this has been my "religion" ever since as it is the only thing that makes sense to me. I've never cared if anyone agrees with me or not, I avoided talking about it realizing that most friends or relatives will not understand. Thank you so much for agreeing with me.

  • @immadisarojini2775
    @immadisarojini2775 3 роки тому +1

    Nice

  • @studyonline-kz1gf
    @studyonline-kz1gf 2 місяці тому +1

    Innate immune systems and adaptive immune system

  • @studyonline-kz1gf
    @studyonline-kz1gf 2 місяці тому +1

    Hematopoietic pluripotent stem cell

  • @MehediHasan-gy8uz
    @MehediHasan-gy8uz Рік тому +1

    Book reference??????

  • @meghashreeguha99
    @meghashreeguha99 Рік тому +1

    ❤❤

  • @kvnkvn9191
    @kvnkvn9191 3 роки тому +1

    I can see you learnd this from kuby

  • @kunalgaurav5181
    @kunalgaurav5181 4 роки тому +1

    U r teaching is 👍!! But why u are faking your accent?🙄

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 роки тому

      As I have spent a long time abroad I have developed this accent ..... cant help it ...any way thanks for the feed back ..please share among friends

  • @studyonline-kz1gf
    @studyonline-kz1gf 2 місяці тому +1

    T cells - bone marrow

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 місяці тому

      i am not understanding the point of these comments, could you please explain ?

  • @youtubeyoutube5887
    @youtubeyoutube5887 3 роки тому +1

    Why you are using fake accent otherwise it is good

  • @studyonline-kz1gf
    @studyonline-kz1gf 2 місяці тому +1

    T cell

  • @teleportvalorant7658
    @teleportvalorant7658 3 роки тому +16

    Hi everyone.If you read this message please read the Holy Quran the direct words and the final message from Almighty God.Ut will guide you to peace truth and happiness in this world and the afterworld with my lovely wishes