MHC 1 vs. MHC 2, T-Cell Activation, T-Cell Differentiation

[@chandanasumesh]

i literally have an exam for this on monday and was scouring through your videos for some sort of assistance! thank you for being such a saviour for us medical students :) this video fell from heaven please keep it up!!

[@Pinkluvrgirl]

These are so helpful, I’ve always struggled with immuno. Thank you for breaking it down!! Looking forward to the rest of the series!!!

[@noorfatimaamjad9997]

this vid is literally an answered prayer. thanks sm

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OMG YESSS I was looking for topic today and couldnt find a good video about it thank youuuu

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SPENT THE WHOLE DAY TRYING TO MAKE SENSE OF THIS FROM FIRST AID, ONLY TO COME TO UA-cam SEVERAL HOURS LATER TO FIND THAT DIRTY HAS A VIDEO ON IT!😭 Anyway, better late than never. Thanks, Dirty. I love you.

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I've been struggling so bad with immunology. Thank you so much!

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Agreed with all the positive comments. I have subscribed, liked, and shared (and commented).

[@tamilspeaker2507]

Please we need some of immunology complicated topics from you

[@amandaeidsnes8296]

this was really useful, thank you!

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Dude. So simple. Thank you!!

[@bricek.371]

Is there a playlist for Immunology?

[@DirtyMedicine]

This is the start of it

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@DirtyMedicine Thank You 🙏🏾

[@MrRandomPerson20]

for costimulatory B7-CD28, that would be involved in activating both t-cells right, CD4 and 8? and for granuloma formation, isn't it that Macrophages release TNF-alpha that forms the granuloma?
from my understanding of granulomas (feel free to correct):
-An APC presents an Antigen via MHC2 to CD4 and activates it. APC releases IL-12 to differentiate the CD4 into a Th1.
- Th1 secretes TNFalpha and IFNgamma which helps activates the Macrophages.
- Activated Macropahge tries to ingest the pathogen (ie TB). Fails to do so. Macrophages release TNFalpha.
- TNFalpha helps form the granuloma

[@lizkendra1349]

yeah also read that B7-CD28 costimulation is involved in both CD4 and CD8

[@zashakarchi]

@@lizkendra1349 @dirtymedicine NBME 27 Section 4 Questions 46 says MHC 1 with Cytotoxic T cells does not require B7 and CD 28 costimulatory signal. Instead, CD8+ T-cell activation often involves additional cytokine signals or stimulation from activated CD4+ helper T cells.
From what I understand and the somehow the diagrams do not comply with Amboss library media which indicates both classes working together and/or NBME Explanation. Please, help me clarify.

[@lizkendra1349]

thank you so much, please could we get full series? seriously struggling with immuno, you're a lifesaver, please how do we support ur channell??

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You can sign up to become a “member” and support the channel with a monthly contribution directly through UA-cam/google

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